MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Gene	Rank	description	Value Type	Interaction Map	Network Comparison Type	Filtered	green	red	network_comparison

Results: HTML CSV LaTeX

Showing element 2551 to 2600 of 3228 in total

Value Type  : Ranked
Interaction Map  : High confidence
Network Comparison Type  : Divided
Filtered  : 1

Rank	description	green	red	network_comparison
2551	fructose-1,6-bisphosphatase isozyme 2 (ec 3.1.3.11) (d-fructose-1,6- bisphosphate 1-phosphohydrolase) (fbpase). [swissprot;acc:o00757]	210.148	209.766	1.00182
2552	testis-specific chromodomain y protein 1. [swissprot;acc:q9y6f8]	193.467	193.12	1.0018
2553	chromodomain protein, y chromosome-like isoform a; cdy-like, autosomal; testis-specific chromodomain y-like protein. [refseq;acc:nm_004824]
2554	testis-specific chromodomain protein y protein 2. [swissprot;acc:q9y6f7]
2555	s-adenosylmethionine synthetase gamma form (ec 2.5.1.6) (methionine adenosyltransferase) (adomet synthetase) (mat-ii). [swissprot;acc:p31153]	212.572	212.953	1.00179
2556	chromodomain y-like protein 2. [refseq;acc:nm_152342]	193.46	193.119	1.00177
2557	elongation factor 2 (ef-2). [swissprot;acc:p13639]	223.047	222.658	1.00175
2558	metabotropic glutamate receptor 2 precursor (mglur2). [swissprot;acc:q14416]
2559	metabotropic glutamate receptor 3 precursor (mglur3). [swissprot;acc:q14832]
2560	monoglyceride lipase; lysophospholipase-like. [refseq;acc:nm_007283]	202.042	202.395
2561	fructose-1,6-bisphosphatase (ec 3.1.3.11) (d-fructose-1,6-bisphosphate 1-phosphohydrolase) (fbpase). [swissprot;acc:p09467]	210.18	209.825	1.00169
2562	glycogenin-1 (ec 2.4.1.186). [swissprot;acc:p46976]	208.779	208.429	1.00168
2563	adenosine kinase (ec 2.7.1.20) (ak) (adenosine 5'-phosphotransferase). [swissprot;acc:p55263]
2564	protein x 0001. [refseq;acc:nm_016302]
2565	glycogenin-2 (ec 2.4.1.186) (gn-2) (gn2). [swissprot;acc:o15488]
2566	serine/threonine protein kinase 12 (ec 2.7.1.37) (aurora- and ipl1- like midbody-associated protein 1) (aim-1) (aurora/ipl1-related kinase 2) (aurora-related kinase 2) (stk-1) (aurora-b). [swissprot;acc:q96gd4]	220.267	219.907	1.00164
2567	kinesin-like protein kif23 (mitotic kinesin-like protein-1) (kinesin- like protein 5). [swissprot;acc:q02241]
2568	serine/threonine protein kinase 13 (ec 2.7.1.37) (aurora/ipl1/eg2 protein 2) (aurora/ipl1-related kinase 3) (aurora-c). [swissprot;acc:q9uqb9]
2569	serine/threonine kinase 6 (ec 2.7.1.37) (serine/threonine kinase 15) (aurora/ipl1-related kinase 1) (aurora-related kinase 1) (hark1) (aurora-a) (breast-tumor-amplified kinase). [swissprot;acc:o14965]
2570	cylindromatosis (turban tumor syndrome); cylindromatosis 1, turban tumor syndrome. [refseq;acc:nm_015247]
2571	protein-tyrosine phosphatase, non-receptor type 1 (ec 3.1.3.48) (protein-tyrosine phosphatase 1b) (ptp-1b). [swissprot;acc:p18031]	209.205	209.549
2572	transcription initiation factor tfiid 20/15 kda subunits (tafii- 20/tafii-15) (tafii20/tafii15). [swissprot;acc:q16514]	204.285	203.953	1.00163
2573	peroxiredoxin 4 (ec 1.11.1.-) (prx-iv) (thioredoxin peroxidase ao372) (thioredoxin-dependent peroxide reductase a0372) (antioxidant enzyme aoe372) (aoe37-2). [swissprot;acc:q13162]	213.005	213.347	1.00161
2574	swi/snf-related matrix-associated actin-dependent regulator of chromatin c1; mammalian chromatin remodeling complex brg1-associated factor 155; swi/snf complex 155 kda subunit; chromatin remodeling complex baf155 subunit. [refseq;acc:nm_003074]	219.667	220.016	1.00159
2575	protein-tyrosine phosphatase, non-receptor type 2 (ec 3.1.3.48) (t- cell protein-tyrosine phosphatase) (tcptp). [swissprot;acc:p17706]	209.255	209.583	1.00157
2576	beta-1-syntrophin (59 kda dystrophin-associated protein a1, basic component 1) (dapa1b) (tax interaction protein 43) (tip-43) (syntrophin 2) (bsyn2). [swissprot;acc:q13884]	213.75	213.422	1.00154
2577	ca2+-dependent endoplasmic reticulum nucleoside diphosphatase; apyrase; soluble calcium-activated nucleotidase scan-1. [refseq;acc:nm_138793]	192.922	192.625
2578	beta-2-syntrophin (59 kda dystrophin-associated protein a1, basic component 2) (syntrophin 3) (snt3) (syntrophin-like) (sntl). [swissprot;acc:q13425]	213.75	213.422
2579	nitrilase 1. [refseq;acc:nm_005600]
2580	utrophin (dystrophin-related protein 1) (drp1) (drp). [swissprot;acc:p46939]
2581	dystrobrevin beta (beta-dystrobrevin) (dtn-b). [swissprot;acc:o60941]	213.756	213.428
2582	lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial precursor (ec 2.3.1.-) (e2) (dihydrolipoamide branched chain transacylase) (bckad e2 subunit). [swissprot;acc:p11182]	213.75	213.422
2583	dystrobrevin alpha (dystrobrevin-alpha). [swissprot;acc:q9y4j8]	213.743	213.415
2584	dystrophin. [swissprot;acc:p11532]	213.75	213.422
2585	angiomotin. [refseq;acc:nm_133265]
2586	angiomotin like 2; leman coiled-coil protein; angiomotin-like protein 2. [refseq;acc:nm_016201]
2587	alpha-1-syntrophin (59 kda dystrophin-associated protein a1, acidic component 1) (pro-tgf-alpha cytoplasmic domain-interacting protein 1) (tacip1) (syntrophin 1). [swissprot;acc:q13424]
2588	60 kda heat shock protein, mitochondrial precursor (hsp60) (60 kda chaperonin) (cpn60) (heat shock protein 60) (hsp-60) (mitochondrial matrix protein p1) (p60 lymphocyte protein) (hucha60). [swissprot;acc:p10809]	222.64	222.305	1.00151
2589	membrane protein expressed in epithelial-like lung adenocarcinoma. [refseq;acc:nm_024792]	212.422	212.74	1.0015
2590	proteasome subunit alpha type 6 (ec 3.4.25.1) (proteasome iota chain) (macropain iota chain) (multicatalytic endopeptidase complex iota chain) (27 kda prosomal protein) (pros-27) (p27k). [swissprot;acc:p34062]	214.287	214.605	1.00148
2591	polybromo 1. [refseq;acc:nm_018165]	219.696	220.02	1.00147
2592	swi/snf-related matrix-associated actin-dependent regulator of chromatin a5; sucrose nonfermenting-like 5. [refseq;acc:nm_003601]
2593	possible global transcription activator snf2l4 (snf2-beta) (brg-1 protein) (mitotic growth and transcription activator) (brahma protein homolog 1). [swissprot;acc:p51532]
2594	possible global transcription activator snf2l1. [swissprot;acc:p28370]
2595	tbp-associated factor 172 (taf-172) (taf(ii)170). [swissprot;acc:o14981]
2596	possible global transcription activator snf2l2 (snf2-alpha). [swissprot;acc:p51531]
2597	ran binding protein 11. [refseq;acc:nm_016338]	212.401	212.711	1.00146
2598	transcription initiation factor tfiid 100 kda subunit (tafii-100) (tafii100). [swissprot;acc:q15542]	202.436	202.142	1.00145
2599	ba207c16.2 (fragment). [sptrembl;acc:q9nql7]	211.361	211.662	1.00142
2600	interferon-related developmental regulator 2 (skmc15 protein). [swissprot;acc:q12894]	225.193	224.877	1.00141

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.