MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	description	Hugo	Value Type	Network Comparison Type	Interaction Map	red	Filtered	green	network_comparison

Results: HTML CSV LaTeX

Showing element 1025 to 1074 of 8289 in total

Value Type  : Ranked
Network Comparison Type  : Divided
Filtered  : 1

Rank	description	Hugo	Interaction Map	red	green	network_comparison
513	myoglobin. [swissprot;acc:p02144]	no value	Low confidence	205.157	198.715	1.03242
	segment polarity protein dishevelled homolog dvl-1 (dishevelled-1) (dsh homolog 1). [swissprot;acc:o14640]	DVL1	High confidence	218.596	204.344	1.06975
514	hemoglobin theta-1 chain. [swissprot;acc:p09105]	HBQ1	Low confidence	205.157	198.715	1.03242
	segment polarity protein dishevelled homolog dvl-2 (dishevelled-2) (dsh homolog 2). [swissprot;acc:o14641]	DVL2	High confidence	218.613	204.382	1.06963
515	pescadillo homolog 1. [swissprot;acc:o00541]	PES1		251.297	234.941	1.06962
	tweety homolog 1; tweety homolog. [refseq;acc:nm_020659]	TTYH1	Low confidence	205.156	198.715	1.03241
516	cytoglobin (histoglobin) (hgb) (stellate cell activation-associated protein). [swissprot;acc:q8wwm9]	CYGB
	u6 snrna-associated sm-like protein lsm8. [swissprot;acc:o95777]	LSM8	High confidence	228.255	213.422	1.0695
517	forkhead box protein o3a (forkhead in rhabdomyosarcoma-like 1) (af6q21 protein). [swissprot;acc:o43524]	FOXO3	Low confidence	205.156	198.715	1.03241
	metaxin 2. [swissprot;acc:o75431]	MTX2	High confidence	219.537	234.793	1.06949
518	amyloid-like protein 2 precursor (amyloid protein homolog) (apph) (cdei-box binding protein) (cdebp). [swissprot;acc:q06481]	APLP2	Low confidence	205.156	198.715	1.03241
	nucleostemin; putative nucleotide binding protein, estradiol-induced. [refseq;acc:nm_014366]	GNL3	High confidence	250.858	234.563	1.06947
519	sam-domain protein samsn-1 (sam domain, sh3 domain and nuclear localisation signals protein 1). [swissprot;acc:q9nsi8]	SAMSN1	Low confidence	204.278	210.893	1.03238
	segment polarity protein dishevelled homolog dvl-3 (dishevelled-3) (dsh homolog 3). [swissprot;acc:q92997]	DVL3	High confidence	218.702	204.582	1.06902
520	glycogenin-1 (ec 2.4.1.186). [swissprot;acc:p46976]	GYG1	Low confidence	200.014	193.745	1.03236
	sqv-7-like protein (fragment). [sptrembl;acc:o95454]	SLC35D2	High confidence	214.754	229.565	1.06897
521	arg/abl-interacting protein 2 isoform 2; arg binding protein 2. [refseq;acc:nm_021069]	SORBS2	Low confidence	205.451	199.011	1.03236
	exosome complex exonuclease rrp41 (ec 3.1.13.-) (ribosomal rna processing protein 41) (p12a). [swissprot;acc:q9npd3]	EXOSC4	High confidence	215.237	230.07	1.06891
522	pleiotropic regulator 1 (prl1homolog, arabidopsis); pleiotropic regulator 1 (prl1, arabidopsis homolog). [refseq;acc:nm_002669]	PLRG1		222.893	208.523
	sam and sh3 domain containing 1. [refseq;acc:nm_015278]	SASH1	Low confidence	204.276	210.886	1.03236
523	exosome complex exonuclease rrp4 (ec 3.1.13.-) (ribosomal rna processing protein 4). [swissprot;acc:q13868]	EXOSC2	High confidence	215.237	230.07	1.06891
	ring finger protein 7; sensitive to apoptosis gene. [refseq;acc:nm_014245]	RNF7	Low confidence	203.162	196.796	1.03235
524	exosome complex exonuclease rrp40 (ec 3.1.13.-) (ribosomal rna processing protein 40) (p10) (cgi-102). [swissprot;acc:q9nqt5]	EXOSC3	High confidence	215.237	230.07	1.06891
	solute carrier family 2, facilitated glucose transporter, member 11 (glucose transporter type 11) (glucose transporter type 10). [swissprot;acc:q9byw1]	SLC2A11	Low confidence	205.551	199.117	1.03231
525	exosome complex exonuclease rrp46 (ec 3.1.13.-) (ribosomal rna processing protein 46) (p12b) (chronic myelogenous leukemia tumor antigen 28). [swissprot;acc:q9nqt4]	EXOSC5	High confidence	215.237	230.07	1.06891
	solute carrier family 2, facilitated glucose transporter, member 5 (glucose transporter type 5, small intestine) (fructose transporter). [swissprot;acc:p22732]	SLC2A5	Low confidence	205.548	199.116	1.0323
526	nnp-1 protein (novel nuclear protein 1) (nucleolar protein nop52) (nop52) (d21s2056e). [swissprot;acc:p56182]	RRP1	High confidence	250.538	234.401	1.06884
	solute carrier family 2, facilitated glucose transporter, member 9 (glucose transporter type 9). [swissprot;acc:q9nrm0]	SLC2A9	Low confidence	205.549	199.117	1.0323
527	dead (asp-glu-ala-asp) box polypeptide 31 isoform 1; dead/dexh helicase ddx31. [refseq;acc:nm_022779]	DDX31	High confidence	248.56	232.579	1.06871
	eukaryotic translation initiation factor 5 (eif-5). [swissprot;acc:p55010]	EIF5	Low confidence	208.004	201.497	1.03229
528	solute carrier family 2, facilitated glucose transporter, member 2 (glucose transporter type 2, liver). [swissprot;acc:p11168]	SLC2A2		205.543	199.115	1.03228
	yme1-like 1 isoform 3; atp-dependent metalloprotease ftsh1 homolog. [refseq;acc:nm_014263]	YME1L1	High confidence	222.146	237.393	1.06864
529	atp-dependent rna helicase ddx18 (dead-box protein 18) (myc-regulated dead-box protein) (mrdb). [swissprot;acc:q9nvp1]	DDX18		251.653	235.506	1.06856
	zinc finger protein 183-like 1. [refseq;acc:nm_178861]	RNF113B	Low confidence	205.116	198.702	1.03228
530	solute carrier family 2, facilitated glucose transporter, member 3 (glucose transporter type 3, brain). [swissprot;acc:p11169]	no value		205.541	199.114
	u6 snrna-associated sm-like protein lsm6 (sm protein f). [swissprot;acc:q9y4y8]	LSM6	High confidence	227.483	212.994	1.06803
531	nuclear matrix protein nmp200 related to splicing factor prp19. [refseq;acc:nm_014502]	PRPF19		223.356	209.149	1.06793
	solute carrier family 2, facilitated glucose transporter, member 4 (glucose transporter type 4, insulin-responsive). [swissprot;acc:p14672]	SLC2A4	Low confidence	205.54	199.114	1.03227
532	glucose transporter 14. [refseq;acc:nm_153449]	SLC2A14		205.541	199.115
	zinc finger-like protein 9. [refseq;acc:nm_033414]	ZNF622	High confidence	250.942	235.004	1.06782
533	membrane-associated transporter protein (aim-1 protein) (melanoma antigen aim1). [swissprot;acc:q9umx9]	SLC45A2
	solute carrier family 2, facilitated glucose transporter, member 1 (glucose transporter type 1, erythrocyte/brain) (hepg2 glucose transporter). [swissprot;acc:p11166]	SLC2A1	Low confidence	205.533	199.112	1.03225
534	guanine nucleotide-binding protein-like 1 (gtp-binding protein hsr1). [swissprot;acc:p36915]	no value	High confidence	250.942	235.004	1.06782
	zinc finger protein 216. [swissprot;acc:o76080]	ZFAND5	Low confidence	184.361	178.613	1.03218
535	dna-directed rna polymerases i, ii, and iii 17.1 kda polypeptide (ec 2.7.7.6) (rpb17) (rpb8) (rpabc3). [swissprot;acc:p52434]	POLR2H	High confidence	236.662	252.708	1.0678
	protein associated with prk1. [refseq;acc:nm_019006]	ZFAND6	Low confidence	184.361	178.613	1.03218
536	lupus la protein (sjogren syndrome type b antigen) (ss-b) (la ribonucleoprotein) (la autoantigen). [swissprot;acc:p05455]	SSB	High confidence	242.531	227.136	1.06778
	ran binding protein 9; novel centrosomal protein ranbpm; ran binding protein, centrosomal. [refseq;acc:nm_005493]	RANBP9	Low confidence	203.519	197.195	1.03207
537	megf11 protein. [refseq;acc:nm_032445]	MEGF11		207.951	201.517	1.03193
	putative pre-mrna splicing factor rna helicase (deah box protein 15) (atp-dependent rna helicase #46). [swissprot;acc:o43143]	DHX15	High confidence	229.803	215.301	1.06736

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.