MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

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Value Type	Gene	description	Rank	Interaction Map	Network Comparison Type	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 1230 to 1279 of 3228 in total

Value Type  : Ranked
Interaction Map  : High confidence
Network Comparison Type  : Divided
Filtered  : 1

description	Rank	red	green	network_comparison
heat-shock 20 kda like-protein p20. [swissprot;acc:o14558]	3225	0.00001	0.00001	1
heat-shock protein, beta-2 (hspb2) (dmpk-binding protein) (mkbp). [swissprot;acc:q16082]	2824
hect domain containing protein 1 (fragment). [swissprot;acc:q9ult8]	586	237.28	252.492	1.06411
hect type e3 ubiquitin ligase. [refseq;acc:nm_015052]	1171	219.399	213.784	1.02626
helicase (fragment). [sptrembl;acc:q92771]	1719	187.204	189.679	1.01322
hemk protein homolog (ec 2.1.1.-) (m.hsahemkp). [swissprot;acc:q9y5r4]	765	229.045	218.343	1.04901
heparan sulfate 6-o-sulfotransferase 2. [refseq;acc:nm_147174]	1534	228.419	232.376	1.01732
heparan sulfate 6-o-sulfotransferase; heparan-sulfate 6-sulfotransferase. [refseq;acc:nm_004807]	1535
heparan sulfate d-glucosaminyl 3-o-sulfotransferase 2; heparin-glucosamine 3-o-sulfotransferase. [refseq;acc:nm_006043]	263	219.421	196.978	1.11394
heparan sulfate d-glucosaminyl 3-o-sulfotransferase 3a1; heparin-glucosamine 3-o-sulfotransferase. [refseq;acc:nm_006042]	261
heparan sulfate d-glucosaminyl 3-o-sulfotransferase 3b1. [refseq;acc:nm_006041]	262
heparan sulfate n-deacetylase/n-sulfotransferase (ec 2.8.2.8) (n-hsst) (hsnst) ([heparan sulfate]-glucosamine n-sulfotransferase) (n-heparan sulfate sulfotransferase) (glucosaminyl n-deacetylase/n- sulfotransferase). [swissprot;acc:p52848]	1356	228.409	223.475	1.02208
heparin sulfate n-deacetylase/n-sulfotransferase (ec 2.8.2.-) (n- hsst) (n-heparin sulfate sulfotransferase) (glucosaminyl n- deacetylase/n-sulfotransferase). [swissprot;acc:p52849]	1353
hepatitis c virus core-binding protein 6; cervical cancer oncogene 3. [refseq;acc:nm_023934]	2488	194.527	195.08	1.00284
hepatocellular carcinoma susceptibility protein; x 003 protein; hdcmc29p; hspc260; likely ortholog of mouse cd40 ligand-activated specific transcript 3 (clast3). [refseq;acc:nm_020232]	2379	212.724	213.574	1.004
hepatocellular carcinoma-associated protein hca1. [refseq;acc:nm_020932]	88	88.2482	110.265	1.24949
hepatocellular carcinoma-associated protein hca3. [refseq;acc:nm_138703]	84
hepatocyte growth factor-regulated tyrosine kinase substrate; human growth factor-regulated tyrosine kinase substrate. [refseq;acc:nm_004712]	2749	190.522	190.496	1.00014
hepatocyte nuclear factor 3-alpha (hnf-3a) (forkhead box protein a1). [swissprot;acc:p55317]	1605	217.322	213.916	1.01592
hepatocyte nuclear factor 3-beta (hnf-3b) (forkhead box protein a2). [swissprot;acc:q9y261]	1614	217.233	213.897	1.0156
hepatocyte nuclear factor 3-gamma (hnf-3g) (forkhead box protein a3) (fork head-related protein fkh h3). [swissprot;acc:p55318]	1528	217.785	214.021	1.01759
hepatocyte nuclear factor 4-alpha (hnf-4-alpha) (transcription factor hnf-4) (transcription factor 14). [swissprot;acc:p41235]	1115	251.863	258.829	1.02766
hepatocyte nuclear factor 4-gamma (hnf-4-gamma). [swissprot;acc:q14541]	1112
hepatoma-derived growth factor (hdgf) (high-mobility group protein 1- like 2) (hmg-1l2). [swissprot;acc:p51858]	835	231.734	222.222	1.0428
hepatoma-derived growth factor-related protein 2. [refseq;acc:nm_032631]	831
heterogeneous nuclear ribonucleoprotein a1 (helix-destabilizing protein) (single-strand binding protein) (hnrnp core protein a1). [swissprot;acc:p09651]	2129	221.248	222.788	1.00696
heterogeneous nuclear ribonucleoprotein a3 (hnrnp a3) (d10s102). [swissprot;acc:p51991]	2121
heterogeneous nuclear ribonucleoprotein f (hnrnp f). [swissprot;acc:p52597]	1858	217.893	215.545	1.01089
heterogeneous nuclear ribonucleoprotein h (hnrnp h). [swissprot;acc:p31943]	1859	217.895	215.547
heterogeneous nuclear ribonucleoprotein h' (hnrnp h') (ftp-3). [swissprot;acc:p55795]	1860
heterogeneous nuclear ribonucleoprotein h3 (hnrnp h3) (hnrnp 2h9). [swissprot;acc:p31942]	1856	217.892	215.543	1.0109
heterogeneous nuclear ribonucleoprotein k (hnrnp k) (dc-stretch binding protein) (csbp) (transformation upregulated nuclear protein) (tunp). [swissprot;acc:q07244]	872	224.413	233.272	1.03948
heterogeneous nuclear ribonucleoprotein l (hnrnp l). [swissprot;acc:p14866]	1041	186.774	181.099	1.03134
heterogeneous nuclear ribonucleoprotein m (hnrnp m). [swissprot;acc:p52272]	367	234.146	256.627	1.09601
heterogeneous nuclear ribonucleoprotein r (hnrnp r). [swissprot;acc:o43390]	250	237.302	212.41	1.11719
heterogeneous nuclear ribonucleoproteins a2/b1 (hnrnp a2 / hnrnp b1). [swissprot;acc:p22626]	2134	221.248	222.788	1.00696
heterogenous nuclear ribonucleoprotein u (hnrnp u) (scaffold attachment factor a) (saf-a). [swissprot;acc:q00839]	482	237.109	254.667	1.07405
hexaprenyldihydroxybenzoate methyltransferase, mitochondrial precursor (ec 2.1.1.114) (dihydroxyhexaprenylbenzoate methyltransferase) (3,4- dihydroxy-5-hexaprenylbenzoate methyltransferase) (dhhb methyltransferase) (dhhb-mt) (dhhb-mtase). [swissprot;acc:q9nzj6]	2021	208.601	210.464	1.00893
high mobility group protein 1 (hmg-1). [swissprot;acc:p09429]	2989	0.00001	0.00001	1
high mobility group protein 1-like 10 (hmg-1l10). [swissprot;acc:q9ugv6]	3144
high mobility group protein 2 (hmg-2). [swissprot;acc:p26583]	2856
high mobility group protein 4 (hmg-4) (high mobility group protein 2a) (hmg-2a). [swissprot;acc:o15347]	3203
high mobility group protein 4-like (hmg-4l). [swissprot;acc:q9uj13]	2787
high-affinity cgmp-specific 3',5'-cyclic phosphodiesterase 9a (ec 3.1.4.17). [swissprot;acc:o76083]	2876
high-glucose-regulated protein 8 (ny-ren-2 antigen). [swissprot;acc:q9y5a9]	2863
high-mobility group 20a. [refseq;acc:nm_018200]	125	208.588	171.778	1.21429
high-mobility group 20b; sox-like transcriptional factor; swi/snf-related matrix-associated actin-dependent regulator of chromatin subfamily e, member 1-related. [refseq;acc:nm_006339]	124	208.52	171.595	1.21519
highly expressed in cancer, rich in leucine heptad repeats. [refseq;acc:nm_006101]	440	231.802	249.983	1.07843
hira-interacting protein 5 (cgi-33). [swissprot;acc:q9ums0]	788	138.705	132.538	1.04653
histidine ammonia-lyase (ec 4.3.1.3) (histidase). [swissprot;acc:p42357]	2169	215.925	214.481	1.00673

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.