MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Value Type	description	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 510 to 559 of 6456 in total

Value Type  : Measured
Interaction Map  : High confidence
Filtered  : 1

Rank	description	Network Comparison Type	red	green	network_comparison
255	proto-oncogene tyrosine-protein kinase fgr (ec 2.7.1.112) (p55-fgr) (c-fgr). [swissprot;acc:p09769]	Divided	6417.18	7859.6	1.22477
256	grb2-related adaptor protein 2 (gads protein) (growth factor receptor binding protein) (grblg) (grf40 adaptor protein) (grf-40) (grb-2-like protein) (grb2l) (grbx) (p38) (hematopoietic cell-associated adaptor protein grpl) (adapter protein grid) (sh3-sh2-sh3 adaptor mona). [swissprot;acc:o75791]		6417.19	7859.51	1.22476
	max interacting protein 1 (mxi1 protein). [swissprot;acc:p50539]	Subtracted	4456.67	5773.77	1317.1
257	ccaat displacement protein (cdp) (cut-like 1). [swissprot;acc:p39880]	Divided	6417.31	7858.12	1.22452
	max-interacting transcriptional repressor mad4 (max-associated protein 4) (max dimerization protein 4). [swissprot;acc:q14582]	Subtracted	4456.93	5773.67	1316.74
258	homeobox protein cux-2 (cut-like 2) (fragment). [swissprot;acc:o14529]	Divided	6417.33	7857.93	1.22449
	max dimerization protein 3; likely ortholog of mouse max dimerization protein 3. [refseq;acc:nm_031300]	Subtracted	4457.06	5773.63	1316.57
259	neural wiskott-aldrich syndrome protein (n-wasp). [swissprot;acc:o00401]	Divided	6417.81	7852.52	1.22355
	small nuclear ribonucleoprotein sm d3 (snrnp core protein d3) (sm-d3). [swissprot;acc:p43331]	Subtracted	4569.48	5885.79	1316.31
260	cytidine triphosphate synthase ii; ctp synthetase type 2; utp-ammonia ligase; ctp synthetase isoform; cytidine 5'-triphosphate synthetase 2. [refseq;acc:nm_019857]		12515.4	11221.1	1294.3
	signal recognition particle 9 kda protein (srp9). [swissprot;acc:p49458]	Divided	4244.95	5193.42	1.22343
261			4247.36	5192.61	1.22255
	source of immunodominant mhc-associated peptides; homolog of yeast stt3 gene. [refseq;acc:nm_178862]	Subtracted	4571.89	5864.86	1292.97
262	cleavage and polyadenylation specific factor 4, 30kd subunit; cleavage-polyadenylation specificity factor, 30kd; no arches-like (zebrafish) zinc finger protein; cleavage-polyadenylation specificity factor. [refseq;acc:nm_006693]	Divided	24896.4	20431.7	1.21852
	oligosaccharyl transferase stt3 subunit homolog (b5) (integral membrane protein 1) (tmc). [swissprot;acc:p46977]	Subtracted	4571.89	5864.86	1292.97
263	dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kda subunit precursor (ec 2.4.1.119) (oligosaccharyl transferase 48 kda subunit) (ddost 48 kda subunit). [swissprot;acc:p39656]
	trs85 homolog. [swissprot;acc:q9y2l5]	Divided	24896.4	20431.7	1.21852
264	cop9 constitutive photomorphogenic homolog subunit 3; cop9 complex subunit 3; jab1-containing signalosome subunit 3. [refseq;acc:nm_003653]		4987.58	4094.57	1.2181
	ctp synthase (ec 6.3.4.2) (utp--ammonia ligase) (ctp synthetase). [swissprot;acc:p17812]	Subtracted	12503.3	11212	1291.3
265	splicing factor 3b subunit 1 (spliceosome associated protein 155) (sap 155) (sf3b155) (pre-mrna splicing factor sf3b 155 kda subunit). [swissprot;acc:o75533]		4638.1	5923.4	1285.3
	wd-repeat protein wdc146. [swissprot;acc:q9c0j8]	Divided	24806.9	20369.9	1.21782
266	cleavage and polyadenylation specificity factor, 160 kda subunit (cpsf 160 kda subunit). [swissprot;acc:q10570]
	solute carrier family 4 (anion exchanger), member 1, adaptor protein; kidney anion exchanger adaptor protein; kanadaptin; lung cancer oncogene 3. [refseq;acc:nm_018158]	Subtracted	11222.2	9948.93	1273.27
267	cyclin-dependent kinases regulatory subunit 2 (cks-2). [swissprot;acc:p33552]
	ral guanine nucleotide dissociation stimulator (ralgef) (ralgds). [swissprot;acc:q12967]	Divided	14021.4	11523	1.21682
268	catenin (cadherin-associated protein), alpha-like 1; alpha-catulin. [refseq;acc:nm_003798]	Subtracted	11222.2	9948.93	1273.27
	cleavage and polyadenylation specificity factor, 100 kda subunit (cpsf 100 kda subunit) (fragment). [swissprot;acc:q9p2i0]	Divided	24473.9	20127.8	1.21593
269	crk-associated substrate (p130cas) (breast cancer anti-estrogen resistance 1 protein). [swissprot;acc:p56945]	Subtracted	4808.79	6074.21	1265.42
	u6 snrna-associated sm-like protein lsm8. [swissprot;acc:o95777]	Divided	4590.18	5575.52	1.21466
270	fip1-like 1; rearranged in hypereosinophilia. [refseq;acc:nm_030917]		23640.2	19479.8	1.21358
	t-complex protein 1, delta subunit (tcp-1-delta) (cct-delta) (stimulator of tar rna binding). [swissprot;acc:p50991]	Subtracted	4810.22	6075.04	1264.82
271	chromatin accessibility complex protein 1 (chrac-1) (chrac-15) (huchrac15) (dna polymerase epsilon subunit p15). [swissprot;acc:q9nrg0]	Divided	2554.89	3093.78	1.21092
	enhancer of filamentation 1 (hef1) (crk-associated substrate-related protein) (cas-l) (casl) (pp105) (neural precursor cell expressed developmentally down-regulated 9). [swissprot;acc:q14511]	Subtracted	4812.01	6076.09	1264.08
272	histone acetyltransferase type b catalytic subunit (ec 2.3.1.48). [swissprot;acc:o14929]	Divided	3858.52	4669.27	1.21012
	nadh-ubiquinone oxidoreductase subunit b17.2 (ec 1.6.5.3) (ec 1.6.99.3) (complex i-b17.2) (ci-b17.2) (cib17.2) (13 kda differentiation-associated protein). [swissprot;acc:q9ui09]	Subtracted	1991.03	3221.38	1230.35
273	eukaryotic translation initiation factor 5 (eif-5). [swissprot;acc:p55010]	Divided	3199.4	3870.8	1.20985
	ribosomal protein s6 kinase, 52kda, polypeptide 1; ribosomal protein s6 kinase, 52kd, polypeptide 1. [refseq;acc:nm_012424]	Subtracted	5181.2	6410.58	1229.38
274	chromosome 3p21.1 gene sequence. [refseq;acc:nm_013286]	Divided	3119.98	2579.49	1.20953
	ribosomal protein s6 kinase-like 1. [refseq;acc:nm_031464]	Subtracted	5181.2	6410.58	1229.38
275	deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial precursor (ec 3.6.1.23) (dutpase) (dutp pyrophosphatase). [swissprot;acc:p33316]		10264.9	9043.51	1221.39
	regulator of g-protein signaling 19 (rgs19) (g-alpha interacting protein) (gaip protein). [swissprot;acc:p49795]	Divided	3119.98	2579.49	1.20953
276	gbp protein isoform a. [refseq;acc:nm_017870]	Subtracted	699.76	1894.39	1194.63
	putative rna-binding protein 15 (rna binding motif protein 15) (one-twenty two protein). [swissprot;acc:q96t37]	Divided	3119.98	2579.49	1.20953
277	mitochondrial import receptor subunit tom20 homolog (mitochondrial 20 kda outer membrane protein) (outer mitochondrial membrane receptor tom20). [swissprot;acc:q15388]	Subtracted	8600.02	9792.49	1192.47
	regulator of g-protein signaling 20 (rgs20) (regulator of gz- selective protein signaling 1) (gz-selective gtpase-activating protein) (g(z)gap). [swissprot;acc:o76081]	Divided	3119.98	2579.49	1.20953
278	peroxisomal farnesylated protein (33 kda housekeeping protein) (peroxin 19). [swissprot;acc:p40855]	Subtracted	8600.02	9792.49	1192.47
	transcription factor lbx1. [swissprot;acc:p52954]	Divided	3119.98	2579.49	1.20953
279	mosaic protein lgn. [swissprot;acc:p81274]
	splicing factor 3b subunit 3 (spliceosome associated protein 130) (sap 130) (sf3b130) (pre-mrna splicing factor sf3b 130 kda subunit). [swissprot;acc:q15393]	Subtracted	4771.21	5961.43	1190.22
280	protein phosphatase 1, regulatory (inhibitor) subunit 14a; 17-kda pkc-potentiated inhibitory protein of pp1. [refseq;acc:nm_033256]		677.5	1865.5	1188

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.