MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	Network Comparison Type	description	Value Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 1 to 50 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

Rank	Hugo	Network Comparison Type	description	red	green	network_comparison
1	HLX	Subtracted	homeobox protein hlx1 (homeobox protein hb24). [swissprot;acc:q14774]	215	322	107
	UBAC1	Divided	putative glialblastoma cell differentiation-related; putative glialblastoma cell differentiation-related protein. [refseq;acc:nm_016172]	10	24	2.4
2	no value		mannosyl-oligosaccharide 1,2-alpha-mannosidase ib (ec 3.2.1.113) (processing alpha-1,2-mannosidase ib) (alpha-1,2-mannosidase ib) (mannosidase alpha class 1a member 2). [swissprot;acc:o60476]	15	28	1.86667
	HBS1L	Subtracted	hbs1-like. [refseq;acc:nm_006620]	215	322	107
3	PSCD1	Divided	cytohesin 1 (sec7 homolog b2-1). [swissprot;acc:q15438]	15	28	1.86667
	RINT1	Subtracted	rad50-interacting protein 1. [refseq;acc:nm_021930]	337	232	105
4	PSCD2	Divided	cytohesin 2 (arf nucleotide-binding site opener) (arno protein) (arf exchange factor). [swissprot;acc:q99418]	15	28	1.86667
	RHOBTB2	Subtracted	rho-related btb domain-containing protein 2 (deleted in breast cancer 2 gene protein) (p83). [swissprot;acc:q9byz6]	337	232	105
5	PSCD4	Divided	cytohesin 4. [swissprot;acc:q9uia0]	15	28	1.86667
	XAB1	Subtracted	xpa binding protein 1; mbd2 interactor protein; putative atp(gtp)-binding protein. [refseq;acc:nm_007266]	212	309	97
6	ATPBD1C		protein x 0004. [refseq;acc:nm_016301]
	PSCD3	Divided	cytohesin 3 (arf nucleotide-binding site opener 3) (arno3 protein) (general receptor of phosphoinositides 1) (grp1). [swissprot;acc:o43739]	15	28	1.86667
7	HLX		homeobox protein hlx1 (homeobox protein hb24). [swissprot;acc:q14774]	215	322	1.49767
	UFC1	Subtracted	protein cgi-126 (protein hspc155). [swissprot;acc:q9y3c8]	288.754	212.554	76.2
8	HBS1L	Divided	hbs1-like. [refseq;acc:nm_006620]	215	322	1.49767
	JPH3	Subtracted	junctophilin 3 (junctophilin type 3) (jp-3). [swissprot;acc:q8wxh2]	288	362	74
9	JPH2		junctophilin 2 (junctophilin type 2) (jp-2). [swissprot;acc:q9br39]
	XAB1	Divided	xpa binding protein 1; mbd2 interactor protein; putative atp(gtp)-binding protein. [refseq;acc:nm_007266]	212	309	1.45755
10	ATPBD1C		protein x 0004. [refseq;acc:nm_016301]
	SMPD2	Subtracted	sphingomyelin phosphodiesterase 2 (ec 3.1.4.12) (neutral sphingomyelinase) (nsmase) (n-smase) (lyso-platelet activating factor- phospholipase c) (lyso-paf-plc). [swissprot;acc:o60906]	288	362	74
11	RINT1	Divided	rad50-interacting protein 1. [refseq;acc:nm_021930]	337	232	1.45259
	TMEM33	Subtracted	db83 protein. [swissprot;acc:p57088]	288	362	74
12	no value		guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-7 subunit. [swissprot;acc:o60262]	266.856	336.233	69.377
	RHOBTB2	Divided	rho-related btb domain-containing protein 2 (deleted in breast cancer 2 gene protein) (p83). [swissprot;acc:q9byz6]	337	232	1.45259
13	GNG12	Subtracted	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-12 subunit. [swissprot;acc:q9ubi6]	266.856	336.233	69.377
	UFC1	Divided	protein cgi-126 (protein hspc155). [swissprot;acc:q9y3c8]	288.754	212.554	1.3585
14	ATG4A		cysteine endopeptidase aut-like 2 isoform a; autophagy-related cysteine endopeptidase 2; autophagin 2. [refseq;acc:nm_052936]	56.6768	75.3531	1.32952
	GNG4	Subtracted	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-4 subunit. [swissprot;acc:p50150]	266.863	336.191	69.328
15	GNG3		guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-3 subunit. [swissprot;acc:p29798]		336.19	69.327
	MAP1LC3B	Divided	microtubule-associated proteins 1a/1b light chain 3b (map1a/map1b lc3 b) (map1a/1b light chain 3 b). [swissprot;acc:q9gzq8]	56.7244	75.3948	1.32914
16	GNG8	Subtracted	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-8 subunit (gamma-9). [swissprot;acc:q9uk08]	266.864	336.184	69.32
	MAP1LC3A	Divided	microtubule-associated proteins 1a/1b light chain 3a (map1a/map1b lc3 a) (map1a/1b light chain 3 a). [swissprot;acc:q9h492]	56.7252	75.3954	1.32913
17	ATG4B		cysteine endopeptidase aut-like isoform b. [refseq;acc:nm_178326]	56.7841	75.447	1.32866
	GNG5	Subtracted	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-5 subunit. [swissprot;acc:p30670]	266.864	336.182	69.318
18	GBE1	Divided	1,4-alpha-glucan branching enzyme (ec 2.4.1.18) (glycogen branching enzyme) (brancher enzyme). [swissprot;acc:q04446]	185.678	245.247	1.32082
	GNG10	Subtracted	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-10 subunit. [swissprot;acc:p50151]	266.865	336.181	69.316
19	no value		guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-5 like subunit. [swissprot;acc:q9y3k8]		336.178	69.313
	PYGB	Divided	glycogen phosphorylase, brain form (ec 2.4.1.1). [swissprot;acc:p11216]	185.678	245.247	1.32082
20	GNG11	Subtracted	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-11 subunit. [swissprot;acc:p50152]	266.868	336.159	69.291
	PYGL	Divided	glycogen phosphorylase, liver form (ec 2.4.1.1). [swissprot;acc:p06737]	185.678	245.247	1.32082
21	MYO15A		myosin xv (unconventional myosin-15). [swissprot;acc:q9ukn7]
	TMEM132A	Subtracted	gbp protein isoform a. [refseq;acc:nm_017870]	325.586	256.492	69.094
22	PPP1R14A		protein phosphatase 1, regulatory (inhibitor) subunit 14a; 17-kda pkc-potentiated inhibitory protein of pp1. [refseq;acc:nm_033256]	322	253	69
	PYGM	Divided	glycogen phosphorylase, muscle form (ec 2.4.1.1) (myophosphorylase). [swissprot;acc:p11217]	185.678	245.247	1.32082
23	MFAP4	Subtracted	microfibril-associated glycoprotein 4 precursor. [swissprot;acc:p55083]	322	253	69
	MRPS17	Divided	28s ribosomal protein s17, mitochondrial precursor (mrp-s17) (hspc011). [swissprot;acc:q9y2r5]	58	44	1.31818
24	PANK1		pantothenate kinase 1 (ec 2.7.1.33) (pantothenic acid kinase 1) (hpank1) (hpank). [swissprot;acc:q8te04]
	PPP1R14D	Subtracted	protein phosphatase 1, regulatory subunit 14d; pkc-dependent pp1 inhibitory protein. [refseq;acc:nm_017726]	322	253	69
25	FCN2		ficolin 2 precursor (collagen/fibrinogen domain-containing protein 2) (ficolin-b) (ficolin b) (serum lectin p35) (ebp-37) (hucolin) (l- ficolin). [swissprot;acc:q15485]
	PANK2	Divided	pantothenate kinase 2, mitochondrial precursor (ec 2.7.1.33) (pantothenic acid kinase 2) (hpank2). [swissprot;acc:q9bz23]	58	44	1.31818

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.