MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 2908 to 2957 of 8289 in total

Value Type  : Ranked
Network Comparison Type  : Divided
Filtered  : 1

Rank	Hugo	description	Interaction Map	red	green	network_comparison
1454	SAP18	sin3 associated polypeptide p18 (2hor0202). [swissprot;acc:o00422]	High confidence	207.024	211.089	1.01964
1455	no value	cg4853 gene product. [refseq;acc:nm_145313]	Low confidence	203.116	198.823	1.02159
	EHD1	eh-domain containing protein 1 (testilin) (hpast1). [swissprot;acc:q9h4m9]	High confidence	207.024	211.085	1.01962
1456	EHD4	eh-domain containing protein 4 (eh domain-containing protein fksg7) (hepatocellular carcinoma-associated protein 10/11). [swissprot;acc:q9h223]			211.086
	RASGEF1B	gpi-gamma 4; likely ortholog of mouse gpi-gamma 4. [refseq;acc:nm_152545]	Low confidence	203.119	198.826	1.02159
1457	EHD2	eh-domain containing protein 2. [swissprot;acc:q9nzn4]	High confidence	207.024	211.086	1.01962
	WISP2	connective tissue growth factor-like protein precursor (ctgf-l) (wnt1 inducible signaling pathway protein 2) (wisp-2) (connective tissue growth factor-related protein 58). [swissprot;acc:o76076]	Low confidence	208.154	203.755	1.02159
1458	ARL6IP1	arl-6 interacting protein-1 (aip-1). [swissprot;acc:q15041]		201.463	197.207	1.02158
	EHD3	eh-domain containing protein 3. [swissprot;acc:q9nzn3]	High confidence	207.024	211.086	1.01962
1459	CSE1L	importin-alpha re-exporter (chromosome segregation 1-like protein) (cellular apoptosis susceptibility protein). [swissprot;acc:p55060]		192.336	188.637	1.01961
	SLC37A1	glycerol-3-phosphate transporter (g-3-p transporter) (g-3-p permease). [swissprot;acc:p57057]	Low confidence	201.463	197.207	1.02158
1460	ECH1	delta3,5-delta2,4-dienoyl-coa isomerase, mitochondrial precursor (ec 5.3.3.-). [swissprot;acc:q13011]		206.759	202.391
	TRIP12	thyroid receptor interacting protein 12 (trip12). [swissprot;acc:q14669]	High confidence	205.817	209.851	1.0196
1461	PRODH	proline oxidase, mitochondrial precursor (ec 1.5.3.-) (proline dehydrogenase). [swissprot;acc:o43272]	Low confidence	201.463	197.207	1.02158
	RTN1	reticulon 1 (neuroendocrine-specific protein). [swissprot;acc:q16799]	High confidence	207.019	211.077	1.0196
1462	AIFM2	apoptosis-inducing factor (aif)-homologous mitochondrion-associated inducer of death; p53-responsive gene 3. [refseq;acc:nm_032797]	Low confidence	200.475	196.24	1.02158
	DLSTP	dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial precursor (ec 2.3.1.61) (e2) (e2k). [swissprot;acc:p36957]	High confidence	205.817	209.851	1.0196
1463	no value	pnas-18. [sptrembl;acc:q9bzu3]		161.056	164.211	1.01959
	LYZ	lysozyme c precursor (ec 3.2.1.17) (1,4-beta-n-acetylmuramidase c). [swissprot;acc:p00695]	Low confidence	202.621	198.342	1.02157
1464	no value	mitogen-activated protein kinase kinase kinase 3 (ec 2.7.1.-) (mapk/erk kinase kinase 3) (mek kinase 3) (mekk 3). [swissprot;acc:q99759]		197.045	192.884
		poly (adp-ribose) glycohydrolase. [refseq;acc:nm_003631]	High confidence	217.351	213.18	1.01957
1465	MAP3K2	mitogen-activated protein kinase kinase kinase 2 (ec 2.7.1.-) (mapk/erk kinase kinase 2) (mek kinase 2) (mekk 2). [swissprot;acc:q9y2u5]	Low confidence	197.06	192.901	1.02156
	MTO1	mto1 protein homolog (cgi-02). [swissprot;acc:q9y2z2]	High confidence	217.351	213.18	1.01957
1466	no value	vesicle trafficking protein sec22b. [refseq;acc:nm_004892]	Low confidence	202.483	198.21	1.02156
	RTN2	reticulon protein 2 (neuroendocrine-specific protein-like 1) (nsp-like protein 1) (nspli). [swissprot;acc:o75298]	High confidence	207.022	211.073	1.01957
1467	ADD3	gamma adducin (adducin-like protein 70). [swissprot;acc:q9uey8]	Low confidence	205.917	201.572	1.02156
	MPP2	maguk p55 subfamily member 2 (mpp2 protein) (discs, large homolog 2). [swissprot;acc:q14168]	High confidence	228.513	232.983	1.01956
1468	DRAP1	dr1-associated protein 1; negative cofactor 2 alpha; dr1-associated corepressor. [refseq;acc:nm_006442]		212.001	207.937	1.01954
	VCL	vinculin (metavinculin). [swissprot;acc:p18206]	Low confidence	202.572	198.298	1.02155
1469	RTN3	reticulon protein 3 (neuroendocrine-specific protein-like 2) (nsp-like protein ii) (nsplii). [swissprot;acc:o95197]	High confidence	207.013	211.05	1.0195
	RXRA	retinoic acid receptor rxr-alpha. [swissprot;acc:p19793]	Low confidence	203.215	198.93	1.02154
1470	QARS	glutaminyl-trna synthetase (ec 6.1.1.18) (glutamine--trna ligase) (glnrs). [swissprot;acc:p47897]	High confidence	221.412	217.199	1.0194
	UTY	ubiquitously transcribed y chromosome tetratricopeptide repeat protein (ubiquitously transcribed tpr protein on the y chromosome). [swissprot;acc:o14607]	Low confidence	200.929	196.693	1.02154
1471	DMAP1	dna methyltransferase 1-associated protein 1 (dnmt1-associated protein 1) (dnmap1). [swissprot;acc:q9npf5]		203.488	199.197
	SRM	spermidine synthase (ec 2.5.1.16) (putrescine aminopropyltransferase) (spdsy). [swissprot;acc:p19623]	High confidence	221.412	217.199	1.0194
1472	GARS	glycyl-trna synthetase (ec 6.1.1.14) (glycine--trna ligase) (glyrs). [swissprot;acc:p41250]
	UTX	ubiquitously transcribed x chromosome tetratricopeptide repeat protein (ubiquitously transcribed tpr protein on the x chromosome). [swissprot;acc:o15550]	Low confidence	200.93	196.694	1.02154
1473	no value	ptd016 protein. [refseq;acc:nm_016125]		203.488	199.197
	EARS2	glutamyl trna synthetase. [sptrembl;acc:o14563]	High confidence	221.412	217.199	1.0194
1474	ELAVL4	elav-like protein 4 (paraneoplastic encephalomyelitis antigen hud) (hu-antigen d). [swissprot;acc:p26378]	Low confidence	202.941	198.663	1.02153
	RANBP5	importin beta-3 subunit (karyopherin beta-3 subunit) (ran-binding protein 5). [swissprot;acc:o00410]	High confidence	218.582	214.427	1.01938
1475	KYNU	kynureninase (ec 3.7.1.3) (l-kynurenine hydrolase). [swissprot;acc:q16719]		181.882	178.438	1.0193
	VPS52	suppressor of actin mutations 2-like isoform b; dj1033b10.5. [refseq;acc:nm_022553]	Low confidence	198.197	194.02	1.02153
1476	EYA1	eyes absent homolog 1. [swissprot;acc:q99502]		203.162	198.88
	RANBP6	ran-gtp binding protein (fragment). [sptrembl;acc:o60518]	High confidence	218.591	214.457	1.01928
1477	no value	transformer-2 protein homolog (tra-2 alpha). [swissprot;acc:q13595]		215.328	211.267	1.01922
	HN1L	hn1 like. [refseq;acc:nm_144570]	Low confidence	190.569	186.552	1.02153
1478	SFRS10	arginine/serine-rich splicing factor 10 (transformer-2-beta) (htra2- beta) (transformer 2 protein homolog) (silica-induced protein 41) (ra301). [swissprot;acc:q15815]	High confidence	215.122	211.066	1.01922
	TBX1	t-box transcription factor tbx1 (t-box protein 1) (testis-specific t-box protein). [swissprot;acc:o43435]	Low confidence	198.794	194.608	1.02151
1479	MPP6	maguk p55 subfamily member 6 (veli-associated maguk 1) (vam-1). [swissprot;acc:q9nzw5]	High confidence	228.469	232.855	1.0192

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.