MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 1236 to 1285 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

Rank	Hugo	description	Network Comparison Type	red	green	network_comparison
618	GABRG3	gamma-aminobutyric-acid receptor gamma-3 subunit precursor (gaba(a) receptor). [swissprot;acc:q99928]	Divided	214.256	202.139	1.05994
619	FOXG1	forkhead box protein g1c (forkhead-related protein fkhl3) (hfk3) (fragment). [swissprot;acc:q14488]
	VPS39	vam6/vps39-like protein (hvam6p). [swissprot;acc:q96jc1]	Subtracted	206.274	218.792	12.518
620	GABRG1	gamma-aminobutyric-acid receptor gamma-1 subunit precursor (gaba(a) receptor). [swissprot;acc:q8n1c3]	Divided	214.256	202.14	1.05994
	MAP4	microtubule-associated protein 4 (map 4). [swissprot;acc:p27816]	Subtracted	206.274	218.792	12.518
621	GABRA2	gamma-aminobutyric-acid receptor alpha-2 subunit precursor (gaba(a) receptor). [swissprot;acc:p47869]	Divided	214.256	202.14	1.05994
	RPLP2	60s acidic ribosomal protein p2. [swissprot;acc:p05387]	Subtracted	231.92	244.435	12.515
622	GABRA6	gamma-aminobutyric-acid receptor alpha-6 subunit precursor (gaba(a) receptor). [swissprot;acc:q16445]	Divided	214.256	202.14	1.05994
	SYN3	synapsin iii. [swissprot;acc:o14994]	Subtracted	229.072	216.576	12.496
623	no value	aspartate beta-hydroxylase isoform b; junctin isoform 1; junctate; aspartyl/asparaginyl-beta-hydroxylase; peptide-aspartate beta-dioxygenase; humbug. [refseq;acc:nm_032468]
	GABRG2	gamma-aminobutyric-acid receptor gamma-2 subunit precursor (gaba(a) receptor). [swissprot;acc:p18507]	Divided	214.256	202.14	1.05994
624	no value	interleukin-1 receptor-associated kinase 4; interleukin-1 receptor associated kinase 4. [refseq;acc:nm_016123]			202.139
	HEY1	hairy/enhancer-of-split related with yrpw motif 1 (hairy and enhancer of split related-1) (hesr-1) (cardiovascular helix-loop-helix factor 2) (hes-related repressor protein 2 herp2). [swissprot;acc:q9y5j3]	Subtracted	229.072	216.576	12.496
625	ABLIM2	actin binding lim protein 2. [refseq;acc:nm_032432]
	GABRA4	gamma-aminobutyric-acid receptor alpha-4 subunit precursor (gaba(a) receptor). [swissprot;acc:p48169]	Divided	214.256	202.14	1.05994
626	GABRE	gamma-aminobutyric-acid receptor epsilon subunit precursor (gaba(a) receptor). [swissprot;acc:p78334]
	HEYL	hairy/enhancer-of-split related with yrpw motif-like. [refseq;acc:nm_014571]	Subtracted	229.072	216.576	12.496
627	JMJD6	phosphatidylserine receptor; phosphatidylserine receptor beta. [refseq;acc:nm_015167]	Divided	214.256	202.139	1.05994
	SYN2	synapsin ii. [swissprot;acc:q92777]	Subtracted	229.072	216.576	12.496
628	GABRA1	gamma-aminobutyric-acid receptor alpha-1 subunit precursor (gaba(a) receptor). [swissprot;acc:p14867]	Divided	214.256	202.14	1.05994
	MRRF	mitochondrial ribosome recycling factor. [refseq;acc:nm_138777]	Subtracted	229.072	216.576	12.496
629	GABRA3	gamma-aminobutyric-acid receptor alpha-3 subunit precursor (gaba(a) receptor). [swissprot;acc:p34903]	Divided	214.256	202.14	1.05994
	PEX5	peroxisomal targeting signal 1 receptor (peroxismore receptor 1) (peroxisomal c-terminal targeting signal import receptor) (pts1-bp) (peroxin-5) (pts1 receptor). [swissprot;acc:p50542]	Subtracted	229.072	216.576	12.496
630	HEY2	hairy/enhancer-of-split related with yrpw motif 2; gridlock; hes-related repressor protein 1. [refseq;acc:nm_012259]
	NDUFA6	nadh-ubiquinone oxidoreductase b14 subunit (ec 1.6.5.3) (ec 1.6.99.3) (complex i-b14) (ci-b14). [swissprot;acc:p56556]	Divided	214.256	202.141	1.05993
631	HES1	transcription factor hes-1 (hairy and enhancer of split 1) (hairy- like) (hhl) (hairy homolog). [swissprot;acc:q14469]	Subtracted	229.072	216.576	12.496
	PDXDC1	similar to expressed sequence aa415817. [sptrembl;acc:q8n4q9]	Divided	214.256	202.141	1.05993
632	ECH1	delta3,5-delta2,4-dienoyl-coa isomerase, mitochondrial precursor (ec 5.3.3.-). [swissprot;acc:q13011]	Subtracted	229.072	216.576	12.496
	HOXD9	homeobox protein hox-d9 (hox-4c) (hox-5.2). [swissprot;acc:p28356]	Divided	214.254	202.166	1.05979
633	AARS	alanyl-trna synthetase (ec 6.1.1.7) (alanine--trna ligase) (alars). [swissprot;acc:p49588]		234.106	248.104
	ABLIM1	actin-binding lim protein 1 isoform a; lim actin-binding protein 1; limatin; actin-binding lim protein. [refseq;acc:nm_002313]	Subtracted	229.072	216.576	12.496
634	no value	dead-box protein abstrakt homolog. [swissprot;acc:q9ujv9]	Divided	226.523	213.786	1.05958
	SYN1	synapsin i (brain protein 4.1). [swissprot;acc:p17600]	Subtracted	229.072	216.576	12.496
635	MVK	mevalonate kinase (ec 2.7.1.36) (mk). [swissprot;acc:q03426]		235.296	247.673	12.377
	RPL37	60s ribosomal protein l37 (g1.16). [swissprot;acc:p02403]	Divided	228.639	242.258	1.05957
636	SFRS1	splicing factor, arginine/serine-rich 1 (pre-mrna splicing factor sf2, p33 subunit) (alternative splicing factor asf-1). [swissprot;acc:q07955]
	VAV1	vav proto-oncogene. [swissprot;acc:p15498]	Subtracted	212.2	199.849	12.351
637	PPAT	amidophosphoribosyltransferase precursor (ec 2.4.2.14) (glutamine phosphoribosylpyrophosphate amidotransferase) (atase) (gpat). [swissprot;acc:q06203]	Divided	228.639	242.258	1.05957
	VAV3	vav-3 protein. [swissprot;acc:q9ukw4]	Subtracted	212.253	199.908	12.345
638	SNX17	sorting nexin 17. [swissprot;acc:q15036]	Divided	228.639	242.258	1.05957
	VAV2	vav-2 protein. [swissprot;acc:p52735]	Subtracted	212.526	200.212	12.314
639	HRB	nucleoporin-like protein rip (hiv-1 rev-binding protein) (rev interacting protein) (rev/rex activation domain-binding protein). [swissprot;acc:p52594]	Divided	217.67	230.596	1.05938
	NOVA1	rna-binding protein nova-1 (neuro-oncological ventral antigen 1) (onconeural ventral antigen-1) (paraneoplastic ri antigen) (ventral neuron-specific protein 1). [swissprot;acc:p51513]	Subtracted	222.554	234.847	12.293
640	no value	histone h3.3 (h3.a) (h3.b) (h3.3q). [swissprot;acc:p06351]		244.842	232.577	12.265
		intersectin 1 (sh3 domain-containing protein 1a) (sh3p17). [swissprot;acc:q15811]	Divided	217.67	230.596	1.05938
641		dj1099d15.1 (putative dnaj protein). [sptrembl;acc:q9h4j9]	Subtracted	244.842	232.577	12.265
	PRAM1	pram-1 protein; pml-rara target gene encoding an adaptor molecule-1. [refseq;acc:nm_032152]	Divided	217.67	230.596	1.05938
642	no value	intersectin 2 (sh3 domain-containing protein 1b) (sh3p18) (sh3p18-like wasp associated protein). [swissprot;acc:q9nzm3]
	LSM4	u6 snrna-associated sm-like protein lsm4 (glycine-rich protein) (grp). [swissprot;acc:q9y4z0]	Subtracted	228.944	216.745	12.199
643	HRBL	hiv-1 rev binding protein-like; rev/rex activation domain binding protein-related. [refseq;acc:nm_006076]	Divided	217.67	230.596	1.05938

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.