Scientific

MK5 Microarray Data


Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

  • value_type as 'ranked' since this provides a very robust analysis method.
  • intercation map as 'high confidence'
  • network_comparison type as 'Divided' since this leads to a natural grouping of similar proteins
  • filtered as 'true' since this will only use the microarray measurements that have a sufficiently large confidence level.

  • Navigation/Query Panel:
    Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].
    description Gene Network Comparison Type Rank Value Type Filtered Interaction Map red network_comparison green
    Results: HTML CSV LaTeX Showing element 76474 to 76523 of 77072 in total
    
    \def\wcA{0.1\textwidth}
    \def\wcB{0.1\textwidth}
    \def\wcC{0.1\textwidth}
    \def\wcD{0.1\textwidth}
    \def\wcE{0.1\textwidth}
    \def\wcF{0.1\textwidth}
    \def\wcG{0.1\textwidth}
    \def\wcH{0.1\textwidth}
    \def\wcI{0.1\textwidth}
    \begin{longtable}{|c|c|c|c|c|c|c|c|c|}
    \hline
    \parbox{\wcA}{\vspace{3pt}\noindent
    description\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent
    Network Comparison Type\vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent
    Rank\vspace{3pt}}&\parbox{\wcD}{\vspace{3pt}\noindent
    Value Type\vspace{3pt}}&\parbox{\wcE}{\vspace{3pt}\noindent
    Filtered\vspace{3pt}}&\parbox{\wcF}{\vspace{3pt}\noindent
    Interaction Map\vspace{3pt}}&\parbox{\wcG}{\vspace{3pt}\noindent
    red\vspace{3pt}}&\parbox{\wcH}{\vspace{3pt}\noindent
    network\_comparison\vspace{3pt}}&\parbox{\wcI}{\vspace{3pt}\noindent
    green\vspace{3pt}}\\
    \hline
    \hline
    \multirow{15}{*}{\parbox{\wcA}{\vspace{3pt}\noindent
    zinc finger protein gli1 (glioma-associated oncogene) (oncogene gli). [source:swissprot;acc:p08151]\vspace{3pt}}}&\multirow{7}{*}{\parbox{\wcB}{\vspace{3pt}\noindent
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    1\vspace{3pt}}}&\multirow{2}{*}{\parbox{\wcF}{\vspace{3pt}\noindent
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    17134.4\vspace{3pt}}&\parbox{\wcH}{\vspace{3pt}\noindent
    1.14674\vspace{3pt}}&\parbox{\wcI}{\vspace{3pt}\noindent
    19648.7\vspace{3pt}}\\\cline{3-4}\cline{7-9}
    &&\parbox{\wcC}{\vspace{3pt}\noindent
    1184\vspace{3pt}}&\parbox{\wcD}{\vspace{3pt}\noindent
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    4392.63\vspace{3pt}}&\parbox{\wcH}{\vspace{3pt}\noindent
    1.08732\vspace{3pt}}&\parbox{\wcI}{\vspace{3pt}\noindent
    4776.19\vspace{3pt}}\\\cline{3-4}\cline{6-9}
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    203.074\vspace{3pt}}&\parbox{\wcH}{\vspace{3pt}\noindent
    1.02237\vspace{3pt}}&\parbox{\wcI}{\vspace{3pt}\noindent
    198.63\vspace{3pt}}\\\cline{3-4}\cline{6-9}
    &&\parbox{\wcC}{\vspace{3pt}\noindent
    1663\vspace{3pt}}&\multirow{2}{*}{\parbox{\wcD}{\vspace{3pt}\noindent
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    54.1965\vspace{3pt}}&\parbox{\wcH}{\vspace{3pt}\noindent
    1.0337\vspace{3pt}}&\parbox{\wcI}{\vspace{3pt}\noindent
    56.0231\vspace{3pt}}\\\cline{3-3}\cline{6-9}
    &&\parbox{\wcC}{\vspace{3pt}\noindent
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    Low confidence\vspace{3pt}}&\parbox{\wcG}{\vspace{3pt}\noindent
    71.893\vspace{3pt}}&\parbox{\wcH}{\vspace{3pt}\noindent
    1.03506\vspace{3pt}}&\parbox{\wcI}{\vspace{3pt}\noindent
    74.4133\vspace{3pt}}\\\cline{3-4}\cline{6-9}
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    2466\vspace{3pt}}&\parbox{\wcD}{\vspace{3pt}\noindent
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    235.812\vspace{3pt}}&\parbox{\wcH}{\vspace{3pt}\noindent
    1.00308\vspace{3pt}}&\parbox{\wcI}{\vspace{3pt}\noindent
    235.088\vspace{3pt}}\\\cline{3-4}\cline{6-9}
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    3481\vspace{3pt}}&\parbox{\wcD}{\vspace{3pt}\noindent
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    Low confidence\vspace{3pt}}}&\parbox{\wcG}{\vspace{3pt}\noindent
    8069.85\vspace{3pt}}&\parbox{\wcH}{\vspace{3pt}\noindent
    1.0261\vspace{3pt}}&\parbox{\wcI}{\vspace{3pt}\noindent
    8280.48\vspace{3pt}}\\\cline{2-4}\cline{7-9}
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    807\vspace{3pt}}&\parbox{\wcD}{\vspace{3pt}\noindent
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    46721\vspace{3pt}}&\parbox{\wcH}{\vspace{3pt}\noindent
    2202\vspace{3pt}}&\parbox{\wcI}{\vspace{3pt}\noindent
    44519\vspace{3pt}}\\\cline{3-4}\cline{7-9}
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    19648.7\vspace{3pt}}\\\cline{3-4}\cline{7-9}
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    383.56\vspace{3pt}}&\parbox{\wcI}{\vspace{3pt}\noindent
    4776.19\vspace{3pt}}\\\cline{3-4}\cline{7-9}
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    54.1965\vspace{3pt}}&\parbox{\wcH}{\vspace{3pt}\noindent
    1.8266\vspace{3pt}}&\parbox{\wcI}{\vspace{3pt}\noindent
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    71.893\vspace{3pt}}&\parbox{\wcH}{\vspace{3pt}\noindent
    2.5203\vspace{3pt}}&\parbox{\wcI}{\vspace{3pt}\noindent
    74.4133\vspace{3pt}}\\\cline{3-4}\cline{6-9}
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    2431\vspace{3pt}}&\parbox{\wcD}{\vspace{3pt}\noindent
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    235.812\vspace{3pt}}&\parbox{\wcH}{\vspace{3pt}\noindent
    0.724\vspace{3pt}}&\parbox{\wcI}{\vspace{3pt}\noindent
    235.088\vspace{3pt}}\\\cline{3-4}\cline{6-9}
    &&\parbox{\wcC}{\vspace{3pt}\noindent
    3399\vspace{3pt}}&\parbox{\wcD}{\vspace{3pt}\noindent
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    8069.85\vspace{3pt}}&\parbox{\wcH}{\vspace{3pt}\noindent
    210.63\vspace{3pt}}&\parbox{\wcI}{\vspace{3pt}\noindent
    8280.48\vspace{3pt}}\\\cline{1-4}\cline{7-9}
    \multirow{16}{*}{\parbox{\wcA}{\vspace{3pt}\noindent
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    44523.8\vspace{3pt}}\\\cline{3-3}\cline{6-9}
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    17134.4\vspace{3pt}}&\parbox{\wcH}{\vspace{3pt}\noindent
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    19648.7\vspace{3pt}}\\\cline{3-4}\cline{7-9}
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    203.073\vspace{3pt}}&\parbox{\wcH}{\vspace{3pt}\noindent
    1.02242\vspace{3pt}}&\parbox{\wcI}{\vspace{3pt}\noindent
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    1.0337\vspace{3pt}}&\parbox{\wcI}{\vspace{3pt}\noindent
    56.0231\vspace{3pt}}\\\cline{3-3}\cline{6-9}
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    1.02608\vspace{3pt}}&\parbox{\wcI}{\vspace{3pt}\noindent
    8281.29\vspace{3pt}}\\\cline{2-4}\cline{7-9}
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    19648.7\vspace{3pt}}\\\cline{3-4}\cline{7-9}
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    4392.63\vspace{3pt}}&\parbox{\wcH}{\vspace{3pt}\noindent
    383.56\vspace{3pt}}&\parbox{\wcI}{\vspace{3pt}\noindent
    4776.19\vspace{3pt}}\\\cline{3-4}\cline{7-9}
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    54.1965\vspace{3pt}}&\parbox{\wcH}{\vspace{3pt}\noindent
    1.8266\vspace{3pt}}&\parbox{\wcI}{\vspace{3pt}\noindent
    56.0231\vspace{3pt}}\\\cline{3-3}\cline{6-9}
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    Low confidence\vspace{3pt}}&\parbox{\wcG}{\vspace{3pt}\noindent
    71.896\vspace{3pt}}&\parbox{\wcH}{\vspace{3pt}\noindent
    2.5221\vspace{3pt}}&\parbox{\wcI}{\vspace{3pt}\noindent
    74.4181\vspace{3pt}}\\\cline{3-4}\cline{6-9}
    &&\parbox{\wcC}{\vspace{3pt}\noindent
    2436\vspace{3pt}}&\parbox{\wcD}{\vspace{3pt}\noindent
    Ranked\vspace{3pt}}&&\parbox{\wcF}{\vspace{3pt}\noindent
    High confidence\vspace{3pt}}&\parbox{\wcG}{\vspace{3pt}\noindent
    235.812\vspace{3pt}}&\parbox{\wcH}{\vspace{3pt}\noindent
    0.724\vspace{3pt}}&\parbox{\wcI}{\vspace{3pt}\noindent
    235.088\vspace{3pt}}\\\cline{3-4}\cline{6-9}
    &&\parbox{\wcC}{\vspace{3pt}\noindent
    3401\vspace{3pt}}&\parbox{\wcD}{\vspace{3pt}\noindent
    Measured\vspace{3pt}}&&\multirow{2}{*}{\parbox{\wcF}{\vspace{3pt}\noindent
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    8070.79\vspace{3pt}}&\parbox{\wcH}{\vspace{3pt}\noindent
    210.5\vspace{3pt}}&\parbox{\wcI}{\vspace{3pt}\noindent
    8281.29\vspace{3pt}}\\\cline{1-4}\cline{7-9}
    \multirow{16}{*}{\parbox{\wcA}{\vspace{3pt}\noindent
    zinc finger protein gli3. [source:swissprot;acc:p10071]\vspace{3pt}}}&\multirow{8}{*}{\parbox{\wcB}{\vspace{3pt}\noindent
    Divided\vspace{3pt}}}&\parbox{\wcC}{\vspace{3pt}\noindent
    801\vspace{3pt}}&\multirow{2}{*}{\parbox{\wcD}{\vspace{3pt}\noindent
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    46876.8\vspace{3pt}}&\parbox{\wcH}{\vspace{3pt}\noindent
    1.05126\vspace{3pt}}&\parbox{\wcI}{\vspace{3pt}\noindent
    44591.2\vspace{3pt}}\\\cline{3-3}\cline{6-9}
    &&\parbox{\wcC}{\vspace{3pt}\noindent
    1073\vspace{3pt}}&&&\multirow{2}{*}{\parbox{\wcF}{\vspace{3pt}\noindent
    High confidence\vspace{3pt}}}&\parbox{\wcG}{\vspace{3pt}\noindent
    17134.4\vspace{3pt}}&\parbox{\wcH}{\vspace{3pt}\noindent
    1.14674\vspace{3pt}}&\parbox{\wcI}{\vspace{3pt}\noindent
    19648.7\vspace{3pt}}\\\cline{3-4}\cline{7-9}
    &&\parbox{\wcC}{\vspace{3pt}\noindent
    1186\vspace{3pt}}&\parbox{\wcD}{\vspace{3pt}\noindent
    Measured\vspace{3pt}}&&&\parbox{\wcG}{\vspace{3pt}\noindent
    4392.63\vspace{3pt}}&\parbox{\wcH}{\vspace{3pt}\noindent
    1.08732\vspace{3pt}}&\parbox{\wcI}{\vspace{3pt}\noindent
    4776.19\vspace{3pt}}\\\cline{3-4}\cline{6-9}
    &&\parbox{\wcC}{\vspace{3pt}\noindent
    1191\vspace{3pt}}&\parbox{\wcD}{\vspace{3pt}\noindent
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    Low confidence\vspace{3pt}}&\parbox{\wcG}{\vspace{3pt}\noindent
    203.052\vspace{3pt}}&\parbox{\wcH}{\vspace{3pt}\noindent
    1.02311\vspace{3pt}}&\parbox{\wcI}{\vspace{3pt}\noindent
    198.466\vspace{3pt}}\\\cline{3-4}\cline{6-9}
    &&\parbox{\wcC}{\vspace{3pt}\noindent
    1665\vspace{3pt}}&\multirow{2}{*}{\parbox{\wcD}{\vspace{3pt}\noindent
    Rooted\vspace{3pt}}}&&\parbox{\wcF}{\vspace{3pt}\noindent
    High confidence\vspace{3pt}}&\parbox{\wcG}{\vspace{3pt}\noindent
    54.1965\vspace{3pt}}&\parbox{\wcH}{\vspace{3pt}\noindent
    1.0337\vspace{3pt}}&\parbox{\wcI}{\vspace{3pt}\noindent
    56.0231\vspace{3pt}}\\\cline{3-3}\cline{6-9}
    &&\parbox{\wcC}{\vspace{3pt}\noindent
    1871\vspace{3pt}}&&&\parbox{\wcF}{\vspace{3pt}\noindent
    Low confidence\vspace{3pt}}&\parbox{\wcG}{\vspace{3pt}\noindent
    71.9383\vspace{3pt}}&\parbox{\wcH}{\vspace{3pt}\noindent
    1.03539\vspace{3pt}}&\parbox{\wcI}{\vspace{3pt}\noindent
    74.484\vspace{3pt}}\\\cline{3-4}\cline{6-9}
    &&\parbox{\wcC}{\vspace{3pt}\noindent
    2468\vspace{3pt}}&\parbox{\wcD}{\vspace{3pt}\noindent
    Ranked\vspace{3pt}}&&\parbox{\wcF}{\vspace{3pt}\noindent
    High confidence\vspace{3pt}}&\parbox{\wcG}{\vspace{3pt}\noindent
    235.812\vspace{3pt}}&\parbox{\wcH}{\vspace{3pt}\noindent
    1.00308\vspace{3pt}}&\parbox{\wcI}{\vspace{3pt}\noindent
    235.088\vspace{3pt}}\\\cline{3-4}\cline{6-9}
    &&\parbox{\wcC}{\vspace{3pt}\noindent
    3527\vspace{3pt}}&\parbox{\wcD}{\vspace{3pt}\noindent
    Measured\vspace{3pt}}&&\multirow{3}{*}{\parbox{\wcF}{\vspace{3pt}\noindent
    Low confidence\vspace{3pt}}}&\parbox{\wcG}{\vspace{3pt}\noindent
    8083.75\vspace{3pt}}&\parbox{\wcH}{\vspace{3pt}\noindent
    1.02583\vspace{3pt}}&\parbox{\wcI}{\vspace{3pt}\noindent
    8292.55\vspace{3pt}}\\\cline{2-4}\cline{7-9}
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    745\vspace{3pt}}&\parbox{\wcD}{\vspace{3pt}\noindent
    Squared\vspace{3pt}}&&&\parbox{\wcG}{\vspace{3pt}\noindent
    46876.8\vspace{3pt}}&\parbox{\wcH}{\vspace{3pt}\noindent
    2285.6\vspace{3pt}}&\parbox{\wcI}{\vspace{3pt}\noindent
    44591.2\vspace{3pt}}\\\cline{3-4}\cline{7-9}
    &&\parbox{\wcC}{\vspace{3pt}\noindent
    1144\vspace{3pt}}&\parbox{\wcD}{\vspace{3pt}\noindent
    Ranked\vspace{3pt}}&&&\parbox{\wcG}{\vspace{3pt}\noindent
    203.052\vspace{3pt}}&\parbox{\wcH}{\vspace{3pt}\noindent
    4.586\vspace{3pt}}&\parbox{\wcI}{\vspace{3pt}\noindent
    198.466\vspace{3pt}}\\\cline{3-4}\cline{6-9}
    &&\parbox{\wcC}{\vspace{3pt}\noindent
    1604\vspace{3pt}}&\parbox{\wcD}{\vspace{3pt}\noindent
    Squared\vspace{3pt}}&&\multirow{2}{*}{\parbox{\wcF}{\vspace{3pt}\noindent
    High confidence\vspace{3pt}}}&\parbox{\wcG}{\vspace{3pt}\noindent
    17134.4\vspace{3pt}}&\parbox{\wcH}{\vspace{3pt}\noindent
    2514.3\vspace{3pt}}&\parbox{\wcI}{\vspace{3pt}\noindent
    19648.7\vspace{3pt}}\\\cline{3-4}\cline{7-9}
    &&\parbox{\wcC}{\vspace{3pt}\noindent
    1812\vspace{3pt}}&\parbox{\wcD}{\vspace{3pt}\noindent
    Measured\vspace{3pt}}&&&\parbox{\wcG}{\vspace{3pt}\noindent
    4392.63\vspace{3pt}}&\parbox{\wcH}{\vspace{3pt}\noindent
    383.56\vspace{3pt}}&\parbox{\wcI}{\vspace{3pt}\noindent
    4776.19\vspace{3pt}}\\\cline{3-4}\cline{6-9}
    &&\parbox{\wcC}{\vspace{3pt}\noindent
    1897\vspace{3pt}}&\multirow{2}{*}{\parbox{\wcD}{\vspace{3pt}\noindent
    Rooted\vspace{3pt}}}&&\parbox{\wcF}{\vspace{3pt}\noindent
    Low confidence\vspace{3pt}}&\parbox{\wcG}{\vspace{3pt}\noindent
    71.9383\vspace{3pt}}&\parbox{\wcH}{\vspace{3pt}\noindent
    2.5457\vspace{3pt}}&\parbox{\wcI}{\vspace{3pt}\noindent
    74.484\vspace{3pt}}\\\cline{3-3}\cline{6-9}
    &&\parbox{\wcC}{\vspace{3pt}\noindent
    1927\vspace{3pt}}&&&\multirow{2}{*}{\parbox{\wcF}{\vspace{3pt}\noindent
    High confidence\vspace{3pt}}}&\parbox{\wcG}{\vspace{3pt}\noindent
    54.1965\vspace{3pt}}&\parbox{\wcH}{\vspace{3pt}\noindent
    1.8266\vspace{3pt}}&\parbox{\wcI}{\vspace{3pt}\noindent
    56.0231\vspace{3pt}}\\\cline{3-4}\cline{7-9}
    &&\parbox{\wcC}{\vspace{3pt}\noindent
    2433\vspace{3pt}}&\parbox{\wcD}{\vspace{3pt}\noindent
    Ranked\vspace{3pt}}&&&\parbox{\wcG}{\vspace{3pt}\noindent
    235.812\vspace{3pt}}&\parbox{\wcH}{\vspace{3pt}\noindent
    0.724\vspace{3pt}}&\parbox{\wcI}{\vspace{3pt}\noindent
    235.088\vspace{3pt}}\\\cline{3-4}\cline{6-9}
    &&\parbox{\wcC}{\vspace{3pt}\noindent
    3438\vspace{3pt}}&\multirow{2}{*}{\parbox{\wcD}{\vspace{3pt}\noindent
    Measured\vspace{3pt}}}&&\multirow{4}{*}{\parbox{\wcF}{\vspace{3pt}\noindent
    Low confidence\vspace{3pt}}}&\parbox{\wcG}{\vspace{3pt}\noindent
    8083.75\vspace{3pt}}&\parbox{\wcH}{\vspace{3pt}\noindent
    208.8\vspace{3pt}}&\parbox{\wcI}{\vspace{3pt}\noindent
    8292.55\vspace{3pt}}\\\cline{1-3}\cline{5-5}\cline{7-9}
    \multirow{3}{*}{\parbox{\wcA}{\vspace{3pt}\noindent
    zinc finger protein loc163140 (fragment). [source:sptrembl;acc:q86wm6]\vspace{3pt}}}&\multirow{3}{*}{\parbox{\wcB}{\vspace{3pt}\noindent
    Divided\vspace{3pt}}}&\parbox{\wcC}{\vspace{3pt}\noindent
    198\vspace{3pt}}&&\multirow{3}{*}{\parbox{\wcE}{\vspace{3pt}\noindent
    0\vspace{3pt}}}&&\parbox{\wcG}{\vspace{3pt}\noindent
    2350.92\vspace{3pt}}&\parbox{\wcH}{\vspace{3pt}\noindent
    1.19455\vspace{3pt}}&\parbox{\wcI}{\vspace{3pt}\noindent
    1968.04\vspace{3pt}}\\\cline{3-4}\cline{7-9}
    &&\parbox{\wcC}{\vspace{3pt}\noindent
    242\vspace{3pt}}&\parbox{\wcD}{\vspace{3pt}\noindent
    Rooted\vspace{3pt}}&&&\parbox{\wcG}{\vspace{3pt}\noindent
    45.298\vspace{3pt}}&\parbox{\wcH}{\vspace{3pt}\noindent
    1.11284\vspace{3pt}}&\parbox{\wcI}{\vspace{3pt}\noindent
    40.7049\vspace{3pt}}\\\cline{3-4}\cline{7-9}
    &&\parbox{\wcC}{\vspace{3pt}\noindent
    254\vspace{3pt}}&\parbox{\wcD}{\vspace{3pt}\noindent
    Ranked\vspace{3pt}}&&&\parbox{\wcG}{\vspace{3pt}\noindent
    4257.81\vspace{3pt}}&\parbox{\wcH}{\vspace{3pt}\noindent
    1.14021\vspace{3pt}}&\parbox{\wcI}{\vspace{3pt}\noindent
    4854.79\vspace{3pt}}\\\hline
    nd{longtable}
    
    Legend:
    - Rank is the rank after comparing the two networks
    - Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
    - Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
    - Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
    - Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
    - Filtered specifies whether we only included the high confidence microarry measurements or not.

    - http://analysis.yellowcouch.org/