MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 1975 to 2024 of 14920 in total

Network Comparison Type  : Divided
Interaction Map  : High confidence

Rank	description	Value Type	Filtered	red	green	network_comparison
247	rna-binding protein. [refseq;acc:nm_019027]	Ranked	1	237.302	212.41	1.11719
	wiskott-aldrich syndrome protein (wasp). [swissprot;acc:p42768]	Measured		6416.68	7865.15	1.22574
248	apobec-1 complementation factor isoform 1; apobec-1 stimulating protein; apo-b rna editing protein. [refseq;acc:nm_014576]	Ranked		237.302	212.41	1.11719
	dna mismatch repair protein mlh1 (mutl protein homolog 1). [swissprot;acc:p40692]	Rooted	0	30.7397	27.7265	1.10868
	keratin associated protein 1.5. [refseq;acc:nm_031957]	Ranked		10551.6	11573.7	1.09687
	keratin associated protein 4-10; keratin associated protein 4.10. [refseq;acc:nm_033060]	Measured		1225.09	1079.37	1.135
	myosin xv (unconventional myosin-15). [swissprot;acc:q9ukn7]	Squared	1	8875.01	6768.05	1.31131
	proto-oncogene c-crk (p38) (adapter molecule crk). [swissprot;acc:p46108]	Measured		6417.18	7859.6	1.22477
	u6 snrna-associated sm-like protein lsm5. [swissprot;acc:q9y4y9]	Rooted		56.0466	63.4808	1.13264
	ubiquitin-like protein smt3b (sentrin 2) (hsmt3). [swissprot;acc:p55855]	Squared	0	42556.5	33335.4	1.27662
249	fructose-1,6-bisphosphatase isozyme 2 (ec 3.1.3.11) (d-fructose-1,6- bisphosphate 1-phosphohydrolase) (fbpase). [swissprot;acc:o00757]			35446.2	27772	1.27633
	glycogen phosphorylase, muscle form (ec 2.4.1.1) (myophosphorylase). [swissprot;acc:p11217]		1	8875.01	6768.05	1.31131
	hepatitis c virus core-binding protein 6; cervical cancer oncogene 3. [refseq;acc:nm_023934]	Rooted	0	23.5797	26.096	1.10671
	keratin associated protein 4-14; keratin associated protein 4.14. [refseq;acc:nm_033059]	Measured		1225.08	1079.37	1.135
	keratin, ultra high-sulfur matrix protein a (uhs keratin a) (uhs kera). [swissprot;acc:p26371]	Ranked		10551.6	11573.7	1.09687
	ns1-associated protein 1. [refseq;acc:nm_006372]		1	237.302	212.41	1.11719
	transcription factor iiib 90 kda subunit (tfiiib90) (htfiiib90) (b- related factor 1) (hbrf) (tata box-binding protein-associated factor, rna polymerase iii, subunit 2) (taf3b2). [swissprot;acc:q92994]	Rooted		55.5965	62.9349	1.13199
	tyrosine-protein kinase abl2 (ec 2.7.1.112) (tyrosine kinase arg). [swissprot;acc:p42684]	Measured		6417.18	7859.59	1.22477
250	c-terminal binding protein 2 (ctbp2). [swissprot;acc:p56545]	Squared		69201.8	53013.4	1.30536
	dc11 protein. [refseq;acc:nm_020186]	Rooted	0	23.5797	26.096	1.10671
	disks large-associated protein 2 (dap-2) (sap90/psd-95-associated protein 2) (sapap2) (psd-95/sap90 binding protein 2) (fragment). [swissprot;acc:q9p1a6]	Squared		504.762	643.571	1.275
	heterogeneous nuclear ribonucleoprotein r (hnrnp r). [swissprot;acc:o43390]	Ranked	1	237.302	212.41	1.11719
	keratin associated protein 1-3; keratin associated protein 1.3. [refseq;acc:nm_030966]		0	10551.6	11573.7	1.09687
	keratin associated protein 4.9 (fragment). [sptrembl;acc:q9byq8]	Measured		1225.08	1079.37	1.135
	nucleolar protein family a, member 1; gar1 protein. [refseq;acc:nm_018983]	Rooted	1	55.5965	62.9349	1.13199
	proto-oncogene tyrosine-protein kinase src (ec 2.7.1.112) (p60-src) (c-src). [swissprot;acc:p12931]	Measured		6417.18	7859.6	1.22477
251	40s ribosomal protein s15 (rig protein). [swissprot;acc:p11174]	Rooted	0	21.3142	23.5833	1.10646
	b-cell cll/lymphoma 6, member b (zinc finger protein); zinc finger protein 62. [refseq;acc:nm_181844]	Squared	1	69165.6	52992.1	1.30521
	keratin associated protein 4-10; keratin associated protein 4.10. [refseq;acc:nm_033060]	Ranked	0	10551.6	11573.6	1.09686
	keratin associated protein 4-12; keratin associated protein 4.12. [refseq;acc:nm_031854]	Measured		1225.08	1079.38	1.13498
	max protein. [swissprot;acc:p25912]	Rooted	1	56.3054	63.7148	1.13159
	oligopeptide transporter, small intestine isoform (peptide transporter 1) (intestinal h+/peptide cotransporter) (solute carrier family 15, member 1). [swissprot;acc:p46059]	Ranked		186.172	166.661	1.11707
	tyrosine-protein kinase hck (ec 2.7.1.112) (p59-hck/p60-hck) (hemopoietic cell kinase). [swissprot;acc:p08631]	Measured		6417.18	7859.6	1.22477
	wiskott-aldrich syndrome protein family member 3 (wasp-family protein member 3) (verprolin homology domain-containing protein 3). [swissprot;acc:q9upy6]	Squared	0	25574.2	20063.8	1.27464
252	crk-like protein. [swissprot;acc:p46109]	Measured	1	6417.18	7859.6	1.22477
	eukaryotic translation initiation factor 4 gamma (eif-4-gamma) (eif- 4g) (eif4g) (p220). [swissprot;acc:q04637]	Ranked		237.292	212.457	1.11689
	keratin associated protein 4-14; keratin associated protein 4.14. [refseq;acc:nm_033059]		0	10551.6	11573.5	1.09685
	lon protease homolog, mitochondrial precursor (ec 3.4.21.-) (lon protease-like protein) (lonp) (lonhs). [swissprot;acc:p36776]	Rooted		21.1331	19.1063	1.10608
	nuclear transcription factor y subunit beta (nf-y protein chain b) (nf-yb) (ccaat-binding transcription factor subunit a) (cbf-a) (caat- box dna binding protein subunit b). [swissprot;acc:p25208]		1	51.6736	58.4422	1.13099
	pas domain containing serine/threonine kinase; pas-serine/threonine kinase. [refseq;acc:nm_015148]	Squared		69165	52991.7	1.3052
	sirtuin 7; sir2-related protein type 7; sirtuin type 7; sirtuin (silent mating type information regulation 2, s.cerevisiae, homolog) 7; silent mating type information regulation 2, s.cerevisiae, homolog 7; sirtuin silent mating type information regulation 2 homolog 7 (s. cerevisiae). [refseq;acc:nm_016538]		0	803.941	631.169	1.27373
	star-related lipid transfer protein 6 (stard6) (start domain- containing protein 6). [swissprot;acc:p59095]	Measured		1225.08	1079.38	1.13498
253	b-cell lymphoma 6 protein (bcl-6) (zinc finger protein 51) (laz-3 protein) (bcl-5). [swissprot;acc:p41182]	Squared	1	69165	52991.7	1.3052
	espin. [refseq;acc:nm_031475]	Measured	0	1225.07	1079.38	1.13498
	keratin associated protein 4.9 (fragment). [sptrembl;acc:q9byq8]	Ranked		10551.6	11573.5	1.09685
	mad protein (max dimerizer). [swissprot;acc:q05195]		1	228	204.333	1.11583
	nif3-like protein 1 (amyotrophic lateral sclerosis 2 chromosomal region candidate gene protein 1) (my018 protein) (mds015). [swissprot;acc:q9gzt8]	Squared	0	46977	36903.3	1.27298
	proto-oncogene tyrosine-protein kinase abl1 (ec 2.7.1.112) (p150) (c-abl). [swissprot;acc:p00519]	Measured	1	6417.18	7859.59	1.22477
	ras-related c3 botulinum toxin substrate 1 (p21-rac1) (ras-like protein tc25). [swissprot;acc:p15154]	Rooted	0	8.05424	8.90701	1.10588
	signal recognition particle 9 kda protein (srp9). [swissprot;acc:p49458]		1	53.5956	60.465	1.12817

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.