MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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description	Network Comparison Type	red	Gene	Rank	Hugo	network_comparison	Value Type	Interaction Map	Filtered	green

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Showing element 1525 to 1574 of 2060 in total

Network Comparison Type  : Subtracted
red  : 0
network_comparison  : 0
Filtered  : 1
green  : 0

description	Rank	Hugo	Value Type	Interaction Map
sex comb on midleg-like 2; sex comb on midleg like 2. [refseq;acc:nm_006089]	3120	SCML2	Measured	High confidence
			Ranked
			Squared
			Rooted
sh2-b homolog; likely ortholog of mouse sh2 domain-containing putative adapter sh2-b; sh2-b gamma signaling protein; sh2-b alpha signaling protein. [refseq;acc:nm_015503]	2794	SH2B1	Measured
			Ranked
			Squared
			Rooted
sh3 adapter protein spin90 (sh3 protein interacting with nck, 90 kda) (vaca-interacting protein, 54 kda) (vip54) (af3p21) (diaphanous protein interacting protein) (dia interacting protein-1) (dip-1). [swissprot;acc:q9nzq3]	2867	no value	Measured
			Ranked
			Squared
			Rooted
signal recognition particle 14 kda protein (srp14) (18 kda alu rna binding protein). [swissprot;acc:p37108]	5032	SRP14	Ranked	Low confidence
	5033		Measured
			Squared
			Rooted
similar to cg5057 gene product. [sptrembl;acc:q9btt4]	2984	MED10	Measured	High confidence
			Ranked
			Squared
			Rooted
similar to lysozyme c-1 (1,4-beta-n-acylmuramidase c, ec 3.2.1.17). [refseq;acc:nm_032517]	3032	LYZL1	Measured
			Ranked
			Squared
			Rooted
similar to mob-lak. [refseq;acc:nm_145279]	2937	MOBKL2C	Measured
			Ranked
			Squared
			Rooted
skd1 protein (vacuolar sorting protein 4b). [swissprot;acc:o75351]	3037	VPS4B	Measured
			Ranked
			Squared
			Rooted
skeletal muscle and kidney enriched inositol phosphatase isoform 1; 43-kda form skeletal muscle and kidney enriched inositol phosphatase. [refseq;acc:nm_016532]	2994	no value	Measured
			Ranked
			Squared
			Rooted
small edrk-rich factor 2. [refseq;acc:nm_005770]	2947	SERF2	Measured
			Ranked
			Squared
			Rooted
small nuclear ribonucleoprotein associated protein n (snrnp-n) (sm protein n) (sm-n) (smn) (sm-d) (tissue-specific splicing protein). [swissprot;acc:p14648]	3004	SNRPN	Measured
			Ranked
			Squared
			Rooted
small nuclear ribonucleoprotein associated proteins b and b' (snrnp-b) (sm protein b/b') (sm-b/sm-b') (smb/smb'). [swissprot;acc:p14678]	3012	SNRPB	Measured
			Ranked
			Squared
			Rooted
snrna activating protein complex 50 kda subunit (snapc 50 kda subunit) (proximal sequence element-binding transcription factor beta subunit) (pse-binding factor beta subunit) (ptf beta subunit). [swissprot;acc:q92966]	2849	SNAPC3	Measured
			Ranked

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.