MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Value Type	Gene	Hugo	description	Network Comparison Type	Interaction Map	Filtered	red	network_comparison	green

Results: HTML CSV LaTeX

Showing element 1 to 50 of 66312 in total

Filtered  : 1

Rank	Value Type	Hugo	description	Network Comparison Type	Interaction Map	red	network_comparison	green
1	Measured	no value	mannosyl-oligosaccharide 1,2-alpha-mannosidase ib (ec 3.2.1.113) (processing alpha-1,2-mannosidase ib) (alpha-1,2-mannosidase ib) (mannosidase alpha class 1a member 2). [swissprot;acc:o60476]	Subtracted	High confidence	41482.5	8126	33356.5
		CPD	carboxypeptidase d precursor (ec 3.4.17.-) (gp180). [swissprot;acc:o75976]		Low confidence	40899	8870.5	32028.5
		LAMP1	lysosome-associated membrane glycoprotein 1 precursor (lamp-1) (cd107a antigen). [swissprot;acc:p11279]	Divided		2399.5	4.4149	543.5
		RINT1	rad50-interacting protein 1. [refseq;acc:nm_021930]		High confidence	450.5	5.31521	2394.5
	Ranked	CPD	carboxypeptidase d precursor (ec 3.4.17.-) (gp180). [swissprot;acc:o75976]		Low confidence	16	2	32
		HLX	homeobox protein hlx1 (homeobox protein hb24). [swissprot;acc:q14774]	Subtracted	High confidence	215	107	322
		LAMP1	lysosome-associated membrane glycoprotein 1 precursor (lamp-1) (cd107a antigen). [swissprot;acc:p11279]		Low confidence	223		330
		UBAC1	putative glialblastoma cell differentiation-related; putative glialblastoma cell differentiation-related protein. [refseq;acc:nm_016172]	Divided	High confidence	10	2.4	24
	Squared	CPD	carboxypeptidase d precursor (ec 3.4.17.-) (gp180). [swissprot;acc:o75976]	Subtracted	Low confidence	395912	153113	242799
		LAMP1	lysosome-associated membrane glycoprotein 1 precursor (lamp-1) (cd107a antigen). [swissprot;acc:p11279]	Divided		1362.75	19.4914	69.9153
		RINT1	rad50-interacting protein 1. [refseq;acc:nm_021930]		High confidence	48.0356	28.2513	1357.07
		UBAC1	putative glialblastoma cell differentiation-related; putative glialblastoma cell differentiation-related protein. [refseq;acc:nm_016172]	Subtracted		468498	145743	322755
	Rooted	LAMP1	lysosome-associated membrane glycoprotein 1 precursor (lamp-1) (cd107a antigen). [swissprot;acc:p11279]	Divided	Low confidence	48.9847	2.10117	23.3131
				Subtracted			25.6716
		RINT1	rad50-interacting protein 1. [refseq;acc:nm_021930]	Divided	High confidence	21.225	2.30547	48.9336
				Subtracted			27.7086
2	Measured	CDK4	cell division protein kinase 4 (ec 2.7.1.37) (cyclin-dependent kinase 4) (psk-j3). [swissprot;acc:p11802]	Divided	Low confidence	2399.5	4.4149	543.5
		MRPS17	28s ribosomal protein s17, mitochondrial precursor (mrp-s17) (hspc011). [swissprot;acc:q9y2r5]	Subtracted		21185	7307	28492
		PSCD1	cytohesin 1 (sec7 homolog b2-1). [swissprot;acc:q15438]		High confidence	41482.5	8126	33356.5
		RHOBTB2	rho-related btb domain-containing protein 2 (deleted in breast cancer 2 gene protein) (p83). [swissprot;acc:q9byz6]	Divided		450.5	5.31521	2394.5
	Ranked	no value	mannosyl-oligosaccharide 1,2-alpha-mannosidase ib (ec 3.2.1.113) (processing alpha-1,2-mannosidase ib) (alpha-1,2-mannosidase ib) (mannosidase alpha class 1a member 2). [swissprot;acc:o60476]			15	1.86667	28
		CDK4	cell division protein kinase 4 (ec 2.7.1.37) (cyclin-dependent kinase 4) (psk-j3). [swissprot;acc:p11802]	Subtracted	Low confidence	223	107	330
		HBS1L	hbs1-like. [refseq;acc:nm_006620]		High confidence	215		322
		LAMP1	lysosome-associated membrane glycoprotein 1 precursor (lamp-1) (cd107a antigen). [swissprot;acc:p11279]	Divided	Low confidence	223	1.47982	330
	Squared	no value	mannosyl-oligosaccharide 1,2-alpha-mannosidase ib (ec 3.2.1.113) (processing alpha-1,2-mannosidase ib) (alpha-1,2-mannosidase ib) (mannosidase alpha class 1a member 2). [swissprot;acc:o60476]	Subtracted	High confidence	407289	143938	263351
		BEST1	bestrophin (vitelliform macular dystrophy protein) (tu15b). [swissprot;acc:o76090]		Low confidence	333556	141563	475119
		CDK4	cell division protein kinase 4 (ec 2.7.1.37) (cyclin-dependent kinase 4) (psk-j3). [swissprot;acc:p11802]	Divided		1362.75	19.4914	69.9153
		RHOBTB2	rho-related btb domain-containing protein 2 (deleted in breast cancer 2 gene protein) (p83). [swissprot;acc:q9byz6]		High confidence	48.0356	28.2513	1357.07
	Rooted	CDK4	cell division protein kinase 4 (ec 2.7.1.37) (cyclin-dependent kinase 4) (psk-j3). [swissprot;acc:p11802]		Low confidence	48.9847	2.10117	23.3131
				Subtracted			25.6716
		RHOBTB2	rho-related btb domain-containing protein 2 (deleted in breast cancer 2 gene protein) (p83). [swissprot;acc:q9byz6]	Divided	High confidence	21.225	2.30547	48.9336
				Subtracted			27.7086
3	Measured	CDK6	cell division protein kinase 6 (ec 2.7.1.37) (serine/threonine protein kinase plstire). [swissprot;acc:q00534]	Divided	Low confidence	2399.5	4.4149	543.5
		HLX	homeobox protein hlx1 (homeobox protein hb24). [swissprot;acc:q14774]		High confidence	2597.5	3.71868	698.5
		PSCD2	cytohesin 2 (arf nucleotide-binding site opener) (arno protein) (arf exchange factor). [swissprot;acc:q99418]	Subtracted		41482.5	8126	33356.5
		SLC25A43	mitochondrial solute carrier protein. [refseq;acc:nm_145305]		Low confidence	21185	7307	28492
	Ranked	CDK4	cell division protein kinase 4 (ec 2.7.1.37) (cyclin-dependent kinase 4) (psk-j3). [swissprot;acc:p11802]	Divided		223	1.47982	330
		CDK6	cell division protein kinase 6 (ec 2.7.1.37) (serine/threonine protein kinase plstire). [swissprot;acc:q00534]	Subtracted			107
		PSCD1	cytohesin 1 (sec7 homolog b2-1). [swissprot;acc:q15438]	Divided	High confidence	15	1.86667	28
		RINT1	rad50-interacting protein 1. [refseq;acc:nm_021930]	Subtracted		337	105	232
	Squared	BEST4	vitelliform macular dystrophy 2-like protein 2. [refseq;acc:nm_153274]		Low confidence	333506	141539	475045
		CDK6	cell division protein kinase 6 (ec 2.7.1.37) (serine/threonine protein kinase plstire). [swissprot;acc:q00534]	Divided		1362.75	19.4914	69.9153
		HLX	homeobox protein hlx1 (homeobox protein hb24). [swissprot;acc:q14774]		High confidence	1596.92	13.8285	115.48
		PSCD1	cytohesin 1 (sec7 homolog b2-1). [swissprot;acc:q15438]	Subtracted		407289	143938	263351
	Rooted	CDK6	cell division protein kinase 6 (ec 2.7.1.37) (serine/threonine protein kinase plstire). [swissprot;acc:q00534]	Divided	Low confidence	48.9847	2.10117	23.3131
				Subtracted			25.6716
		HLX	homeobox protein hlx1 (homeobox protein hb24). [swissprot;acc:q14774]	Divided	High confidence	50.9657	1.92839	26.4292
				Subtracted			24.5365
4	Measured	BEST1	bestrophin (vitelliform macular dystrophy protein) (tu15b). [swissprot;acc:o76090]		Low confidence	36474.3	7035.1	43509.4
		HBS1L	hbs1-like. [refseq;acc:nm_006620]	Divided	High confidence	2597.5	3.71868	698.5

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.