MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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description	Network Comparison Type	Rank	Gene	Hugo	Value Type	Interaction Map	Filtered	red	network_comparison	green

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Showing element 9114 to 9163 of 16578 in total

Value Type  : Ranked
Filtered  : 1

description	Network Comparison Type	Rank	Hugo	Interaction Map	red	network_comparison	green
neurogenic differentiation factor 6 (neurod6) (my051 protein). [swissprot;acc:q96nk8]	Divided	688	NEUROD6	Low confidence	216.552	1.02806	210.641
	Subtracted	160		High confidence	312	28	284
		602		Low confidence	216.552	5.911	210.641
neurogenic locus notch homolog protein 1 precursor (notch 1) (hn1) (translocation-associated notch protein tan-1). [swissprot;acc:p46531]	Divided	4072	NOTCH1		201.952	1.01111	199.732
	Subtracted	4066				2.22
neurogenic locus notch homolog protein 2 precursor (notch 2) (hn2). [swissprot;acc:q04721]	Divided	4073	NOTCH2			1.01111
	Subtracted	4067				2.22
neurogenin 2 (fragment). [swissprot;acc:q9h2a3]	Divided	686	NEUROG2		216.554	1.02807	210.642
	Subtracted	600				5.912
neurolysin, mitochondrial precursor (ec 3.4.24.16) (neurotensin endopeptidase) (mitochondrial oligopeptidase m) (microsomal endopeptidase) (mep). [swissprot;acc:q9byt8]	Divided	1987	NLN		196.336	1.01952	192.576
	Subtracted	2156				3.76
neuromedin u receptor 2. [refseq;acc:nm_020167]	Divided	2991	NMUR2	High confidence	0.00001	1	0.00001
		4173		Low confidence	199.766	1.01039	197.712
	Subtracted	2991		High confidence	0	0	0
		4199		Low confidence	199.766	2.054	197.712
neuromedin-b receptor (nmb-r) (neuromedin-b-preferring bombesin receptor). [swissprot;acc:p28336]	Divided	216	NMBR		199.671	1.05	209.654
	Subtracted	214				9.983
neuron navigator 1; neuron navigator-1; pore membrane and/or filament interacting like protein 3. [refseq;acc:nm_020443]	Divided	444	NAV1	High confidence	223.801	1.0783	207.549
		593		Low confidence	204.074	1.03031	198.071
	Subtracted	449		High confidence	223.801	16.252	207.549
		591		Low confidence	204.074	6.003	198.071
neuron navigator 2 isoform l; retinoic acid inducible in neuroblastoma; pore membrane and/or filament interacting like protein 2; helicase helad1. [refseq;acc:nm_145117]	Divided	443	NAV2	High confidence	223.79	1.0783	207.539
		589		Low confidence	204.056	1.03035	198.046
	Subtracted	451		High confidence	223.79	16.251	207.539
		590		Low confidence	204.056	6.01	198.046
neuron navigator 3; pore membrane and/or filament interacting like protein 1; steerin 3. [refseq;acc:nm_014903]	Divided	445	NAV3	High confidence	223.801	1.0783	207.549
		594		Low confidence	204.073	1.03031	198.07
	Subtracted	450		High confidence	223.801	16.252	207.549
		592		Low confidence	204.073	6.003	198.07
neuron specific calcium-binding protein hippocalcin (p23k) (calcium- binding protein bdr-2). [swissprot;acc:p32076]	Divided	1183	HPCA	High confidence	225.103	1.02588	230.928
		3145		Low confidence	202.636	1.01626	199.394
	Subtracted	1091		High confidence	225.103	5.825	230.928
		3105		Low confidence	202.636	3.242	199.394
neuronal acetylcholine receptor protein, alpha-2 chain precursor. [swissprot;acc:q15822]	Divided	1272	CHRNA2	High confidence	171.231	1.02425	167.177
		4814		Low confidence	202.962	1.004	203.774
	Subtracted	1470		High confidence	171.231	4.054	167.177
		4811		Low confidence	202.962	0.812	203.774
neuronal acetylcholine receptor protein, alpha-3 chain precursor. [swissprot;acc:p32297]	Divided	1276	CHRNA3	High confidence	171.231	1.02425	167.177
		4815		Low confidence	202.953	1.004	203.765
	Subtracted	1474		High confidence	171.231	4.054	167.177
		4812		Low confidence	202.953	0.812	203.765
neuronal acetylcholine receptor protein, alpha-4 chain precursor. [swissprot;acc:p43681]	Divided	1275	CHRNA4	High confidence	171.231	1.02425	167.177
		4812		Low confidence	202.989	1.00401	203.803
	Subtracted	1473		High confidence	171.231	4.054	167.177
		4810		Low confidence	202.989	0.814	203.803
neuronal acetylcholine receptor protein, alpha-6 chain precursor. [swissprot;acc:q15825]	Divided	1268	CHRNA6	High confidence	171.231	1.02425	167.177
		4813		Low confidence	202.952	1.004	203.763
	Subtracted	1466		High confidence	171.231	4.054	167.177
		4813		Low confidence	202.952	0.811	203.763
neuronal acetylcholine receptor protein, alpha-7 chain precursor. [swissprot;acc:p36544]	Divided	465	CHRNA7	High confidence	248.152	1.07686	267.226

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.