MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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description	Network Comparison Type	Rank	Gene	Hugo	Value Type	Interaction Map	Filtered	red	network_comparison	green

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Showing element 1225 to 1274 of 16578 in total

Value Type  : Ranked
Filtered  : 1

description	Network Comparison Type	Rank	Hugo	Interaction Map	red	network_comparison	green
alpha-2 catenin (alpha-catenin related protein) (alpha n-catenin). [swissprot;acc:p26232]	Divided	3165	CTNNA2	Low confidence	202.715	1.01619	199.486
	Subtracted	3138				3.229
alpha-2-macroglobulin receptor-associated protein precursor (alpha-2-mrap) (low density lipoprotein receptor-related protein- associated protein 1) (rap). [swissprot;acc:p30533]	Divided	1332	LRPAP1		203.765	1.02215	199.349
	Subtracted	1283				4.416
alpha-actinin 1 (alpha-actinin cytoskeletal isoform) (non-muscle alpha-actinin 1) (f-actin cross linking protein). [swissprot;acc:p12814]	Divided	1806	ACTN1	High confidence	217.009	1.01178	214.482
		4748		Low confidence	204.297	1.00528	203.223
	Subtracted	1791		High confidence	217.009	2.527	214.482
		4721		Low confidence	204.297	1.074	203.223
alpha-actinin 2 (alpha actinin skeletal muscle isoform 2) (f-actin cross linking protein). [swissprot;acc:p35609]	Divided	1799	ACTN2	High confidence	217.016	1.01182	214.481
		4762		Low confidence	204.331	1.00497	203.321
	Subtracted	1787		High confidence	217.016	2.535	214.481
		4762		Low confidence	204.331	1.01	203.321
alpha-actinin 4 (non-muscle alpha-actinin 4) (f-actin cross linking protein). [swissprot;acc:o43707]	Divided	1805	ACTN4	High confidence	217.008	1.01178	214.482
		4751		Low confidence	204.3	1.0052	203.243
	Subtracted	1792		High confidence	217.008	2.526	214.482
		4728		Low confidence	204.3	1.057	203.243
alpha-aminoadipate aminotransferase; l-kynurenine/alpha-aminoadipate aminotransferase; kynurenine aminotransferase ii. [refseq;acc:nm_016228]	Divided	988	AADAT		186.556	1.02459	182.079
	Subtracted	1238				4.477
alpha-amylase, salivary precursor (ec 3.2.1.1) (1,4-alpha-d-glucan glucanohydrolase). [swissprot;acc:p04745]	Divided	282	AMY1C		219.742	1.04391	210.498
		3914	no value		207.449	1.01258	204.872
	Subtracted	250	AMY1C		219.742	9.244	210.498
		3858	no value		207.449	2.577	204.872
alpha-centractin (centractin) (centrosome-associated actin homolog) (actin-rpv) (arp1). [swissprot;acc:p42024]	Divided	1509	ACTR1A	High confidence	225.148	1.01795	221.177
		3622		Low confidence	198.731	1.01423	195.943
	Subtracted	1481		High confidence	225.148	3.971	221.177
		3656		Low confidence	198.731	2.788	195.943
alpha-fetoprotein enhancer binding protein (at motif-binding factor) (at-binding transcription factor 1). [swissprot;acc:q15911]	Divided	2075	ZFHX3		201.219	1.01929	197.41
		2255		High confidence	202.366	1.00595	203.57
	Subtracted	2063		Low confidence	201.219	3.809	197.41
		2257		High confidence	202.366	1.204	203.57
alpha-mannosidase 2c1 (ec 3.2.1.24) (alpha-d-mannoside mannohydrolase) (mannosidase alpha class 2c member 1) (alpha mannosidase 6a8b). [swissprot;acc:q9ntj4]	Divided	1823	MAN2C1	Low confidence	202.662	1.02002	198.685
	Subtracted	1765				3.977
alpha-methylacyl-coa racemase (ec 5.1.99.4) (2-methylacyl-coa racemase). [swissprot;acc:q9uhk6]	Divided	4015	C1QTNF3		201.679	1.0116	199.366
	Subtracted	4009				2.313
alpha-n-acetylgalactosaminidase precursor (ec 3.2.1.49) (alpha- galactosidase b). [swissprot;acc:p17050]	Divided	3228	no value		204.526	1.01595	201.316
	Subtracted	3174				3.21
alpha-n-acetylglucosaminidase precursor (ec 3.2.1.50) (n-acetyl-alpha- glucosaminidase) (nag). [swissprot;acc:p54802]	Divided	2393	NAGLU		211.07	1.0185	207.237
	Subtracted	2020				3.833
alpha-nac protein. [sptrembl;acc:q9h009]	Divided	889	no value	High confidence	212.028	1.03908	204.053
		2026		Low confidence	199.011	1.01942	195.219
	Subtracted	900		High confidence	212.028	7.975	204.053
		2096		Low confidence	199.011	3.792	195.219
alpha-parvin (calponin-like integrin-linked kinase binding protein) (ch-ilkbp). [swissprot;acc:q9nvd7]	Divided	1249		High confidence	219.354	1.02437	224.7
		2796		Low confidence	201.856	1.01731	198.422
	Subtracted	1188		High confidence	219.354	5.346	224.7
		2755		Low confidence	201.856	3.434	198.422
alpha-soluble nsf attachment protein (snap-alpha) (n-ethylmaleimide- sensitive factor attachment protein, alpha). [swissprot;acc:p54920]	Divided	812	NAPA	High confidence	212.386	1.04425	221.785
		3626		Low confidence	203.045	1.01421	200.2
	Subtracted	800		High confidence	212.386	9.399	221.785
		3614		Low confidence	203.045	2.845	200.2

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.