MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

Navigation/Query Panel:
Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].

description	Rank	Gene	Network Comparison Type	Hugo	Value Type	Interaction Map	Filtered	red	network_comparison	green

Results: HTML CSV LaTeX

Showing element 208 to 257 of 16578 in total

Value Type  : Ranked
Filtered  : 1

description	Rank	Network Comparison Type	Hugo	Interaction Map	red	network_comparison	green
3 beta-hydroxy-delta 5-c27-steroid oxidoreductase. [refseq;acc:nm_025193]	1737	Subtracted	HSD3B7	Low confidence	197.872	4.006	193.866
	3147	Divided		High confidence	0.00001	1	0.00001
		Subtracted			0	0	0
3 beta-hydroxysteroid dehydrogenase (fragments). [sptrembl;acc:q9udk8]	1663	Divided	no value	Low confidence	197.872	1.02066	193.866
	1733	Subtracted				4.006
	2756	Divided		High confidence	0.00001	1	0.00001
		Subtracted			0	0	0
3 beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase type i (3beta-hsd i) (trophoblast antigen fdo161g) [includes: 3-beta-hydroxy- delta(5)-steroid dehydrogenase (ec 1.1.1.145) (3-beta-hydroxy-5-ene steroid dehydrogenase) (progesterone reductase); steroid delta- isomerase (ec 5.3.3.1) (delta-5-3-ketosteroid isomerase)]. [swissprot;acc:p14060]	1665	Divided		Low confidence	197.872	1.02066	193.866
	1735	Subtracted				4.006
	2802	Divided		High confidence	0.00001	1	0.00001
		Subtracted			0	0	0
3'(2'), 5'-bisphosphate nucleotidase 1; bisphosphate 3'-nucleotidase; bpntase; pap-inositol-1,4-phosphatase. [refseq;acc:nm_006085]	164		BPNT1	Low confidence	209.954	11.653	221.607
	178	Divided				1.0555
3'-5' rna exonuclease; polynucleotide phosphorylase-like. [refseq;acc:nm_033109]	1268	Subtracted	PNPT1		206.13	4.434	201.696
	1373	Divided				1.02198
3-hydroxy-3-methylglutaryl-coenzyme a reductase (ec 1.1.1.34) (hmg-coa reductase). [swissprot;acc:p04035]	2303		HMGCR	High confidence	191.567	1.00509	192.542
	2333	Subtracted				0.975
	3261	Divided		Low confidence	199.744	1.01577	196.642
	3322	Subtracted				3.102
3-hydroxyacyl-coa dehydrogenase type ii (ec 1.1.1.35) (type ii hadh) (endoplasmic reticulum-associated amyloid beta-peptide binding protein) (short-chain type dehydrogenase/reductase xh98g2). [swissprot;acc:q99714]	3180	Divided	HSD17B10	High confidence	0.00001	1	0.00001
		Subtracted			0	0	0
	4083			Low confidence	202.282	2.189	200.093
	4091	Divided				1.01094
3-hydroxyanthranilate 3,4-dioxygenase (ec 1.13.11.6) (3-hao) (3-hydroxyanthranilic acid dioxygenase) (3-hydroxyanthranilate oxygenase). [swissprot;acc:p46952]	1250		HAAO		180.665	1.02263	176.667
	1746	Subtracted				3.998
	2189	Divided		High confidence	209.54	1.00662	208.162
	2201	Subtracted				1.378
3-hydroxyisobutyryl-coenzyme a hydrolase. [refseq;acc:nm_014362]	855		no value	Low confidence	203.354	5.07	198.284
	879	Divided				1.02557
	1852			High confidence	196.008	1.01095	198.154
	1914	Subtracted				2.146
3-ketoacyl-coa thiolase, peroxisomal precursor (ec 2.3.1.16) (beta- ketothiolase) (acetyl-coa acyltransferase) (peroxisomal 3-oxoacyl- coa thiolase). [swissprot;acc:p09110]	2300	Divided	ACAA1		191.563	1.00511	192.541
	2331	Subtracted				0.978
	2649	Divided		Low confidence	195.904	1.01776	192.486
	2813	Subtracted				3.418
3-mercaptopyruvate sulfurtransferase (ec 2.8.1.2) (mst). [swissprot;acc:p25325]	1025	Divided	MPST	High confidence	205.632	1.03195	199.266
	1048	Subtracted				6.366
	2252	Divided		Low confidence	196.562	1.01888	192.92
	2394	Subtracted				3.642
3-oxo-5-alpha-steroid 4-dehydrogenase 1 (ec 1.3.99.5) (steroid 5-alpha-reductase 1) (sr type 1) (s5ar). [swissprot;acc:p18405]	914		SRD5A1		204.147	4.951	199.196
	949	Divided				1.02485
	1040	Subtracted		High confidence	220.118	6.433	213.685
	1083	Divided				1.03011
3-oxo-5-alpha-steroid 4-dehydrogenase 2 (ec 1.3.99.5) (steroid 5-alpha-reductase 2) (sr type 2) (5 alpha-sr2). [swissprot;acc:p31213]	915	Subtracted	SRD5A2	Low confidence	204.147	4.951	199.196
	950	Divided				1.02485
	1041	Subtracted		High confidence	220.118	6.433	213.685
	1084	Divided				1.03011
3-oxo-5-beta-steroid 4-dehydrogenase (ec 1.3.99.6) (delta(4)-3- ketosteroid 5-beta-reductase) (aldo-keto reductase family 1 member d1). [swissprot;acc:p51857]	1896	Subtracted	AKR1D1	Low confidence	201.286	3.902	197.384
	1902	Divided				1.01977
3-phosphoinositide dependent protein kinase-1 (ec 2.7.1.37) (hpdk1). [swissprot;acc:o15530]	739	Subtracted	PDPK1	High confidence	272.878	10.594	283.472

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.