MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Gene	Value Type	Rank	description	Interaction Map	Filtered	Network Comparison Type	green	red	network_comparison

Results: HTML CSV LaTeX

Showing element 451 to 500 of 38536 in total

Value Type  : Measured
Network Comparison Type  : Divided

Rank	description	Interaction Map	Filtered	green	red	network_comparison
113	sh2-b homolog; likely ortholog of mouse sh2 domain-containing putative adapter sh2-b; sh2-b gamma signaling protein; sh2-b alpha signaling protein. [refseq;acc:nm_015503]	Low confidence	0	78	107	1.37179
	sh3 domain-binding glutamic acid-rich-like protein 2 (fovea-associated sh3 domain binding protein). [swissprot;acc:q9ujc5]	High confidence		112.25	160	1.42539
114	calponin h2, smooth muscle (neutral calponin). [swissprot;acc:q99439]	Low confidence		1049.11	768.061	1.36592
	daz associated protein 1 isoform b; deleted in azoospermia associated protein 1. [refseq;acc:nm_018959]	High confidence		472.945	671.769	1.4204
	huntingtin interacting protein c. [refseq;acc:nm_012272]		1	5807.72	4300.47	1.35048
	melanoma-associated antigen 11 (mage-11 antigen). [swissprot;acc:p43364]	Low confidence		10318.5	11285.3	1.0937
115	28s ribosomal protein s17, mitochondrial precursor (mrp-s17) (hspc011). [swissprot;acc:q9y2r5]	High confidence		28492	21185	1.34491
	g protein-coupled receptor kinase grk5 (ec 2.7.1.-) (g-protein-coupled receptor kinase 5). [swissprot;acc:p34947]	Low confidence	0	410	556	1.3561
	melanoma-associated antigen 2 (mage-2 antigen). [swissprot;acc:p43356]		1	10318.5	11285.3	1.0937
	zinc finger protein-like 1; zinc-finger protein in men1 region. [refseq;acc:nm_006782]	High confidence	0	543	385	1.41039
116	alpha-parvin (calponin-like integrin-linked kinase binding protein) (ch-ilkbp). [swissprot;acc:q9nvd7]			475	668	1.40632
	g protein-coupled receptor kinase grk6 (ec 2.7.1.-) (g-protein-coupled receptor kinase 6). [swissprot;acc:p43250]	Low confidence		410	556	1.3561
	hepatocellular carcinoma-associated protein hca1. [refseq;acc:nm_020932]		1	10318.5	11285.3	1.0937
	pantothenate kinase 1 (ec 2.7.1.33) (pantothenic acid kinase 1) (hpank1) (hpank). [swissprot;acc:q8te04]	High confidence		28492	21185	1.34491
117	helicase/primase complex protein. [refseq;acc:nm_138336]	Low confidence	0	210	284	1.35238
	melanoma-associated antigen 6 (mage-6 antigen) (mage3b). [swissprot;acc:p43360]		1	10318.5	11285.3	1.0937
	pantothenate kinase 2, mitochondrial precursor (ec 2.7.1.33) (pantothenic acid kinase 2) (hpank2). [swissprot;acc:q9bz23]	High confidence		28492	21185	1.34491
	ubiquitin activating enzyme e1-like protein. [refseq;acc:nm_006395]		0	122	170.5	1.39754
118	methyltransferase like 2. [refseq;acc:nm_018396]			43	31	1.3871
	necdin. [swissprot;acc:q99608]	Low confidence	1	10318.5	11285.3	1.0937
	pantothenate kinase 3 (ec 2.7.1.33) (pantothenic acid kinase 3) (hpank3). [swissprot;acc:q9h999]	High confidence		28492	21185	1.34491
	transcription elongation factor a protein 1 (transcription elongation factor s-ii protein 1) (transcription elongation factor tfiis.o). [swissprot;acc:p23193]	Low confidence	0	113	83.6667	1.3506
119	estrogen-related receptor gamma (estrogen receptor related protein 3) (err gamma-2). [swissprot;acc:o75454]	High confidence		460.2	633.85	1.37734
	melanoma-associated antigen d1 (mage-d1 antigen) (neurotrophin receptor-interacting mage homolog) (pro2292). [swissprot;acc:q9y5v3]	Low confidence	1	10318.5	11285.3	1.0937
	mitochondrial 28s ribosomal protein s22 (s22mt) (mrp-s22) (gk002). [swissprot;acc:p82650]		0	60.8613	81.504	1.33918
	mitochondrial solute carrier protein. [refseq;acc:nm_145305]	High confidence	1	28492	21185	1.34491
120	high-mobility group 20b; sox-like transcriptional factor; swi/snf-related matrix-associated actin-dependent regulator of chromatin subfamily e, member 1-related. [refseq;acc:nm_006339]			6895.98	5136.78	1.34247
	melanoma-associated antigen f1 (mage-f1 antigen). [swissprot;acc:q9hay2]	Low confidence		10318.5	11285.3	1.0937
	proactivator polypeptide precursor [contains: saposin a (protein a); saposin b (sphingolipid activator protein 1) (sap-1) (cerebroside sulfate activator) (csact) (dispersin) (sulfatide/gm1 activator); saposin c (co-beta-glucosidase) (a1 activator) (glucosylceramidase activator) (sphingolipid activator protein 2) (sap-2); saposin d (protein c) (component c)]. [swissprot;acc:p07602]		0	241.74	180.7	1.3378
	signal-induced proliferation-associated 1-like 1. [refseq;acc:nm_015556]	High confidence		359.631	494.417	1.37479
121	4-aminobutyrate aminotransferase, mitochondrial precursor (ec 2.6.1.19) (gamma-amino-n-butyrate transaminase) (gaba transaminase) (gaba aminotransferase) (gaba-at) (gaba-t). [swissprot;acc:p80404]			14.3333	19.6667	1.3721
	melanoma antigen, family b, 6. [refseq;acc:nm_173523]	Low confidence	1	10318.5	11285.3	1.0937
	sorcin (22 kda protein) (cp-22) (v19). [swissprot;acc:p30626]		0	3953.32	2961.07	1.3351
	transcription factor jun-b. [swissprot;acc:p17275]	High confidence	1	7488.4	5579.18	1.3422
122	high-mobility group 20a. [refseq;acc:nm_018200]			6893.53	5140.14	1.34112
	melanoma-associated antigen 4 (mage-4 antigen) (mage-x2) (mage-41). [swissprot;acc:p43358]	Low confidence		10318.5	11285.3	1.0937
	sh2-b homolog; likely ortholog of mouse sh2 domain-containing putative adapter sh2-b; sh2-b gamma signaling protein; sh2-b alpha signaling protein. [refseq;acc:nm_015503]	High confidence	0	78	107	1.37179
	ubiquitin activating enzyme e1-like protein. [refseq;acc:nm_006395]	Low confidence		3169.35	2376	1.3339
123	cysteine endopeptidase aut-like 2 isoform a; autophagy-related cysteine endopeptidase 2; autophagin 2. [refseq;acc:nm_052936]	High confidence	1	18172.1	24260.3	1.33503
	maspin precursor (protease inhibitor 5). [swissprot;acc:p36952]	Low confidence	0	56	42	1.33333
	melanoma-associated antigen 9 (mage-9 antigen). [swissprot;acc:p43362]		1	10318.5	11285.3	1.0937
	ret finger protein 2 (leukemia associated protein 5) (b-cell chronic lymphocytic leukemia tumor suppressor leu5) (putative tumor suppressor rfp2) (tripartite motif protein 13). [swissprot;acc:o60858]	High confidence	0	1681.3	2285.62	1.35944
124	melanoma-associated antigen 8 (mage-8 antigen). [swissprot;acc:p43361]	Low confidence	1	10318.5	11285.3	1.0937
	microtubule-associated proteins 1a/1b light chain 3b (map1a/map1b lc3 b) (map1a/1b light chain 3 b). [swissprot;acc:q9gzq8]	High confidence		18168.9	24255.7	1.33501
	regulator of chromosome condensation (cell cycle regulatory protein). [swissprot;acc:p18754]		0	2399.76	3248.95	1.35386
	serpin b11. [swissprot;acc:q96p15]	Low confidence		56	42	1.33333
125	cytoplasmic antiproteinase 2 (cap2) (cap-2) (protease inhibitor 8) (serpin b8). [swissprot;acc:p50452]
	melanoma-associated antigen c1 (mage-c1 antigen) (cancer-testis antigen ct7). [swissprot;acc:o60732]		1	10318.5	11285.3	1.0937
	microtubule-associated proteins 1a/1b light chain 3a (map1a/map1b lc3 a) (map1a/1b light chain 3 a). [swissprot;acc:q9h492]	High confidence		18168.9	24255.7	1.33501
	probable calcium-transporting atpase kiaa0703 (ec 3.6.3.8). [swissprot;acc:o75185]		0	812.166	1095.42	1.34876

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.