MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Value Type	Gene	description	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 1486 to 1535 of 14920 in total

Network Comparison Type  : Divided
Interaction Map  : High confidence

Rank	Value Type	description	Filtered	red	green	network_comparison
186	Squared	huntingtin interacting protein c. [refseq;acc:nm_012272]	0	5086.87	3492.66	1.45645
	Rooted	60s ribosomal protein l15. [swissprot;acc:p39030]		19.482	17.0546	1.14233
		microtubule-associated proteins 1a/1b light chain 3a (map1a/map1b lc3 a) (map1a/1b light chain 3 a). [swissprot;acc:q9h492]	1	153.578	133.176	1.1532
187	Measured	importin 9. [refseq;acc:nm_018085]	0	1143.55	1397.66	1.22221
		small nuclear ribonucleoprotein sm d3 (snrnp core protein d3) (sm-d3). [swissprot;acc:p43331]	1	4569.48	5885.79	1.28807
	Ranked	adenylosuccinate synthase-like 1. [refseq;acc:nm_152328]	0	9955.22	11213.7	1.12641
		rev1-like; rev1 protein; rev1 (yeast homolog)- like. [refseq;acc:nm_016316]	1	226.582	198.444	1.14179
	Squared	heparan sulfate d-glucosaminyl 3-o-sulfotransferase 3b1. [refseq;acc:nm_006041]		41502.9	30836.8	1.34589
		tubulin gamma-1 chain (gamma-1 tubulin) (gamma-tubulin complex component 1) (gcp-1). [swissprot;acc:p23258]	0	8660.1	5963.73	1.45213
	Rooted	cysteine endopeptidase aut-like isoform b. [refseq;acc:nm_178326]	1	153.548	133.153	1.15317
		udp-glucuronosyltransferase 2b17 precursor, microsomal (ec 2.4.1.17) (udpgt) (c19-steroid specific udp-glucuronosyltransferase). [swissprot;acc:o75795]	0	32.4121	28.377	1.1422
188	Measured	nucleosome assembly protein 1-like 4 (nucleosome assembly protein 2) (nap2). [swissprot;acc:q99733]		1143.55	1397.66	1.22221
		source of immunodominant mhc-associated peptides; homolog of yeast stt3 gene. [refseq;acc:nm_178862]	1	4571.89	5864.86	1.28281
	Ranked	60s ribosomal protein l15. [swissprot;acc:p39030]	0	11745.2	13203.1	1.12413
		protein arginine n-methyltransferase 1 (ec 2.1.1.-) (interferon receptor 1-bound protein 4). [swissprot;acc:q99873]	1	226.582	198.444	1.14179
	Squared	heparan sulfate d-glucosaminyl 3-o-sulfotransferase 2; heparin-glucosamine 3-o-sulfotransferase. [refseq;acc:nm_006043]		41502.9	30836.8	1.34589
		transcription factor mafk (erythroid transcription factor nf-e2 p18 subunit). [swissprot;acc:o60675]	0	157.095	228.024	1.4515
	Rooted	transcription factor e2f1 (e2f-1) (retinoblastoma binding protein 3) (rbbp-3) (prb-binding protein e2f-1) (pbr3) (retinoblastoma-associated protein 1) (rbap-1). [swissprot;acc:q01094]	1	46.0352	53.0192	1.15171
		udp-glucuronosyltransferase 2b11 precursor, microsomal (ec 2.4.1.17) (udpgt). [swissprot;acc:o75310]	0	32.4121	28.377	1.1422
189	Measured	oligosaccharyl transferase stt3 subunit homolog (b5) (integral membrane protein 1) (tmc). [swissprot;acc:p46977]	1	4571.89	5864.86	1.28281
		pyrroline-5-carboxylate reductase (ec 1.5.1.2) (p5cr) (p5c reductase). [swissprot;acc:p32322]	0	1249.24	1023.76	1.22025
	Ranked	protein arginine n-methyltransferase 4 (ec 2.1.1.-). [swissprot;acc:q9nr22]	1	226.582	198.444	1.14179
		sal-like protein 4 (zinc finger protein sall4). [swissprot;acc:q9ujq4]	0	10634.4	9465	1.12355
	Squared	mrna decapping enzyme; histidine triad protein member 5; heat shock-like protein 1. [refseq;acc:nm_014026]	1	41502.9	30836.8	1.34589
		nuclear dna-binding protein; small unique nuclear receptor corepressor; c1d dna-binding protein. [refseq;acc:nm_006333]	0	232467	160184	1.45125
	Rooted	transcription factor e2f2 (e2f-2). [swissprot;acc:q14209]	1	46.0352	53.0192	1.15171
		udp-glucuronosyltransferase 2b4 precursor, microsomal (ec 2.4.1.17) (udpgt) (hyodeoxycholic acid) (hlug25) (udpgth-1). [swissprot;acc:p06133]	0	32.4121	28.377	1.1422
190	Measured	dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kda subunit precursor (ec 2.4.1.119) (oligosaccharyl transferase 48 kda subunit) (ddost 48 kda subunit). [swissprot;acc:p39656]	1	4571.89	5864.86	1.28281
		protocadherin 16 precursor (cadherin 19) (cadherin fibroblast 1). [swissprot;acc:q96jq0]	0	14	11.5	1.21739
	Ranked	high-glucose-regulated protein 8 (ny-ren-2 antigen). [swissprot;acc:q9y5a9]		18809.5	16764.2	1.122
		u1 small nuclear ribonucleoprotein 70 kda (u1 snrnp 70 kda) (snrnp70) (u1-70k). [swissprot;acc:p08621]	1	226.582	198.444	1.14179
	Squared	aquaporin 4 (wch4) (mercurial-insensitive water channel) (miwc). [swissprot;acc:p55087]		71389.9	96037.6	1.34525
		transcription factor mafg (v-maf musculoaponeurotic fibrosarcoma oncogene homolog g) (hmaf). [swissprot;acc:o15525]	0	158.413	229.842	1.4509
	Rooted	gaba(a) receptor-associated protein; gaba(a)-receptor-associated protein. [refseq;acc:nm_007278]	1	149.165	129.699	1.15009
		glutamyl aminopeptidase (ec 3.4.11.7) (eap) (aminopeptidase a) (apa) (differentiation antigen gp160). [swissprot;acc:q07075]	0	32.4121	28.377	1.1422
191	Measured	ba395l14.12 (novel protein similar to small nuclear ribonucleoprotein polypeptide a' (snrpa1)). [sptrembl;acc:q9nu36]		743.066	904.149	1.21678
		splicing factor 3b subunit 1 (spliceosome associated protein 155) (sap 155) (sf3b155) (pre-mrna splicing factor sf3b 155 kda subunit). [swissprot;acc:o75533]	1	4638.1	5923.4	1.27712
	Ranked	filamin a (alpha-filamin) (filamin 1) (endothelial actin-binding protein) (abp-280) (nonmuscle filamin). [swissprot;acc:p21333]		226.582	198.444	1.14179
		sh3 adapter protein spin90 (sh3 protein interacting with nck, 90 kda) (vaca-interacting protein, 54 kda) (vip54) (af3p21) (diaphanous protein interacting protein) (dia interacting protein-1) (dip-1). [swissprot;acc:q9nzq3]	0	18809.5	16764.2	1.122
	Squared	aquaporin 5. [swissprot;acc:p55064]	1	71388.5	96035.2	1.34525
		swi/snf related, matrix associated, actin dependent regulator of chromatin subfamily d member 1 (swi/snf complex 60 kda subunit) (brg1- associated factor 60a). [swissprot;acc:q96gm5]	0	40674.4	28034.4	1.45087
	Rooted	pallidin; pallid (mouse) homolog, pallidin. [refseq;acc:nm_012388]	1	63.1192	72.584	1.14995
		udp-glucuronosyltransferase 2b10 precursor, microsomal (ec 2.4.1.17) (udpgt). [swissprot;acc:p36537]	0	32.4121	28.377	1.1422
192	Measured	a-raf proto-oncogene serine/threonine-protein kinase (ec 2.7.1.-) (a-raf-1) (proto-oncogene pks). [swissprot;acc:p10398]	1	17757.5	14008	1.26767
		sal-like protein 4 (zinc finger protein sall4). [swissprot;acc:q9ujq4]	0	1965.47	2389.69	1.21584
	Ranked	musashi 2 isoform a. [refseq;acc:nm_138962]	1	227.491	199.458	1.14055
		t-complex protein 1, zeta subunit (tcp-1-zeta) (cct-zeta) (cct-zeta-1) (tcp20) (htr3). [swissprot;acc:p40227]	0	12715.9	11333.2	1.122
	Squared	aquaporin-cd (aqp-cd) (water channel protein for renal collecting duct) (adh water channel) (aquaporin 2) (collecting duct water channel protein) (wch-cd). [swissprot;acc:p41181]	1	71387.4	96033.4	1.34524
		collagen alpha 5(iv) chain precursor. [swissprot;acc:p29400]	0	3480.56	5039.04	1.44777
	Rooted	splicing factor 4 isoform b; rna-binding protein. [refseq;acc:nm_021164]	1	53.6107	61.5862	1.14877

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.