Scientific

MK5 Microarray Data


Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

  • value_type as 'ranked' since this provides a very robust analysis method.
  • intercation map as 'high confidence'
  • network_comparison type as 'Divided' since this leads to a natural grouping of similar proteins
  • filtered as 'true' since this will only use the microarray measurements that have a sufficiently large confidence level.

  • Navigation/Query Panel:
    Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].
    Rank Gene description Value Type Network Comparison Type Interaction Map Filtered red green network_comparison
    Results: HTML CSV LaTeX Showing element 75 to 124 of 3228 in total
    Value Type	Measured
    Network Comparison Type Divided
    Interaction Map High confidence
    Filtered 1
    Rank description red green network_comparison 75 nadh-ubiquinone oxidoreductase 18 kda subunit, mitochondrial precursor (ec 1.6.5.3) (ec 1.6.99.3) (complex i-18 kda) (ci-18 kda) (complex i- aqdq) (ci-aqdq). [source:swissprot;acc:o43181] 1920.75 2907.43 1.5137 76 serine/threonine protein phosphatase 2a, 65 kda regulatory subunit a, beta isoform (pp2a, subunit a, pr65-beta isoform) (pp2a, subunit a, r1-beta isoform). [source:swissprot;acc:p30154] 4599.26 3058.57 1.50373 77 serine/threonine protein phosphatase 2a, 65 kda regulatory subunit a, alpha isoform (pp2a, subunit a, pr65-alpha isoform) (pp2a, subunit a, r1-alpha isoform) (medium tumor antigen-associated 61 kda protein). [source:swissprot;acc:p30153] 4612.39 3093.6 1.49095 78 cyclic-amp-dependent transcription factor atf-3 (activating transcription factor 3). [source:swissprot;acc:p18847] 4800.81 7132.71 1.48573 79 protein cgi-126 (protein hspc155). [source:swissprot;acc:q9y3c8] 3074.57 4567.51 1.48558 80 nucleolysin tia-1 (rna-binding protein tia-1) (p40-tia-1) [contains: p15-tia-1]. [source:swissprot;acc:p31483] 4133.47 5945.32 1.43834 81 nucleolysin tiar (tia-1 related protein). [source:swissprot;acc:q01085] 4136.36 5943.56 1.43691 82 small nuclear ribonucleoprotein sm d1 (snrnp core protein d1) (sm-d1) (sm-d autoantigen). [source:swissprot;acc:p13641] 4172.91 5954.48 1.42694 83 proto-oncogene protein c-fos (cellular oncogene fos) (g0/g1 switch regulatory protein 7). [source:swissprot;acc:p01100] 4932.27 7033.29 1.42597 84 jun dimerization protein. [source:refseq;acc:nm_130469] 4932.27 7033.29 1.42597 85 fos-related antigen 2. [source:swissprot;acc:p15408] 4941.95 7037.11 1.42395 86 protein fosb (g0/g1 switch regulatory protein 3). [source:swissprot;acc:p53539] 4942.49 7037.32 1.42384 87 fos-related antigen 1 (fra-1). [source:swissprot;acc:p15407] 4944.3 7038.04 1.42347 88 potassium voltage-gated channel, shal-related subfamily, member 2; voltage-sensitive potassium channel; voltage-gated potassium channel kv4.2. [source:refseq;acc:nm_012281] 2411.93 1695.45 1.42259 89 cystathionine gamma-lyase (ec 4.4.1.1) (gamma-cystathionase). [source:swissprot;acc:p32929] 2414.22 1698.12 1.4217 90 potassium voltage-gated channel, shal-related subfamily, member 3 isoform 1; sha1-related potassium channel kv4.3; voltage-gated k+ channel; potassium ionic channel kv4.3; voltage-gated potassium channel kv4.3. [source:refseq;acc:nm_004980] 2414.77 1698.75 1.4215 91 potassium voltage-gated channel, shal-related subfamily, member 1; shal-type potassium channel; voltage-gated potassium channel kv4.1. [source:refseq;acc:nm_004979] 2416.53 1700.8 1.42082 92 dj820b18.1 (similar to nuclear cap binding protein) (fragment). [source:sptrembl;acc:q8wwk2] 4117.67 5801.04 1.40882 93 formin binding protein 3; fas-ligand associated factor 1; huntingtin-interacting protein a; ny-ren-6 antigen. [source:refseq;acc:nm_017892] 4245.52 5942.75 1.39977 94 huntingtin-interacting protein hypa/fbp11 (fragment). [source:sptrembl;acc:o75404] 4247.86 5941.88 1.39879 95 son protein (son3) (negative regulatory element-binding protein) (nre- binding protein) (dbp-5) (bax antagonist selected in saccharomyces 1) (bass1) (protein c21orf50). [source:swissprot;acc:p18583] 2397.19 3343.62 1.39481 96 lag1 longevity assurance homolog 2 isoform 1; l3 pigment; tumor metastasis-suppressor. [source:refseq;acc:nm_022075] 4110.14 5694.99 1.3856 97 amyloid beta a4 precursor protein-binding family a member 1 (neuron- specific x11 protein) (neuronal munc18-1-interacting protein 1) (mint-1) (adapter protein x11alpha). [source:swissprot;acc:q02410] 2820.51 3897.1 1.3817 98 presenilin 2 (ps-2) (stm-2) (e5-1) (ad3lp) (ad5). [source:swissprot;acc:p49810] 2353.63 3225.65 1.3705 99 s-phase kinase-associated protein 1a (cyclin a/cdk2-associated protein p19) (p19a) (p19skp1) (rna polymerase ii elongation factor-like protein) (organ of corti protein 2) (ocp-ii protein) (ocp-2) (transcription elongation factor b) (siii). [source:swissprot;acc:p34991] 2353.63 3225.65 1.3705 100 f-box protein fbw7 isoform 2; archipelago, drosophila, homolog of; f-box protein fbw7; f-box protein sel-10; homolog of c elegans sel-10. [source:refseq;acc:nm_018315] 2353.63 3225.65 1.3705 101 cullin homolog 2 (cul-2). [source:swissprot;acc:q13617] 2353.63 3225.65 1.3705 102 presenilin 1 (ps-1) (s182 protein). [source:swissprot;acc:p49768] 2353.63 3225.65 1.3705 103 cullin homolog 1 (cul-1). [source:swissprot;acc:q13616] 2353.63 3225.65 1.3705 104 musashi 2 isoform a. [source:refseq;acc:nm_138962] 4241.57 5810.79 1.36996 105 musashi 1. [source:refseq;acc:nm_002442] 4241.57 5810.79 1.36996 106 nuclear protein ukp68. [source:refseq;acc:nm_024824] 4241.57 5810.79 1.36996 107 20 kda nuclear cap binding protein (ncbp 20 kda subunit) (cbp20) (ncbp interacting protein 1) (nip1). [source:swissprot;acc:p52298] 4266.04 5843.51 1.36977 108 filamin b, beta (actin binding protein 278); beta filamin; filamin 1 (actin-binding protein-280)-like; filamin b, beta (actin-binding protein-278); filamin b, beta. [source:refseq;acc:nm_001457] 4366.44 5899.76 1.35116 109 rev1-like; rev1 protein; rev1 (yeast homolog)- like. [source:refseq;acc:nm_016316] 4366.44 5899.76 1.35116 110 protein arginine n-methyltransferase 1 (ec 2.1.1.-) (interferon receptor 1-bound protein 4). [source:swissprot;acc:q99873] 4366.44 5899.76 1.35116 111 protein arginine n-methyltransferase 4 (ec 2.1.1.-). [source:swissprot;acc:q9nr22] 4366.44 5899.76 1.35116 112 u1 small nuclear ribonucleoprotein 70 kda (u1 snrnp 70 kda) (snrnp70) (u1-70k). [source:swissprot;acc:p08621] 4366.44 5899.76 1.35116 113 filamin a (alpha-filamin) (filamin 1) (endothelial actin-binding protein) (abp-280) (nonmuscle filamin). [source:swissprot;acc:p21333] 4366.44 5899.76 1.35116 114 huntingtin interacting protein c. [source:refseq;acc:nm_012272] 4300.47 5807.72 1.35048 115 28s ribosomal protein s17, mitochondrial precursor (mrp-s17) (hspc011). [source:swissprot;acc:q9y2r5] 21185 28492 1.34491 116 pantothenate kinase 1 (ec 2.7.1.33) (pantothenic acid kinase 1) (hpank1) (hpank). [source:swissprot;acc:q8te04] 21185 28492 1.34491 117 pantothenate kinase 2, mitochondrial precursor (ec 2.7.1.33) (pantothenic acid kinase 2) (hpank2). [source:swissprot;acc:q9bz23] 21185 28492 1.34491 118 pantothenate kinase 3 (ec 2.7.1.33) (pantothenic acid kinase 3) (hpank3). [source:swissprot;acc:q9h999] 21185 28492 1.34491 119 mitochondrial solute carrier protein. [source:refseq;acc:nm_145305] 21185 28492 1.34491 120 high-mobility group 20b; sox-like transcriptional factor; swi/snf-related matrix-associated actin-dependent regulator of chromatin subfamily e, member 1-related. [source:refseq;acc:nm_006339] 5136.78 6895.98 1.34247 121 transcription factor jun-b. [source:swissprot;acc:p17275] 5579.18 7488.4 1.3422 122 high-mobility group 20a. [source:refseq;acc:nm_018200] 5140.14 6893.53 1.34112 123 cysteine endopeptidase aut-like 2 isoform a; autophagy-related cysteine endopeptidase 2; autophagin 2. [source:refseq;acc:nm_052936] 24260.3 18172.1 1.33503 124 microtubule-associated proteins 1a/1b light chain 3b (map1a/map1b lc3 b) (map1a/1b light chain 3 b). [source:swissprot;acc:q9gzq8] 24255.7 18168.9 1.33501 Legend: - Rank is the rank after comparing the two networks - Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions. - Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them - Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions. - Filtered specifies whether we only included the high confidence microarry measurements or not.

    - http://analysis.yellowcouch.org/