MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Gene	Rank	Value Type	description	Network Comparison Type	Interaction Map	Filtered	network_comparison	green	red

Results: HTML CSV LaTeX

Showing element 1 to 50 of 16578 in total

Value Type  : Ranked
Filtered  : 1

Rank	description	Network Comparison Type	Interaction Map	network_comparison	green	red
1	carboxypeptidase d precursor (ec 3.4.17.-) (gp180). [swissprot;acc:o75976]	Divided	Low confidence	2	32	16
	homeobox protein hlx1 (homeobox protein hb24). [swissprot;acc:q14774]	Subtracted	High confidence	107	322	215
	lysosome-associated membrane glycoprotein 1 precursor (lamp-1) (cd107a antigen). [swissprot;acc:p11279]		Low confidence		330	223
	putative glialblastoma cell differentiation-related; putative glialblastoma cell differentiation-related protein. [refseq;acc:nm_016172]	Divided	High confidence	2.4	24	10
2	cell division protein kinase 4 (ec 2.7.1.37) (cyclin-dependent kinase 4) (psk-j3). [swissprot;acc:p11802]	Subtracted	Low confidence	107	330	223
	hbs1-like. [refseq;acc:nm_006620]		High confidence		322	215
	lysosome-associated membrane glycoprotein 1 precursor (lamp-1) (cd107a antigen). [swissprot;acc:p11279]	Divided	Low confidence	1.47982	330	223
	mannosyl-oligosaccharide 1,2-alpha-mannosidase ib (ec 3.2.1.113) (processing alpha-1,2-mannosidase ib) (alpha-1,2-mannosidase ib) (mannosidase alpha class 1a member 2). [swissprot;acc:o60476]		High confidence	1.86667	28	15
3	cell division protein kinase 4 (ec 2.7.1.37) (cyclin-dependent kinase 4) (psk-j3). [swissprot;acc:p11802]		Low confidence	1.47982	330	223
	cell division protein kinase 6 (ec 2.7.1.37) (serine/threonine protein kinase plstire). [swissprot;acc:q00534]	Subtracted		107
	cytohesin 1 (sec7 homolog b2-1). [swissprot;acc:q15438]	Divided	High confidence	1.86667	28	15
	rad50-interacting protein 1. [refseq;acc:nm_021930]	Subtracted		105	232	337
4	cell division protein kinase 6 (ec 2.7.1.37) (serine/threonine protein kinase plstire). [swissprot;acc:q00534]	Divided	Low confidence	1.47982	330	223
	cytohesin 2 (arf nucleotide-binding site opener) (arno protein) (arf exchange factor). [swissprot;acc:q99418]		High confidence	1.86667	28	15
	lysosome-associated membrane glycoprotein 2 precursor (lamp-2) (cd107b antigen). [swissprot;acc:p13473]	Subtracted	Low confidence	107	330	223
	rho-related btb domain-containing protein 2 (deleted in breast cancer 2 gene protein) (p83). [swissprot;acc:q9byz6]		High confidence	105	232	337
5	cytohesin 4. [swissprot;acc:q9uia0]	Divided		1.86667	28	15
	lysosome-associated membrane glycoprotein 2 precursor (lamp-2) (cd107b antigen). [swissprot;acc:p13473]		Low confidence	1.47982	330	223
	oxysterol binding protein-related protein 6 (osbp-related protein 6) (orp-6). [swissprot;acc:q9bzf3]	Subtracted		78	240	318
	xpa binding protein 1; mbd2 interactor protein; putative atp(gtp)-binding protein. [refseq;acc:nm_007266]		High confidence	97	309	212
6	cytohesin 3 (arf nucleotide-binding site opener 3) (arno3 protein) (general receptor of phosphoinositides 1) (grp1). [swissprot;acc:o43739]	Divided		1.86667	28	15
	oxysterol binding protein-related protein 3 (osbp-related protein 3) (orp-3). [swissprot;acc:q9h4l5]	Subtracted	Low confidence	78	240	318
	oxysterol binding protein-related protein 6 (osbp-related protein 6) (orp-6). [swissprot;acc:q9bzf3]	Divided		1.325
	protein x 0004. [refseq;acc:nm_016301]	Subtracted	High confidence	97	309	212
7	homeobox protein hlx1 (homeobox protein hb24). [swissprot;acc:q14774]	Divided		1.49767	322	215
	oxysterol binding protein-related protein 3 (osbp-related protein 3) (orp-3). [swissprot;acc:q9h4l5]		Low confidence	1.325	240	318
	oxysterol binding protein-related protein 7 (osbp-related protein 7) (orp-7). [swissprot;acc:q9bzf2]	Subtracted		78
	protein cgi-126 (protein hspc155). [swissprot;acc:q9y3c8]		High confidence	76.2	212.554	288.754
8	hbs1-like. [refseq;acc:nm_006620]	Divided		1.49767	322	215
	junctophilin 3 (junctophilin type 3) (jp-3). [swissprot;acc:q8wxh2]	Subtracted		74	362	288
	oxysterol binding protein-related protein 7 (osbp-related protein 7) (orp-7). [swissprot;acc:q9bzf2]	Divided	Low confidence	1.325	240	318
	thyroid receptor interacting protein 8 (trip-8) (fragment). [swissprot;acc:q15652]	Subtracted		58.226	247.246	305.472
9	28s ribosomal protein s17, mitochondrial precursor (mrp-s17) (hspc011). [swissprot;acc:q9y2r5]	Divided		1.31818	44	58
	gbp protein isoform a. [refseq;acc:nm_017870]	Subtracted		58.186	247.213	305.399
	junctophilin 2 (junctophilin type 2) (jp-2). [swissprot;acc:q9br39]		High confidence	74	362	288
	xpa binding protein 1; mbd2 interactor protein; putative atp(gtp)-binding protein. [refseq;acc:nm_007266]	Divided		1.45755	309	212
10	jumonji domain containing 1; zinc finger protein; testis-specific protein a. [refseq;acc:nm_018433]	Subtracted	Low confidence	58.134	247.169	305.303
	mitochondrial solute carrier protein. [refseq;acc:nm_145305]	Divided		1.31818	44	58
	protein x 0004. [refseq;acc:nm_016301]		High confidence	1.45755	309	212
	sphingomyelin phosphodiesterase 2 (ec 3.1.4.12) (neutral sphingomyelinase) (nsmase) (n-smase) (lyso-platelet activating factor- phospholipase c) (lyso-paf-plc). [swissprot;acc:o60906]	Subtracted		74	362	288
11	bestrophin (vitelliform macular dystrophy protein) (tu15b). [swissprot;acc:o76090]	Divided	Low confidence	1.30966	28.4944	37.318
	db83 protein. [swissprot;acc:p57088]	Subtracted	High confidence	74	362	288
	rad50-interacting protein 1. [refseq;acc:nm_021930]	Divided		1.45259	232	337
	trypsin iii precursor (ec 3.4.21.4) (brain trypsinogen) (mesotrypsinogen) (trypsin iv). [swissprot;acc:p35030]	Subtracted	Low confidence	57.724	246.824	304.548
12	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-7 subunit. [swissprot;acc:o60262]		High confidence	69.377	336.233	266.856
	rho-related btb domain-containing protein 2 (deleted in breast cancer 2 gene protein) (p83). [swissprot;acc:q9byz6]	Divided		1.45259	232	337
	trypsin i precursor (ec 3.4.21.4) (cationic trypsinogen). [swissprot;acc:p07477]	Subtracted	Low confidence	57.622	246.737	304.359
	vitelliform macular dystrophy 2-like protein 2. [refseq;acc:nm_153274]	Divided		1.30933	28.5242	37.3475
13	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-12 subunit. [swissprot;acc:q9ubi6]	Subtracted	High confidence	69.377	336.233	266.856
	nuclear dna-binding protein; small unique nuclear receptor corepressor; c1d dna-binding protein. [refseq;acc:nm_006333]	Divided	Low confidence	1.30207	29.1831	37.9984

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.