MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	description	Gene	Network Comparison Type	Interaction Map	Filtered	Value Type	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 451 to 500 of 66312 in total

Filtered  : 1

Rank	description	Network Comparison Type	Interaction Map	Value Type	red	green	network_comparison
29	cyclic-amp-dependent transcription factor atf-3 (activating transcription factor 3). [swissprot;acc:p18847]	Divided	Low confidence	Ranked	203.115	170.557	1.19089
	cytohesin 2 (arf nucleotide-binding site opener) (arno protein) (arf exchange factor). [swissprot;acc:q99418]	Subtracted		Squared	92930.5	71802.4	21128.1
	cytoplasmic polyadenylation element binding protein 3. [refseq;acc:nm_014912]	Divided		Rooted	48.8531	56.7071	1.16077
	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-8 subunit (gamma-9). [swissprot;acc:q9uk08]		High confidence	Measured	1834.52	895.507	2.04858
	guanine nucleotide-binding protein g(z), alpha subunit (g(x) alpha chain) (gz-alpha). [swissprot;acc:p19086]	Subtracted		Ranked	267.139	336.075	68.936
	hepatocellular carcinoma-associated protein hca3. [refseq;acc:nm_138703]	Divided	Low confidence	Squared	82347.8	61881.5	1.33073
	melanoma-associated antigen d1 (mage-d1 antigen) (neurotrophin receptor-interacting mage homolog) (pro2292). [swissprot;acc:q9y5v3]	Subtracted	High confidence	Measured	23693.7	18263	5430.7
	melanoma-associated antigen d2 (mage-d2 antigen) (breast cancer associated gene 1 protein) (bcg-1) (11b6) (hepatocellular carcinoma associated protein jcl-1). [swissprot;acc:q9unf1]			Squared	219048	129762	89286
	protein phosphatase 1, regulatory (inhibitor) subunit 14a; 17-kda pkc-potentiated inhibitory protein of pp1. [refseq;acc:nm_033256]	Divided		Rooted	26.0288	43.1914	1.65937
	putative glialblastoma cell differentiation-related; putative glialblastoma cell differentiation-related protein. [refseq;acc:nm_016172]	Subtracted			210.928	192.165	18.763
	retinoblastoma-associated factor 600. [refseq;acc:nm_020765]		Low confidence		76.5734	88.6244	12.051
	septin 10 isoform 1. [refseq;acc:nm_144710]			Measured	13081.2	14872.6	1791.4
	tob1 protein (transducer of erbb-2 1). [swissprot;acc:p50616]	Divided			3121.28	3739.84	1.19818
	uncharacterized hematopoietic stem/progenitor cells protein mds026. [sptrembl;acc:q9nz48]		High confidence	Ranked	187.458	243.678	1.29991
30	bcl2-related ovarian killer. [refseq;acc:nm_032515]		Low confidence		265.638	223.235	1.18995
	bestrophin (vitelliform macular dystrophy protein) (tu15b). [swissprot;acc:o76090]			Measured	36474.3	43509.4	1.19288
	cyclic-amp-dependent transcription factor atf-3 (activating transcription factor 3). [swissprot;acc:p18847]	Subtracted	High confidence	Rooted	60.8022	79.5099	18.7077
	cyclin-dependent kinase 2-associated protein 1 (cdk2-associated protein 1) (putative oral cancer suppressor) (deleted in oral cancer- 1) (doc-1). [swissprot;acc:o14519]	Divided		Squared	143.692	457.521	3.18404
	cytoplasmic polyadenylation element binding protein 4. [refseq;acc:nm_030627]		Low confidence	Rooted	48.8781	56.7253	1.16055
	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-5 subunit. [swissprot;acc:p30670]		High confidence	Measured	1834.59	895.633	2.04837
	guanine nucleotide-binding protein g(t), alpha-2 subunit (transducin alpha-2 chain). [swissprot;acc:p19087]	Subtracted		Ranked	267.14	336.075	68.935
	mannosyl-oligosaccharide 1,2-alpha-mannosidase ib (ec 3.2.1.113) (processing alpha-1,2-mannosidase ib) (alpha-1,2-mannosidase ib) (mannosidase alpha class 1a member 2). [swissprot;acc:o60476]		Low confidence	Squared	92930	71802.1	21127.9
	melanoma-associated antigen 3 (mage-3 antigen) (antigen mz2-d). [swissprot;acc:p43357]	Divided			82347.8	61881.5	1.33073
	melanoma-associated antigen f1 (mage-f1 antigen). [swissprot;acc:q9hay2]	Subtracted	High confidence	Measured	23693.7	18263	5430.7
	microfibril-associated glycoprotein 4 precursor. [swissprot;acc:p55083]	Divided		Rooted	26.0288	43.1914	1.65937
	phosphatidylinositol-glycan biosynthesis, class f protein (pig-f). [swissprot;acc:q07326]	Subtracted	Low confidence	Measured	3278	5058.5	1780.5
	protein kinase, interferon-inducible double stranded rna dependent activator; protein activator of the interferon-induced protein kinase. [refseq;acc:nm_003690]			Rooted	44.4168	55.937	11.5202
	serine/threonine protein phosphatase 2a, 55 kda regulatory subunit b, alpha isoform (pp2a, subunit b, b-alpha isoform) (pp2a, subunit b, b55-alpha isoform) (pp2a, subunit b, pr55-alpha isoform) (pp2a, subunit b, r2-alpha isoform). [swissprot;acc:q00007]	Divided	High confidence	Ranked	187.457	243.678	1.29991
	son protein (son3) (negative regulatory element-binding protein) (nre- binding protein) (dbp-5) (bax antagonist selected in saccharomyces 1) (bass1) (protein c21orf50). [swissprot;acc:p18583]	Subtracted	Low confidence		255.382	223.538	31.844
	trophinin. [swissprot;acc:q12816]		High confidence	Squared	219048	129762	89286
31	28s ribosomal protein s17, mitochondrial precursor (mrp-s17) (hspc011). [swissprot;acc:q9y2r5]	Divided	Low confidence	Rooted	145.551	168.796	1.1597
		Subtracted	High confidence	Squared	106226	192141	85915
	atlastin; guanylate-binding protein 3. [refseq;acc:nm_015915]		Low confidence	Ranked	142	170	28
	beta-arrestin 2 (arrestin, beta 2). [swissprot;acc:p32121]	Divided	High confidence	Squared	9924.76	25146.6	2.53372
	cytohesin 3 (arf nucleotide-binding site opener 3) (arno3 protein) (general receptor of phosphoinositides 1) (grp1). [swissprot;acc:o43739]	Subtracted	Low confidence		92920.4	71796.4	21124
	deoxyribonuclease ii beta isoform 1 precursor; deoxyribonuclease ii beta; endonuclease dlad. [refseq;acc:nm_021233]	Divided		Ranked	57.395	48.8186	1.17568
	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-10 subunit. [swissprot;acc:p50151]		High confidence	Measured	1834.63	895.697	2.04827
	guanine nucleotide-binding protein g(t), alpha-1 subunit (transducin alpha-1 chain). [swissprot;acc:p11488]	Subtracted		Ranked	267.14	336.075	68.935
	histidine triad nucleotide-binding protein 1 (adenosine 5'- monophosphoramidase) (protein kinase c inhibitor 1) (protein kinase c- interacting protein 1) (pkci-1). [swissprot;acc:p49773]		Low confidence	Rooted	67.7094	56.875	10.8344
	melanoma antigen, family b, 6. [refseq;acc:nm_173523]		High confidence	Measured	23693.7	18263	5430.7
	melanoma-associated antigen 11 (mage-11 antigen). [swissprot;acc:p43364]	Divided	Low confidence	Squared	82347.8	61881.5	1.33073
	n33 protein. [swissprot;acc:q13454]	Subtracted		Measured	3278	5058.5	1780.5
	protein cgi-126 (protein hspc155). [swissprot;acc:q9y3c8]		High confidence	Rooted	40.0958	58.7986	18.7028
	protein phosphatase 1, regulatory subunit 14d; pkc-dependent pp1 inhibitory protein. [refseq;acc:nm_017726]	Divided			26.0288	43.1914	1.65937
	serine/threonine protein phosphatase 2a, 55 kda regulatory subunit b, beta isoform (pp2a, subunit b, b-beta isoform) (pp2a, subunit b, b55- beta isoform) (pp2a, subunit b, pr55-beta isoform) (pp2a, subunit b, r2-beta isoform). [swissprot;acc:q00005]			Ranked	187.458	243.677	1.2999
	vitelliform macular dystrophy 2-like protein 2. [refseq;acc:nm_153274]		Low confidence	Measured	36469.3	43503.3	1.19287
32	beta-arrestin 1 (arrestin, beta 1). [swissprot;acc:p49407]		High confidence	Squared	9924.76	25146.6	2.53372
	cytohesin 4. [swissprot;acc:q9uia0]	Subtracted	Low confidence		92262.9	71400.2	20862.7
	ficolin 2 precursor (collagen/fibrinogen domain-containing protein 2) (ficolin-b) (ficolin b) (serum lectin p35) (ebp-37) (hucolin) (l- ficolin). [swissprot;acc:q15485]	Divided	High confidence	Rooted	26.0288	43.1914	1.65937
	gbp protein isoform a. [refseq;acc:nm_017870]	Subtracted			23.9771	42.4773	18.5002

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.