MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Value Type	Hugo	red	Filtered	description	green	Interaction Map	network_comparison	Network Comparison Type

Results: HTML CSV LaTeX

Showing element 501 to 550 of 3228 in total

Value Type  : Ranked
Filtered  : 1
Interaction Map  : High confidence
Network Comparison Type  : Divided

Rank	Hugo	red	description	green	network_comparison
501	CYC1	238.704	cytochrome c1, heme protein, mitochondrial precursor (cytochrome c-1). [swissprot;acc:p08574]	255.68	1.07112
502	ARHGAP26		oligophrenin-1 like protein (gtpase regulator associated with focal adhesion kinase). [swissprot;acc:q9una1]
503	RGN		senescence marker protein-30 (smp-30) (regucalcin) (rc). [swissprot;acc:q15493]
504	OPHN1		oligophrenin 1. [swissprot;acc:o60890]
505	NOC3L	251.334	ad24 protein. [refseq;acc:nm_022451]	234.672	1.071
506	ING1	224.535	inhibitor of growth family, member 1; inhibitor of growth 1. [refseq;acc:nm_005537]	240.476
507	WDR12	251.299	wd-repeat protein 12 (ytm1 homolog). [swissprot;acc:q9gzl7]	234.729	1.07059
508	CPA3	177.698	mast cell carboxypeptidase a precursor (ec 3.4.17.1) (mc-cpa) (carboxypeptidase a3). [swissprot;acc:p15088]	190.24	1.07058
509	CPA6		carboxypeptidase b precursor. [refseq;acc:nm_020361]	190.239	1.07057
510	CPB2	177.699	plasma carboxypeptidase b2 isoform a preproprotein; carboxypeptidase u; thrombin-activatable fibrinolysis inhibitor; carboxypeptidase b-like protein; thrombin-activable fibrinolysis inhibitor. [refseq;acc:nm_001872]	190.24
511	NOL1	250.053	proliferating-cell nucleolar antigen p120 (proliferation-associated nucleolar protein p120). [swissprot;acc:p46087]	233.725	1.06986
512	BOP1	250.794	block of proliferation 1. [swissprot;acc:q14137]	234.433	1.06979
513	DVL1	218.596	segment polarity protein dishevelled homolog dvl-1 (dishevelled-1) (dsh homolog 1). [swissprot;acc:o14640]	204.344	1.06975
514	DVL2	218.613	segment polarity protein dishevelled homolog dvl-2 (dishevelled-2) (dsh homolog 2). [swissprot;acc:o14641]	204.382	1.06963
515	PES1	251.297	pescadillo homolog 1. [swissprot;acc:o00541]	234.941	1.06962
516	LSM8	228.255	u6 snrna-associated sm-like protein lsm8. [swissprot;acc:o95777]	213.422	1.0695
517	MTX2	219.537	metaxin 2. [swissprot;acc:o75431]	234.793	1.06949
518	GNL3	250.858	nucleostemin; putative nucleotide binding protein, estradiol-induced. [refseq;acc:nm_014366]	234.563	1.06947
519	DVL3	218.702	segment polarity protein dishevelled homolog dvl-3 (dishevelled-3) (dsh homolog 3). [swissprot;acc:q92997]	204.582	1.06902
520	SLC35D2	214.754	sqv-7-like protein (fragment). [sptrembl;acc:o95454]	229.565	1.06897
521	EXOSC4	215.237	exosome complex exonuclease rrp41 (ec 3.1.13.-) (ribosomal rna processing protein 41) (p12a). [swissprot;acc:q9npd3]	230.07	1.06891
522	PLRG1	222.893	pleiotropic regulator 1 (prl1homolog, arabidopsis); pleiotropic regulator 1 (prl1, arabidopsis homolog). [refseq;acc:nm_002669]	208.523
523	EXOSC2	215.237	exosome complex exonuclease rrp4 (ec 3.1.13.-) (ribosomal rna processing protein 4). [swissprot;acc:q13868]	230.07
524	EXOSC3		exosome complex exonuclease rrp40 (ec 3.1.13.-) (ribosomal rna processing protein 40) (p10) (cgi-102). [swissprot;acc:q9nqt5]
525	EXOSC5		exosome complex exonuclease rrp46 (ec 3.1.13.-) (ribosomal rna processing protein 46) (p12b) (chronic myelogenous leukemia tumor antigen 28). [swissprot;acc:q9nqt4]
526	RRP1	250.538	nnp-1 protein (novel nuclear protein 1) (nucleolar protein nop52) (nop52) (d21s2056e). [swissprot;acc:p56182]	234.401	1.06884
527	DDX31	248.56	dead (asp-glu-ala-asp) box polypeptide 31 isoform 1; dead/dexh helicase ddx31. [refseq;acc:nm_022779]	232.579	1.06871
528	YME1L1	222.146	yme1-like 1 isoform 3; atp-dependent metalloprotease ftsh1 homolog. [refseq;acc:nm_014263]	237.393	1.06864
529	DDX18	251.653	atp-dependent rna helicase ddx18 (dead-box protein 18) (myc-regulated dead-box protein) (mrdb). [swissprot;acc:q9nvp1]	235.506	1.06856
530	LSM6	227.483	u6 snrna-associated sm-like protein lsm6 (sm protein f). [swissprot;acc:q9y4y8]	212.994	1.06803
531	PRPF19	223.356	nuclear matrix protein nmp200 related to splicing factor prp19. [refseq;acc:nm_014502]	209.149	1.06793
532	ZNF622	250.942	zinc finger-like protein 9. [refseq;acc:nm_033414]	235.004	1.06782
533	SLC45A2		membrane-associated transporter protein (aim-1 protein) (melanoma antigen aim1). [swissprot;acc:q9umx9]
534	no value		guanine nucleotide-binding protein-like 1 (gtp-binding protein hsr1). [swissprot;acc:p36915]
535	POLR2H	236.662	dna-directed rna polymerases i, ii, and iii 17.1 kda polypeptide (ec 2.7.7.6) (rpb17) (rpb8) (rpabc3). [swissprot;acc:p52434]	252.708	1.0678
536	SSB	242.531	lupus la protein (sjogren syndrome type b antigen) (ss-b) (la ribonucleoprotein) (la autoantigen). [swissprot;acc:p05455]	227.136	1.06778
537	DHX15	229.803	putative pre-mrna splicing factor rna helicase (deah box protein 15) (atp-dependent rna helicase #46). [swissprot;acc:o43143]	215.301	1.06736
538	POLR2L	237.627	dna-directed rna polymerase ii 7.6 kda polypeptide (ec 2.7.7.6) (rpb10) (rpb7.6) (rpabc5). [swissprot;acc:p52436]	253.604	1.06724
539	MEMO1P	236.964	protein cgi-27 (c21orf19-like protein). [swissprot;acc:q9y316]	252.86	1.06708
540	SEPHS2	222.156	selenide,water dikinase 2 (ec 2.7.9.3) (selenophosphate synthetase 2) (selenium donor protein 2). [swissprot;acc:q99611]	208.201	1.06703
541	MICAL2		flavoprotein oxidoreductase mical2. [refseq;acc:nm_014632]
542	INPP4B		inositol polyphosphate-4-phosphatase, type ii, 105kd; inositol polyphosphate 4-phosphatase ii; 4-phosphatase ii. [refseq;acc:nm_003866]
543	SEPHS1		selenide,water dikinase 1 (ec 2.7.9.3) (selenophosphate synthetase 1) (selenium donor protein 1). [swissprot;acc:p49903]
544	INPP4A		inositol polyphosphate-4-phosphatase, type 1 isoform b; inositol polyphosphate-4-phosphatase, type i, 107kd; 4-phosphatase i; inositol polyphosphate-4-phosphatase i. [refseq;acc:nm_001566]
545	EIF6	248.866	eukaryotic translation initiation factor 6 (eif-6) (b4 integrin interactor) (cab) (p27(bbp)) (b(2)gcn homolog). [swissprot;acc:p56537]	233.287	1.06678
546	WAS	207.222	wiskott-aldrich syndrome protein (wasp). [swissprot;acc:p42768]	194.262	1.06671
547	CRK	207.26	proto-oncogene c-crk (p38) (adapter molecule crk). [swissprot;acc:p46108]	194.346	1.06645
548	ABL2		tyrosine-protein kinase abl2 (ec 2.7.1.112) (tyrosine kinase arg). [swissprot;acc:p42684]
549	no value		proto-oncogene tyrosine-protein kinase src (ec 2.7.1.112) (p60-src) (c-src). [swissprot;acc:p12931]
550	HCK		tyrosine-protein kinase hck (ec 2.7.1.112) (p59-hck/p60-hck) (hemopoietic cell kinase). [swissprot;acc:p08631]

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.