MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 818 to 867 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

Rank	description	Network Comparison Type	red	green	network_comparison
409	runt-related transcription factor 2 (core-binding factor, alpha 1 subunit) (cbf-alpha 1) (acute myeloid leukemia 3 protein) (oncogene aml-3) (polyomavirus enhancer binding protein 2 alpha a subunit) (pebp2-alpha a) (pea2-alpha a) (sl3-3 enhancer factor 1 alpha a subunit) (sl3/akv core-binding factor alpha a subunit) (osteoblast- specific transcription factor 2) (osf-2). [swissprot;acc:q13950]	Subtracted	237.109	254.667	17.558
410	e1b-55kda-associated protein 5 isoform a. [refseq;acc:nm_007040]
	tfiih basal transcription factor complex p44 subunit (basic transcription factor 2 44 kda subunit) (btf2-p44) (general transcription factor iih polypeptide 2). [swissprot;acc:q13888]	Divided	233.376	253.539	1.0864
411	60s ribosomal protein l18. [swissprot;acc:q07020]	Subtracted	237.109	254.667	17.558
	tfiih basal transcription factor complex p62 subunit (basic transcription factor 62 kda subunit) (btf2-p62) (general transcription factor iih polypeptide 1). [swissprot;acc:p32780]	Divided	233.376	253.539	1.0864
412	saccharomyces cerevisiae nip7p homolog. [refseq;acc:nm_016101]	Subtracted	251.926	234.547	17.379
	ubiquinol-cytochrome c reductase iron-sulfur subunit, mitochondrial precursor (ec 1.10.2.2) (rieske iron-sulfur protein) (risp). [swissprot;acc:p47985]	Divided	240.788	261.416	1.08567
413	dna-directed rna polymerase i 40 kda polypeptide (ec 2.7.7.6) (rpa40) (rpa39). [swissprot;acc:o15160]		240.913	261.45	1.08525
	tuftelin-interacting protein 11 (hspc006). [swissprot;acc:q9ubb9]	Subtracted	223.202	205.9	17.302
414	katanin p60 subunit a 1. [refseq;acc:nm_007044]	Divided	232.431	252.238	1.08522
	max protein. [swissprot;acc:p25912]	Subtracted	227.828	210.561	17.267
415	katanin p80 subunit b 1; katanin (80 kda); katanin p80 (wd40-containing) subunit b 1. [refseq;acc:nm_005886]	Divided	232.382	252.166	1.08514
	transcription initiation factor tfiid 55 kda subunit (tafii-55) (tafii55). [swissprot;acc:q15545]	Subtracted	200.586	183.423	17.163
416	dna-directed rna polymerase i 135 kda polypeptide (ec 2.7.7.6) (rna polymerase i subunit 2) (rpa135). [swissprot;acc:q9h9y6]	Divided	240.6	261.041	1.08496
	tata box binding protein-associated factor, rna polymerase ii, q; taf7-like rna polymerase ii, tata box binding protein (tbp)-associated factor, 50 kd; tbp-associated factor, rna polymerase ii, q. [refseq;acc:nm_024885]	Subtracted	200.791	183.66	17.131
417	set domain and mariner transposase fusion gene. [refseq;acc:nm_006515]	Divided	233.539	253.197	1.08417
	signal recognition particle 9 kda protein (srp9). [swissprot;acc:p49458]	Subtracted	235.94	218.837	17.103
418	cd209 antigen-like; putative type ii membrane protein. [refseq;acc:nm_014257]	Divided	233.539	253.197	1.08417
	n-terminal acetyltransferase complex ard1 subunit homolog (ec 2.3.1.-). [swissprot;acc:p41227]	Subtracted	233.723	216.674	17.049
419	low affinity immunoglobulin epsilon fc receptor (lymphocyte ige receptor) (fc-epsilon-rii) (cd23) (blast-2) (immunoglobulin e-binding factor). [swissprot;acc:p06734]	Divided	233.539	253.197	1.08417
	signal recognition particle 9 kda protein (srp9). [swissprot;acc:p49458]	Subtracted	235.922	218.925	16.997
420	cd209 antigen; dendritic cell-specific icam3-grabbing nonintegrin. [refseq;acc:nm_021155]	Divided	233.539	253.197	1.08417
	cytochrome c1, heme protein, mitochondrial precursor (cytochrome c-1). [swissprot;acc:p08574]	Subtracted	238.704	255.68	16.976
421	oligophrenin-1 like protein (gtpase regulator associated with focal adhesion kinase). [swissprot;acc:q9una1]
	tuftelin-interacting protein 11 (hspc006). [swissprot;acc:q9ubb9]	Divided	223.202	205.9	1.08403
422	ras-related protein rab-37. [swissprot;acc:q96ax2]		240.287	260.193	1.08284
	senescence marker protein-30 (smp-30) (regucalcin) (rc). [swissprot;acc:q15493]	Subtracted	238.704	255.68	16.976
423	oligophrenin 1. [swissprot;acc:o60890]
	ras-related protein rab-26. [swissprot;acc:q9ulw5]	Divided	240.287	260.193	1.08284
424	dna-directed rna polymerase ii 33 kda polypeptide (ec 2.7.7.6) (rpb3) (rna polymerase ii subunit 3) (rpb33) (rpb31). [swissprot;acc:p19387]
	nucleolar gtp-binding protein 1 (chronic renal failure gene protein) (gtp-binding protein ngb). [swissprot;acc:q9bze4]	Subtracted	251.83	234.951	16.879
425	endonuclease g, mitochondrial precursor (ec 3.1.30.-) (endo g). [swissprot;acc:q14249]		212.547	229.411	16.864
	max protein. [swissprot;acc:p25912]	Divided	227.828	210.561	1.082
426	dynactin 4. [refseq;acc:nm_032486]		233.142	252.253	1.08197
	programmed cell death protein 8, mitochondrial precursor (ec 1.-.-.-) (apoptosis-inducing factor). [swissprot;acc:o95831]	Subtracted	212.547	229.411	16.864
427	dna-directed rna polymerase ii 23 kda polypeptide (ec 2.7.7.6) (rpb25) (xap4) (rpb5) (rpabc1). [swissprot;acc:p19388]	Divided	239.977	259.525	1.08146
	t-box transcription factor tbx6 (t-box protein 6). [swissprot;acc:o95947]	Subtracted	212.547	229.411	16.864
428	atp-dependent rna helicase mgc2835; atp-dependent rna helicase; apoptosis related protein apr-5; dead box helicase 97 kda. [refseq;acc:nm_024072]	Divided	253.852	234.808	1.0811
	u6 snrna-associated sm-like protein lsm5. [swissprot;acc:q9y4y9]	Subtracted	227.748	210.888	16.86
429	polymerase (rna) iii (dna directed) (32kd). [refseq;acc:nm_006467]	Divided	239.709	259.038	1.08064
	probable rrna processing protein ebp2 (ebna1 binding protein 2) (nucleolar protein p40). [swissprot;acc:q99848]	Subtracted	251.344	234.514	16.83
430	suppressor of swi4 1 homolog (ssf-1) (peter pan homolog). [swissprot;acc:q9nq55]		250.938	234.134	16.804
	u6 snrna-associated sm-like protein lsm5. [swissprot;acc:q9y4y9]	Divided	227.748	210.888	1.07995
431	bag-family molecular chaperone regulator-3 (bcl-2 binding athanogene- 3) (bag-3) (bcl-2-binding protein bis) (docking protein cair-1). [swissprot;acc:o95817]	Subtracted	233.529	216.737	16.792
	trub pseudouridine (psi) synthase homolog 1. [refseq;acc:nm_139169]	Divided	236.245	255.113	1.07987
432	endonuclease g, mitochondrial precursor (ec 3.1.30.-) (endo g). [swissprot;acc:q14249]		212.547	229.411	1.07934
	mct-1 protein. [refseq;acc:nm_014060]	Subtracted	226.313	243.03	16.717
433	mitochondrial ribosomal protein l22. [refseq;acc:nm_014180]
	programmed cell death protein 8, mitochondrial precursor (ec 1.-.-.-) (apoptosis-inducing factor). [swissprot;acc:o95831]	Divided	212.547	229.411	1.07934
434	ad24 protein. [refseq;acc:nm_022451]	Subtracted	251.334	234.672	16.662

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.