MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Gene	Rank	description	Value Type	green	Network Comparison Type	red	Interaction Map	Filtered	network_comparison

Results: HTML CSV LaTeX

Showing element 101 to 150 of 25824 in total

Interaction Map  : High confidence
Filtered  : 1

Rank	description	Value Type	green	Network Comparison Type	red	network_comparison
13	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-12 subunit. [swissprot;acc:q9ubi6]	Ranked	336.233	Subtracted	266.856	69.377
	melanoma-associated antigen 11 (mage-11 antigen). [swissprot;acc:p43364]	Squared	129762		219048	89286
	myosin vb (myosin 5b) (fragment). [swissprot;acc:q9ulv0]	Measured	27904.5		21591.5	6313
	protein cgi-126 (protein hspc155). [swissprot;acc:q9y3c8]	Ranked	212.554	Divided	288.754	1.3585
14	cysteine endopeptidase aut-like 2 isoform a; autophagy-related cysteine endopeptidase 2; autophagin 2. [refseq;acc:nm_052936]		75.3531		56.6768	1.32952
	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-4 subunit. [swissprot;acc:p50150]		336.191	Subtracted	266.863	69.328
	melanoma-associated antigen 2 (mage-2 antigen). [swissprot;acc:p43356]	Squared	129762		219048	89286
	myosin vc (myosin 5c). [swissprot;acc:q9nqx4]	Measured	27904.5		21591.5	6313
	ras gtpase-activating protein ngap (ras protein activator like 1). [swissprot;acc:q9ujf2]		1281.5	Divided	398.5	3.21581
		Squared	388.696		37.5863	10.3414
		Rooted	35.798		19.9625	1.79326
	spermatogenesis associated 6. [refseq;acc:nm_019073]		101.526	Subtracted	80.4705	21.0555
15	amp deaminase 2 (ec 3.5.4.6) (amp deaminase isoform l). [swissprot;acc:q01433]
	gbp protein isoform a. [refseq;acc:nm_017870]		42.4773	Divided	23.9771	1.77158
	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-3 subunit. [swissprot;acc:p29798]	Ranked	336.19	Subtracted	266.863	69.327
	hepatocellular carcinoma-associated protein hca1. [refseq;acc:nm_020932]	Squared	129762		219048	89286
	microtubule-associated proteins 1a/1b light chain 3b (map1a/map1b lc3 b) (map1a/1b light chain 3 b). [swissprot;acc:q9gzq8]	Ranked	75.3948	Divided	56.7244	1.32914
	myosin va (myosin 5a) (dilute myosin heavy chain, non-muscle) (myosin heavy chain 12) (myoxin). [swissprot;acc:q9y4i1]	Measured	27904.5	Subtracted	21591.5	6313
	xpa binding protein 1; mbd2 interactor protein; putative atp(gtp)-binding protein. [refseq;acc:nm_007266]		871	Divided	2671	3.06659
		Squared	179.56		1688.58	9.40399
16	cysteine endopeptidase aut-like 2 isoform a; autophagy-related cysteine endopeptidase 2; autophagin 2. [refseq;acc:nm_052936]	Measured	18172.1	Subtracted	24260.3	6088.2
	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-8 subunit (gamma-9). [swissprot;acc:q9uk08]	Ranked	336.184		266.864	69.32
	mannosyl-oligosaccharide 1,2-alpha-mannosidase ib (ec 3.2.1.113) (processing alpha-1,2-mannosidase ib) (alpha-1,2-mannosidase ib) (mannosidase alpha class 1a member 2). [swissprot;acc:o60476]	Rooted	182.638		203.673	21.035
	melanoma-associated antigen 6 (mage-6 antigen) (mage3b). [swissprot;acc:p43360]	Squared	129762		219048	89286
	microtubule-associated proteins 1a/1b light chain 3a (map1a/map1b lc3 a) (map1a/1b light chain 3 a). [swissprot;acc:q9h492]	Ranked	75.3954	Divided	56.7252	1.32913
	protein x 0004. [refseq;acc:nm_016301]	Measured	871		2671	3.06659
		Squared	179.56		1688.58	9.40399
	xpa binding protein 1; mbd2 interactor protein; putative atp(gtp)-binding protein. [refseq;acc:nm_007266]	Rooted	29.5127		51.6817	1.75117
17	cysteine endopeptidase aut-like isoform b. [refseq;acc:nm_178326]	Ranked	75.447		56.7841	1.32866
	cytohesin 1 (sec7 homolog b2-1). [swissprot;acc:q15438]	Rooted	182.638	Subtracted	203.673	21.035
	dgcr14 protein (digeorge syndrome critical region 14) (es2 protein). [swissprot;acc:q96df8]	Measured	1365	Divided	460	2.96739
		Squared	441		50.0828	8.80542
	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-5 subunit. [swissprot;acc:p30670]	Ranked	336.182	Subtracted	266.864	69.318
	microtubule-associated proteins 1a/1b light chain 3b (map1a/map1b lc3 b) (map1a/1b light chain 3 b). [swissprot;acc:q9gzq8]	Measured	18168.9		24255.7	6086.8
	necdin. [swissprot;acc:q99608]	Squared	129762		219048	89286
	protein x 0004. [refseq;acc:nm_016301]	Rooted	29.5127	Divided	51.6817	1.75117
18	1,4-alpha-glucan branching enzyme (ec 2.4.1.18) (glycogen branching enzyme) (brancher enzyme). [swissprot;acc:q04446]	Ranked	245.247		185.678	1.32082
	cytohesin 2 (arf nucleotide-binding site opener) (arno protein) (arf exchange factor). [swissprot;acc:q99418]	Rooted	182.638	Subtracted	203.673	21.035
	dgcr14 protein (digeorge syndrome critical region 14) (es2 protein). [swissprot;acc:q96df8]		36.9459	Divided	21.4476	1.72261
	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-10 subunit. [swissprot;acc:p50151]	Ranked	336.181	Subtracted	266.865	69.316
	melanoma-associated antigen d1 (mage-d1 antigen) (neurotrophin receptor-interacting mage homolog) (pro2292). [swissprot;acc:q9y5v3]	Squared	129762		219048	89286
	microtubule-associated proteins 1a/1b light chain 3a (map1a/map1b lc3 a) (map1a/1b light chain 3 a). [swissprot;acc:q9h492]	Measured	18168.9		24255.7	6086.8
	protein phosphatase 1, regulatory (inhibitor) subunit 14a; 17-kda pkc-potentiated inhibitory protein of pp1. [refseq;acc:nm_033256]		1865.5	Divided	677.5	2.75351
		Squared	823.69		108.641	7.58176
19	cysteine endopeptidase aut-like isoform b. [refseq;acc:nm_178326]	Measured	18164.9	Subtracted	24250	6085.1
	cytohesin 4. [swissprot;acc:q9uia0]	Rooted	182.638		203.673	21.035
	glycogen phosphorylase, brain form (ec 2.4.1.1). [swissprot;acc:p11216]	Ranked	245.247	Divided	185.678	1.32082
	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-5 like subunit. [swissprot;acc:q9y3k8]		336.178	Subtracted	266.865	69.313
	melanoma-associated antigen f1 (mage-f1 antigen). [swissprot;acc:q9hay2]	Squared	129762		219048	89286
	microfibril-associated glycoprotein 4 precursor. [swissprot;acc:p55083]	Measured	1865.5	Divided	677.5	2.75351

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.