MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Filtered	Value Type	Network Comparison Type	Gene	green	red	network_comparison	Interaction Map	Rank	description

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Showing element 1 to 50 of 77072 in total

Filtered  : 0
Value Type  : Measured
Network Comparison Type  : Divided

green	red	network_comparison	Interaction Map	Rank	description
0.00001	0.00001	1	High confidence	494	histone h2a.c/d/i/n/p (h2a.1) (h2a/c) (h2a/d) (h2a/i) (h2a/n) (h2a/p) (h2a.1b). [swissprot;acc:p02261]
				495	histone h2a.a (h2a/a) (h2a.2). [swissprot;acc:p28001]
				496	mitochondrial 28s ribosomal protein s6 (mrp-s6). [swissprot;acc:p82932]
				497	histone h2a; h2a histone family, member r. [refseq;acc:nm_170745]
				498	translin-associated protein x (translin-associated factor x). [swissprot;acc:q99598]
				499	homogentisate 1,2-dioxygenase (ec 1.13.11.5) (homogentisicase) (homogentisate oxygenase) (homogentisic acid oxidase). [swissprot;acc:q93099]
				500	rwd domain containing 1; ptd013 protein; cgi-24 protein. [refseq;acc:nm_015952]
				501	h2a histone family, member j isoform 1. [refseq;acc:nm_018267]
				502	brca1 associated protein. [refseq;acc:nm_006768]
			Low confidence	837	gamma-glutamyltranspeptidase 2 (ec 2.3.2.2) (gamma-glutamyltransferase 2) (fragment). [swissprot;acc:p36268]
				838	gamma-glutamyltransferase-like activity 4; gamma-glutamyltranspeptidase-like. [refseq;acc:nm_080920]
				839	cobw-like protein. [refseq;acc:nm_018491]
				840	translin-associated protein x (translin-associated factor x). [swissprot;acc:q99598]
				841	gamma-glutamyltransferase. [sptrembl;acc:q14390]
				842	gamma-glutamyltranspeptidase 1 precursor (ec 2.3.2.2) (gamma- glutamyltransferase 1) (cd224 antigen). [swissprot;acc:p19440]
				843	gamma-glutamyltranspeptidase 5 precursor (ec 2.3.2.2) (gamma- glutamyltransferase 5) (ggt-rel). [swissprot;acc:p36269]
	2.31962	231962		7	tbc1 domain family, member 8 (with gram domain); vascular rab-gap/tbc-containing. [refseq;acc:nm_007063]
	13	1300000		6	homogentisate 1,2-dioxygenase (ec 1.13.11.5) (homogentisicase) (homogentisate oxygenase) (homogentisic acid oxidase). [swissprot;acc:q93099]
	18	1800000	High confidence	65	rna helicase-related protein; rna helicase-like protein; sf3b125 dead-box protein. [refseq;acc:nm_007372]
	35	3500000		31	dok-like protein. [refseq;acc:nm_024872]
	37	3700000	Low confidence	22	carbohydrate (n-acetylglucosamine 6-o) sulfotransferase 6; macular dystrophy, corneal, 1; carbohydate sulfotransferase 6; corneal n-acetylglucosamine 6-sulfotransferase. [refseq;acc:nm_021615]
				23	carbohydrate (n-acetylglucosamine-6-o) sulfotransferase 2; carbohydrate (chondroitin 6/keratan) sulfotransferase 2. [refseq;acc:nm_004267]
	60	6000000	High confidence	22	similar to lysozyme c-1 (1,4-beta-n-acylmuramidase c, ec 3.2.1.17). [refseq;acc:nm_032517]
	82	8200000		20	ero1-like. [refseq;acc:nm_014584]
	154	15400000		95	nuclear receptor co-repressor/hdac3 complex subunit tblr1 (tbl1- related protein 1). [swissprot;acc:q9bzk7]
				96	transducin beta-like 1y protein (transducin-beta-like 1, y-linked). [swissprot;acc:q9bq87]
	286	28600000	Low confidence	44	neurogenic locus notch homolog protein 1 precursor (notch 1) (hn1) (translocation-associated notch protein tan-1). [swissprot;acc:p46531]
				45	neurogenic locus notch homolog protein 2 precursor (notch 2) (hn2). [swissprot;acc:q04721]
	364	36400000	High confidence	1	mitochondrial 28s ribosomal protein s32 (s32mt) (mrp-s32) (ptd007) (hspc204). [swissprot;acc:q9y6g3]
			Low confidence
5.56738	199.549	35.8425	High confidence	11	serpin b12. [swissprot;acc:q96p63]
			Low confidence	10
5.71669	199.249	34.8539	High confidence	12	hurpin (hacat uv-repressible serpin) (protease inhibitor 13) (headpin) (serpin b13). [swissprot;acc:q9uiv8]
			Low confidence	11
6.50325	130.512	20.0687	High confidence	14	cyclin h (mo15-associated protein) (p37) (p34). [swissprot;acc:p51946]
10.6048	383.762	36.1876	Low confidence	9	ubiquitously transcribed y chromosome tetratricopeptide repeat protein (ubiquitously transcribed tpr protein on the y chromosome). [swissprot;acc:o14607]
11.5	14	1.21739	High confidence	190	protocadherin 16 precursor (cadherin 19) (cadherin fibroblast 1). [swissprot;acc:q96jq0]
			Low confidence	176
14.3333	19.6667	1.3721	High confidence	121	4-aminobutyrate aminotransferase, mitochondrial precursor (ec 2.6.1.19) (gamma-amino-n-butyrate transaminase) (gaba transaminase) (gaba aminotransferase) (gaba-at) (gaba-t). [swissprot;acc:p80404]
15	1	15		16	protein transport protein sec24c (sec24-related protein c). [swissprot;acc:p53992]
17.5166	0.00001	1751660	Low confidence	5	jumonji protein. [swissprot;acc:q92833]
17.6611	118.878	6.73106	High confidence	21	syntaxin 10 (syn10). [swissprot;acc:o60499]
18	0.00001	1800000		64	phosphatidylinositol-4-phosphate 3-kinase c2 domain-containing beta polypeptide (ec 2.7.1.154) (phosphoinositide 3-kinase-c2-beta) (ptdins-3-kinase c2 beta) (pi3k-c2beta) (c2-pi3k). [swissprot;acc:o00750]
19	23	1.21053		195	adp-ribosylation factor-like protein 7 (adp-ribosylation factor-like protein lak). [swissprot;acc:p56559]
			Low confidence	184
	99	5.21053		18	camp-regulated phosphoprotein 19 (arpp-19) [contains: camp-regulated phosphoprotein 16 (arpp-16)]. [swissprot;acc:p56211]
21	44	2.09524	High confidence	50	transcription factor 4 (immunoglobulin transcription factor 2) (itf-2) (sl3-3 enhancer factor 2) (sef-2). [swissprot;acc:p15884]
23.6984	48.2534	2.03615	Low confidence	64	dna helicase homolog (fragment). [sptrembl;acc:q9y645]
26.1599	305.45	11.6763	High confidence	18	60s ribosomal protein l37a. [swissprot;acc:p12751]
				19	25-hydroxyvitamin d-1 alpha hydroxylase, mitochondrial precursor (ec 1.14.-.-) (25-ohd-1 alpha-hydroxylase) (25-hydroxyvitamin d3 1- alpha-hydroxylase) (vd3 1a hydroxylase) (p450c1 alpha) (p450vd1- alpha). [swissprot;acc:o15528]

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.