MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Value Type	description	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 708 to 757 of 12912 in total

Network Comparison Type  : Divided
Interaction Map  : High confidence
Filtered  : 1

Rank	Value Type	description	red	green	network_comparison
177	Rooted	mitochondrial solute carrier protein. [refseq;acc:nm_145305]	145.551	168.796	1.1597
178	Measured	myosin vb (myosin 5b) (fragment). [swissprot;acc:q9ulv0]	21591.5	27904.5	1.29238
	Ranked	formin binding protein 3; fas-ligand associated factor 1; huntingtin-interacting protein a; ny-ren-6 antigen. [refseq;acc:nm_017892]	226.887	194.72	1.1652
	Squared	carboxypeptidase b precursor. [refseq;acc:nm_020361]	25326.4	18354.1	1.37988
	Rooted	transcription factor dp-2 (e2f dimerization partner 2). [swissprot;acc:q14188]	45.7414	52.932	1.1572
179	Measured	myosin vc (myosin 5c). [swissprot;acc:q9nqx4]	21591.5	27904.5	1.29238
	Ranked	huntingtin-interacting protein hypa/fbp11 (fragment). [sptrembl;acc:o75404]	226.884	194.79	1.16476
	Squared	mast cell carboxypeptidase a precursor (ec 3.4.17.1) (mc-cpa) (carboxypeptidase a3). [swissprot;acc:p15088]	25326.3	18354.1	1.37987
	Rooted	palmitoyl-protein thioesterase 2 precursor (ec 3.1.2.22) (palmitoyl- protein hydrolase 2) (ppt-2) (g14). [swissprot;acc:q9umr5]	50.272	43.4634	1.15665
180	Measured	myosin va (myosin 5a) (dilute myosin heavy chain, non-muscle) (myosin heavy chain 12) (myoxin). [swissprot;acc:q9y4i1]	21591.5	27904.5	1.29238
	Ranked	tar dna-binding protein-43 (tdp-43). [swissprot;acc:q13148]	256.228	298.438	1.16474
	Squared	plasma carboxypeptidase b2 isoform a preproprotein; carboxypeptidase u; thrombin-activatable fibrinolysis inhibitor; carboxypeptidase b-like protein; thrombin-activable fibrinolysis inhibitor. [refseq;acc:nm_001872]	25326.2	18354.1	1.37987
	Rooted	egf-like-domain, multiple 7; neu1 protein. [refseq;acc:nm_016215]	50.2801	43.4779	1.15645
181	Measured	eukaryotic translation initiation factor 4 gamma, 3. [refseq;acc:nm_003760]	4068.56	5252.6	1.29102
	Ranked	b9 protein; likely ortholog of mouse endothelial precursor protein b9. [refseq;acc:nm_015681]	229.818	267.265	1.16294
	Squared	hira-interacting protein 5 (cgi-33). [swissprot;acc:q9ums0]	55630.4	76083.7	1.36766
	Rooted	crk-associated substrate (p130cas) (breast cancer anti-estrogen resistance 1 protein). [swissprot;acc:p56945]	57.4432	66.3307	1.15472
182	Measured	rna-binding protein. [refseq;acc:nm_019027]	4069.83	5252.17	1.29051
	Ranked	histone acetyltransferase type b catalytic subunit (ec 2.3.1.48). [swissprot;acc:o14929]	277.546	240.461	1.15422
	Squared	deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial precursor (ec 3.6.1.23) (dutpase) (dutp pyrophosphatase). [swissprot;acc:p33316]	61733.5	45224.1	1.36506
	Rooted	t-complex protein 1, delta subunit (tcp-1-delta) (cct-delta) (stimulator of tar rna binding). [swissprot;acc:p50991]	57.45	66.332	1.1546
183	Measured	apobec-1 complementation factor isoform 1; apobec-1 stimulating protein; apo-b rna editing protein. [refseq;acc:nm_014576]	4069.83	5252.17	1.29051
	Ranked	20 kda nuclear cap binding protein (ncbp 20 kda subunit) (cbp20) (ncbp interacting protein 1) (nip1). [swissprot;acc:p52298]	228.306	198.011	1.153
	Squared	acyl-coa dehydrogenase, very-long-chain specific, mitochondrial precursor (ec 1.3.99.-) (vlcad). [swissprot;acc:p49748]	79779.8	108084	1.35478
	Rooted	enhancer of filamentation 1 (hef1) (crk-associated substrate-related protein) (cas-l) (casl) (pp105) (neural precursor cell expressed developmentally down-regulated 9). [swissprot;acc:q14511]	57.4586	66.3336	1.15446
184	Measured	ns1-associated protein 1. [refseq;acc:nm_006372]	4069.83	5252.17	1.29051
	Ranked	odd-skipped related 1; odz (odd oz/ten-m) related 1. [refseq;acc:nm_145260]	274.027	237.79	1.15239
	Squared	small glutamine rich protein with tetratricopeptide repeats 2. [refseq;acc:nm_019072]	72886.3	98544.5	1.35203
	Rooted	cysteine endopeptidase aut-like 2 isoform a; autophagy-related cysteine endopeptidase 2; autophagin 2. [refseq;acc:nm_052936]	153.602	133.195	1.15321
185	Measured	heterogeneous nuclear ribonucleoprotein r (hnrnp r). [swissprot;acc:o43390]	4069.83	5252.17	1.29051
	Ranked	adiponectin receptor 2. [refseq;acc:nm_024551]	281.582	246.371	1.14292
	Squared	c439a6.1 (novel protein similar to heparan sulfate (glucosamine) 3-o- sulfotransferases) (fragment). [sptrembl;acc:q96qi5]	41502.9	30836.8	1.34589
	Rooted	microtubule-associated proteins 1a/1b light chain 3b (map1a/map1b lc3 b) (map1a/1b light chain 3 b). [swissprot;acc:q9gzq8]	153.578	133.176	1.1532
186	Measured	eukaryotic translation initiation factor 4 gamma (eif-4-gamma) (eif- 4g) (eif4g) (p220). [swissprot;acc:q04637]	4071.1	5251.75	1.29001
	Ranked	filamin b, beta (actin binding protein 278); beta filamin; filamin 1 (actin-binding protein-280)-like; filamin b, beta (actin-binding protein-278); filamin b, beta. [refseq;acc:nm_001457]	226.582	198.444	1.14179
	Squared	heparan sulfate d-glucosaminyl 3-o-sulfotransferase 3a1; heparin-glucosamine 3-o-sulfotransferase. [refseq;acc:nm_006042]	41502.9	30836.8	1.34589
	Rooted	microtubule-associated proteins 1a/1b light chain 3a (map1a/map1b lc3 a) (map1a/1b light chain 3 a). [swissprot;acc:q9h492]	153.578	133.176	1.1532
187	Measured	small nuclear ribonucleoprotein sm d3 (snrnp core protein d3) (sm-d3). [swissprot;acc:p43331]	4569.48	5885.79	1.28807
	Ranked	rev1-like; rev1 protein; rev1 (yeast homolog)- like. [refseq;acc:nm_016316]	226.582	198.444	1.14179
	Squared	heparan sulfate d-glucosaminyl 3-o-sulfotransferase 3b1. [refseq;acc:nm_006041]	41502.9	30836.8	1.34589
	Rooted	cysteine endopeptidase aut-like isoform b. [refseq;acc:nm_178326]	153.548	133.153	1.15317
188	Measured	source of immunodominant mhc-associated peptides; homolog of yeast stt3 gene. [refseq;acc:nm_178862]	4571.89	5864.86	1.28281
	Ranked	protein arginine n-methyltransferase 1 (ec 2.1.1.-) (interferon receptor 1-bound protein 4). [swissprot;acc:q99873]	226.582	198.444	1.14179
	Squared	heparan sulfate d-glucosaminyl 3-o-sulfotransferase 2; heparin-glucosamine 3-o-sulfotransferase. [refseq;acc:nm_006043]	41502.9	30836.8	1.34589
	Rooted	transcription factor e2f1 (e2f-1) (retinoblastoma binding protein 3) (rbbp-3) (prb-binding protein e2f-1) (pbr3) (retinoblastoma-associated protein 1) (rbap-1). [swissprot;acc:q01094]	46.0352	53.0192	1.15171
189	Measured	oligosaccharyl transferase stt3 subunit homolog (b5) (integral membrane protein 1) (tmc). [swissprot;acc:p46977]	4571.89	5864.86	1.28281
	Ranked	protein arginine n-methyltransferase 4 (ec 2.1.1.-). [swissprot;acc:q9nr22]	226.582	198.444	1.14179
	Squared	mrna decapping enzyme; histidine triad protein member 5; heat shock-like protein 1. [refseq;acc:nm_014026]	41502.9	30836.8	1.34589
	Rooted	transcription factor e2f2 (e2f-2). [swissprot;acc:q14209]	46.0352	53.0192	1.15171
190	Measured	dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kda subunit precursor (ec 2.4.1.119) (oligosaccharyl transferase 48 kda subunit) (ddost 48 kda subunit). [swissprot;acc:p39656]	4571.89	5864.86	1.28281

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.