MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Value Type	description	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 732 to 781 of 14920 in total

Network Comparison Type  : Divided
Interaction Map  : High confidence

Rank	Value Type	description	Filtered	red	green	network_comparison
92	Ranked	melanoma-associated antigen f1 (mage-f1 antigen). [swissprot;acc:q9hay2]	1	88.2482	110.265	1.24949
	Squared	metalloprotease 1; metalloprotease 1 (pitrilysin family). [refseq;acc:nm_014889]		29570.7	18601.8	1.58967
		sh3 domain-binding glutamic acid-rich-like protein 2 (fovea-associated sh3 domain binding protein). [swissprot;acc:q9ujc5]	0	12.5892	5.42219	2.32179
	Rooted	hepatocyte growth factor-regulated tyrosine kinase substrate; human growth factor-regulated tyrosine kinase substrate. [refseq;acc:nm_004712]		25.1701	33.2721	1.32189
		presenilin 1 (ps-1) (s182 protein). [swissprot;acc:p49768]	1	37.3005	48.4141	1.29795
93	Measured	dj681n20.2 (novel protein similar to ferritin, light polypeptide (ftl)). [sptrembl;acc:q9byw6]	0	528.5	816.5	1.54494
		formin binding protein 3; fas-ligand associated factor 1; huntingtin-interacting protein a; ny-ren-6 antigen. [refseq;acc:nm_017892]	1	4245.52	5942.75	1.39977
	Ranked	melanoma antigen, family b, 6. [refseq;acc:nm_173523]		88.2482	110.265	1.24949
		pms1 protein homolog 2 (dna mismatch repair protein pms2). [swissprot;acc:p54278]	0	7739.47	9580.95	1.23793
	Squared	beta-1,4 mannosyltransferase. [refseq;acc:nm_019109]	1	29567	18601.6	1.58949
		myosin vi. [swissprot;acc:q9um54]	0	39.56	17.2035	2.29953
	Rooted	cab2. [refseq;acc:nm_033419]		0.00001	13.1909	1319090
		cullin homolog 1 (cul-1). [swissprot;acc:q13616]	1	37.3005	48.4141	1.29795
94	Measured	huntingtin-interacting protein hypa/fbp11 (fragment). [sptrembl;acc:o75404]		4247.86	5941.88	1.39879
		myosin vi. [swissprot;acc:q9um54]	0	345.865	224.096	1.54338
	Ranked	melanoma-associated antigen 4 (mage-4 antigen) (mage-x2) (mage-41). [swissprot;acc:p43358]	1	88.2482	110.265	1.24949
		transketolase-like 1 (ec 2.2.1.1) (transketolase 2) (tk 2) (transketolase related protein). [swissprot;acc:p51854]	0	12946.3	10519.7	1.23067
	Squared	atp-dependent dna helicase ii, 70 kda subunit (lupus ku autoantigen protein p70) (ku70) (70 kda subunit of ku antigen) (thyroid-lupus autoantigen) (tlaa) (ctc box binding factor 75 kda subunit) (ctcbf) (ctc75). [swissprot;acc:p12956]		122.543	53.9854	2.26993
		ral guanine nucleotide dissociation stimulator-like 1 (ralgds-like 1). [swissprot;acc:q9nzl6]	1	84857.8	53402.4	1.58903
	Rooted	chromosome 3p21.1 gene sequence. [refseq;acc:nm_013286]		47.6504	36.9304	1.29028
		hsp90 co-chaperone cdc37 (hsp90 chaperone protein kinase-targeting subunit) (p50cdc37). [swissprot;acc:q16543]	0	24.7769	18.7862	1.31889
95	Measured	nuclear receptor co-repressor/hdac3 complex subunit tblr1 (tbl1- related protein 1). [swissprot;acc:q9bzk7]		154	0.00001	15400000
		son protein (son3) (negative regulatory element-binding protein) (nre- binding protein) (dbp-5) (bax antagonist selected in saccharomyces 1) (bass1) (protein c21orf50). [swissprot;acc:p18583]	1	2397.19	3343.62	1.39481
	Ranked	melanoma-associated antigen 9 (mage-9 antigen). [swissprot;acc:p43362]		88.2482	110.265	1.24949
		pp3111 protein. [refseq;acc:nm_022156]	0	6185	7603	1.22926
	Squared	protein phosphatase 1, regulatory subunit 7; sds22. [refseq;acc:nm_002712]	1	256169	162517	1.57626
		transducin beta-like 2 protein (ws beta-transducin repeats protein) (ws-betatrp) (williams-beuren syndrome chromosome region 13 protein). [swissprot;acc:q9y4p3]	0	631.532	280.389	2.25234
	Rooted	metaxin 1. [swissprot;acc:q13505]		14.7289	11.2174	1.31304
		regulator of g-protein signaling 19 (rgs19) (g-alpha interacting protein) (gaip protein). [swissprot;acc:p49795]	1	47.6504	36.9304	1.29028
96	Measured	lag1 longevity assurance homolog 2 isoform 1; l3 pigment; tumor metastasis-suppressor. [refseq;acc:nm_022075]		4110.14	5694.99	1.3856
		transducin beta-like 1y protein (transducin-beta-like 1, y-linked). [swissprot;acc:q9bq87]	0	154	0.00001	15400000
	Ranked	imp2 inner mitochondrial membrane protease-like; inner mitochondrial membrane peptidase 2 like. [refseq;acc:nm_032549]		8335.82	10228.3	1.22703
		melanoma-associated antigen 8 (mage-8 antigen). [swissprot;acc:p43361]	1	88.2482	110.265	1.24949
	Squared	atlastin; guanylate-binding protein 3. [refseq;acc:nm_015915]		7744.68	4959.41	1.56161
		glutathione s-transferase theta 2 (ec 2.5.1.18) (gst class-theta). [swissprot;acc:p30712]	0	52.0821	116.513	2.2371
	Rooted	putative rna-binding protein 15 (rna binding motif protein 15) (one-twenty two protein). [swissprot;acc:q96t37]	1	47.6504	36.9304	1.29028
		ubiquitin-like protein smt3b (sentrin 2) (hsmt3). [swissprot;acc:p55855]	0	65.4535	49.8523	1.31295
97	Measured	60s ribosomal protein l22 (epstein-barr virus small rna associated protein) (eber associated protein) (eap) (heparin binding protein hbp15). [swissprot;acc:p35268]		728.65	476.619	1.52879
		amyloid beta a4 precursor protein-binding family a member 1 (neuron- specific x11 protein) (neuronal munc18-1-interacting protein 1) (mint-1) (adapter protein x11alpha). [swissprot;acc:q02410]	1	2820.51	3897.1	1.3817
	Ranked	melanoma-associated antigen c1 (mage-c1 antigen) (cancer-testis antigen ct7). [swissprot;acc:o60732]		88.2482	110.265	1.24949
		microsomal signal peptidase 18 kda subunit (ec 3.4.-.-) (spase 18 kda subunit) (spc18) (endopeptidase sp18). [swissprot;acc:p21378]	0	8335.82	10228.3	1.22703
	Squared	cleavage and polyadenylation specific factor 4, 30kd subunit; cleavage-polyadenylation specificity factor, 30kd; no arches-like (zebrafish) zinc finger protein; cleavage-polyadenylation specificity factor. [refseq;acc:nm_006693]	1	227160	146079	1.55505
		nucleoporin nup43 (p42). [swissprot;acc:q8nfh3]	0	10489.8	23426.5	2.23326
	Rooted	regulator of g-protein signaling 20 (rgs20) (regulator of gz- selective protein signaling 1) (gz-selective gtpase-activating protein) (g(z)gap). [swissprot;acc:o76081]	1	47.6504	36.9304	1.29028
		ribulose-5-phosphate-3-epimerase; ribulose 5-phosphate 3-epimerase. [refseq;acc:nm_006916]	0	13.2903	17.4395	1.3122
98	Measured	pp3111 protein. [refseq;acc:nm_022156]		789	530	1.48868
		presenilin 2 (ps-2) (stm-2) (e5-1) (ad3lp) (ad5). [swissprot;acc:p49810]	1	2353.63	3225.65	1.3705
	Ranked	melanoma-associated antigen 12 (mage-12 antigen) (mage12f). [swissprot;acc:p43365]		88.2482	110.265	1.24949
		orphan nuclear receptor nr2e1 (nuclear receptor tlx) (tailless homolog) (tll) (htll). [swissprot;acc:q9y466]	0	7234.6	8858.94	1.22452
	Squared	pp3111 protein. [refseq;acc:nm_022156]		147.342	66.4852	2.21616

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.