MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 6408 to 6457 of 16578 in total

Value Type  : Ranked
Filtered  : 1

Rank	description	Network Comparison Type	Interaction Map	red	green	network_comparison
1602	phosphomannomutase 1 (ec 5.4.2.8) (pmm 1) (pmmh-22). [swissprot;acc:q92871]	Divided	High confidence	217.334	213.914	1.01599
1603	early endosome antigen 1, 162kd; early endosome-associated protein. [refseq;acc:nm_003566]	Subtracted		228.654	231.933	3.279
	heat shock factor binding protein 1. [swissprot;acc:o75506]	Divided		216.62	213.22	1.01595
	putative atp-dependent clp protease proteolytic subunit, mitochondrial precursor (ec 3.4.21.92) (endopeptidase clp). [swissprot;acc:q16740]		Low confidence	204.216	200.037	1.02089
	septin-like protein kiaa0202 (fragment). [swissprot;acc:q92599]	Subtracted		152.572	148.47	4.102
1604	autophagy protein 5-like (apg5-like) (apoptosis-specific protein). [swissprot;acc:q9h1y0]	Divided		204.216	200.037	1.02089
	inhibitor of nuclear factor kappa-b kinase epsilon subunit (ec 2.7.1.-) (i kappa-b kinase epsilon) (ikbke) (ikk-epsilon) (ikk-e) (inducible i kappa-b kinase) (ikk-i). [swissprot;acc:q14164]	Subtracted		204.39	200.288	4.102
	mitotic checkpoint protein bub3. [swissprot;acc:o43684]		High confidence	221.934	218.658	3.276
	protein kinase clk2 (ec 2.7.1.-) (cdc-like kinase 2). [swissprot;acc:p49760]	Divided		214.984	211.614	1.01593
1605	asparaginyl-trna synthetase, cytoplasmic (ec 6.1.1.22) (asparagine-- trna ligase) (asnrs). [swissprot;acc:o43776]	Subtracted	Low confidence	201.291	197.189	4.102
	dual specificity protein phosphatase 15 (ec 3.1.3.48) (ec 3.1.3.16). [swissprot;acc:q9h1r2]	Divided		199.691	195.607	1.02088
	hepatocyte nuclear factor 3-alpha (hnf-3a) (forkhead box protein a1). [swissprot;acc:p55317]		High confidence	217.322	213.916	1.01592
	zinc finger protein 207. [swissprot;acc:o43670]	Subtracted		221.934	218.658	3.276
1606	apolipoprotein a-i binding protein; apoa-i binding protein. [refseq;acc:nm_144772]	Divided		207.916	204.662	1.0159
	delta-interacting protein a (hepatitis delta antigen interacting protein a). [swissprot;acc:q15834]	Subtracted	Low confidence	201.993	197.894	4.099
	dna polymerase epsilon p17 subunit (dna polymerase epsilon subunit 3) (chromatin accessibility complex 17) (huchrac17) (chrac-17). [swissprot;acc:q9nrf9]	Divided		204.475	200.292	1.02088
	transcription factor-like protein mrgx (morf-related gene x protein) (mortality factor 4-like 2) (msl3-2 protein). [swissprot;acc:q15014]	Subtracted	High confidence	228.477	231.747	3.27
1607	dual specificity protein phosphatase 5 (ec 3.1.3.48) (ec 3.1.3.16) (dual specificity protein phosphatase hvh3). [swissprot;acc:q16690]	Divided	Low confidence	199.691	195.607	1.02088
	protein kinase clk3 (ec 2.7.1.-) (cdc-like kinase 3). [swissprot;acc:p49761]		High confidence	214.982	211.622	1.01588
	transcription factor-like protein morf4 (mortality factor 4) (cellular senescence-related protein 1) (sen1). [swissprot;acc:q9y690]	Subtracted		228.484	231.74	3.256
	transketolase (ec 2.2.1.1) (tk). [swissprot;acc:p29401]		Low confidence	201.817	197.718	4.099
1608	adenylosuccinate lyase (ec 4.3.2.2) (adenylosuccinase) (asl) (asase). [swissprot;acc:p30566]	Divided		199.691	195.607	1.02088
	ctf18, chromosome transmission fidelity factor 18 homolog; homolog of yeast chl12. [refseq;acc:nm_022092]	Subtracted		200.714	196.617	4.097
	g1 to s phase transition protein 1 homolog (gtp-binding protein gst1-hs). [swissprot;acc:p15170]		High confidence	218.789	215.533	3.256
	ubiquitin-conjugating enzyme e2 variant 1 isoform b; dna-binding protein. [refseq;acc:nm_003349]	Divided		208.106	204.867	1.01581
1609	apolipoprotein a-i binding protein; apoa-i binding protein. [refseq;acc:nm_144772]	Subtracted		207.916	204.662	3.254
	dual specificity protein phosphatase 13 (ec 3.1.3.48) (ec 3.1.3.16) (testis- and skeletal-muscle-specific dsp). [swissprot;acc:q9uii6]	Divided	Low confidence	199.691	195.607	1.02088
	homeobox protein hox-c8 (hox-3a). [swissprot;acc:p31273]	Subtracted		203.127	199.033	4.094
	utp--glucose-1-phosphate uridylyltransferase 2 (ec 2.7.7.9) (udp- glucose pyrophosphorylase 2) (udpgp 2) (ugpase 2). [swissprot;acc:q16851]	Divided	High confidence	208.113	204.876	1.0158
1610	c18b11 homolog (44.9kd). [refseq;acc:nm_152260]	Subtracted		217.446	214.2	3.246
	mawd binding protein (unknown protein 32 from 2d-page of liver tissue). [swissprot;acc:p30039]		Low confidence	185.205	181.112	4.093
	mus81 endonuclease. [refseq;acc:nm_025128]	Divided		195.31	191.317	1.02087
	ubiquitin-conjugating enzyme e2 variant 2; 1 alpha,25-dihydroxyvitamin d3-inducible; enterocyte differentiation promoting factor; methyl methanesulfonate sensitive 2, s. cerevisiae, homolog of. [refseq;acc:nm_003350]		High confidence	208.122	204.886	1.01579
1611	hyaluronan synthase 2 (ec 2.4.1.212) (hyaluronate synthase 2) (hyaluronic acid synthase 2) (ha synthase 2). [swissprot;acc:q92819]	Subtracted	Low confidence	197.747	193.656	4.091
	p10-binding protein. [refseq;acc:nm_024491]	Divided	High confidence	221.313	217.877	1.01577
	similar to hepatocellular carcinoma-associated antigen hca557b. [refseq;acc:nm_145280]		Low confidence	195.31	191.317	1.02087
	z-protein (protein cgi-119) (s1r protein). [swissprot;acc:q9hc24]	Subtracted	High confidence	217.446	214.2	3.246
1612	enthoprotin; epsin 4; clathrin interacting protein localized in the trans-golgi region. [refseq;acc:nm_014666]	Divided		221.426	224.902	1.0157
	hepatocellularcarcinoma-associated antigen hca557a. [refseq;acc:nm_015433]		Low confidence	195.31	191.317	1.02087
	hyaluronan synthase 1 (ec 2.4.1.212) (hyaluronate synthase 1) (hyaluronic acid synthase 1) (ha synthase 1) (huhas1). [swissprot;acc:q92839]	Subtracted		197.752	193.661	4.091
	pp1201 protein. [refseq;acc:nm_022152]		High confidence	217.446	214.2	3.246
1613	hiv-1 tat interactive protein 2, 30kda; tat-interacting protein (30kd); hiv-1 tat interactive protein 2, 30 kda; hiv-1 tat interactive protein 2, 30 kd. [refseq;acc:nm_006410]	Divided		182.378	185.241	1.0157
	hyaluronan synthase 3 (ec 2.4.1.212) (hyaluronate synthase 3) (hyaluronic acid synthase 3) (ha synthase 3). [swissprot;acc:o00219]	Subtracted	Low confidence	197.74	193.65	4.09
	lifeguard; kiaa0950 protein. [refseq;acc:nm_012306]		High confidence	217.446	214.2	3.246
	mitochondrial gtp binding protein isoform v. [refseq;acc:nm_032620]	Divided	Low confidence	192.787	188.847	1.02086
1614	hepatocyte nuclear factor 3-beta (hnf-3b) (forkhead box protein a2). [swissprot;acc:q9y261]		High confidence	217.233	213.897	1.0156
	ras-related protein rap-2b. [swissprot;acc:p17964]		Low confidence	202.026	197.9	1.02085
	sterol regulatory element binding protein-2 (srebp-2) (sterol regulatory element-binding transcription factor 2). [swissprot;acc:q12772]	Subtracted	High confidence	217.446	214.2	3.246
	zinc finger-like protein 9. [refseq;acc:nm_033414]		Low confidence	202.494	198.406	4.088
1615	cpg binding protein (protein containing phd finger and cxxc domain 1). [swissprot;acc:q9p0u4]	Divided		205.179	200.988	1.02085

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.