MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 323 to 372 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

Rank	Hugo	description	Network Comparison Type	red	green	network_comparison
162	no value	atlastin; guanylate-binding protein 3. [refseq;acc:nm_015915]	Subtracted	142	170	28
	NOSTRIN	nostrin. [refseq;acc:nm_052946]	Divided	209.299	249.187	1.19058
163	ARRB2	beta-arrestin 2 (arrestin, beta 2). [swissprot;acc:p32121]	Subtracted	133	105	28
	SNF8	eap30 subunit of ell complex. [refseq;acc:nm_007241]	Divided	209.299	249.187	1.19058
164	ARRB1	beta-arrestin 1 (arrestin, beta 1). [swissprot;acc:p49407]	Subtracted	133	105	28
	SLC39A6	liv-1 protein, estrogen regulated. [refseq;acc:nm_012319]	Divided	209.299	249.187	1.19058
165	GAD2	glutamate decarboxylase, 65 kda isoform (ec 4.1.1.15) (gad-65) (65 kda glutamic acid decarboxylase). [swissprot;acc:q05329]
	SPATA6	spermatogenesis associated 6. [refseq;acc:nm_019073]	Subtracted	133	105	28
166	NAPG	gamma-soluble nsf attachment protein (snap-gamma) (n-ethylmaleimide- sensitive factor attachment protein, gamma). [swissprot;acc:q99747]	Divided	209.299	249.187	1.19058
	NEUROD4	neurogenic differentiation factor 4 (neurod4). [swissprot;acc:q9hd90]	Subtracted	312	284	28
167	AMPD2	amp deaminase 2 (ec 3.5.4.6) (amp deaminase isoform l). [swissprot;acc:q01433]		133	105
	GAD1	glutamate decarboxylase, 67 kda isoform (ec 4.1.1.15) (gad-67) (67 kda glutamic acid decarboxylase). [swissprot;acc:q99259]	Divided	209.299	249.187	1.19058
168	no value	gaba-a receptor-associated protein. [sptrembl;acc:q9by60]		82.5916	98.0548	1.18722
	CHD5	chromodomain helicase dna binding protein 5. [refseq;acc:nm_015557]	Subtracted	312	284	28
169	ATG3	apg3p; pc3-96 protein. [refseq;acc:nm_022488]	Divided	82.5916	98.0548	1.18722
	CDK2AP1	cyclin-dependent kinase 2-associated protein 1 (cdk2-associated protein 1) (putative oral cancer suppressor) (deleted in oral cancer- 1) (doc-1). [swissprot;acc:o14519]	Subtracted	312	284	28
170	PRPF40B	huntingtin interacting protein c. [refseq;acc:nm_012272]		227.971	200.417	27.554
	TIA1	nucleolysin tia-1 (rna-binding protein tia-1) (p40-tia-1) [contains: p15-tia-1]. [swissprot;acc:p31483]	Divided	227.199	192.715	1.17894
171	TIAL1	nucleolysin tiar (tia-1 related protein). [swissprot;acc:q01085]		227.202	192.823	1.17829
	TRPC4	short transient receptor potential channel 4 (trpc4) (trp-related protein 4) (htrp-4) (htrp4). [swissprot;acc:q9ubn4]	Subtracted	201.478	228.784	27.306
172	TBC1D10A	ebp50-pdz interactor of 64 kda (epi64 protein). [swissprot;acc:q9bxi6]		201.515	228.752	27.237
	TIPRL	cg9578-like; yeast ypr037w and worm c02c2.6 predicted proteins-like. [refseq;acc:nm_152902]	Divided	174.667	205.556	1.17685
173	SNRPD1	small nuclear ribonucleoprotein sm d1 (snrnp core protein d1) (sm-d1) (sm-d autoantigen). [swissprot;acc:p13641]		227.032	193.056	1.17599
	TRPC5	short transient receptor potential channel 5 (trpc5) (htrp-5) (htrp5). [swissprot;acc:q9ul62]	Subtracted	201.515	228.752	27.237
174	DGCR14	dgcr14 protein (digeorge syndrome critical region 14) (es2 protein). [swissprot;acc:q96df8]	Divided	335	286	1.17133
	LUC7L2	luc7-like 2; cgi-74 protein; cgi-59 protein. [refseq;acc:nm_016019]	Subtracted	228.1	200.968	27.132
175	COPS3	cop9 constitutive photomorphogenic homolog subunit 3; cop9 complex subunit 3; jab1-containing signalosome subunit 3. [refseq;acc:nm_003653]	Divided	199.949	234.187	1.17123
	LUC7L	luc7-like; sarcoplasmic reticulum protein luc7b1. [refseq;acc:nm_018032]	Subtracted	228.085	201.006	27.079
176	EIF5	eukaryotic translation initiation factor 5 (eif-5). [swissprot;acc:p55010]		271.016	244.167	26.849
	POLE4	dna polymerase epsilon p12 subunit (dna polymerase epsilon subunit 4). [swissprot;acc:q9nr33]	Divided	275.754	235.908	1.1689
177	NCBP2L	dj820b18.1 (similar to nuclear cap binding protein) (fragment). [sptrembl;acc:q8wwk2]		229.406	196.695	1.1663
	SIN3A	transcriptional co-repressor sin3a; transcriptional regulator, sin3a (yeast). [refseq;acc:nm_015477]	Subtracted	241.07	267.88	26.81
178	no value	formin binding protein 3; fas-ligand associated factor 1; huntingtin-interacting protein a; ny-ren-6 antigen. [refseq;acc:nm_017892]	Divided	226.887	194.72	1.1652
	DENR	density-regulated protein (drp) (drp1 protein) (smooth muscle cell associated protein-3) (smap-3). [swissprot;acc:o43583]	Subtracted	241.07	267.88	26.81
179	no value	huntingtin-interacting protein hypa/fbp11 (fragment). [sptrembl;acc:o75404]	Divided	226.884	194.79	1.16476
	PAH	phenylalanine-4-hydroxylase (ec 1.14.16.1) (pah) (phe-4- monooxygenase). [swissprot;acc:p00439]	Subtracted	227.357	254.15	26.793
180	DUS1L	pp3111 protein. [refseq;acc:nm_022156]
	TARDBP	tar dna-binding protein-43 (tdp-43). [swissprot;acc:q13148]	Divided	256.228	298.438	1.16474
181	B9D1	b9 protein; likely ortholog of mouse endothelial precursor protein b9. [refseq;acc:nm_015681]		229.818	267.265	1.16294
	STX18	syntaxin 18. [swissprot;acc:q9p2w9]	Subtracted	227.357	254.15	26.793
182	no value	rd protein. [swissprot;acc:p18615]
	HAT1	histone acetyltransferase type b catalytic subunit (ec 2.3.1.48). [swissprot;acc:o14929]	Divided	277.546	240.461	1.15422
183	GSTO1	glutathione transferase omega 1 (ec 2.5.1.18) (gsto 1-1). [swissprot;acc:p78417]	Subtracted	227.357	254.15	26.793
	NCBP2	20 kda nuclear cap binding protein (ncbp 20 kda subunit) (cbp20) (ncbp interacting protein 1) (nip1). [swissprot;acc:p52298]	Divided	228.306	198.011	1.153
184	AIG1	androgen-induced 1; cgi-103 protein; androgen induced protein. [refseq;acc:nm_016108]	Subtracted	227.357	254.15	26.793
	OSR1	odd-skipped related 1; odz (odd oz/ten-m) related 1. [refseq;acc:nm_145260]	Divided	274.027	237.79	1.15239
185	ADIPOR2	adiponectin receptor 2. [refseq;acc:nm_024551]		281.582	246.371	1.14292
	ATP5F1	atp synthase b chain, mitochondrial precursor (ec 3.6.3.14). [swissprot;acc:p24539]	Subtracted	227.357	254.15	26.793
186	DNAJC12	j domain containing protein 1. [swissprot;acc:q9ukb3]
	FLNB	filamin b, beta (actin binding protein 278); beta filamin; filamin 1 (actin-binding protein-280)-like; filamin b, beta (actin-binding protein-278); filamin b, beta. [refseq;acc:nm_001457]	Divided	226.582	198.444	1.14179

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.