MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	network_comparison	green

Results: HTML CSV LaTeX

Showing element 1075 to 1124 of 12912 in total

Network Comparison Type  : Divided
Interaction Map  : High confidence
Filtered  : 1

Rank	Hugo	description	Value Type	red	network_comparison	green
269	PCYT1A	cholinephosphate cytidylyltransferase a (ec 2.7.7.15) (phosphorylcholine transferase a) (ctp:phosphocholine cytidylyltransferase a) (ct a) (cct a) (cct-alpha). [swissprot;acc:p49585]	Ranked	241.373	1.10763	267.352
	SLC46A2	thymic stromal co-transporter. [refseq;acc:nm_033051]	Squared	26157.6	1.29261	20236.2
270	C16orf80	transcription factor iib. [refseq;acc:nm_013242]		64739.9	1.28706	50300.6
	CRKL	crk-like protein. [swissprot;acc:p46109]	Rooted	66.1064	1.12103	74.1074
	FIP1L1	fip1-like 1; rearranged in hypereosinophilia. [refseq;acc:nm_030917]	Measured	23640.2	1.21358	19479.8
	FLAD1	fad synthetase. [refseq;acc:nm_025207]	Ranked	241.373	1.10763	267.352
271	no value	bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthethase 2 (paps synthethase 2) (papss 2) (sulfurylase kinase 2) (sk2) (sk 2) [includes: sulfate adenylyltransferase (ec 2.7.7.4) (sulfate adenylate transferase) (sat) (atp-sulfurylase); adenylylsulfate kinase (ec 2.7.1.25) (adenylylsulfate 3'-phosphotransferase) (aps kinase) (adenosine-5'-phosphosulfate 3'-phosphotransferase) (3'- phosphoadenosine-5'-phosphosulfate synthetase)]. [swissprot;acc:o95340]
	ABL1	proto-oncogene tyrosine-protein kinase abl1 (ec 2.7.1.112) (p150) (c-abl). [swissprot;acc:p00519]	Rooted	66.1064	1.12103	74.1073
	CHRAC1	chromatin accessibility complex protein 1 (chrac-1) (chrac-15) (huchrac15) (dna polymerase epsilon subunit p15). [swissprot;acc:q9nrg0]	Measured	2554.89	1.21092	3093.78
	SFRS8	splicing factor, arginine/serine-rich 8 (suppressor of white apricot protein homolog). [swissprot;acc:q12872]	Squared	64739.9	1.28706	50300.6
272	FDX1	adrenodoxin, mitochondrial precursor (adrenal ferredoxin) (hepatoredoxin) (ferredoxin 1). [swissprot;acc:p10109]		36563.7	1.28464	46971.1
	FYN	proto-oncogene tyrosine-protein kinase fyn (ec 2.7.1.112) (p59-fyn) (syn) (slk). [swissprot;acc:p06241]	Rooted	66.1064	1.12103	74.1074
	HAT1	histone acetyltransferase type b catalytic subunit (ec 2.3.1.48). [swissprot;acc:o14929]	Measured	3858.52	1.21012	4669.27
	LGTN	ligatin (hepatocellular carcinoma-associated antigen 56). [swissprot;acc:p41214]	Ranked	241.373	1.10763	267.352
273	EIF5	eukaryotic translation initiation factor 5 (eif-5). [swissprot;acc:p55010]	Measured	3199.4	1.20985	3870.8
	FGR	proto-oncogene tyrosine-protein kinase fgr (ec 2.7.1.112) (p55-fgr) (c-fgr). [swissprot;acc:p09769]	Rooted	66.1064	1.12103	74.1074
	FLNB	filamin b, beta (actin binding protein 278); beta filamin; filamin 1 (actin-binding protein-280)-like; filamin b, beta (actin-binding protein-278); filamin b, beta. [refseq;acc:nm_001457]	Squared	16120.1	1.28198	20665.7
	PAPSS1	bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthethase 1 (paps synthethase 1) (papss 1) (sulfurylase kinase 1) (sk1) (sk 1) [includes: sulfate adenylyltransferase (ec 2.7.7.4) (sulfate adenylate transferase) (sat) (atp-sulfurylase); adenylylsulfate kinase (ec 2.7.1.25) (adenylylsulfate 3'-phosphotransferase) (aps kinase) (adenosine-5'-phosphosulfate 3'-phosphotransferase) (3'- phosphoadenosine-5'-phosphosulfate synthetase)]. [swissprot;acc:o43252]	Ranked	241.373	1.10763	267.352
274	GRAP2	grb2-related adaptor protein 2 (gads protein) (growth factor receptor binding protein) (grblg) (grf40 adaptor protein) (grf-40) (grb-2-like protein) (grb2l) (grbx) (p38) (hematopoietic cell-associated adaptor protein grpl) (adapter protein grid) (sh3-sh2-sh3 adaptor mona). [swissprot;acc:o75791]	Rooted	66.1063	1.12102	74.1068
	POR	nadph-cytochrome p450 reductase (ec 1.6.2.4) (cpr) (p450r). [swissprot;acc:p16435]	Ranked	241.373	1.10763	267.352
	RBM15B	chromosome 3p21.1 gene sequence. [refseq;acc:nm_013286]	Measured	3119.98	1.20953	2579.49
	REV1	rev1-like; rev1 protein; rev1 (yeast homolog)- like. [refseq;acc:nm_016316]	Squared	16120.1	1.28198	20665.7
275	CUTL1	ccaat displacement protein (cdp) (cut-like 1). [swissprot;acc:p39880]	Rooted	66.1048	1.12091	74.0977
	PCYT1B	cholinephosphate cytidylyltransferase b (ec 2.7.7.15) (phosphorylcholine transferase b) (ctp:phosphocholine cytidylyltransferase b) (ct b) (cct b) (cct-beta). [swissprot;acc:q9y5k3]	Ranked	241.373	1.10763	267.352
	PRMT1	protein arginine n-methyltransferase 1 (ec 2.1.1.-) (interferon receptor 1-bound protein 4). [swissprot;acc:q99873]	Squared	16120.1	1.28198	20665.7
	RGS19	regulator of g-protein signaling 19 (rgs19) (g-alpha interacting protein) (gaip protein). [swissprot;acc:p49795]	Measured	3119.98	1.20953	2579.49
276	CUTL2	homeobox protein cux-2 (cut-like 2) (fragment). [swissprot;acc:o14529]	Rooted	66.1046	1.1209	74.0964
	PRMT8	protein arginine n-methyltransferase 4 (ec 2.1.1.-). [swissprot;acc:q9nr22]	Squared	16120.1	1.28198	20665.7
	RBM15	putative rna-binding protein 15 (rna binding motif protein 15) (one-twenty two protein). [swissprot;acc:q96t37]	Measured	3119.98	1.20953	2579.49
	SNORA7A	60s ribosomal protein l32. [swissprot;acc:p02433]	Ranked	241.13	1.10716	266.969
277	no value	40s ribosomal protein s29. [swissprot;acc:p30054]		241.849	1.10665	267.642
	RGS20	regulator of g-protein signaling 20 (rgs20) (regulator of gz- selective protein signaling 1) (gz-selective gtpase-activating protein) (g(z)gap). [swissprot;acc:o76081]	Measured	3119.98	1.20953	2579.49
	RPS6KC1	ribosomal protein s6 kinase, 52kda, polypeptide 1; ribosomal protein s6 kinase, 52kd, polypeptide 1. [refseq;acc:nm_012424]	Rooted	65.9938	1.12048	73.9449
	SNRP70	u1 small nuclear ribonucleoprotein 70 kda (u1 snrnp 70 kda) (snrnp70) (u1-70k). [swissprot;acc:p08621]	Squared	16120.1	1.28198	20665.7
278	no value	filamin a (alpha-filamin) (filamin 1) (endothelial actin-binding protein) (abp-280) (nonmuscle filamin). [swissprot;acc:p21333]
		ribosomal protein s6 kinase-like 1. [refseq;acc:nm_031464]	Rooted	65.9938	1.12048	73.9449
	LBX1	transcription factor lbx1. [swissprot;acc:p52954]	Measured	3119.98	1.20953	2579.49
	RPS11	40s ribosomal protein s11. [swissprot;acc:p04643]	Ranked	241.399	1.10642	267.088
279	GPSM2	mosaic protein lgn. [swissprot;acc:p81274]	Measured	3119.98	1.20953	2579.49
	MSI2	musashi 2 isoform a. [refseq;acc:nm_138962]	Squared	15569.5	1.28158	19953.6
	RBBP7	histone acetyltransferase type b subunit 2 (retinoblastoma binding protein p46) (retinoblastoma-binding protein 7) (rbbp-7). [swissprot;acc:q16576]	Ranked	252.644	1.10605	228.42
	WASL	neural wiskott-aldrich syndrome protein (n-wasp). [swissprot;acc:o00401]	Rooted	66.0989	1.12046	74.0609
280	no value	ba395l14.12 (novel protein similar to small nuclear ribonucleoprotein polypeptide a' (snrpa1)). [sptrembl;acc:q9nu36]		57.9068	1.12001	64.8562
	MSI1	musashi 1. [refseq;acc:nm_002442]	Squared	15569.5	1.28158	19953.6
	MTA1	metastasis-associated protein mta1. [swissprot;acc:q13330]	Ranked	252.512	1.10578	228.356
	RGS17	regulator of g-protein signaling 17 (rgs17). [swissprot;acc:q9ugc6]	Measured	3119.98	1.20953	2579.49
281	no value	60s ribosomal protein l17 (l23). [swissprot;acc:p18621]	Ranked	241.808	1.10557	267.335
	GNAO1	guanine nucleotide-binding protein g(o), alpha subunit 1. [swissprot;acc:p09471]	Measured	3119.98	1.20953	2579.49
	SNRPA1	u2 small nuclear ribonucleoprotein a' (u2 snrnp-a'). [swissprot;acc:p09661]	Rooted	57.9068	1.12001	64.8562
	ZC3H14	nuclear protein ukp68. [refseq;acc:nm_024824]	Squared	15569.5	1.28158	19953.6

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.