MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	Network Comparison Type	description	Value Type	Interaction Map	Filtered	red	network_comparison	green

Results: HTML CSV LaTeX

Showing element 1201 to 1250 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

Rank	Hugo	Network Comparison Type	description	red	network_comparison	green
601	FYN	Subtracted	proto-oncogene tyrosine-protein kinase fyn (ec 2.7.1.112) (p59-fyn) (syn) (slk). [swissprot;acc:p06241]	207.26	12.914	194.346
	VPS39	Divided	vam6/vps39-like protein (hvam6p). [swissprot;acc:q96jc1]	206.274	1.06069	218.792
602	FGR	Subtracted	proto-oncogene tyrosine-protein kinase fgr (ec 2.7.1.112) (p55-fgr) (c-fgr). [swissprot;acc:p09769]	207.26	12.914	194.346
	MAP4	Divided	microtubule-associated protein 4 (map 4). [swissprot;acc:p27816]	206.274	1.06069	218.792
603	CUTL1	Subtracted	ccaat displacement protein (cdp) (cut-like 1). [swissprot;acc:p39880]	207.27	12.902	194.368
	LEF1	Divided	lymphoid enhancer binding factor 1 (lef-1) (t cell-specific transcription factor 1-alpha) (tcf1-alpha). [swissprot;acc:q9uju2]	225.829	1.0605	212.945
604	CUTL2	Subtracted	homeobox protein cux-2 (cut-like 2) (fragment). [swissprot;acc:o14529]	207.272	12.901	194.371
	RPL15	Divided	60s ribosomal protein l15. [swissprot;acc:p39030]	217.862	1.0602	230.978
605	HIST1H2BL		histone h2b.c (h2b/c). [swissprot;acc:q99880]	247.47	1.0601	233.441
	LEF1	Subtracted	lymphoid enhancer binding factor 1 (lef-1) (t cell-specific transcription factor 1-alpha) (tcf1-alpha). [swissprot;acc:q9uju2]	225.829	12.884	212.945
606	HIST2H2BA	Divided	histone h2b.q (h2b/q) (h2b-gl105). [swissprot;acc:q16778]	247.47	1.0601	233.441
	WASL	Subtracted	neural wiskott-aldrich syndrome protein (n-wasp). [swissprot;acc:o00401]	207.309	12.857	194.452
607	no value	Divided	histone h3.1 (h3/a) (h3/c) (h3/d) (h3/f) (h3/h) (h3/i) (h3/j) (h3/k) (h3/l). [swissprot;acc:p16106]	247.47	1.0601	233.441
	SCOC	Subtracted	short coiled-coil protein; short coiled coil protein. [refseq;acc:nm_032547]	216.731	12.818	229.549
608	no value	Divided	histone h2b. [refseq;acc:nm_175055]	247.47	1.0601	233.441
	DYNLL2	Subtracted	dynein light chain 2. [refseq;acc:nm_080677]	216.731	12.818	229.549
609	no value	Divided	histone h2b.s (h2b/s). [swissprot;acc:p57053]	247.47	1.0601	233.441
		Subtracted	dead-box protein abstrakt homolog. [swissprot;acc:q9ujv9]	226.523	12.737	213.786
610		Divided	histone h2b.d (h2b/d). [swissprot;acc:q99877]	247.47	1.0601	233.441
	SOS1	Subtracted	son of sevenless protein homolog 1 (sos-1). [swissprot;acc:q07889]	205.74	12.719	193.021
611	no value		u6 snrna-associated sm-like protein lsm7. [swissprot;acc:q9uk45]	228.986	12.71	216.276
	HIST3H3	Divided	histone h3.4 (h3t) (h3/t) (h3/g). [swissprot;acc:q16695]	247.47	1.0601	233.441
612	HIST1H2BA		testis-specific histone h2b; h2b histone family, member u, (testis-specific). [refseq;acc:nm_170610]
	SOS2	Subtracted	son of sevenless protein homolog 2 (sos-2). [swissprot;acc:q07890]	205.89	12.707	193.183
613	no value	Divided	histone h2b.e (h2b/e). [swissprot;acc:q99879]	247.47	1.0601	233.441
	NOL5A	Subtracted	nucleolar protein nop56 (nucleolar protein 5a). [swissprot;acc:o00567]	247.769	12.695	235.074
614	HOXA10	Divided	homeobox protein hox-a10 (hox-1h) (hox-1.8) (pl). [swissprot;acc:p31260]	214.257	1.06002	202.125
	YARS	Subtracted	tyrosyl-trna synthetase (ec 6.1.1.1) (tyrosyl--trna ligase) (tyrrs). [swissprot;acc:p54577]	232.468	12.58	245.048
615	HOXB9	Divided	homeobox protein hox-b9 (hox-2e) (hox-2.5). [swissprot;acc:p17482]	214.257	1.05999	202.132
	POLE	Subtracted	dna polymerase epsilon, catalytic subunit a (ec 2.7.7.7) (dna polymerase ii subunit a). [swissprot;acc:q07864]	241.907	12.557	229.35
616	CPA3		mast cell carboxypeptidase a precursor (ec 3.4.17.1) (mc-cpa) (carboxypeptidase a3). [swissprot;acc:p15088]	177.698	12.542	190.24
	HOXA9	Divided	homeobox protein hox-a9 (hox-1g). [swissprot;acc:p31269]	214.257	1.05999	202.132
617	CPA6	Subtracted	carboxypeptidase b precursor. [refseq;acc:nm_020361]	177.698	12.541	190.239
	HOXC9	Divided	homeobox protein hox-c9 (hox-3b). [swissprot;acc:p31274]	214.257	1.05997	202.135
618	CPB2	Subtracted	plasma carboxypeptidase b2 isoform a preproprotein; carboxypeptidase u; thrombin-activatable fibrinolysis inhibitor; carboxypeptidase b-like protein; thrombin-activable fibrinolysis inhibitor. [refseq;acc:nm_001872]	177.699	12.541	190.24
	GABRG3	Divided	gamma-aminobutyric-acid receptor gamma-3 subunit precursor (gaba(a) receptor). [swissprot;acc:q99928]	214.256	1.05994	202.139
619	FOXG1		forkhead box protein g1c (forkhead-related protein fkhl3) (hfk3) (fragment). [swissprot;acc:q14488]
	VPS39	Subtracted	vam6/vps39-like protein (hvam6p). [swissprot;acc:q96jc1]	206.274	12.518	218.792
620	GABRG1	Divided	gamma-aminobutyric-acid receptor gamma-1 subunit precursor (gaba(a) receptor). [swissprot;acc:q8n1c3]	214.256	1.05994	202.14
	MAP4	Subtracted	microtubule-associated protein 4 (map 4). [swissprot;acc:p27816]	206.274	12.518	218.792
621	GABRA2	Divided	gamma-aminobutyric-acid receptor alpha-2 subunit precursor (gaba(a) receptor). [swissprot;acc:p47869]	214.256	1.05994	202.14
	RPLP2	Subtracted	60s acidic ribosomal protein p2. [swissprot;acc:p05387]	231.92	12.515	244.435
622	GABRA6	Divided	gamma-aminobutyric-acid receptor alpha-6 subunit precursor (gaba(a) receptor). [swissprot;acc:q16445]	214.256	1.05994	202.14
	SYN3	Subtracted	synapsin iii. [swissprot;acc:o14994]	229.072	12.496	216.576
623	no value		aspartate beta-hydroxylase isoform b; junctin isoform 1; junctate; aspartyl/asparaginyl-beta-hydroxylase; peptide-aspartate beta-dioxygenase; humbug. [refseq;acc:nm_032468]
	GABRG2	Divided	gamma-aminobutyric-acid receptor gamma-2 subunit precursor (gaba(a) receptor). [swissprot;acc:p18507]	214.256	1.05994	202.14
624	no value		interleukin-1 receptor-associated kinase 4; interleukin-1 receptor associated kinase 4. [refseq;acc:nm_016123]			202.139
	HEY1	Subtracted	hairy/enhancer-of-split related with yrpw motif 1 (hairy and enhancer of split related-1) (hesr-1) (cardiovascular helix-loop-helix factor 2) (hes-related repressor protein 2 herp2). [swissprot;acc:q9y5j3]	229.072	12.496	216.576
625	ABLIM2		actin binding lim protein 2. [refseq;acc:nm_032432]
	GABRA4	Divided	gamma-aminobutyric-acid receptor alpha-4 subunit precursor (gaba(a) receptor). [swissprot;acc:p48169]	214.256	1.05994	202.14

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.