MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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description	Rank	Gene	Hugo	Network Comparison Type	Value Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 1925 to 1974 of 8289 in total

Network Comparison Type  : Divided
Value Type  : Ranked
Filtered  : 1

description	Rank	Hugo	Interaction Map	red	green	network_comparison
dimethylaniline monooxygenase [n-oxide forming] 4 (ec 1.14.13.8) (hepatic flavin-containing monooxygenase 4) (fmo 4) (dimethylaniline oxidase 4). [swissprot;acc:p31512]	2289	FMO4	High confidence	216.605	215.46	1.00531
dimethylaniline monooxygenase [n-oxide forming] 5 (ec 1.14.13.8) (hepatic flavin-containing monooxygenase 5) (fmo 5) (dimethylaniline oxidase 5). [swissprot;acc:p49326]	190	FMO5	Low confidence	210.557	200.074	1.0524
	2271		High confidence	216.622	215.436	1.00551
dipeptidyl aminopeptidase-like protein 6 (dipeptidylpeptidase vi) (dipeptidylpeptidase 6) (dipeptidyl peptidase iv like protein) (dipeptidyl aminopeptidase-related protein) (dppx). [swissprot;acc:p42658]	429	DPP6	Low confidence	202.75	195.879	1.03508
	1516		High confidence	213.267	209.511	1.01793
dipeptidyl peptidase 8 isoform 2; dipeptidyl peptidase 8. [refseq;acc:nm_017743]	395	DPP8		218.827	238.407	1.08948
	4742		Low confidence	196.768	197.824	1.00537
dipeptidylpeptidase 10; dipeptidyl peptidase iv-related protein 3. [refseq;acc:nm_020868]	430	DPP10		202.75	195.88	1.03507
	1515		High confidence	213.267	209.511	1.01793
dipeptidylpeptidase 9; dipeptidyl peptidase 9; dipeptidyl peptidase iv-related protein-2. [refseq;acc:nm_139159]	394	DPP9		218.827	238.407	1.08948
	4743		Low confidence	196.767	197.822	1.00536
diphosphomevalonate decarboxylase (ec 4.1.1.33) (mevalonate pyrophosphate decarboxylase) (mevalonate (diphospho)decarboxylase). [swissprot;acc:p53602]	868	MVD	High confidence	233.298	242.571	1.03975
	3163		Low confidence	202.715	199.486	1.01619
diphthamide biosynthesis-like protein 2. [refseq;acc:nm_001384]	1202	DPH2	High confidence	227.274	233.041	1.02537
	3723		Low confidence	201.544	198.846	1.01357
discoidin domain receptor 2 precursor (ec 2.7.1.112) (receptor protein-tyrosine kinase tkt) (tyrosine-protein kinase tyro 10) (neurotrophic tyrosine kinase, receptor-related 3). [swissprot;acc:q16832]	2724	DDR2		200.78	197.329	1.01749
discs, large homolog 5 (placenta and prostate dlg) (discs large protein p-dlg). [swissprot;acc:q8tdm6]	3911	DLG5		207.449	204.872	1.01258
dishevelled-associated activator of morphogenesis 1. [refseq;acc:nm_014992]	3531	DAAM1		202.898	199.949	1.01475
disks large-associated protein 1 (dap-1) (guanylate kinase-associated protein) (hgkap) (sap90/psd-95-associated protein 1) (sapap1) (psd- 95/sap90 binding protein 1). [swissprot;acc:o14490]	114	DLGAP1		197.779	211.983	1.07182
	701		High confidence	220.438	209.118	1.05413
disks large-associated protein 2 (dap-2) (sap90/psd-95-associated protein 2) (sapap2) (psd-95/sap90 binding protein 2) (fragment). [swissprot;acc:q9p1a6]	110	no value	Low confidence	197.752	212.031	1.07221
	708		High confidence	220.438	209.118	1.05413
disks large-associated protein 3 (dap-3) (sap90/psd-95-associated protein 3) (sapap3) (psd-95/sap90 binding protein 3) (fragment). [swissprot;acc:o95886]	108	DLGAP3	Low confidence	197.731	212.069	1.07251
	706		High confidence	220.438	209.118	1.05413
disks large-associated protein 4 (dap-4) (sap90/psd-95-associated protein 4) (sapap4) (psd-95/sap90 binding protein 4). [swissprot;acc:q9y2h0]	115	DLGAP4	Low confidence	197.779	211.983	1.07182
	710		High confidence	220.438	209.118	1.05413
disrupter of silencing 10. [refseq;acc:nm_020368]	1068	UTP3	Low confidence	199.958	195.283	1.02394
	1905		High confidence	191.411	193.39	1.01034
dj1099d15.1 (putative dnaj protein). [sptrembl;acc:q9h4j9]	632	no value	Low confidence	204.242	198.448	1.0292
	724		High confidence	244.842	232.577	1.05274
dj1100h13.4 (putative rhogap domain containing protein) (fragment). [sptrembl;acc:q9h1g7]	4610	C20orf95	Low confidence	202.937	204.351	1.00697
dj132f21.2 (contains a novel protein similar to the l82e from drosophila) (fragment). [sptrembl;acc:q9h125]	2060	C20orf118	High confidence	218.79	216.981	1.00834
	4114		Low confidence	202.688	200.543	1.0107
dj153g14.2 (possible ca binding protein similar to nefa) (fragment). [sptrembl;acc:q9ujn8]	776	no value	High confidence	225.996	215.535	1.04854
	3768		Low confidence	213.191	216.048	1.0134
dj153g14.3 (novel c2h2 type zinc finger protein) (fragment). [sptrembl;acc:q9ujn7]	4385	ZNF391		197.793	195.963	1.00934
dj18d14.4 (cytochrome p450, subfamily iva, polypeptide 11). [sptrembl;acc:q9ntl5]	448	CYP4A22		203.074	196.277	1.03463
	1287		High confidence	218.368	213.22	1.02414
dj254p11.1 (novel protein similar to rna polymerase ii elongation factor siii, subunit p15). [sptrembl;acc:q9h575]	2967	no value	Low confidence	201.618	198.274	1.01687
dj310o13.4 (novel protein similar to predicted c. elegans and c. intestinalis proteins) (fragment). [sptrembl;acc:q9nug5]	157	XKR7		178.507	168.371	1.0602
dj408b20.3 (novel protein similar to 60s acidic ribosomal protein p2 (rplp2)). [sptrembl;acc:q9h5a9]	576	no value	High confidence	235.18	250.419	1.0648
	2104		Low confidence	205.285	201.409	1.01924
dj422b11.1.1 (dna primase large subunit (polypeptide 2a, p58)) (fragment). [sptrembl;acc:q9h412]	2135	PRIM2		199.028	195.285	1.01917
dj467n11.1 protein. [refseq;acc:nm_022091]	1814	ASCC3		199.184	195.266	1.02006
dj470l14.3 (novel protein similar to the arp2/3 protein complex subunit p21-arc (arc21)). [sptrembl;acc:q9h5b6]	568	no value		202.86	196.783	1.03088
	2621		High confidence	224.891	225.195	1.00135
dj545l17.2 (novel protein similar to rad21 (s. pombe) homolog (kiaa0078)) (fragment). [sptrembl;acc:q9h4i0]	1813		Low confidence	202.127	198.153	1.02006
dj54b20.2 (novel krab box containing c2h2 type zinc finger protein) (fragment). [sptrembl;acc:q96qh9]	4363	ZNF630		197.793	195.963	1.00934
dj54b20.4 (novel krab box containing c2h2 type zinc finger protein). [sptrembl;acc:q96qh7]	4318	no value
dj570f3.6 (novel protein similar to lysophospholipase ii (lypla2)). [sptrembl;acc:q9uge0]	837			194.47	189.552	1.02595

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.