MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	description	Gene	Network Comparison Type	Value Type	Hugo	Interaction Map	red	Filtered	green	network_comparison

Results: HTML CSV LaTeX

Showing element 1247 to 1296 of 16578 in total

Value Type  : Ranked
Filtered  : 1

Rank	description	Network Comparison Type	Hugo	Interaction Map	red	green	network_comparison
312	transcription regulator protein bach1 (btb and cnc homolog 1) (ha2303). [swissprot;acc:o14867]	Subtracted	BACH1	Low confidence	172.647	164.44	8.207
	u2 small nuclear ribonucleoprotein a' (u2 snrnp-a'). [swissprot;acc:p09661]	Divided	SNRPA1		202.051	193.937	1.04184
313	ba395l14.12 (novel protein similar to small nuclear ribonucleoprotein polypeptide a' (snrpa1)). [sptrembl;acc:q9nu36]		no value		202.05	193.94	1.04182
	melanoma-associated antigen 9 (mage-9 antigen). [swissprot;acc:p43362]	Subtracted	MAGEA9	High confidence	88.2482	110.265	22.0168
	nuclear factor erythroid 2 related factor 2 (nf-e2 related factor 2) (nfe2-related factor 2) (nuclear factor, erythroid derived 2, like 2) (hebp1). [swissprot;acc:q16236]		NFE2L2	Low confidence	172.647	164.44	8.207
	ribonucleotide reductase m2 b (tp53 inducible); p53-inducible ribonucleotide reductase small subunit 2 homolog. [refseq;acc:nm_015713]	Divided	RRM2B	High confidence	232.473	211.207	1.10069
314	melanoma-associated antigen 8 (mage-8 antigen). [swissprot;acc:p43361]	Subtracted	MAGEA8		88.2482	110.265	22.0168
	methionine aminopeptidase 1 (ec 3.4.11.18) (metap 1) (map 1) (peptidase m 1). [swissprot;acc:p53582]	Divided	METAP1		244.126	268.604	1.10027
	splicing factor 3b subunit 1 (spliceosome associated protein 155) (sap 155) (sf3b155) (pre-mrna splicing factor sf3b 155 kda subunit). [swissprot;acc:o75533]		SF3B1	Low confidence	202.057	193.952	1.04179
	transcription regulator protein bach2 (btb and cnc homolog 2). [swissprot;acc:q9byv9]	Subtracted	BACH2		172.647	164.44	8.207
315	glioma tumor suppressor candidate region gene 2 protein (p60). [swissprot;acc:q9nzm5]		SNORD23		207.402	199.219	8.183
	melanoma-associated antigen c1 (mage-c1 antigen) (cancer-testis antigen ct7). [swissprot;acc:o60732]		MAGEC1	High confidence	88.2482	110.265	22.0168
	methionine aminopeptidase 2 (ec 3.4.11.18) (metap 2) (peptidase m 2) (initiation factor 2 associated 67 kda glycoprotein) (p67) (p67eif2). [swissprot;acc:p50579]	Divided	METAP2		244.126	268.604	1.10027
	tankyrase 1 (ec 2.4.2.30) (tank1) (tankyrase i) (tnks-1) (trf1- interacting ankyrin-related adp-ribose polymerase). [swissprot;acc:o95271]		TNKS	Low confidence	214.067	205.509	1.04164
316	melanoma-associated antigen 12 (mage-12 antigen) (mage12f). [swissprot;acc:p43365]	Subtracted	MAGEA4	High confidence	88.2482	110.265	22.0168
	potassium voltage-gated channel subfamily a member 2 (potassium channel kv1.2) (rbk2) (hbk5) (ngk1) (mk2) (hukiv). [swissprot;acc:p16389]	Divided	KCNA2	Low confidence	209.583	201.251	1.0414
	protein translation factor sui1 homolog (sui1iso1). [swissprot;acc:p41567]		EIF1	High confidence	242.694	267.017	1.10022
	u2 small nuclear ribonucleoprotein a' (u2 snrnp-a'). [swissprot;acc:p09661]	Subtracted	SNRPA1	Low confidence	202.051	193.937	8.114
317	melanoma-associated antigen 1 (mage-1 antigen) (antigen mz2-e). [swissprot;acc:p43355]		no value	High confidence	88.2482	110.265	22.0168
	microsomal signal peptidase 18 kda subunit (ec 3.4.-.-) (spase 18 kda subunit) (spc18) (endopeptidase sp18). [swissprot;acc:p21378]			Low confidence	200.213	192.103	8.11
	potassium voltage-gated channel subfamily a member 1 (potassium channel kv1.1) (huki) (hbk1). [swissprot;acc:q09470]	Divided	KCNA1		209.58	201.251	1.04139
	splicing factor 3b subunit 3 (spliceosome associated protein 130) (sap 130) (sf3b130) (pre-mrna splicing factor sf3b 130 kda subunit). [swissprot;acc:q15393]		no value	High confidence	224.445	204.044	1.09998
318	ba395l14.12 (novel protein similar to small nuclear ribonucleoprotein polypeptide a' (snrpa1)). [sptrembl;acc:q9nu36]	Subtracted		Low confidence	202.05	193.94	8.11
	melanoma-associated antigen 10 (mage-10 antigen). [swissprot;acc:p43363]		MAGEA10	High confidence	88.2482	110.265	22.0168
	mitochondrial 60s ribosomal protein l3 (l3mt). [swissprot;acc:p09001]	Divided	MRPL3		242.011	266.18	1.09987
	potassium voltage-gated channel subfamily a member 4 (potassium channel kv1.4) (hk1) (hpcn2) (hbk4) (hukii). [swissprot;acc:p22459]		KCNA4	Low confidence	209.579	201.251	1.04138
319	60s ribosomal protein l19. [swissprot;acc:p14118]		RPL19	High confidence	240.73	264.729	1.09969
	heat-shock protein, beta-2 (hspb2) (dmpk-binding protein) (mkbp). [swissprot;acc:q16082]		HSPB2	Low confidence	212.752	204.328	1.04123
	melanoma-associated antigen b1 (mage-b1 antigen) (mage-xp antigen) (dss-ahc critical interval mage superfamily 10) (dam10). [swissprot;acc:p43366]	Subtracted	MAGEB4	High confidence	88.2482	110.265	22.0168
	mitochondrial ribosomal protein l44. [refseq;acc:nm_022915]		MRPL44	Low confidence	216.283	208.173	8.11
320	epithelial-cadherin precursor (e-cadherin) (uvomorulin) (cadherin-1) (cam 120/80). [swissprot;acc:p12830]	Divided	CDH1	High confidence	241.892	265.96	1.0995
	melanoma-associated antigen d2 (mage-d2 antigen) (breast cancer associated gene 1 protein) (bcg-1) (11b6) (hepatocellular carcinoma associated protein jcl-1). [swissprot;acc:q9unf1]	Subtracted	MAGED2		88.2482	110.265	22.0168
	phosphorylase b kinase gamma catalytic chain, testis/liver isoform (ec 2.7.1.38) (phk-gamma-t) (phosphorylase kinase gamma subunit 2) (psk-c3). [swissprot;acc:p15735]	Divided	PHKG2	Low confidence	217.756	226.722	1.04117
	splicing factor 3b subunit 1 (spliceosome associated protein 155) (sap 155) (sf3b155) (pre-mrna splicing factor sf3b 155 kda subunit). [swissprot;acc:o75533]	Subtracted	SF3B1		202.057	193.952	8.105
321	c367g8.3 (novel protein similar to rpl23a (60s ribosomal protein l23a)) (60s ribosomal protein l23a like). [sptrembl;acc:q9br02]	Divided	no value	High confidence	241.892	265.959	1.09949
	dynein intermediate chain 1, cytosolic (dh ic-1) (cytoplasmic dynein intermediate chain 1). [swissprot;acc:o14576]	Subtracted	DYNC1I1	Low confidence	209.495	201.474	8.021
	glioma tumor suppressor candidate region gene 2 protein (p60). [swissprot;acc:q9nzm5]	Divided	SNORD23		207.402	199.219	1.04108
	trophinin. [swissprot;acc:q12816]	Subtracted	TRO	High confidence	88.2482	110.265	22.0168
322	cleavage and polyadenylation specific factor 5, 25 kd subunit; pre-mrna cleavage factor im (25kd); pre-mrna cleavage factor im, 25kd subunit. [refseq;acc:nm_007006]	Divided	NUDT21	Low confidence	212.262	203.991	1.04055
	deoxyribonuclease ii beta isoform 1 precursor; deoxyribonuclease ii beta; endonuclease dlad. [refseq;acc:nm_021233]		DNASE2B	High confidence	86.7483	78.8995	1.09948
	geranylgeranyl pyrophosphate synthetase (ggpp synthetase) (ggppsase) (geranylgeranyl diphosphate synthase) [includes: dimethylallyltransferase (ec 2.5.1.1); geranyltranstransferase (ec 2.5.1.10); farnesyltranstransferase (ec 2.5.1.29)]. [swissprot;acc:o95749]	Subtracted	GGPS1	Low confidence	209.518	201.554	7.964
	ribonucleoside-diphosphate reductase m2 chain (ec 1.17.4.1) (ribonucleotide reductase small chain). [swissprot;acc:p31350]		RRM2	High confidence	231.969	210.064	21.905
323	40s ribosomal protein s14 (pro2640). [swissprot;acc:p06366]		RPS14		242.238	264.11	21.872
	60s ribosomal protein l23a. [swissprot;acc:p29316]	Divided	no value		241.884	265.945	1.09947
	integrin beta-1 binding protein 2 (melusin) (mstp015). [swissprot;acc:q9ukp3]		ITGB1BP2	Low confidence	212.262	203.991	1.04055
	protein c20orf43 (hspc164/hspc169) (ad-007) (cda05). [swissprot;acc:q9by42]	Subtracted	C20orf43		200.482	208.446	7.964
324	40s ribosomal protein s18 (ke-3) (ke3). [swissprot;acc:p25232]		no value	High confidence	242.238	264.11	21.872
	40s ribosomal protein s23. [swissprot;acc:p39028]	Divided	RPS23		243.944	268.195	1.09941
	rab3 gtpase-activating protein, non-catalytic subunit. [refseq;acc:nm_012414]		RAB3GAP2	Low confidence	212.262	203.991	1.04055
	spry domain-containing socs box protein ssb-4. [refseq;acc:nm_080862]	Subtracted	SPSB4		219.655	211.763	7.892

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.