MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Gene	description	Rank	Filtered	Interaction Map	green	network_comparison	Value Type	red	Network Comparison Type

Results: HTML CSV LaTeX

Showing element 3180 to 3229 of 38536 in total

Filtered  : 1
Network Comparison Type  : Divided

description	Rank	Interaction Map	green	network_comparison	Value Type	red
aminoacylase-1 (ec 3.5.1.14) (n-acyl-l-amino-acid amidohydrolase) (acy-1). [swissprot;acc:q03154]	724	Low confidence	196.371	1.02747	Ranked	201.765
	1420	High confidence	208.229	1.02084		203.979
	2349		8001.45	1.04406	Measured	8353.97
	2479		71.2783	1.01173	Rooted	72.1147
	4594	Low confidence	43959.6	1.01814	Squared	44757.2
aminoadipate-semialdehyde synthase; lysine-ketoglutarate reductase /saccharopine dehydrogenase; lysine-2-oxoglutarate reductase; aminoadipic semialdehyde synthase. [refseq;acc:nm_005763]	379	High confidence	40732.2	1.23391		33010.8
	818		7543.28	1.10804	Measured	6807.78
	1319		70.1972	1.04236	Rooted	67.3443
	1863	Low confidence	8345.43	1.03267	Measured	8081.38
	2064	High confidence	205.939	1.00833	Ranked	207.655
	2651	Low confidence	74.5089	1.03322	Rooted	72.1132
	3212		199.028	1.016	Ranked	202.212
	4276		45390.2	1.02468	Squared	46510.6
aminomethyltransferase, mitochondrial precursor (ec 2.1.2.10) (glycine cleavage system t protein) (gcvt). [swissprot;acc:p48728]	1237		8613.43	1.03593	Measured	8314.67
	1317	High confidence	28816.9	1.12809	Squared	25544.9
	1545		6380.28	1.07304	Measured	5945.96
	1877		65.5763	1.0295	Rooted	63.6973
	2544		212.262	1.00192	Ranked	212.67
	2841	Low confidence	76.6619	1.03267	Rooted	74.2363
	2903		192.845	1.01706	Ranked	196.135
	4813		45391.7	1.00996	Squared	45843.7
ammecr1 protein. [refseq;acc:nm_015365]	1062	High confidence	5913.4	1.0926	Measured	5412.23
	1155		62.8125	1.0481	Rooted	59.9298
	1229	Low confidence	8924.44	1.03601	Measured	8614.27
	1577	High confidence	218.982	1.01645	Ranked	222.585
	1675		26223.8	1.10585	Squared	23713.7
	2922	Low confidence	190.73	1.01702	Ranked	193.976
	2953		77.9118	1.03229	Rooted	75.4744
	4999		49046.2	1.00085	Squared	49004.6
amp deaminase 2 (ec 3.5.4.6) (amp deaminase isoform l). [swissprot;acc:q01433]	34	High confidence	25146.6	2.53372		9924.76
	52		105	1.26667	Ranked	133
	70		10307.5	1.59177	Measured	6475.5
	116		101.526	1.26165	Rooted	80.4705
	560	Low confidence	8350.82	1.04636	Measured	7980.85
	586		75.1214	1.04391	Rooted	71.9616
	799		196.11	1.02643	Ranked	201.294
	4787		44575.6	1.01152	Squared	45089.2
amphiphysin. [swissprot;acc:p49418]	840		44304.4	1.05051		46542.4
	2389		198.416	1.01851	Ranked	202.089
	2559		74.4539	1.03345	Rooted	72.0438
	3426		8276.52	1.0264	Measured	8063.62
amyloid beta a4 precursor protein-binding family a member 1 (neuron- specific x11 protein) (neuronal munc18-1-interacting protein 1) (mint-1) (adapter protein x11alpha). [swissprot;acc:q02410]	69		67.1136	1.10405	Rooted	60.7884
	79		208.803	1.09742	Ranked	229.144
	87	High confidence	54.9687	1.30003	Rooted	42.2825
	97		3897.1	1.3817	Measured	2820.51
	139		225.68	1.20415	Ranked	271.752
	170	Low confidence	6633.65	1.08194	Measured	6131.26
	892		32745.9	1.04933	Squared	34361.2
	2112	High confidence	12711	1.088		11682.9
amyloid beta a4 protein precursor (app) (abpp) (alzheimer's disease amyloid protein) (cerebral vascular amyloid peptide) (cvap) (protease nexin-ii) (pn-ii) (appi) (prea4) [contains: soluble app-alpha (s-app- alpha); soluble app-beta (s-app-beta); c99; beta-amyloid protein 42 (beta-app42); beta-amyloid protein 40 (beta-app40); c83; p3(42); p3(40); gamma-ctf(59) (gamma-secretase c-terminal fragment 59) (amyloid intracellular domain 59) (aid(59)); gamma-ctf(57) (gamma- secretase c-terminal fragment 57) (amyloid intracellular domain 57) (aid(57)); gamma-ctf(50) (gamma-secretase c-terminal fragment 50) (amyloid intracellular domain 50) (aid(50)); c31]. [swissprot;acc:p05067]	508	Low confidence	198.715	1.03242	Ranked	205.157

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.