MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Gene	Rank	description	Network Comparison Type	Value Type	Interaction Map	green	Filtered	red	network_comparison

Results: HTML CSV LaTeX

Showing element 101 to 150 of 7460 in total

Value Type  : Measured
Interaction Map  : High confidence

Rank	description	Network Comparison Type	green	Filtered	red	network_comparison
26	fatty acid desaturase 1; linoleoyl-coa desaturase (delta-6-desaturase)-like 1; delta-5 desaturase; delta-5 fatty acid desaturase. [refseq;acc:nm_013402]	Divided	662	0	153	4.3268
	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-12 subunit. [swissprot;acc:q9ubi6]		892.67	1	1833.01	2.0534
	hepatocellular carcinoma-associated protein hca1. [refseq;acc:nm_020932]	Subtracted	18263		23693.7	5430.7
	ribosomal protein s6 kinase-like 1. [refseq;acc:nm_031464]		2063	0	2965.5	902.5
27	baculoviral iap repeat-containing protein 5 (apoptosis inhibitor survivin) (apoptosis inhibitor 4). [swissprot;acc:o15392]		13463.1		14357.1	894
	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-4 subunit. [swissprot;acc:p50150]	Divided	895.134	1	1834.33	2.04922
	melanoma-associated antigen 6 (mage-6 antigen) (mage3b). [swissprot;acc:p43360]	Subtracted	18263		23693.7	5430.7
	phenylethanolamine n-methyltransferase (ec 2.1.1.28) (pnmtase) (noradrenaline n-methyltransferase). [swissprot;acc:p11086]	Divided	139	0	570	4.10072
28	beta-carotene dioxygenase 2; putative b,b-carotene-9',10'-dioxygenase. [refseq;acc:nm_031938]
	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-3 subunit. [swissprot;acc:p29798]		895.194	1	1834.36	2.04912
	necdin. [swissprot;acc:q99608]	Subtracted	18263		23693.7	5430.7
	spectrin beta chain, brain 4 (spectrin, non-erythroid beta chain 4) (beta-v spectrin) (bspecv). [swissprot;acc:q9nrc6]		4543.75	0	5418.2	874.45
29	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-8 subunit (gamma-9). [swissprot;acc:q9uk08]	Divided	895.507	1	1834.52	2.04858
	melanoma-associated antigen d1 (mage-d1 antigen) (neurotrophin receptor-interacting mage homolog) (pro2292). [swissprot;acc:q9y5v3]	Subtracted	18263		23693.7	5430.7
	potassium voltage-gated channel, shal-related subfamily, member 2; voltage-sensitive potassium channel; voltage-gated potassium channel kv4.2. [refseq;acc:nm_012281]	Divided	434.911	0	111.278	3.90833
	regulator of chromosome condensation (cell cycle regulatory protein). [swissprot;acc:p18754]	Subtracted	2399.76		3248.95	849.19
30	cleavage and polyadenylation specificity factor, 160 kda subunit (cpsf 160 kda subunit). [swissprot;acc:q10570]		4102.97		3265.25	837.72
	dystrophin. [swissprot;acc:p11532]	Divided	111.739		427.217	3.82335
	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-5 subunit. [swissprot;acc:p30670]		895.633	1	1834.59	2.04837
	melanoma-associated antigen f1 (mage-f1 antigen). [swissprot;acc:q9hay2]	Subtracted	18263		23693.7	5430.7
31	dok-like protein. [refseq;acc:nm_024872]	Divided	0.00001	0	35	3500000
	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-10 subunit. [swissprot;acc:p50151]		895.697	1	1834.63	2.04827
	melanoma antigen, family b, 6. [refseq;acc:nm_173523]	Subtracted	18263		23693.7	5430.7
	spectrin alpha chain, brain (spectrin, non-erythroid alpha chain) (alpha-ii spectrin) (fodrin alpha chain). [swissprot;acc:q13813]		2637	0	1833	804
32	cell division protein kinase 8 (ec 2.7.1.-) (protein kinase k35). [swissprot;acc:p49336]	Divided	184		598	3.25
	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-5 like subunit. [swissprot;acc:q9y3k8]		895.893	1	1834.73	2.04793
	melanoma-associated antigen 4 (mage-4 antigen) (mage-x2) (mage-41). [swissprot;acc:p43358]	Subtracted	18263		23693.7	5430.7
	mln 64 protein (star-related lipid transfer protein 3) (stard3) (start domain-containing protein 3) (cab1 protein). [swissprot;acc:q14849]		58	0	859	801
33	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-11 subunit. [swissprot;acc:p50152]	Divided	896.972	1	1835.3	2.04611
	lim domain binding 1; carboxy terminal lim domain protein 2; lim domain-binding factor-1. [refseq;acc:nm_003893]		39.8063	0	12.6208	3.15402
	melanoma-associated antigen 9 (mage-9 antigen). [swissprot;acc:p43362]	Subtracted	18263	1	23693.7	5430.7
	protein cgi-147. [swissprot;acc:q9y3e5]		9192.38	0	8396.12	796.26
34	acrc protein; putative nuclear protein. [refseq;acc:nm_052957]		3340.03		4131.06	791.03
	glucosamine-6-phosphate isomerase (ec 3.5.99.6) (glucosamine-6- phosphate deaminase) (gnpda) (glcn6p deaminase) (oscillin). [swissprot;acc:p46926]	Divided	47		143	3.04255
	guanine nucleotide-binding protein g(y), alpha subunit (alpha-11). [swissprot;acc:p29992]		907.546	1	1836.71	2.02382
	melanoma-associated antigen 8 (mage-8 antigen). [swissprot;acc:p43361]	Subtracted	18263		23693.7	5430.7
35	adp,atp carrier protein, liver isoform t2 (adp/atp translocase 3) (adenine nucleotide translocator 3) (ant 3). [swissprot;acc:p12236]	Divided	1377	0	459.5	2.99674
	filamin a (alpha-filamin) (filamin 1) (endothelial actin-binding protein) (abp-280) (nonmuscle filamin). [swissprot;acc:p21333]	Subtracted	898		1603	705
	guanine nucleotide-binding protein g(q), alpha subunit. [swissprot;acc:p50148]	Divided	907.564	1	1836.71	2.02378
	melanoma-associated antigen c1 (mage-c1 antigen) (cancer-testis antigen ct7). [swissprot;acc:o60732]	Subtracted	18263		23693.7	5430.7
36	guanine nucleotide-binding protein g(z), alpha subunit (g(x) alpha chain) (gz-alpha). [swissprot;acc:p19086]	Divided	907.741		1836.76	2.02344
	heparan sulfate 6-o-sulfotransferase 2. [refseq;acc:nm_147174]		56	0	157	2.80357
	melanoma-associated antigen 12 (mage-12 antigen) (mage12f). [swissprot;acc:p43365]	Subtracted	18263	1	23693.7	5430.7
	oligosaccharyl transferase stt3 subunit homolog (b5) (integral membrane protein 1) (tmc). [swissprot;acc:p46977]		925.298	0	1586.07	660.772
37	1,4-alpha-glucan branching enzyme (ec 2.4.1.18) (glycogen branching enzyme) (brancher enzyme). [swissprot;acc:q04446]	Divided	934.348		334.401	2.79409
	guanine nucleotide-binding protein g(t), alpha-1 subunit (transducin alpha-1 chain). [swissprot;acc:p11488]		907.763	1	1836.76	2.02339
	melanoma-associated antigen 1 (mage-1 antigen) (antigen mz2-e). [swissprot;acc:p43355]	Subtracted	18263		23693.7	5430.7
	wiskott-aldrich syndrome protein family member 3 (wasp-family protein member 3) (verprolin homology domain-containing protein 3). [swissprot;acc:q9upy6]		4550.64	0	5202.89	652.25
38	clathrin heavy chain 2 (clh-22). [swissprot;acc:p53675]		6127.24		5497.01	630.23
	guanine nucleotide-binding protein g(t), alpha-2 subunit (transducin alpha-2 chain). [swissprot;acc:p19087]	Divided	907.774	1	1836.76	2.02337

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.