MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 1401 to 1450 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

Rank	Hugo	description	Network Comparison Type	red	green	network_comparison
701	AHCYL1	putative adenosylhomocysteinase 2 (ec 3.3.1.1) (s-adenosyl-l- homocysteine hydrolase) (adohcyase). [swissprot;acc:o43865]	Subtracted	220.438	209.118	11.32
	DLGAP1	disks large-associated protein 1 (dap-1) (guanylate kinase-associated protein) (hgkap) (sap90/psd-95-associated protein 1) (sapap1) (psd- 95/sap90 binding protein 1). [swissprot;acc:o14490]	Divided			1.05413
702	AHCYL1	putative adenosylhomocysteinase 2 (ec 3.3.1.1) (s-adenosyl-l- homocysteine hydrolase) (adohcyase). [swissprot;acc:o43865]
	KIAA0430	limkain b1. [refseq;acc:nm_019081]	Subtracted			11.32
703	no value	putative adenosylhomocysteinase 3 (ec 3.3.1.1) (s-adenosyl-l- homocysteine hydrolase) (adohcyase). [swissprot;acc:q96hn2]
	KIAA0430	limkain b1. [refseq;acc:nm_019081]	Divided			1.05413
704	no value	putative adenosylhomocysteinase 3 (ec 3.3.1.1) (s-adenosyl-l- homocysteine hydrolase) (adohcyase). [swissprot;acc:q96hn2]
	CREG1	cellular repressor of e1a-stimulated genes. [refseq;acc:nm_003851]	Subtracted			11.32
705			Divided			1.05413
	DLGAP3	disks large-associated protein 3 (dap-3) (sap90/psd-95-associated protein 3) (sapap3) (psd-95/sap90 binding protein 3) (fragment). [swissprot;acc:o95886]	Subtracted			11.32
706			Divided			1.05413
	KNG1	kininogen precursor (alpha-2-thiol proteinase inhibitor) [contains: bradykinin]. [swissprot;acc:p01042]	Subtracted			11.32
707	no value	disks large-associated protein 2 (dap-2) (sap90/psd-95-associated protein 2) (sapap2) (psd-95/sap90 binding protein 2) (fragment). [swissprot;acc:q9p1a6]
	KNG1	kininogen precursor (alpha-2-thiol proteinase inhibitor) [contains: bradykinin]. [swissprot;acc:p01042]	Divided			1.05413
708	no value	disks large-associated protein 2 (dap-2) (sap90/psd-95-associated protein 2) (sapap2) (psd-95/sap90 binding protein 2) (fragment). [swissprot;acc:q9p1a6]
	FTL	ferritin light chain (ferritin l subunit). [swissprot;acc:p02792]	Subtracted			11.32
709	DLGAP4	disks large-associated protein 4 (dap-4) (sap90/psd-95-associated protein 4) (sapap4) (psd-95/sap90 binding protein 4). [swissprot;acc:q9y2h0]
	FTL	ferritin light chain (ferritin l subunit). [swissprot;acc:p02792]	Divided			1.05413
710	DLGAP4	disks large-associated protein 4 (dap-4) (sap90/psd-95-associated protein 4) (sapap4) (psd-95/sap90 binding protein 4). [swissprot;acc:q9y2h0]
	FTMT	mitochondrial ferritin; ferritin heavy chain-like; ferritin h subunit. [refseq;acc:nm_177478]	Subtracted	220.437		11.319
711	FTHL17	ferritin heavy polypeptide-like 17. [swissprot;acc:q9bxu8]		220.431	209.123	11.308
	YARS	tyrosyl-trna synthetase (ec 6.1.1.1) (tyrosyl--trna ligase) (tyrrs). [swissprot;acc:p54577]	Divided	232.468	245.048	1.05411
712	FTHL17	ferritin heavy polypeptide-like 17. [swissprot;acc:q9bxu8]		220.431	209.123	1.05407
	POLR2F	dna-directed rna polymerase ii 14.4 kda polypeptide (ec 2.7.7.6) (rpb6) (rpb14.4) (rpabc2). [swissprot;acc:p41584]	Subtracted	232.762	243.933	11.171
713	EIF3M	dendritic cell protein. [refseq;acc:nm_006360]	Divided	223.121	211.685	1.05402
	LBP	lipopolysaccharide-binding protein precursor (lbp). [swissprot;acc:p18428]	Subtracted	224.434	235.583	11.149
714	CPXM2	potential carboxypeptidase-like protein x2 precursor. [swissprot;acc:q8n436]	Divided	223.121	211.685	1.05402
	SPCS2	microsomal signal peptidase 25 kda subunit (ec 3.4.-.-) (spase 25 kda subunit) (spc25). [swissprot;acc:q15005]	Subtracted	224.434	235.583	11.149
715	CPN1	carboxypeptidase n catalytic chain precursor (ec 3.4.17.3) (arginine carboxypeptidase) (kininase 1) (serum carboxypeptidase n) (scpn) (anaphylatoxin inactivator) (plasma carboxypeptidase b). [swissprot;acc:p15169]	Divided	223.121	211.685	1.05402
	UMPS	uridine 5'-monophosphate synthase (ump synthase) [includes: orotate phosphoribosyltransferase (ec 2.4.2.10) (oprtase); orotidine 5'- phosphate decarboxylase (ec 4.1.1.23) (ompdecase)]. [swissprot;acc:p11172]	Subtracted	224.434	235.583	11.149
716	CLPTM1	cleft lip and palate associated transmembrane protein 1. [refseq;acc:nm_001294]
	CPZ	cpz gene product. [refseq;acc:nm_003652]	Divided	223.121	211.685	1.05402
717	BPI	bactericidal permeability-increasing protein precursor (bpi) (cap 57). [swissprot;acc:p17213]	Subtracted	224.434	235.583	11.149
	CPE	carboxypeptidase h precursor (ec 3.4.17.10) (cph) (carboxypeptidase e) (cpe) (enkephalin convertase) (prohormone processing carboxypeptidase). [swissprot;acc:p16870]	Divided	223.121	211.685	1.05402
718	CPXM1	potential carboxypeptidase x precursor (ec 3.4.17.-) (metallocarboxypeptidase cpx-1). [swissprot;acc:q96sm3]
	PLTP	phospholipid transfer protein precursor (lipid transfer protein ii). [swissprot;acc:p55058]	Subtracted	224.434	235.583	11.149
719	DCTD	deoxycytidylate deaminase (ec 3.5.4.12) (dcmp deaminase). [swissprot;acc:p32321]		230.516	241.641	11.125
	NOL5A	nucleolar protein nop56 (nucleolar protein 5a). [swissprot;acc:o00567]	Divided	247.769	235.074	1.054
720	RPLP2	60s acidic ribosomal protein p2. [swissprot;acc:p05387]		231.92	244.435	1.05396
	TREH	trehalase precursor (ec 3.2.1.28) (alpha,alpha-trehalase) (alpha,alpha-trehalose glucohydrolase). [swissprot;acc:o43280]	Subtracted	217.952	206.902	11.05
721	EXOC5	exocyst complex component sec10 (hsec10). [swissprot;acc:o00471]	Divided	214.765	203.8	1.0538
			Subtracted			10.965
722	NET1	neuroepithelial cell transforming gene 1; guanine nucleotide regulatory protein (oncogene); rho guanine nucleotide exchange factor (gef) 8. [refseq;acc:nm_005863]		244.447	233.508	10.939
	TREH	trehalase precursor (ec 3.2.1.28) (alpha,alpha-trehalase) (alpha,alpha-trehalose glucohydrolase). [swissprot;acc:o43280]	Divided	217.952	206.902	1.05341
723	no value	histone h3.3 (h3.a) (h3.b) (h3.3q). [swissprot;acc:p06351]		244.842	232.577	1.05274
	ARHGEF3	rho guanine nucleotide exchange factor 3; rhogef protein; 59.8 kda protein; exchange factor found in platelets and leukemic and neuronal tissues, xpln. [refseq;acc:nm_019555]	Subtracted	244.447	233.508	10.939
724	no value	dj1099d15.1 (putative dnaj protein). [sptrembl;acc:q9h4j9]	Divided	244.842	232.577	1.05274
	UTP20	down-regulated in metastasis. [refseq;acc:nm_014503]	Subtracted	244.447	233.508	10.939
725	MVK	mevalonate kinase (ec 2.7.1.36) (mk). [swissprot;acc:q03426]	Divided	235.296	247.673	1.0526
	SLC35B1	solute carrier family 35, member b1; udp-galactose transporter related. [refseq;acc:nm_005827]	Subtracted	214.679	225.568	10.889

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.