MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Network Comparison Type	network_comparison	Value Type	description	Interaction Map	red	green	Hugo	Filtered

Results: HTML CSV LaTeX

Showing element 1 to 50 of 3228 in total

Network Comparison Type  : Divided
Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

Rank	network_comparison	description	red	green	Hugo
1	2.4	putative glialblastoma cell differentiation-related; putative glialblastoma cell differentiation-related protein. [refseq;acc:nm_016172]	10	24	UBAC1
2	1.86667	mannosyl-oligosaccharide 1,2-alpha-mannosidase ib (ec 3.2.1.113) (processing alpha-1,2-mannosidase ib) (alpha-1,2-mannosidase ib) (mannosidase alpha class 1a member 2). [swissprot;acc:o60476]	15	28	no value
3		cytohesin 1 (sec7 homolog b2-1). [swissprot;acc:q15438]			PSCD1
4		cytohesin 2 (arf nucleotide-binding site opener) (arno protein) (arf exchange factor). [swissprot;acc:q99418]			PSCD2
5		cytohesin 4. [swissprot;acc:q9uia0]			PSCD4
6		cytohesin 3 (arf nucleotide-binding site opener 3) (arno3 protein) (general receptor of phosphoinositides 1) (grp1). [swissprot;acc:o43739]			PSCD3
7	1.49767	homeobox protein hlx1 (homeobox protein hb24). [swissprot;acc:q14774]	215	322	HLX
8		hbs1-like. [refseq;acc:nm_006620]			HBS1L
9	1.45755	xpa binding protein 1; mbd2 interactor protein; putative atp(gtp)-binding protein. [refseq;acc:nm_007266]	212	309	XAB1
10		protein x 0004. [refseq;acc:nm_016301]			ATPBD1C
11	1.45259	rad50-interacting protein 1. [refseq;acc:nm_021930]	337	232	RINT1
12		rho-related btb domain-containing protein 2 (deleted in breast cancer 2 gene protein) (p83). [swissprot;acc:q9byz6]			RHOBTB2
13	1.3585	protein cgi-126 (protein hspc155). [swissprot;acc:q9y3c8]	288.754	212.554	UFC1
14	1.32952	cysteine endopeptidase aut-like 2 isoform a; autophagy-related cysteine endopeptidase 2; autophagin 2. [refseq;acc:nm_052936]	56.6768	75.3531	ATG4A
15	1.32914	microtubule-associated proteins 1a/1b light chain 3b (map1a/map1b lc3 b) (map1a/1b light chain 3 b). [swissprot;acc:q9gzq8]	56.7244	75.3948	MAP1LC3B
16	1.32913	microtubule-associated proteins 1a/1b light chain 3a (map1a/map1b lc3 a) (map1a/1b light chain 3 a). [swissprot;acc:q9h492]	56.7252	75.3954	MAP1LC3A
17	1.32866	cysteine endopeptidase aut-like isoform b. [refseq;acc:nm_178326]	56.7841	75.447	ATG4B
18	1.32082	1,4-alpha-glucan branching enzyme (ec 2.4.1.18) (glycogen branching enzyme) (brancher enzyme). [swissprot;acc:q04446]	185.678	245.247	GBE1
19		glycogen phosphorylase, brain form (ec 2.4.1.1). [swissprot;acc:p11216]			PYGB
20		glycogen phosphorylase, liver form (ec 2.4.1.1). [swissprot;acc:p06737]			PYGL
21		myosin xv (unconventional myosin-15). [swissprot;acc:q9ukn7]			MYO15A
22		glycogen phosphorylase, muscle form (ec 2.4.1.1) (myophosphorylase). [swissprot;acc:p11217]			PYGM
23	1.31818	28s ribosomal protein s17, mitochondrial precursor (mrp-s17) (hspc011). [swissprot;acc:q9y2r5]	58	44	MRPS17
24		pantothenate kinase 1 (ec 2.7.1.33) (pantothenic acid kinase 1) (hpank1) (hpank). [swissprot;acc:q8te04]			PANK1
25		pantothenate kinase 2, mitochondrial precursor (ec 2.7.1.33) (pantothenic acid kinase 2) (hpank2). [swissprot;acc:q9bz23]			PANK2
26		pantothenate kinase 3 (ec 2.7.1.33) (pantothenic acid kinase 3) (hpank3). [swissprot;acc:q9h999]			PANK3
27		mitochondrial solute carrier protein. [refseq;acc:nm_145305]			SLC25A43
28	1.31416	cyclic-amp-dependent transcription factor atf-3 (activating transcription factor 3). [swissprot;acc:p18847]	201.949	153.671	ATF3
29	1.29991	uncharacterized hematopoietic stem/progenitor cells protein mds026. [sptrembl;acc:q9nz48]	187.458	243.678	PPP2R2D
30		serine/threonine protein phosphatase 2a, 55 kda regulatory subunit b, alpha isoform (pp2a, subunit b, b-alpha isoform) (pp2a, subunit b, b55-alpha isoform) (pp2a, subunit b, pr55-alpha isoform) (pp2a, subunit b, r2-alpha isoform). [swissprot;acc:q00007]	187.457		no value
31	1.2999	serine/threonine protein phosphatase 2a, 55 kda regulatory subunit b, beta isoform (pp2a, subunit b, b-beta isoform) (pp2a, subunit b, b55- beta isoform) (pp2a, subunit b, pr55-beta isoform) (pp2a, subunit b, r2-beta isoform). [swissprot;acc:q00005]	187.458	243.677	PPP2R2B
32	1.29985	serine/threonine protein phosphatase 2a, 55 kda regulatory subunit b, gamma isoform (pp2a, subunit b, b-gamma isoform) (pp2a, subunit b, b55-gamma isoform) (pp2a, subunit b, pr55-gamma isoform) (pp2a, subunit b, r2-gamma isoform) (imypno1). [swissprot;acc:q9y2t4]	187.462	243.673	PPP2R2C
33	1.28647	serine/threonine protein phosphatase 2a, 65 kda regulatory subunit a, beta isoform (pp2a, subunit a, pr65-beta isoform) (pp2a, subunit a, r1-beta isoform). [swissprot;acc:p30154]	188.688	242.742	PPP2R1B
34	1.28235	serine/threonine protein phosphatase 2a, 65 kda regulatory subunit a, alpha isoform (pp2a, subunit a, pr65-alpha isoform) (pp2a, subunit a, r1-alpha isoform) (medium tumor antigen-associated 61 kda protein). [swissprot;acc:p30153]	189.07	242.453	PPP2R1A
35	1.27519	nuclear transcription factor y subunit gamma (nf-y protein chain c) (nuclear factor yc) (nf-yc) (ccaat-binding transcription factor subunit c) (cbf-c) (transactivator hsm-1/2). [swissprot;acc:q13952]	260.532	204.309	NFYC
36		ccaat-binding transcription factor subunit b (cbf-b) (nf-y protein chain a) (nf-ya) (caat-box dna binding protein subunit a). [swissprot;acc:p23511]			NFYA
37	1.27273	protein phosphatase 1, regulatory (inhibitor) subunit 14a; 17-kda pkc-potentiated inhibitory protein of pp1. [refseq;acc:nm_033256]	322	253	PPP1R14A
38		microfibril-associated glycoprotein 4 precursor. [swissprot;acc:p55083]			MFAP4
39		protein phosphatase 1, regulatory subunit 14d; pkc-dependent pp1 inhibitory protein. [refseq;acc:nm_017726]			PPP1R14D
40		ficolin 2 precursor (collagen/fibrinogen domain-containing protein 2) (ficolin-b) (ficolin b) (serum lectin p35) (ebp-37) (hucolin) (l- ficolin). [swissprot;acc:q15485]			FCN2
41		protein phosphatase 1, regulatory (inhibitor) subunit 14c; serologically defined breast cancer antigen ny-br-81; pkc-potentiated pp1 inhibitory protein. [refseq;acc:nm_030949]			no value
42	1.2714	proto-oncogene protein c-fos (cellular oncogene fos) (g0/g1 switch regulatory protein 7). [swissprot;acc:p01100]	204.641	160.957	FOS
43		jun dimerization protein. [refseq;acc:nm_130469]			no value
44	1.2707	fos-related antigen 2. [swissprot;acc:p15408]		161.046	FOSL2
45	1.27066	protein fosb (g0/g1 switch regulatory protein 3). [swissprot;acc:p53539]		161.051	FOSB
46	1.27053	fos-related antigen 1 (fra-1). [swissprot;acc:p15407]	204.642	161.068	FOSL1
47	1.26938	gbp protein isoform a. [refseq;acc:nm_017870]	325.586	256.492	TMEM132A
48	1.26868	gaba(a) receptor-associated protein; gaba(a)-receptor-associated protein. [refseq;acc:nm_007278]	65.4586	83.0461	GABARAP
49	1.26667	beta-arrestin 2 (arrestin, beta 2). [swissprot;acc:p32121]	133	105	ARRB2
50		beta-arrestin 1 (arrestin, beta 1). [swissprot;acc:p49407]			ARRB1

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.