MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Value Type	Hugo	description	Network Comparison Type	Interaction Map	Filtered	network_comparison	red	green

Results: HTML CSV LaTeX

Showing element 951 to 1000 of 66312 in total

Filtered  : 1

Rank	Value Type	Hugo	description	Network Comparison Type	Interaction Map	network_comparison	red	green
60	Ranked	GNG8	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-8 subunit (gamma-9). [swissprot;acc:q9uk08]	Divided	High confidence	1.25976	266.864	336.184
		LENG4	malignant cell expression-enhanced gene/tumor progression-enhanc. [refseq;acc:nm_024298]	Subtracted	Low confidence	20.635	211	231.635
	Squared	C1GALT1	core1 udp-galactose:n-acetylgalactosamine-alpha-r beta 1,3-galac. [refseq;acc:nm_020156]			16178.9	73677.6	57498.7
		MAGEA6	melanoma-associated antigen 6 (mage-6 antigen) (mage3b). [swissprot;acc:p43360]	Divided	High confidence	1.68808	219048	129762
		PPP1R2	protein phosphatase inhibitor 2 (ipp-2). [swissprot;acc:p41236]	Subtracted		66737	192904	126167
		PSCD2	cytohesin 2 (arf nucleotide-binding site opener) (arno protein) (arf exchange factor). [swissprot;acc:q99418]	Divided	Low confidence	1.29425	92930.5	71802.4
	Rooted	no value	cysteine-rich protein 1 (cysteine-rich intestinal protein) (crip) (cysteine-rich heart protein) (hcrhp). [swissprot;acc:p50238]			1.11478	59.2532	66.0541
		MAGEC1	melanoma-associated antigen c1 (mage-c1 antigen) (cancer-testis antigen ct7). [swissprot;acc:o60732]	Subtracted	High confidence	16.623	137.446	120.823
		SON	son protein (son3) (negative regulatory element-binding protein) (nre- binding protein) (dbp-5) (bax antagonist selected in saccharomyces 1) (bass1) (protein c21orf50). [swissprot;acc:p18583]	Divided		1.39806	35.6294	49.8119
		TEX28P2	testis-specific protein tex28. [swissprot;acc:o15482]	Subtracted	Low confidence	7.4602	51.7058	59.166
61	Measured	ARRB2	beta-arrestin 2 (arrestin, beta 2). [swissprot;acc:p32121]		High confidence	3832	6475.5	10307.5
		HOXB5	homeobox protein hox-b5 (hox-2a) (hho.c10) (hu-1). [swissprot;acc:p09067]	Divided	Low confidence	1.13635	15464.1	17572.7
		JUND	transcription factor jun-d. [swissprot;acc:p17535]	Subtracted		1065.74	6614.51	7680.25
		PYGB	glycogen phosphorylase, brain form (ec 2.4.1.1). [swissprot;acc:p11216]	Divided	High confidence	1.6231	4489.19	2765.82
	Ranked	APBA1	amyloid beta a4 precursor protein-binding family a member 1 (neuron- specific x11 protein) (neuronal munc18-1-interacting protein 1) (mint-1) (adapter protein x11alpha). [swissprot;acc:q02410]	Subtracted	Low confidence	20.341	229.144	208.803
		FOSB	protein fosb (g0/g1 switch regulatory protein 3). [swissprot;acc:p53539]	Divided		1.10831	202.792	182.974
		GNG5	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-5 subunit. [swissprot;acc:p30670]		High confidence	1.25975	266.864	336.182
		KCND3	potassium voltage-gated channel, shal-related subfamily, member 3 isoform 1; sha1-related potassium channel kv4.3; voltage-gated k+ channel; potassium ionic channel kv4.3; voltage-gated potassium channel kv4.3. [refseq;acc:nm_004980]	Subtracted		58.394	269.248	327.642
	Squared	NCDN	neurochondrin. [refseq;acc:nm_014284]		Low confidence	16178.9	73677.6	57498.7
		NDN	necdin. [swissprot;acc:q99608]	Divided	High confidence	1.68808	219048	129762
		PPP1R2P9	type 1 protein phosphatase inhibitor. [refseq;acc:nm_025210]	Subtracted		66684	192779	126095
		PSCD3	cytohesin 3 (arf nucleotide-binding site opener 3) (arno3 protein) (general receptor of phosphoinositides 1) (grp1). [swissprot;acc:o43739]	Divided	Low confidence	1.29422	92920.4	71796.4
	Rooted	GOSR2	27 kda golgi snare protein (golgi snap receptor complex member 2) (membrin). [swissprot;acc:o14653]	Subtracted		7.4602	51.7058	59.166
		KCNIP1	kv channel interacting protein 1; vesicle apc-binding protein; a-type potassium channel modulatory protein 1. [refseq;acc:nm_014592]	Divided	High confidence	1.36932	43.4291	31.7159
		MAGEA4	melanoma-associated antigen 12 (mage-12 antigen) (mage12f). [swissprot;acc:p43365]	Subtracted		16.623	137.446	120.823
		SMYD2	set and mynd domain containing 2; hskm-b protein; zinc finger, mynd domain containing 14. [refseq;acc:nm_020197]	Divided	Low confidence	1.11478	59.2532	66.0541
62	Measured	ARRB1	beta-arrestin 1 (arrestin, beta 1). [swissprot;acc:p49407]	Subtracted	High confidence	3832	6475.5	10307.5
		HOXA5	homeobox protein hox-a5 (hox-1c). [swissprot;acc:p20719]	Divided	Low confidence	1.13635	15464.1	17572.7
		JUNB	transcription factor jun-b. [swissprot;acc:p17275]	Subtracted		1065.34	6613.42	7678.76
		PYGL	glycogen phosphorylase, liver form (ec 2.4.1.1). [swissprot;acc:p06737]	Divided	High confidence	1.6231	4489.19	2765.82
	Ranked	FOS	proto-oncogene protein c-fos (cellular oncogene fos) (g0/g1 switch regulatory protein 7). [swissprot;acc:p01100]	Subtracted	Low confidence	20.072	202.802	182.73
		FOSL1	fos-related antigen 1 (fra-1). [swissprot;acc:p15407]	Divided		1.10804	202.79	183.017
		GNG10	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-10 subunit. [swissprot;acc:p50151]		High confidence	1.25974	266.865	336.181
		KCND1	potassium voltage-gated channel, shal-related subfamily, member 1; shal-type potassium channel; voltage-gated potassium channel kv4.1. [refseq;acc:nm_004979]	Subtracted		58.371	269.23	327.601
	Squared	BNC1	zinc finger protein basonuclin. [swissprot;acc:q01954]		Low confidence	15083.7	105225	90141.3
		MAGED1	melanoma-associated antigen d1 (mage-d1 antigen) (neurotrophin receptor-interacting mage homolog) (pro2292). [swissprot;acc:q9y5v3]	Divided	High confidence	1.68808	219048	129762
		PSCD4	cytohesin 4. [swissprot;acc:q9uia0]		Low confidence	1.29219	92262.9	71400.2
		RRS1	ribosome biogenesis regulatory protein homolog. [swissprot;acc:q15050]	Subtracted	High confidence	65496	189976	124480
	Rooted	no value	melanoma-associated antigen 1 (mage-1 antigen) (antigen mz2-e). [swissprot;acc:p43355]			16.623	137.446	120.823
		BACH1	transcription regulator protein bach1 (btb and cnc homolog 1) (ha2303). [swissprot;acc:o14867]		Low confidence	7.4298	79.2778	86.7076
		KCNIP4	potassium channel-interacting protein 4 isoform 4; calsenilin-like protein. [refseq;acc:nm_147183]	Divided	High confidence	1.36847	43.4519	31.7522
		SMYD1	set and mynd domain containing protein 1. [sptrembl;acc:q8nb12]		Low confidence	1.11478	59.2532	66.0541
63	Measured	no value	homeobox protein hox-a4 (hox-1d) (hox-1.4). [swissprot;acc:q00056]			1.13635	15464.1	17572.7
		MYO15A	myosin xv (unconventional myosin-15). [swissprot;acc:q9ukn7]		High confidence	1.6231	4489.19	2765.82
		RRAGB	ras-related gtp binding b short isoform; gtp-binding protein ragb. [refseq;acc:nm_006064]	Subtracted	Low confidence	1062.5	10618.8	11681.3
		SPATA6	spermatogenesis associated 6. [refseq;acc:nm_019073]		High confidence	3832	6475.5	10307.5
	Ranked	no value	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-5 like subunit. [swissprot;acc:q9y3k8]	Divided		1.25973	266.865	336.178
			jun dimerization protein. [refseq;acc:nm_130469]	Subtracted	Low confidence	20.072	202.802	182.73
		NFYC	nuclear transcription factor y subunit gamma (nf-y protein chain c) (nuclear factor yc) (nf-yc) (ccaat-binding transcription factor subunit c) (cbf-c) (transactivator hsm-1/2). [swissprot;acc:q13952]		High confidence	56.223	260.532	204.309
		RBM7	putative rna-binding protein 7 (rna binding motif protein 7). [swissprot;acc:q9y580]	Divided	Low confidence	1.10749	265.688	239.902

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.