MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 613 to 662 of 3730 in total

Value Type  : Ranked
Network Comparison Type  : Divided
Interaction Map  : High confidence

Rank	description	Filtered	red	green	network_comparison
307	ba271b5.1 (similar to ribosomal protein s7). [sptrembl;acc:q9h1s9]	0	1091	1021	1.06856
	serine racemase (ec 5.1.1.-). [swissprot;acc:q9gzt4]	1	242.153	266.673	1.10126
308	60s ribosomal protein l34. [swissprot;acc:p49207]
	intersectin 1 (sh3 domain-containing protein 1a) (sh3p17). [swissprot;acc:q15811]	0	11414.1	12191.8	1.06814
309	lipopolysaccharide-binding protein precursor (lbp). [swissprot;acc:p18428]		13651	14572	1.06747
	protein transport protein sec61 alpha subunit isoform 2 (sec61 alpha- 2). [swissprot;acc:q9y2r3]	1	242.153	266.673	1.10126
310	glycine cleavage system h protein, mitochondrial precursor. [swissprot;acc:p23434]	0	9328.78	8741.55	1.06718
	protein transport protein sec61 alpha subunit isoform 1 (sec61 alpha- 1). [swissprot;acc:p38378]	1	242.153	266.673	1.10126
311	60s ribosomal protein l23 (l17). [swissprot;acc:p23131]	0	10253.5	9622.45	1.06558
	protein translation factor sui1 homolog gc20. [swissprot;acc:o60739]	1	242.627	267.151	1.10108
312	60s ribosomal protein l3-like. [swissprot;acc:q92901]		242.195	266.663	1.10103
	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-5 like subunit. [swissprot;acc:q9y3k8]	0	11959.8	12731.1	1.06449
313	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-4 subunit. [swissprot;acc:p50150]		11935.6	12698.9	1.06395
	ribonucleotide reductase m2 b (tp53 inducible); p53-inducible ribonucleotide reductase small subunit 2 homolog. [refseq;acc:nm_015713]	1	232.473	211.207	1.10069
314	clathrin heavy chain 2 (clh-22). [swissprot;acc:p53675]	0	10301.4	10957.5	1.06369
	methionine aminopeptidase 1 (ec 3.4.11.18) (metap 1) (map 1) (peptidase m 1). [swissprot;acc:p53582]	1	244.126	268.604	1.10027
315	methionine aminopeptidase 2 (ec 3.4.11.18) (metap 2) (peptidase m 2) (initiation factor 2 associated 67 kda glycoprotein) (p67) (p67eif2). [swissprot;acc:p50579]
	ribonucleoside-diphosphate reductase m1 chain (ec 1.17.4.1) (ribonucleotide reductase large chain). [swissprot;acc:p23921]	0	12121.6	12887.6	1.06319
316	dj718p11.1.2 (novel class ii aminotransferase similar to serine palmotyltransferase (isoform 2)) (fragment). [sptrembl;acc:q9ugb5]		10768.5	11444	1.06273
	protein translation factor sui1 homolog (sui1iso1). [swissprot;acc:p41567]	1	242.694	267.017	1.10022
317	protein transport protein sec24c (sec24-related protein c). [swissprot;acc:p53992]	0	19939	18778	1.06183
	splicing factor 3b subunit 3 (spliceosome associated protein 130) (sap 130) (sf3b130) (pre-mrna splicing factor sf3b 130 kda subunit). [swissprot;acc:q15393]	1	224.445	204.044	1.09998
318	mitochondrial 60s ribosomal protein l3 (l3mt). [swissprot;acc:p09001]		242.011	266.18	1.09987
	ubiquitous tropomodulin (u-tmod) (tropomodulin 3). [swissprot;acc:q9nyl9]	0	8918.54	9465.32	1.06131
319	60s ribosomal protein l19. [swissprot;acc:p14118]	1	240.73	264.729	1.09969
	sorting nexin 9 (sh3 and px domain-containing protein 1) (sdp1 protein). [swissprot;acc:q9y5x1]	0	8918.54	9465.32	1.06131
320	adp-ribosylation factor 3. [swissprot;acc:p16587]		11627.8	10958.2	1.0611
	epithelial-cadherin precursor (e-cadherin) (uvomorulin) (cadherin-1) (cam 120/80). [swissprot;acc:p12830]	1	241.892	265.96	1.0995
321	adenine phosphoribosyltransferase (ec 2.4.2.7) (aprt). [swissprot;acc:p07741]	0	11634.4	10989.9	1.05864
	c367g8.3 (novel protein similar to rpl23a (60s ribosomal protein l23a)) (60s ribosomal protein l23a like). [sptrembl;acc:q9br02]	1	241.892	265.959	1.09949
322	deoxyribonuclease ii beta isoform 1 precursor; deoxyribonuclease ii beta; endonuclease dlad. [refseq;acc:nm_021233]		86.7483	78.8995	1.09948
	estradiol 17 beta-dehydrogenase 1 (ec 1.1.1.62) (17-beta-hsd 1) (placental 17-beta-hydroxysteroid dehydrogenase) (20 alpha- hydroxysteroid dehydrogenase) (20-alpha-hsd) (e2dh). [swissprot;acc:p14061]	0	11634.4	10989.9	1.05864
323	60s ribosomal protein l23a. [swissprot;acc:p29316]	1	241.884	265.945	1.09947
	ras-related c3 botulinum toxin substrate 1 (p21-rac1) (ras-like protein tc25). [swissprot;acc:p15154]	0	17387.1	16427.3	1.05843
324	40s ribosomal protein s23. [swissprot;acc:p39028]	1	243.944	268.195	1.09941
	ras-related c3 botulinum toxin substrate 3 (p21-rac3). [swissprot;acc:o14658]	0	17387.1	16427.3	1.05843
325	28s ribosomal protein s12, mitochondrial precursor (mpr-s12) (mt- rps12). [swissprot;acc:o15235]	1	243.944	268.195	1.09941
	mstp028 protein. [refseq;acc:nm_031954]	0	7965.66	7528.21	1.05811
326	60s ribosomal protein l5. [swissprot;acc:p46777]	1	241.899	265.924	1.09932
	dead/h (asp-glu-ala-asp/his) box polypeptide 11; dead/h box-11 (chl1-related helicase gene-1); yeast chl1 homolog. [refseq;acc:nm_030655]	0	11948.4	11295.6	1.05779
327	3-hydroxyisobutyryl-coenzyme a hydrolase. [refseq;acc:nm_014362]		9897.29	10466.5	1.05751
	dna-directed rna polymerase ii largest subunit (ec 2.7.7.6) (rpb1). [swissprot;acc:p24928]	1	243.817	267.962	1.09903
328	atp-dependent rna helicase ddx24 (dead-box protein 24). [swissprot;acc:q9gzr7]		258.437	235.183	1.09888
	putative rna-binding protein 15 (rna binding motif protein 15) (one-twenty two protein). [swissprot;acc:q96t37]	0	10897	11520	1.05717
329	neurogenic differentiation factor 2 (neurod2). [swissprot;acc:q15784]	1	312	284	1.09859
	signal-induced proliferation-associated 1-like 1. [refseq;acc:nm_015556]	0	15977.3	15115.5	1.05701
330	chromodomain helicase-dna-binding protein 3 (chd-3) (mi-2 autoantigen 240 kda protein) (mi2-alpha). [swissprot;acc:q12873]	1	312	284	1.09859
	pram-1 protein; pml-rara target gene encoding an adaptor molecule-1. [refseq;acc:nm_032152]	0	12320.2	13018.5	1.05668
331	40s ribosomal protein s3a. [swissprot;acc:p49241]		10405.1	10992.4	1.05644
	doc-1 related protein (doc-1r). [swissprot;acc:o75956]	1	312	284	1.09859

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.