MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Value Type	Gene	description	Network Comparison Type	Filtered	Interaction Map	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 451 to 500 of 9634 in total

Value Type  : Ranked
Network Comparison Type  : Divided

Rank	description	Filtered	Interaction Map	red	green	network_comparison
113	kh domain containing, rna binding, signal transduction associated 3; sam68-like phosphotyrosine protein, t-star. [refseq;acc:nm_006558]	1	High confidence	332.874	267.246	1.24557
	segment polarity protein dishevelled homolog dvl-1 (dishevelled-1) (dsh homolog 1). [swissprot;acc:o14640]	0		5673.33	6797.56	1.19816
114	bloom's syndrome protein (ec 3.6.1.-) (recq protein-like 3) (dna helicase, recq-like, type 2). [swissprot;acc:p54132]			8871.11	10603.2	1.19525
	disks large-associated protein 1 (dap-1) (guanylate kinase-associated protein) (hgkap) (sap90/psd-95-associated protein 1) (sapap1) (psd- 95/sap90 binding protein 1). [swissprot;acc:o14490]	1	Low confidence	197.779	211.983	1.07182
	kh domain containing, rna binding, signal transduction associated 1; gap-associated tyrosine phosphoprotein p62 (sam68). [refseq;acc:nm_006559]		High confidence	332.874	267.246	1.24557
	transcription factor tel-2 (ets-related protein tel2) (tel related ets factor). [swissprot;acc:q9y603]	0	Low confidence	7730.67	9278.67	1.20024
115	disks large-associated protein 4 (dap-4) (sap90/psd-95-associated protein 4) (sapap4) (psd-95/sap90 binding protein 4). [swissprot;acc:q9y2h0]	1		197.779	211.983	1.07182
	kh domain-containing, rna-binding, signal transduction-associated protein 2; sam68-like mammalian protein 1. [refseq;acc:nm_152688]		High confidence	332.874	267.246	1.24557
	small nuclear ribonucleoprotein e (snrnp-e) (sm protein e) (sm-e) (sme). [swissprot;acc:p08578]	0	Low confidence	10216.9	12255.4	1.19952
	spir-2 protein (fragment). [sptrembl;acc:q8wwl2]		High confidence	18662.8	15627	1.19427
116	guanine nucleotide-binding protein g(i)/g(s)/g(t) beta subunit 3 (transducin beta chain 3). [swissprot;acc:p16520]	1		268.565	334.483	1.24545
	metaxin 1. [swissprot;acc:q13505]	0		13761.3	16422.1	1.19335
	segment polarity protein dishevelled homolog dvl-1 (dishevelled-1) (dsh homolog 1). [swissprot;acc:o14640]		Low confidence	5673.33	6797.56	1.19816
	vacuolar protein sorting 18 (hvps18). [swissprot;acc:q9p253]	1		204.161	190.791	1.07008
117	basic proline-rich peptide p-e (ib-9). [swissprot;acc:p02811]	0	High confidence	11545	13771.5	1.19285
	coagulation factor xiii a chain precursor (ec 2.3.2.13) (protein- glutamine gamma-glutamyltransferase a chain) (transglutaminase a chain). [swissprot;acc:p00488]	1	Low confidence	226.395	211.713	1.06935
	neuralized-like. [refseq;acc:nm_004210]		High confidence	332.326	266.948	1.24491
	protein hspc134 (protein cda04). [swissprot;acc:q9by43]	0	Low confidence	11114.8	13288.7	1.19559
118	aquaporin-cd (aqp-cd) (water channel protein for renal collecting duct) (adh water channel) (aquaporin 2) (collecting duct water channel protein) (wch-cd). [swissprot;acc:p41181]		High confidence	12049	14370.7	1.19269
	lipopolysaccharide-responsive and beige-like anchor protein (cdc4-like protein) (beige-like protein). [swissprot;acc:p50851]		Low confidence	11535.2	9652.56	1.19504
	nadh-ubiquinone oxidoreductase subunit b17.2 (ec 1.6.5.3) (ec 1.6.99.3) (complex i-b17.2) (ci-b17.2) (cib17.2) (13 kda differentiation-associated protein). [swissprot;acc:q9ui09]	1	High confidence	284.753	228.934	1.24382
	protein-glutamine gamma-glutamyltransferase k (ec 2.3.2.13) (transglutaminase k) (tgase k) (tgk) (tg(k)) (transglutaminase 1) (epidermal tgase). [swissprot;acc:p22735]		Low confidence	226.395	211.713	1.06935
119	cdc42-binding protein kinase beta; cdc42-binding protein kinase beta (dmpk-like); mrck beta; dmpk-like. [refseq;acc:nm_006035]	0		5797	4873	1.18962
	mesoderm induction early response 1. [refseq;acc:nm_020948]		High confidence	3609	4302.5	1.19216
	nadh-ubiquinone oxidoreductase 18 kda subunit, mitochondrial precursor (ec 1.6.5.3) (ec 1.6.99.3) (complex i-18 kda) (ci-18 kda) (complex i- aqdq) (ci-aqdq). [swissprot;acc:o43181]	1		318.982	259.004	1.23157
	natural resistance-associated macrophage protein 1 (nramp 1). [swissprot;acc:p49279]		Low confidence	225.666	211.107	1.06897
120	potassium voltage-gated channel, shal-related subfamily, member 2; voltage-sensitive potassium channel; voltage-gated potassium channel kv4.2. [refseq;acc:nm_012281]		High confidence	269.278	327.709	1.21699
	presenilin-like protein 1 (ec 3.4.99.-) (sppl2b protein). [swissprot;acc:q8tct7]	0		5797	4873	1.18962
			Low confidence
	segment polarity protein dishevelled homolog dvl-1 (dishevelled-1) (dsh homolog 1). [swissprot;acc:o14640]	1		203.016	189.965	1.0687
121	adp-ribosylation factor gtpase-activating protein 3 (arf gap 3). [swissprot;acc:q9np61]	0		10652.4	12636.7	1.18628
	cystathionine gamma-lyase (ec 4.4.1.1) (gamma-cystathionase). [swissprot;acc:p32929]	1	High confidence	269.254	327.655	1.2169
	segment polarity protein dishevelled homolog dvl-2 (dishevelled-2) (dsh homolog 2). [swissprot;acc:o14641]		Low confidence	203.007	189.985	1.06854
	zinc finger protein 232. [swissprot;acc:q9uny5]	0	High confidence	11523.7	13686.9	1.18772
122	hepatocyte growth factor-regulated tyrosine kinase substrate; human growth factor-regulated tyrosine kinase substrate. [refseq;acc:nm_004712]		Low confidence	12458.3	10506.7	1.18575
	nanos (fragment). [sptrembl;acc:q8wy41]	1		203.66	217.479	1.06785
	potassium voltage-gated channel, shal-related subfamily, member 3 isoform 1; sha1-related potassium channel kv4.3; voltage-gated k+ channel; potassium ionic channel kv4.3; voltage-gated potassium channel kv4.3. [refseq;acc:nm_004980]		High confidence	269.248	327.642	1.21688
	zinc finger protein 24 (zinc finger protein 191) (zinc finger protein kox17) (retinoic acid suppression protein a) (rsg-a). [swissprot;acc:p17028]	0		11523	13685.4	1.18766
123	potassium voltage-gated channel, shal-related subfamily, member 1; shal-type potassium channel; voltage-gated potassium channel kv4.1. [refseq;acc:nm_004979]	1		269.23	327.601	1.21681
	putative rna-binding protein 15 (rna binding motif protein 15) (one-twenty two protein). [swissprot;acc:q96t37]	0	Low confidence	11725.7	13865.5	1.18249
	segment polarity protein dishevelled homolog dvl-3 (dishevelled-3) (dsh homolog 3). [swissprot;acc:q92997]	1		202.96	190.094	1.06768
	zinc finger protein 215 (bwscr2 associated zinc-finger protein 2) (baz 2). [swissprot;acc:q9ul58]	0	High confidence	11522.8	13684.9	1.18764
124	high-mobility group 20b; sox-like transcriptional factor; swi/snf-related matrix-associated actin-dependent regulator of chromatin subfamily e, member 1-related. [refseq;acc:nm_006339]	1		208.52	171.595	1.21519
	natural resistance-associated macrophage protein 2 (nramp 2) (divalent metal transporter 1) (dmt1). [swissprot;acc:p49281]		Low confidence	224.763	210.566	1.06742
	trans-prenyltransferase; polyprenyl pyrophosphate synthetase. [refseq;acc:nm_014317]	0		9351.39	11039.5	1.18052
	zinc finger imprinted 2. [swissprot;acc:q9nzv7]		High confidence	11520.7	13680.4	1.18746
125	b9 protein; likely ortholog of mouse endothelial precursor protein b9. [refseq;acc:nm_015681]	1	Low confidence	213.243	227.616	1.0674
	high-mobility group 20a. [refseq;acc:nm_018200]		High confidence	208.588	171.778	1.21429
	phosphatidylinositol-4-phosphate 3-kinase c2 domain-containing beta polypeptide (ec 2.7.1.154) (phosphoinositide 3-kinase-c2-beta) (ptdins-3-kinase c2 beta) (pi3k-c2beta) (c2-pi3k). [swissprot;acc:o00750]	0		22038	18578	1.18624
	small edrk-rich factor 1a. [swissprot;acc:o75920]		Low confidence	4824.5	5690.5	1.1795

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.