MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

Navigation/Query Panel:
Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].

Network Comparison Type	description	Rank	Gene	Value Type	Hugo	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 2701 to 2750 of 16578 in total

Network Comparison Type  : Divided
Value Type  : Ranked
Filtered  : 1

description	Rank	Hugo	Interaction Map	red	green	network_comparison
fzr1 protein; fizzy-related protein; cdc20-like 1b. [refseq;acc:nm_016263]	1498	FZR1	Low confidence	189.066	185.103	1.02141
g protein beta subunit-like. [refseq;acc:nm_022372]	3063	no value		200.202	196.94	1.01656
g protein pathway suppressor 2 (gps2 protein). [swissprot;acc:q13227]	1664			197.872	193.866	1.02066
g protein-coupled receptor 142. [refseq;acc:nm_181790]	2446			200.512	196.901	1.01834
g protein-coupled receptor 66. [refseq;acc:nm_006056]	2815	NMUR1	High confidence	0.00001	0.00001	1
	4171		Low confidence	199.766	197.712	1.01039
g protein-coupled receptor kinase grk4 (ec 2.7.1.-) (iti1). [swissprot;acc:p32298]	4999	GRK4		203.07	203.131	1.0003
g protein-coupled receptor kinase grk5 (ec 2.7.1.-) (g-protein-coupled receptor kinase 5). [swissprot;acc:p34947]	5000	no value
g protein-coupled receptor kinase grk6 (ec 2.7.1.-) (g-protein-coupled receptor kinase 6). [swissprot;acc:p43250]	5002
g-protein-coupled receptor induced protein. [refseq;acc:nm_025195]	1090	TRIB1		203.52	198.79	1.02379
g-rich sequence factor-1 (grsf-1). [swissprot;acc:q12849]	1855	GRSF1	High confidence	217.891	215.542	1.0109
	4244		Low confidence	204.276	202.305	1.00974
g1 to s phase transition protein 1 homolog (gtp-binding protein gst1-hs). [swissprot;acc:p15170]	1631	GSPT1	High confidence	218.789	215.533	1.01511
	4036		Low confidence	201.529	199.243	1.01147
g1/s-specific cyclin e1. [swissprot;acc:p24864]	3603	CCNE1		202.535	199.672	1.01434
g1/s-specific cyclin e2. [swissprot;acc:o96020]	3615	CCNE2		202.539	199.689	1.01427
g10 protein homolog (edg-2). [swissprot;acc:p41223]	591	BUD31		201.67	195.729	1.03035
g2/mitotic-specific cyclin b1. [swissprot;acc:p14635]	1582	CCNB1	High confidence	168.098	170.844	1.01634
	1770		Low confidence	203.013	198.985	1.02024
g2/mitotic-specific cyclin b2. [swissprot;acc:o95067]	1580	CCNB2	High confidence	168.018	170.769	1.01637
	1722		Low confidence	201.688	197.642	1.02047
ga binding protein alpha chain (gabp-alpha subunit) (transcription factor e4tf1-60) (nuclear respiratory factor-2 subunit alpha). [swissprot;acc:q06546]	883	GABPA	High confidence	227.596	219.017	1.03917
	4570		Low confidence	202.587	201.039	1.0077
ga binding protein beta-2 chain (gabp-beta-2 subunit) (transcription factor e4tf1-47) (gapbp-2) (nuclear respiratory factor-2 subunit gamma). [swissprot;acc:q06545]	884	no value	High confidence	227.596	219.017	1.03917
	4571		Low confidence	202.587	201.039	1.0077
gaba(a) receptor-associated protein; gaba(a)-receptor-associated protein. [refseq;acc:nm_007278]	48	GABARAP	High confidence	65.4586	83.0461	1.26868
	4156		Low confidence	190.846	188.86	1.01052
gaba-a receptor-associated protein. [sptrembl;acc:q9by60]	168	no value	High confidence	82.5916	98.0548	1.18722
	4789		Low confidence	178.524	177.756	1.00432
galactose-1-phosphate uridylyltransferase (ec 2.7.7.12) (gal-1-p uridylyltransferase) (udp-glucose--hexose-1-phosphate uridylyltransferase). [swissprot;acc:p07902]	1337		High confidence	215.162	210.412	1.02257
	2420		Low confidence	198.646	195.048	1.01845
galactoside 2-alpha-l-fucosyltransferase 1 (ec 2.4.1.69) (gdp-l- fucose:beta-d-galactoside 2-alpha-l-fucosyltransferase 1) (alpha(1,2)ft 1) (fucosyltransferase 1) (blood group h alpha 2- fucosyltransferase). [swissprot;acc:p19526]	1687	FUT1		201.628	197.561	1.02059
galactoside 2-alpha-l-fucosyltransferase 2 (ec 2.4.1.69) (gdp-l- fucose:beta-d-galactoside 2-alpha-l-fucosyltransferase 2) (alpha(1,2)ft 2) (fucosyltransferase 2) (secretor blood group alpha-2- fucosyltransferase) (secretor factor) (se) (se2). [swissprot;acc:q10981]	1686	FUT2
galectin-4 (lactose-binding lectin 4) (l-36 lactose binding protein) (l36lbp) (antigen ny-co-27). [swissprot;acc:p56470]	2158	LGALS4	High confidence	206.401	207.796	1.00676
	2497		Low confidence	198.856	195.302	1.0182
galectin-8 (gal-8) (prostate carcinoma tumor antigen 1) (pcta-1) (po66 carbohydrate-binding protein) (po66-cbp). [swissprot;acc:o00214]	2637	LGALS8		203.204	199.656	1.01777
galectin-9 (hom-hd-21) (ecalectin). [swissprot;acc:o00182]	2122	LGALS9	High confidence	206.473	207.911	1.00696
	2503		Low confidence	198.665	195.119	1.01817
gamma adducin (adducin-like protein 70). [swissprot;acc:q9uey8]	1467	ADD3		205.917	201.572	1.02156
	1934		High confidence	224.264	222.055	1.00995
gamma enolase (ec 4.2.1.11) (2-phospho-d-glycerate hydro-lyase) (neural enolase) (nse) (enolase 2). [swissprot;acc:p09104]	2360	ENO2		207.186	208.046	1.00415
	4637		Low confidence	201.997	200.674	1.00659
gamma-aminobutyric acid type b receptor, subunit 2 precursor (gaba-b receptor 2) (gaba-b-r2) (gb2) (gababr2) (g protein-coupled receptor 51) (gpr 51) (hg20). [swissprot;acc:o75899]	832	GABBR2		204.064	198.895	1.02599
gamma-aminobutyric-acid receptor alpha-1 subunit precursor (gaba(a) receptor). [swissprot;acc:p14867]	628	GABRA1	High confidence	214.256	202.14	1.05994
	2418		Low confidence	203.126	199.444	1.01846
gamma-aminobutyric-acid receptor alpha-2 subunit precursor (gaba(a) receptor). [swissprot;acc:p47869]	621	GABRA2	High confidence	214.256	202.14	1.05994
	2412		Low confidence	203.126	199.444	1.01846
gamma-aminobutyric-acid receptor alpha-3 subunit precursor (gaba(a) receptor). [swissprot;acc:p34903]	629	GABRA3	High confidence	214.256	202.14	1.05994
	2419		Low confidence	203.126	199.444	1.01846
gamma-aminobutyric-acid receptor alpha-4 subunit precursor (gaba(a) receptor). [swissprot;acc:p48169]	625	GABRA4	High confidence	214.256	202.14	1.05994

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.