MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 1080 to 1129 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

Rank	description	Network Comparison Type	red	green	network_comparison
540	selenide,water dikinase 2 (ec 2.7.9.3) (selenophosphate synthetase 2) (selenium donor protein 2). [swissprot;acc:q99611]	Divided	222.156	208.201	1.06703
541	flavoprotein oxidoreductase mical2. [refseq;acc:nm_014632]
	myosin heavy chain, fast skeletal muscle, embryonic (muscle embryonic myosin heavy chain) (smhce). [swissprot;acc:p11055]	Subtracted	112	126	14
542	inositol polyphosphate-4-phosphatase, type ii, 105kd; inositol polyphosphate 4-phosphatase ii; 4-phosphatase ii. [refseq;acc:nm_003866]	Divided	222.156	208.201	1.06703
	myosin heavy chain, skeletal muscle, adult 1 (myosin heavy chain iix/d) (myhc-iix/d). [swissprot;acc:p12882]	Subtracted	112	126	14
543	myosin heavy chain, cardiac muscle beta isoform (myhc-beta). [swissprot;acc:p12883]
	selenide,water dikinase 1 (ec 2.7.9.3) (selenophosphate synthetase 1) (selenium donor protein 1). [swissprot;acc:p49903]	Divided	222.156	208.201	1.06703
544	dj756n5.1.1 (continues in em:al133324 as dj1161h23.3) (fragment). [sptrembl;acc:q9h430]	Subtracted	112	126	14
	inositol polyphosphate-4-phosphatase, type 1 isoform b; inositol polyphosphate-4-phosphatase, type i, 107kd; 4-phosphatase i; inositol polyphosphate-4-phosphatase i. [refseq;acc:nm_001566]	Divided	222.156	208.201	1.06703
545	eukaryotic translation initiation factor 6 (eif-6) (b4 integrin interactor) (cab) (p27(bbp)) (b(2)gcn homolog). [swissprot;acc:p56537]		248.866	233.287	1.06678
	mitochondrial solute carrier protein. [refseq;acc:nm_145305]	Subtracted	58	44	14
546	myosin heavy chain, skeletal muscle, extraocular (myhc-eo). [swissprot;acc:q9ukx3]		112	126
	wiskott-aldrich syndrome protein (wasp). [swissprot;acc:p42768]	Divided	207.222	194.262	1.06671
547	alanyl-trna synthetase (ec 6.1.1.7) (alanine--trna ligase) (alars). [swissprot;acc:p49588]	Subtracted	234.106	248.104	13.998
	proto-oncogene c-crk (p38) (adapter molecule crk). [swissprot;acc:p46108]	Divided	207.26	194.346	1.06645
548	selenide,water dikinase 2 (ec 2.7.9.3) (selenophosphate synthetase 2) (selenium donor protein 2). [swissprot;acc:q99611]	Subtracted	222.156	208.201	13.955
	tyrosine-protein kinase abl2 (ec 2.7.1.112) (tyrosine kinase arg). [swissprot;acc:p42684]	Divided	207.26	194.346	1.06645
549	flavoprotein oxidoreductase mical2. [refseq;acc:nm_014632]	Subtracted	222.156	208.201	13.955
	proto-oncogene tyrosine-protein kinase src (ec 2.7.1.112) (p60-src) (c-src). [swissprot;acc:p12931]	Divided	207.26	194.346	1.06645
550	inositol polyphosphate-4-phosphatase, type ii, 105kd; inositol polyphosphate 4-phosphatase ii; 4-phosphatase ii. [refseq;acc:nm_003866]	Subtracted	222.156	208.201	13.955
	tyrosine-protein kinase hck (ec 2.7.1.112) (p59-hck/p60-hck) (hemopoietic cell kinase). [swissprot;acc:p08631]	Divided	207.26	194.346	1.06645
551	grb2-related adaptor protein 2 (gads protein) (growth factor receptor binding protein) (grblg) (grf40 adaptor protein) (grf-40) (grb-2-like protein) (grb2l) (grbx) (p38) (hematopoietic cell-associated adaptor protein grpl) (adapter protein grid) (sh3-sh2-sh3 adaptor mona). [swissprot;acc:o75791]		207.261	194.347
	selenide,water dikinase 1 (ec 2.7.9.3) (selenophosphate synthetase 1) (selenium donor protein 1). [swissprot;acc:p49903]	Subtracted	222.156	208.201	13.955
552	crk-like protein. [swissprot;acc:p46109]	Divided	207.26	194.346	1.06645
	inositol polyphosphate-4-phosphatase, type 1 isoform b; inositol polyphosphate-4-phosphatase, type i, 107kd; 4-phosphatase i; inositol polyphosphate-4-phosphatase i. [refseq;acc:nm_001566]	Subtracted	222.156	208.201	13.955
553	proto-oncogene tyrosine-protein kinase abl1 (ec 2.7.1.112) (p150) (c-abl). [swissprot;acc:p00519]	Divided	207.26	194.346	1.06645
	putative pre-mrna splicing factor rna helicase (atp-dependent rna helicase #3) (deah-box protein 16). [swissprot;acc:o60231]	Subtracted	226.3	212.38	13.92
554	proto-oncogene tyrosine-protein kinase fyn (ec 2.7.1.112) (p59-fyn) (syn) (slk). [swissprot;acc:p06241]	Divided	207.26	194.346	1.06645
	t54 protein. [swissprot;acc:q92917]	Subtracted	226.3	212.38	13.92
555	cbf1 interacting corepressor. [refseq;acc:nm_004882]		227.86	213.945	13.915
	proto-oncogene tyrosine-protein kinase fgr (ec 2.7.1.112) (p55-fgr) (c-fgr). [swissprot;acc:p09769]	Divided	207.26	194.346	1.06645
556	ccaat displacement protein (cdp) (cut-like 1). [swissprot;acc:p39880]		207.27	194.368	1.06638
	evolutionarily conserved g-patch domain containing. [refseq;acc:nm_018025]	Subtracted	227.86	213.945	13.915
557	homeobox protein cux-2 (cut-like 2) (fragment). [swissprot;acc:o14529]	Divided	207.272	194.371	1.06637
	shwachman-bodian-diamond syndrome protein (cgi-97). [swissprot;acc:q9y3a5]	Subtracted	216.557	230.362	13.805
558	tgf beta-inducible nuclear protein 1; hairy cell leukemia protein 1. [refseq;acc:nm_014886]		248.994	235.255	13.739
	ubiquitin activating enzyme e1-like protein. [refseq;acc:nm_006395]	Divided	135.087	144.041	1.06628
559	neural wiskott-aldrich syndrome protein (n-wasp). [swissprot;acc:o00401]		207.309	194.452	1.06612
	ribonuclease p protein subunit p30 (ec 3.1.26.5) (rnasep protein p30) (rnase p subunit 2). [swissprot;acc:p78346]	Subtracted	216.72	230.439	13.719
560	son of sevenless protein homolog 1 (sos-1). [swissprot;acc:q07889]	Divided	205.74	193.021	1.06589
	tata-binding protein-associated phosphoprotein (down-regulator of transcription 1) (dr1 protein). [swissprot;acc:q01658]	Subtracted	232.118	218.406	13.712
561	son of sevenless protein homolog 2 (sos-2). [swissprot;acc:q07890]	Divided	205.89	193.183	1.06578
	u6 snrna-associated sm-like protein lsm2 (small nuclear ribonuclear protein d homolog) (g7b) (snrnp core sm-like protein sm-x5). [swissprot;acc:q9y333]	Subtracted	228.215	214.546	13.669
562	enteropeptidase precursor (ec 3.4.21.9) (enterokinase). [swissprot;acc:p98073]		224.606	210.944	13.662
	ptb domain adaptor protein ced-6; engulfment adapter protein. [refseq;acc:nm_016315]	Divided	220.744	207.121	1.06577
563	calcyphosine. [swissprot;acc:q13938]
	splicing factor 3b subunit 2 (spliceosome associated protein 145) (sap 145) (sf3b150) (pre-mrna splicing factor sf3b 145 kda subunit). [swissprot;acc:q13435]	Subtracted	224.606	210.944	13.662
564	crooked neck-like protein 1 (crooked neck homolog) (hcrn) (cgi-201) (mstp021). [swissprot;acc:q9bzj0]	Divided	220.744	207.121	1.06577
	ptb domain adaptor protein ced-6; engulfment adapter protein. [refseq;acc:nm_016315]	Subtracted			13.623
565	calcyphosine. [swissprot;acc:q13938]

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.