MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 1913 to 1962 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

Rank	description	Network Comparison Type	red	green	network_comparison
957	a-raf proto-oncogene serine/threonine-protein kinase (ec 2.7.1.-) (a-raf-1) (proto-oncogene pks). [swissprot;acc:p10398]	Divided	129.913	134.399	1.03453
	ral guanine nucleotide dissociation stimulator-like 1 (ralgds-like 1). [swissprot;acc:q9nzl6]	Subtracted	168.592	161.452	7.14
958	raf proto-oncogene serine/threonine-protein kinase (ec 2.7.1.-) (raf-1) (c-raf). [swissprot;acc:p04049]	Divided	129.921	134.406	1.03452
	serine protease htra2, mitochondrial precursor (ec 3.4.21.-) (high temperature requirement protein a2) (htra2) (omi stress-regulated endoprotease) (serine proteinase omi). [swissprot;acc:o43464]	Subtracted	218.459	211.338	7.121
959	guanine nucleotide-binding protein beta subunit-like protein 12.3 (p205) (receptor of activated protein kinase c 1) (rack1) (receptor for activated c kinase). [swissprot;acc:p25388]	Divided	237.558	229.677	1.03431
	probable serine protease htra4 precursor (ec 3.4.21.-). [swissprot;acc:p83105]	Subtracted	218.461	211.343	7.118
960	probable serine protease htra3 precursor (ec 3.4.21.-). [swissprot;acc:p83110]		218.462	211.345	7.117
	zuotin related factor-1 (m-phase phosphoprotein 11). [swissprot;acc:q99543]	Divided	237.558	229.677	1.03431
961	serine protease htra1 precursor (ec 3.4.21.-) (l56). [swissprot;acc:q92743]	Subtracted	218.468	211.357	7.111
	serine/threonine protein phosphatase 2a, 56 kda regulatory subunit, epsilon isoform (pp2a, b subunit, b' epsilon isoform) (pp2a, b subunit, b56 epsilon isoform) (pp2a, b subunit, pr61 epsilon isoform) (pp2a, b subunit, r5 epsilon isoform). [swissprot;acc:q16537]	Divided	130.066	134.527	1.0343
962	cyclin g2. [swissprot;acc:q16589]
	mitotic spindle assembly checkpoint protein mad2b (mad2-like 2) (hrev7). [swissprot;acc:q9ui95]	Subtracted	219.656	212.547	7.109
963	cyclin g1 (cyclin g). [swissprot;acc:p51959]	Divided	130.066	134.527	1.0343
	mitochondrial 28s ribosomal protein s32 (s32mt) (mrp-s32) (ptd007) (hspc204). [swissprot;acc:q9y6g3]	Subtracted	219.656	212.547	7.109
964	nuclear pore complex protein nup88 (nucleoporin nup88) (88 kda nuclear pore complex protein). [swissprot;acc:q99567]
	serine/threonine protein phosphatase 2a, 56 kda regulatory subunit, alpha isoform (pp2a, b subunit, b' alpha isoform) (pp2a, b subunit, b56 alpha isoform) (pp2a, b subunit, pr61 alpha isoform) (pp2a, b subunit, r5 alpha isoform). [swissprot;acc:q15172]	Divided	130.066	134.527	1.0343
965	partitioning defective-6 homolog gamma (par-6 gamma) (par6d). [swissprot;acc:q9byg4]		211.987	204.964	1.03426
	tetranectin precursor (tn) (plasminogen-kringle 4 binding protein). [swissprot;acc:p05452]	Subtracted	178.514	171.42	7.094
966	tubby protein homolog. [swissprot;acc:p50607]	Divided	211.987	204.964	1.03426
	vinexin (sh3-containing adaptor molecule-1) (scam-1). [swissprot;acc:o60504]	Subtracted	211.812	204.732	7.08
967	dna-directed rna polymerase i 16 kda polypeptide (ec 2.7.7.6) (rpa16). [swissprot;acc:q9y2s0]		231.277	238.356	7.079
	protein kinase c, iota type (ec 2.7.1.37) (npkc-iota) (atypical protein kinase c-lamda/iota) (apkc-lambda/iota). [swissprot;acc:p41743]	Divided	211.987	204.964	1.03426
968	homeobox protein hox-c4 (hox-3e) (cp19). [swissprot;acc:p09017]	Subtracted	132.413	125.389	7.024
	numb protein homolog (h-numb) (protein s171). [swissprot;acc:p49757]	Divided	211.987	204.964	1.03426
969	homeobox protein hox-b4 (hox-2f) (hox-2.6). [swissprot;acc:p17483]	Subtracted	132.413	125.389	7.024
	tbc1 domain family member 5. [swissprot;acc:q92609]	Divided	211.987	204.964	1.03426
970	homeobox protein hox-c5 (hox-3d) (cp11). [swissprot;acc:q00444]	Subtracted	132.413	125.389	7.024
	tubby related protein 1 (tubby-like protein 1). [swissprot;acc:o00294]	Divided	211.987	204.964	1.03426
971	homeobox protein hox-c6 (hox-3c) (hho.c8) (cp25). [swissprot;acc:p09630]	Subtracted	132.413	125.389	7.024
	vacuolar protein sorting 29 (vesicle protein sorting 29) (hvps29) (mds007) (pep11) (dc7/dc15). [swissprot;acc:q9ubq0]	Divided	211.987	204.964	1.03426
972	homeobox protein hox-d4 (hox-4b) (hox-5.1) (hho.c13). [swissprot;acc:p09016]	Subtracted	132.413	125.389	7.024
	numb-like protein (numb-r). [swissprot;acc:q9y6r0]	Divided	211.987	204.964	1.03426
973	homeobox protein hox-b5 (hox-2a) (hho.c10) (hu-1). [swissprot;acc:p09067]	Subtracted	132.413	125.389	7.024
	tubby related protein 3 (tubby-like protein 3). [swissprot;acc:o75386]	Divided	211.987	204.964	1.03426
974	homeobox protein hox-a5 (hox-1c). [swissprot;acc:p20719]	Subtracted	132.413	125.389	7.024
	vacuolar protein sorting 35 (vesicle protein sorting 35) (hvps35) (maternal-embryonic 3). [swissprot;acc:q96qk1]	Divided	211.987	204.964	1.03426
975	homeobox protein hox-a4 (hox-1d) (hox-1.4). [swissprot;acc:q00056]	Subtracted	132.413	125.389	7.024
	protein kinase c, zeta type (ec 2.7.1.37) (npkc-zeta). [swissprot;acc:q05513]	Divided	211.987	204.964	1.03426
976	retinal short-chain dehydrogenase/reductase 3. [refseq;acc:nm_016246]	Subtracted	132.413	125.389	7.024
	t-cell activation wd repeat protein. [refseq;acc:nm_139281]	Divided	243.34	235.322	1.03407
977	partitioning defective-6 homolog gamma (par-6 gamma) (par6d). [swissprot;acc:q9byg4]	Subtracted	211.987	204.964	7.023
	prefoldin subunit 5 (c-myc binding protein mm-1) (myc modulator 1). [swissprot;acc:q99471]	Divided	228.953	221.421	1.03402
978	prefoldin subunit 6 (protein ke2). [swissprot;acc:o15212]
	tubby protein homolog. [swissprot;acc:p50607]	Subtracted	211.987	204.964	7.023
979	gcn5-like protein 1 (rt14 protein). [swissprot;acc:p78537]	Divided	202.027	195.386	1.03399
	protein kinase c, iota type (ec 2.7.1.37) (npkc-iota) (atypical protein kinase c-lamda/iota) (apkc-lambda/iota). [swissprot;acc:p41743]	Subtracted	211.987	204.964	7.023
980	b-raf proto-oncogene serine/threonine-protein kinase (ec 2.7.1.-) (p94) (v-raf murine sarcoma viral oncogene homolog b1). [swissprot;acc:p15056]	Divided	130.289	134.713	1.03396
	numb protein homolog (h-numb) (protein s171). [swissprot;acc:p49757]	Subtracted	211.987	204.964	7.023
981	exocyst complex component sec6. [swissprot;acc:o60645]	Divided	207.186	200.398	1.03387
	tbc1 domain family member 5. [swissprot;acc:q92609]	Subtracted	211.987	204.964	7.023

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.