MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	description	Hugo	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 125 to 174 of 16578 in total

Value Type  : Ranked
Filtered  : 1

Rank	description	Hugo	Network Comparison Type	Interaction Map	red	green	network_comparison
32	guanine nucleotide-binding protein g(i), alpha-2 subunit (adenylate cyclase-inhibiting g alpha protein). [swissprot;acc:p04899]	GNAI2	Subtracted	High confidence	267.142	336.074	68.932
	protein kinase, interferon-inducible double stranded rna dependent activator; protein activator of the interferon-induced protein kinase. [refseq;acc:nm_003690]	PRKRAP1	Divided	Low confidence	273.188	232.49	1.17505
	regulator of g-protein signaling 12 (rgs12). [swissprot;acc:o14924]	RGS12	Subtracted		247.768	219.841	27.927
	serine/threonine protein phosphatase 2a, 55 kda regulatory subunit b, gamma isoform (pp2a, subunit b, b-gamma isoform) (pp2a, subunit b, b55-gamma isoform) (pp2a, subunit b, pr55-gamma isoform) (pp2a, subunit b, r2-gamma isoform) (imypno1). [swissprot;acc:q9y2t4]	PPP2R2C	Divided	High confidence	187.462	243.673	1.29985
33	ba127l20.1 (novel glutathione-s-transferase). [sptrembl;acc:q9h4y5]	GSTO2	Subtracted	Low confidence	228.147	200.55	27.597
	dual specificity mitogen-activated protein kinase kinase 4 (ec 2.7.1.-) (map kinase kinase 4) (jnk activating kinase 1) (c-jun n- terminal kinase kinase 1) (jnkk) (sapk/erk kinase 1) (sek1). [swissprot;acc:p45985]	MAP2K4	Divided		210.241	246.125	1.17068
	guanine nucleotide-binding protein g(i), alpha-1 subunit (adenylate cyclase-inhibiting g alpha protein). [swissprot;acc:p04898]	GNAI1	Subtracted	High confidence	267.144	336.073	68.929
	serine/threonine protein phosphatase 2a, 65 kda regulatory subunit a, beta isoform (pp2a, subunit a, pr65-beta isoform) (pp2a, subunit a, r1-beta isoform). [swissprot;acc:p30154]	PPP2R1B	Divided		188.688	242.742	1.28647
34	glutathione transferase omega 1 (ec 2.5.1.18) (gsto 1-1). [swissprot;acc:p78417]	GSTO1	Subtracted	Low confidence	227.371	200.532	26.839
	guanine nucleotide-binding protein g(k), alpha subunit (g(i) alpha-3). [swissprot;acc:p08754]	GNAI3		High confidence	267.144	336.073	68.929
	putative glialblastoma cell differentiation-related; putative glialblastoma cell differentiation-related protein. [refseq;acc:nm_016172]	UBAC1	Divided	Low confidence	155.56	133.876	1.16197
	serine/threonine protein phosphatase 2a, 65 kda regulatory subunit a, alpha isoform (pp2a, subunit a, pr65-alpha isoform) (pp2a, subunit a, r1-alpha isoform) (medium tumor antigen-associated 61 kda protein). [swissprot;acc:p30153]	PPP2R1A		High confidence	189.07	242.453	1.28235
35	cytoplasmic polyadenylation element binding protein 3. [refseq;acc:nm_014912]	CPEB3	Subtracted	Low confidence	267.448	240.822	26.626
	guanine nucleotide-binding protein beta subunit 5 (transducin beta chain 5). [swissprot;acc:o14775]	GNB5		High confidence	267.636	335.359	67.723
	nuclear transcription factor y subunit gamma (nf-y protein chain c) (nuclear factor yc) (nf-yc) (ccaat-binding transcription factor subunit c) (cbf-c) (transactivator hsm-1/2). [swissprot;acc:q13952]	NFYC	Divided		260.532	204.309	1.27519
	tob2 protein (transducer of erbb-2 2). [swissprot;acc:q14106]	TOB2		Low confidence	297.273	258.59	1.14959
36	ccaat-binding transcription factor subunit b (cbf-b) (nf-y protein chain a) (nf-ya) (caat-box dna binding protein subunit a). [swissprot;acc:p23511]	NFYA		High confidence	260.532	204.309	1.27519
	cytoplasmic polyadenylation element binding protein 4. [refseq;acc:nm_030627]	CPEB4	Subtracted	Low confidence	267.376	240.78	26.596
	protein kinase, interferon-inducible double stranded rna dependent activator; protein activator of the interferon-induced protein kinase. [refseq;acc:nm_003690]	PRKRAP1		High confidence	320.927	254.434	66.493
	tob1 protein (transducer of erbb-2 1). [swissprot;acc:p50616]	TOB1	Divided	Low confidence	296.837	258.33	1.14906
37	chromatin accessibility complex protein 1 (chrac-1) (chrac-15) (huchrac15) (dna polymerase epsilon subunit p15). [swissprot;acc:q9nrg0]	CHRAC1			250.244	217.843	1.14874
	guanine nucleotide-binding protein g(i)/g(s)/g(t) beta subunit 1 (transducin beta chain 1). [swissprot;acc:p04901]	GNB1	Subtracted	High confidence	266.716	333.165	66.449
	junctophilin 3 (junctophilin type 3) (jp-3). [swissprot;acc:q8wxh2]	JPH3		Low confidence	234.802	260.98	26.178
	protein phosphatase 1, regulatory (inhibitor) subunit 14a; 17-kda pkc-potentiated inhibitory protein of pp1. [refseq;acc:nm_033256]	PPP1R14A	Divided	High confidence	322	253	1.27273
38	glucosamine-6-phosphate isomerase. [refseq;acc:nm_138335]	GNPDA2		Low confidence	247.202	282.937	1.14456
	guanine nucleotide-binding protein beta subunit 4 (transducin beta chain 4). [swissprot;acc:q9hav0]	GNB4	Subtracted	High confidence	266.933	333.281	66.348
	junctophilin 2 (junctophilin type 2) (jp-2). [swissprot;acc:q9br39]	JPH2		Low confidence	234.802	260.98	26.178
	microfibril-associated glycoprotein 4 precursor. [swissprot;acc:p55083]	MFAP4	Divided	High confidence	322	253	1.27273
39	glucosamine-6-phosphate isomerase (ec 3.5.99.6) (glucosamine-6- phosphate deaminase) (gnpda) (glcn6p deaminase) (oscillin). [swissprot;acc:p46926]	GNPDA1		Low confidence	247.202	282.937	1.14456
	guanine nucleotide-binding protein g(i)/g(s)/g(t) beta subunit 3 (transducin beta chain 3). [swissprot;acc:p16520]	GNB3	Subtracted	High confidence	268.565	334.483	65.918
	protein phosphatase 1, regulatory subunit 14d; pkc-dependent pp1 inhibitory protein. [refseq;acc:nm_017726]	PPP1R14D	Divided		322	253	1.27273
	sphingomyelin phosphodiesterase 2 (ec 3.1.4.12) (neutral sphingomyelinase) (nsmase) (n-smase) (lyso-platelet activating factor- phospholipase c) (lyso-paf-plc). [swissprot;acc:o60906]	SMPD2	Subtracted	Low confidence	234.802	260.98	26.178
40	db83 protein. [swissprot;acc:p57088]	TMEM33
	deltex 2. [refseq;acc:nm_020892]	DTX2		High confidence	333.144	267.393	65.751
	ficolin 2 precursor (collagen/fibrinogen domain-containing protein 2) (ficolin-b) (ficolin b) (serum lectin p35) (ebp-37) (hucolin) (l- ficolin). [swissprot;acc:q15485]	FCN2	Divided		322	253	1.27273
	son protein (son3) (negative regulatory element-binding protein) (nre- binding protein) (dbp-5) (bax antagonist selected in saccharomyces 1) (bass1) (protein c21orf50). [swissprot;acc:p18583]	SON		Low confidence	255.382	223.538	1.14245
41	ba127l20.1 (novel glutathione-s-transferase). [sptrembl;acc:q9h4y5]	GSTO2			228.147	200.55	1.13761
	deltex homolog 1; hdx-1. [refseq;acc:nm_004416]	DTX1	Subtracted	High confidence	332.925	267.274	65.651
	protein phosphatase 1, regulatory (inhibitor) subunit 14c; serologically defined breast cancer antigen ny-br-81; pkc-potentiated pp1 inhibitory protein. [refseq;acc:nm_030949]	no value	Divided		322	253	1.27273
	putative rna-binding protein 7 (rna binding motif protein 7). [swissprot;acc:q9y580]	RBM7	Subtracted	Low confidence	265.688	239.902	25.786
42	glutathione transferase omega 1 (ec 2.5.1.18) (gsto 1-1). [swissprot;acc:p78417]	GSTO1	Divided		227.371	200.532	1.13384
	protein phosphatase 1, regulatory (inhibitor) subunit 14a; 17-kda pkc-potentiated inhibitory protein of pp1. [refseq;acc:nm_033256]	PPP1R14A	Subtracted		242.742	217.217	25.525
	proto-oncogene protein c-fos (cellular oncogene fos) (g0/g1 switch regulatory protein 7). [swissprot;acc:p01100]	FOS	Divided	High confidence	204.641	160.957	1.2714
	t-lak cell-originated protein kinase; spermatogenesis-related protein kinase; pdz-binding kinase; pbk; mapkk-like protein kinase; serine/threonine protein kinase. [refseq;acc:nm_018492]	PBK	Subtracted		332.874	267.246	65.628
43	jun dimerization protein. [refseq;acc:nm_130469]	no value	Divided		204.641	160.957	1.2714
	kh domain containing, rna binding, signal transduction associated 3; sam68-like phosphotyrosine protein, t-star. [refseq;acc:nm_006558]	KHDRBS3	Subtracted		332.874	267.246	65.628
	microfibril-associated glycoprotein 4 precursor. [swissprot;acc:p55083]	MFAP4		Low confidence	242.742	217.217	25.525
	regulator of g-protein signaling 12 (rgs12). [swissprot;acc:o14924]	RGS12	Divided		247.768	219.841	1.12703
44	fos-related antigen 2. [swissprot;acc:p15408]	FOSL2		High confidence	204.641	161.046	1.2707
	kh domain containing, rna binding, signal transduction associated 1; gap-associated tyrosine phosphoprotein p62 (sam68). [refseq;acc:nm_006559]	KHDRBS1	Subtracted		332.874	267.246	65.628

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.