MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	Value Type	Network Comparison Type	description	Interaction Map	Filtered	green	red	network_comparison

Results: HTML CSV LaTeX

Showing element 101 to 150 of 7460 in total

Value Type  : Ranked
Interaction Map  : High confidence

Rank	Hugo	Network Comparison Type	description	Filtered	green	red	network_comparison
26	no value	Subtracted	protein phosphatase 1, regulatory (inhibitor) subunit 14c; serologically defined breast cancer antigen ny-br-81; pkc-potentiated pp1 inhibitory protein. [refseq;acc:nm_030949]	1	253	322	69
	DTNBP1	Divided	dystrobrevin binding protein 1; dysbindin. [refseq;acc:nm_032122]	0	7533.33	12128.3	1.60995
	MAPRE2	Subtracted	microtubule-associated protein, rp/eb family, member 2; t-cell activation protein, eb1 family; apc-binding protein eb1. [refseq;acc:nm_014268]		17173.8	11284	5889.8
	PANK3	Divided	pantothenate kinase 3 (ec 2.7.1.33) (pantothenic acid kinase 3) (hpank3). [swissprot;acc:q9h999]	1	44	58	1.31818
27	no value		ptd016 protein. [refseq;acc:nm_016125]	0	11234	18050	1.60673
		Subtracted	60s ribosomal protein l37a. [swissprot;acc:p12751]		18499.2	12941.7	5557.5
	GNAQ		guanine nucleotide-binding protein g(q), alpha subunit. [swissprot;acc:p50148]	1	336.077	267.136	68.941
	SLC25A43	Divided	mitochondrial solute carrier protein. [refseq;acc:nm_145305]		44	58	1.31818
28	ATF3		cyclic-amp-dependent transcription factor atf-3 (activating transcription factor 3). [swissprot;acc:p18847]		153.671	201.949	1.31416
	CYP27B1	Subtracted	25-hydroxyvitamin d-1 alpha hydroxylase, mitochondrial precursor (ec 1.14.-.-) (25-ohd-1 alpha-hydroxylase) (25-hydroxyvitamin d3 1- alpha-hydroxylase) (vd3 1a hydroxylase) (p450c1 alpha) (p450vd1- alpha). [swissprot;acc:o15528]	0	18499.2	12941.7	5557.5
	GNA11		guanine nucleotide-binding protein g(y), alpha subunit (alpha-11). [swissprot;acc:p29992]	1	336.077	267.136	68.941
	ING5	Divided	p28 ing5. [refseq;acc:nm_032329]	0	7562.05	12124.8	1.60337
29	no value	Subtracted	ba508n22.1 (hspc025) (fragment). [sptrembl;acc:q9hcw5]		8257	13730.5	5473.5
	GNAZ		guanine nucleotide-binding protein g(z), alpha subunit (g(x) alpha chain) (gz-alpha). [swissprot;acc:p19086]	1	336.075	267.139	68.936
	PNMT	Divided	phenylethanolamine n-methyltransferase (ec 2.1.1.28) (pnmtase) (noradrenaline n-methyltransferase). [swissprot;acc:p11086]	0	11625	7395	1.57201
	PPP2R2D		uncharacterized hematopoietic stem/progenitor cells protein mds026. [sptrembl;acc:q9nz48]	1	243.678	187.458	1.29991
30	no value		beta-carotene dioxygenase 2; putative b,b-carotene-9',10'-dioxygenase. [refseq;acc:nm_031938]	0	11625	7395	1.57201
			serine/threonine protein phosphatase 2a, 55 kda regulatory subunit b, alpha isoform (pp2a, subunit b, b-alpha isoform) (pp2a, subunit b, b55-alpha isoform) (pp2a, subunit b, pr55-alpha isoform) (pp2a, subunit b, r2-alpha isoform). [swissprot;acc:q00007]	1	243.678	187.457	1.29991
		Subtracted	lipopolysaccharide-responsive and beige-like anchor protein (cdc4-like protein) (beige-like protein). [swissprot;acc:p50851]	0	8257	13730.5	5473.5
	GNAT2		guanine nucleotide-binding protein g(t), alpha-2 subunit (transducin alpha-2 chain). [swissprot;acc:p19087]	1	336.075	267.14	68.935
31	ATP9A		potential phospholipid-transporting atpase iia (ec 3.6.1.-). [swissprot;acc:o75110]	0	6248	11627	5379
	GNAT1		guanine nucleotide-binding protein g(t), alpha-1 subunit (transducin alpha-1 chain). [swissprot;acc:p11488]	1	336.075	267.14	68.935
	LRRFIP1	Divided	leucine rich repeat (in flii) interacting protein 1. [refseq;acc:nm_004735]	0	5266.67	8082.33	1.53462
	PPP2R2B		serine/threonine protein phosphatase 2a, 55 kda regulatory subunit b, beta isoform (pp2a, subunit b, b-beta isoform) (pp2a, subunit b, b55- beta isoform) (pp2a, subunit b, pr55-beta isoform) (pp2a, subunit b, r2-beta isoform). [swissprot;acc:q00005]	1	243.677	187.458	1.2999
32	no value		importin 9. [refseq;acc:nm_018085]	0	8691.76	13292.2	1.52929
	GNAI2	Subtracted	guanine nucleotide-binding protein g(i), alpha-2 subunit (adenylate cyclase-inhibiting g alpha protein). [swissprot;acc:p04899]	1	336.074	267.142	68.932
	PPP2R2C	Divided	serine/threonine protein phosphatase 2a, 55 kda regulatory subunit b, gamma isoform (pp2a, subunit b, b-gamma isoform) (pp2a, subunit b, b55-gamma isoform) (pp2a, subunit b, pr55-gamma isoform) (pp2a, subunit b, r2-gamma isoform) (imypno1). [swissprot;acc:q9y2t4]		243.673	187.462	1.29985
	STX10	Subtracted	syntaxin 10 (syn10). [swissprot;acc:o60499]	0	19014.6	13884.4	5130.2
33	no value	Divided	nucleosome assembly protein 1-like 4 (nucleosome assembly protein 2) (nap2). [swissprot;acc:q99733]		8691.76	13292.2	1.52929
	GNAI1	Subtracted	guanine nucleotide-binding protein g(i), alpha-1 subunit (adenylate cyclase-inhibiting g alpha protein). [swissprot;acc:p04898]	1	336.073	267.144	68.929
	LYZL1		similar to lysozyme c-1 (1,4-beta-n-acylmuramidase c, ec 3.2.1.17). [refseq;acc:nm_032517]	0	20387	15264	5123
	PPP2R1B	Divided	serine/threonine protein phosphatase 2a, 65 kda regulatory subunit a, beta isoform (pp2a, subunit a, pr65-beta isoform) (pp2a, subunit a, r1-beta isoform). [swissprot;acc:p30154]	1	242.742	188.688	1.28647
34	no value	Subtracted	fatty acid desaturase 1; linoleoyl-coa desaturase (delta-6-desaturase)-like 1; delta-5 desaturase; delta-5 fatty acid desaturase. [refseq;acc:nm_013402]	0	6812	11543	4731
	GNAI3		guanine nucleotide-binding protein g(k), alpha subunit (g(i) alpha-3). [swissprot;acc:p08754]	1	336.073	267.144	68.929
	MAPRE2	Divided	microtubule-associated protein, rp/eb family, member 2; t-cell activation protein, eb1 family; apc-binding protein eb1. [refseq;acc:nm_014268]	0	17173.8	11284	1.52196
	PPP2R1A		serine/threonine protein phosphatase 2a, 65 kda regulatory subunit a, alpha isoform (pp2a, subunit a, pr65-alpha isoform) (pp2a, subunit a, r1-alpha isoform) (medium tumor antigen-associated 61 kda protein). [swissprot;acc:p30153]	1	242.453	189.07	1.28235
35	no value		nuclear dna-binding protein; small unique nuclear receptor corepressor; c1d dna-binding protein. [refseq;acc:nm_006333]	0	4871.6	3208.8	1.5182
		Subtracted	importin 9. [refseq;acc:nm_018085]		8691.76	13292.2	4600.44
	GNB5		guanine nucleotide-binding protein beta subunit 5 (transducin beta chain 5). [swissprot;acc:o14775]	1	335.359	267.636	67.723
	NFYC	Divided	nuclear transcription factor y subunit gamma (nf-y protein chain c) (nuclear factor yc) (nf-yc) (ccaat-binding transcription factor subunit c) (cbf-c) (transactivator hsm-1/2). [swissprot;acc:q13952]		204.309	260.532	1.27519
36	no value	Subtracted	nucleosome assembly protein 1-like 4 (nucleosome assembly protein 2) (nap2). [swissprot;acc:q99733]	0	8691.76	13292.2	4600.44
	GNB1L	Divided	guanine nucleotide-binding protein beta subunit-like protein 1 (g protein beta-subunit like protein 1) (wd40 repeat containing protein deleted in vcfs) (wdvcf protein) (fksg1 protein) (dgcrk3). [swissprot;acc:q9byb4]		14964	22422	1.4984
	NFYA		ccaat-binding transcription factor subunit b (cbf-b) (nf-y protein chain a) (nf-ya) (caat-box dna binding protein subunit a). [swissprot;acc:p23511]	1	204.309	260.532	1.27519
	PRKRAP1	Subtracted	protein kinase, interferon-inducible double stranded rna dependent activator; protein activator of the interferon-induced protein kinase. [refseq;acc:nm_003690]		254.434	320.927	66.493
37	no value	Divided	dj570f3.6 (novel protein similar to lysophospholipase ii (lypla2)). [sptrembl;acc:q9uge0]	0	2582	3859	1.49458
	DTNBP1	Subtracted	dystrobrevin binding protein 1; dysbindin. [refseq;acc:nm_032122]		7533.33	12128.3	4594.97
	GNB1		guanine nucleotide-binding protein g(i)/g(s)/g(t) beta subunit 1 (transducin beta chain 1). [swissprot;acc:p04901]	1	333.165	266.716	66.449
	PPP1R14A	Divided	protein phosphatase 1, regulatory (inhibitor) subunit 14a; 17-kda pkc-potentiated inhibitory protein of pp1. [refseq;acc:nm_033256]		253	322	1.27273
38	CDK8		cell division protein kinase 8 (ec 2.7.1.-) (protein kinase k35). [swissprot;acc:p49336]	0	10771	7230	1.48976
	GNB4	Subtracted	guanine nucleotide-binding protein beta subunit 4 (transducin beta chain 4). [swissprot;acc:q9hav0]	1	333.281	266.933	66.348

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.