MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	description	Network Comparison Type	Value Type	Interaction Map	Filtered	red	network_comparison	green

Results: HTML CSV LaTeX

Showing element 1 to 50 of 25824 in total

Interaction Map  : High confidence
Filtered  : 1

Rank	Hugo	description	Network Comparison Type	Value Type	red	network_comparison	green
1	no value	mannosyl-oligosaccharide 1,2-alpha-mannosidase ib (ec 3.2.1.113) (processing alpha-1,2-mannosidase ib) (alpha-1,2-mannosidase ib) (mannosidase alpha class 1a member 2). [swissprot;acc:o60476]	Subtracted	Measured	41482.5	8126	33356.5
	HLX	homeobox protein hlx1 (homeobox protein hb24). [swissprot;acc:q14774]		Ranked	215	107	322
	RINT1	rad50-interacting protein 1. [refseq;acc:nm_021930]	Divided	Measured	450.5	5.31521	2394.5
				Squared	48.0356	28.2513	1357.07
				Rooted	21.225	2.30547	48.9336
			Subtracted			27.7086
	UBAC1	putative glialblastoma cell differentiation-related; putative glialblastoma cell differentiation-related protein. [refseq;acc:nm_016172]	Divided	Ranked	10	2.4	24
			Subtracted	Squared	468498	145743	322755
2	no value	mannosyl-oligosaccharide 1,2-alpha-mannosidase ib (ec 3.2.1.113) (processing alpha-1,2-mannosidase ib) (alpha-1,2-mannosidase ib) (mannosidase alpha class 1a member 2). [swissprot;acc:o60476]	Divided	Ranked	15	1.86667	28
			Subtracted	Squared	407289	143938	263351
	HBS1L	hbs1-like. [refseq;acc:nm_006620]		Ranked	215	107	322
	PSCD1	cytohesin 1 (sec7 homolog b2-1). [swissprot;acc:q15438]		Measured	41482.5	8126	33356.5
	RHOBTB2	rho-related btb domain-containing protein 2 (deleted in breast cancer 2 gene protein) (p83). [swissprot;acc:q9byz6]	Divided		450.5	5.31521	2394.5
				Squared	48.0356	28.2513	1357.07
				Rooted	21.225	2.30547	48.9336
			Subtracted			27.7086
3	HLX	homeobox protein hlx1 (homeobox protein hb24). [swissprot;acc:q14774]	Divided	Measured	2597.5	3.71868	698.5
				Squared	1596.92	13.8285	115.48
				Rooted	50.9657	1.92839	26.4292
			Subtracted			24.5365
	PSCD1	cytohesin 1 (sec7 homolog b2-1). [swissprot;acc:q15438]	Divided	Ranked	15	1.86667	28
			Subtracted	Squared	407289	143938	263351
	PSCD2	cytohesin 2 (arf nucleotide-binding site opener) (arno protein) (arf exchange factor). [swissprot;acc:q99418]		Measured	41482.5	8126	33356.5
	RINT1	rad50-interacting protein 1. [refseq;acc:nm_021930]		Ranked	337	105	232
4	HBS1L	hbs1-like. [refseq;acc:nm_006620]	Divided	Measured	2597.5	3.71868	698.5
				Squared	1596.92	13.8285	115.48
				Rooted	50.9657	1.92839	26.4292
			Subtracted			24.5365
	PSCD2	cytohesin 2 (arf nucleotide-binding site opener) (arno protein) (arf exchange factor). [swissprot;acc:q99418]	Divided	Ranked	15	1.86667	28
			Subtracted	Squared	407289	143938	263351
	PSCD4	cytohesin 4. [swissprot;acc:q9uia0]		Measured	41482.5	8126	33356.5
	RHOBTB2	rho-related btb domain-containing protein 2 (deleted in breast cancer 2 gene protein) (p83). [swissprot;acc:q9byz6]		Ranked	337	105	232
5	JPH3	junctophilin 3 (junctophilin type 3) (jp-3). [swissprot;acc:q8wxh2]	Divided	Measured	1153.5	3.39764	339.5
				Squared	314.926	11.544	27.2805
				Rooted	33.9632	1.84327	18.4255
	MRPS17	28s ribosomal protein s17, mitochondrial precursor (mrp-s17) (hspc011). [swissprot;acc:q9y2r5]	Subtracted		145.551	23.245	168.796
	PSCD3	cytohesin 3 (arf nucleotide-binding site opener 3) (arno3 protein) (general receptor of phosphoinositides 1) (grp1). [swissprot;acc:o43739]		Measured	41482.5	8126	33356.5
	PSCD4	cytohesin 4. [swissprot;acc:q9uia0]	Divided	Ranked	15	1.86667	28
			Subtracted	Squared	407289	143938	263351
	XAB1	xpa binding protein 1; mbd2 interactor protein; putative atp(gtp)-binding protein. [refseq;acc:nm_007266]		Ranked	212	97	309
6	ATPBD1C	protein x 0004. [refseq;acc:nm_016301]
	JPH2	junctophilin 2 (junctophilin type 2) (jp-2). [swissprot;acc:q9br39]	Divided	Measured	1153.5	3.39764	339.5
				Squared	314.926	11.544	27.2805
				Rooted	33.9632	1.84327	18.4255
	PANK1	pantothenate kinase 1 (ec 2.7.1.33) (pantothenic acid kinase 1) (hpank1) (hpank). [swissprot;acc:q8te04]	Subtracted		145.551	23.245	168.796
	PSCD3	cytohesin 3 (arf nucleotide-binding site opener 3) (arno3 protein) (general receptor of phosphoinositides 1) (grp1). [swissprot;acc:o43739]	Divided	Ranked	15	1.86667	28
			Subtracted	Squared	407289	143938	263351
	UBAC1	putative glialblastoma cell differentiation-related; putative glialblastoma cell differentiation-related protein. [refseq;acc:nm_016172]		Measured	44490.5	7563	36927.5
7	no value	nuclear dna-binding protein; small unique nuclear receptor corepressor; c1d dna-binding protein. [refseq;acc:nm_006333]		Squared	310840	132153	442993
	HLX	homeobox protein hlx1 (homeobox protein hb24). [swissprot;acc:q14774]	Divided	Ranked	215	1.49767	322

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.