MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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description	Rank	Gene	Value Type	Network Comparison Type	Interaction Map	Filtered	green	red	network_comparison

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Showing element 501 to 550 of 3730 in total

Value Type  : Ranked
Network Comparison Type  : Divided
Interaction Map  : High confidence

description	Rank	Filtered	green	red	network_comparison
blood group rh(d) polypeptide (rhesus d antigen) (rhxiii) (rh polypeptide 2) (rhpii). [swissprot;acc:q02161]	419	0	17183	16684	1.02991
	1928	1	198.935	196.964	1.01001
bloom's syndrome protein (ec 3.6.1.-) (recq protein-like 3) (dna helicase, recq-like, type 2). [swissprot;acc:p54132]	114	0	10603.2	8871.11	1.19525
	1748	1	212.971	215.673	1.01269
bomapin (protease inhibitor 10) (serpin b10). [swissprot;acc:p48595]	793		234.511	224.244	1.04578
bone morphogenetic protein 5 precursor (bmp-5). [swissprot;acc:p22003]	3069		0.00001	0.00001	1
bone morphogenetic protein 6 precursor (bmp-6). [swissprot;acc:p22004]	2896
bone morphogenetic protein 7 precursor (bmp-7) (osteogenic protein 1) (op-1). [swissprot;acc:p18075]	3128
bone morphogenetic protein 8 precursor (bmp-8) (osteogenic protein 2) (op-2). [swissprot;acc:p34820]	91	0	11127.5	13841.2	1.24387
	2773	1	0.00001	0.00001	1
brachyury protein (t protein). [swissprot;acc:o15178]	2040		208.803	210.586	1.00854
brain protein 16. [refseq;acc:nm_016458]	49	0	4854.99	6890.54	1.41927
	1847	1	219.195	216.811	1.011
brain protein 44. [swissprot;acc:o95563]	742		120.078	126.215	1.05111
branched-chain amino acid aminotransferase, cytosolic (ec 2.6.1.42) (bcat(c)) (eca39 protein). [swissprot;acc:p54687]	2672		210.741	210.957	1.00102
branched-chain amino acid aminotransferase, mitochondrial precursor (ec 2.6.1.42) (bcat(m)) (placental protein 18) (pp18). [swissprot;acc:o15382]	2687		210.755	210.939	1.00087
brca1 associated protein. [refseq;acc:nm_006768]	502	0	0.00001	0.00001	1
	3161	1
brca1-associated ring domain protein 1 (bard-1). [swissprot;acc:q99728]	1752		218.991	216.271	1.01258
brca2 and cdkn1a-interacting protein isoform bccipalpha; brca2 and cdkn1a-interacting protein; cdk inhibitor p21 binding protein; bccipalpha; bccipbeta; tok-1alpha; tok-1beta. [refseq;acc:nm_016567]	294		265.717	240.782	1.10356
breast cancer antiestrogen resistance 3. [refseq;acc:nm_003567]	229		202.094	226.401	1.12028
breast cancer type 1 susceptibility protein. [swissprot;acc:p38398]	939		224.27	216.501	1.03588
breast carcinoma amplified sequence 2; spliceosome associated protein, amplified in breast cancer. [refseq;acc:nm_005872]	691		206.195	217.602	1.05532
brefeldin a-inhibited guanine nucleotide-exchange protein 1 (brefeldin a-inhibited gep 1) (p200 arf-gep1) (p200 arf guanine nucleotide exchange factor). [swissprot;acc:q9y6d6]	2713		220.395	220.521	1.00057
brefeldin a-inhibited guanine nucleotide-exchange protein 2 (brefeldin a-inhibited gep 2). [swissprot;acc:q9y6d5]	2711
brg1-binding protein eld/osa1; eld (eyelid)/osa protein. [refseq;acc:nm_020732]	945		205.085	212.44	1.03586
bromodomain and phd finger-containing protein 3 (fragment). [swissprot;acc:q9uld4]	3149		0.00001	0.00001	1
bromodomain containing 7; bromodomain protein; bromodomain-containing 7. [refseq;acc:nm_013263]	2747		201.514	201.477	1.00018
bromodomain-containing protein 1 (br140-like protein). [swissprot;acc:o95696]	3139		0.00001	0.00001	1
bromodomain-containing protein 2 (ring3 protein) (o27.1.1). [swissprot;acc:p25440]	2241		224.338	222.96	1.00618
bromodomain-containing protein 3 (ring3-like protein). [swissprot;acc:q15059]	2237		224.343	222.965
bromodomain-containing protein 4 (hunk1 protein). [swissprot;acc:o60885]	2238		224.337	222.959
bs4 protein (ny-ren-18 antigen). [swissprot;acc:q9y5a7]	3214		0.00001	0.00001	1
bullous pemphigoid antigen 1 isoforms 1/2/3/4/5/8 (230 kda bullous pemphigoid antigen) (bpa) (hemidesmosomal plaque protein) (dystonia musculorum protein) (fragment). [swissprot;acc:q03001]	449		246.33	228.463	1.07821
bup protein. [refseq;acc:nm_012071]	2911		0.00001	0.00001	1
bystin. [swissprot;acc:q13895]	384	0	11244.5	10833.3	1.03796
	1149	1	233.185	239.505	1.0271
c-1-tetrahydrofolate synthase, cytoplasmic (c1-thf synthase) [includes: methylenetetrahydrofolate dehydrogenase (ec 1.5.1.5); methenyltetrahydrofolate cyclohydrolase (ec 3.5.4.9); formyltetrahydrofolate synthetase (ec 6.3.4.3)]. [swissprot;acc:p11586]	1766		231.732	228.932	1.01223
c-jun-amino-terminal kinase interacting protein 3 (jnk-interacting protein 3) (jip-3) (jnk map kinase scaffold protein 3) (mitogen- activated protein kinase 8-interacting protein 3). [swissprot;acc:q9upt6]	2473		217.991	218.644	1.003
c-terminal binding protein 1 (ctbp1). [swissprot;acc:q13363]	1554		193.018	196.215	1.01656
c-terminal binding protein 2 (ctbp2). [swissprot;acc:p56545]	1558		192.977	196.171	1.01655
c-type lectin superfamily member 1 precursor (cartilage-derived c-type lectin). [swissprot;acc:o75596]	844		170.82	178.033	1.04223
c1 domain-containing phosphatase and tensin-like protein isoform 2; putative protein tyrosine phosphatase; c1 domain-containing phosphatase and tensin-like protein; tensin 2. [refseq;acc:nm_015319]	2475		217.571	218.219	1.00298
c18b11 homolog (44.9kd). [refseq;acc:nm_152260]	1625		214.2	217.446	1.01515
c316g12.2 (novel protein similar to predicted yeast, worm and archae- bacterial proteins) (similar to und313) (s. cervisiae) (hypothetical protein). [sptrembl;acc:q9ujk0]	1506		208.339	212.103	1.01807
c367g8.3 (novel protein similar to rpl23a (60s ribosomal protein l23a)) (60s ribosomal protein l23a like). [sptrembl;acc:q9br02]	208	0	10638.4	11846.3	1.11354
	321	1	265.959	241.892	1.09949
c439a6.1 (novel protein similar to heparan sulfate (glucosamine) 3-o- sulfotransferases) (fragment). [sptrembl;acc:q96qi5]	260		196.978	219.421	1.11394
ca2+-dependent endoplasmic reticulum nucleoside diphosphatase; apyrase; soluble calcium-activated nucleotidase scan-1. [refseq;acc:nm_138793]	2577		192.922	192.625	1.00154
caax prenyl protease 1 homolog (ec 3.4.24.-) (prenyl protein-specific endoprotease 1) (farnesylated-proteins converting enzyme 1) (face-1) (zinc metalloproteinase ste24 homolog). [swissprot;acc:o75844]	1448		222.117	226.532	1.01988

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.