MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 2658 to 2707 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

Rank	description	Network Comparison Type	red	green	network_comparison
1329	dj947l8.1.1 (novel cub and sushi (scr repeat) domain protein) (fragment). [sptrembl;acc:q9h4v7]	Divided	218.509	213.648	1.02275
1330	calcipressin 1 (down syndrome critical region protein 1) (myocyte- enriched calcineurin interacting protein 1) (mcip1) (adapt78). [swissprot;acc:p53805]		218.508
	sal-like protein 2 (zinc finger protein sall2) (hsal2). [swissprot;acc:q9y467]	Subtracted	218.471	213.876	4.595
1331	arginine-glutamic acid dipeptide (re) repeats; atrophin 1-like; arginine glutamic acid dipeptide re repeats. [refseq;acc:nm_012102]		218.47	213.875
	calcipressin 3 (down syndrome candidate region 1-like protein 2) (myocyte-enriched calcineurin interacting protein 3) (mcip3). [swissprot;acc:q9uka8]	Divided	218.509	213.649	1.02275
1332	atrophin-1 (dentatorubral-pallidoluysian atrophy protein). [swissprot;acc:p54259]	Subtracted	218.471	213.876	4.595
	cytochrome oxidase biogenesis protein oxa1, mitochondrial precursor (oxa1-like protein) (oxa1hs). [swissprot;acc:q15070]	Divided	220.681	215.78	1.02271
1333	60s ribosomal protein l34, mitochondrial precursor (l34mt). [swissprot;acc:q9bq48]
	dead (asp-glu-ala-asp) box polypeptide 47; hqp0256 protein. [refseq;acc:nm_016355]	Subtracted	218.47	213.875	4.595
1334	jm4 protein. [refseq;acc:nm_007213]	Divided	199.643	204.163	1.02264
	sal-like protein 1 (zinc finger protein sall1) (spalt-like transcription factor 1) (hsal1). [swissprot;acc:q9nsc2]	Subtracted	218.47	213.875	4.595
1335	cytoskeleton related vitamin a responsive protein; glutamate transporter eeac1-associated protein; dermal papilla derived protein 11; putative mapk activating protein pm27. [refseq;acc:nm_006407]	Divided	199.771	204.287	1.02261
	sal-like protein 4 (zinc finger protein sall4). [swissprot;acc:q9ujq4]	Subtracted	218.471	213.876	4.595
1336	2-oxoisovalerate dehydrogenase beta subunit, mitochondrial precursor (ec 1.2.4.4) (branched-chain alpha-keto acid dehydrogenase e1 component beta chain) (bckdh e1-beta). [swissprot;acc:p21953]		218.47	213.875
	n-acetylgalactosamine kinase (ec 2.7.1.-) (galnac kinase) (galactokinase 2). [swissprot;acc:q01415]	Divided	215.162	210.412	1.02257
1337	ccr4-not transcription complex, subunit 4; not4 (negative regulator of transcription 4, yeast) homolog; ccr4-not transcription complex, subunit. [refseq;acc:nm_013316]	Subtracted	218.47	213.875	4.595
	galactose-1-phosphate uridylyltransferase (ec 2.7.7.12) (gal-1-p uridylyltransferase) (udp-glucose--hexose-1-phosphate uridylyltransferase). [swissprot;acc:p07902]	Divided	215.162	210.412	1.02257
1338	phosphatidylinositol-binding clathrin assembly protein (clathrin assembly lymphoid myeloid leukemia protein). [swissprot;acc:q13492]	Subtracted	218.47	213.875	4.595
	udp-glucose 4-epimerase (ec 5.1.3.2) (galactowaldenase) (udp- galactose 4-epimerase). [swissprot;acc:q14376]	Divided	215.162	210.412	1.02257
1339	clathrin coat assembly protein ap180 (clathrin coat associated protein ap180) (91 kda synaptosomal-associated protein). [swissprot;acc:o60641]	Subtracted	218.471	213.876	4.595
	epididymal secretory protein e1 precursor (niemann-pick disease type c2 protein) (epi-1) (he1) (epididymal secretory protein 14.6) (esp14.6). [swissprot;acc:q15668]	Divided	205.204	200.71	1.02239
1340	histone-lysine n-methyltransferase, h3 lysine-9 specific 2 (ec 2.1.1.43) (histone h3-k9 methyltransferase 2) (h3-k9-hmtase 2) (suppressor of variegation 3-9 homolog 2) (su(var)3-9 homolog 2). [swissprot;acc:q9h5i1]		226.433	231.491	1.02234
	membrane-associated nucleic acid binding protein. [refseq;acc:nm_018835]	Subtracted	218.47	213.875	4.595
1341	eukaryotic translation initiation factor 2 subunit 1 (eukaryotic translation initiation factor 2 alpha subunit) (eif-2-alpha) (eif- 2alpha) (eif-2a). [swissprot;acc:p05198]	Divided	226.433	231.491	1.02234
	polypyrimidine tract-binding protein 1 (ptb) (heterogeneous nuclear ribonucleoprotein i) (hnrnp i) (57 kda rna-binding protein pptb-1). [swissprot;acc:p26599]	Subtracted	218.47	213.875	4.595
1342	histone-lysine n-methyltransferase, h3 lysine-9 specific 1 (ec 2.1.1.43) (histone h3-k9 methyltransferase 1) (h3-k9-hmtase 1) (suppressor of variegation 3-9 homolog 1) (su(var)3-9 homolog 1). [swissprot;acc:o43463]	Divided	226.433	231.491	1.02234
	sal-like protein 3 (zinc finger protein sall3) (hsall3). [swissprot;acc:q9bxa9]	Subtracted	218.47	213.876	4.594
1343	m-phase inducer phosphatase 1 (ec 3.1.3.48) (dual specificity phosphatase cdc25a). [swissprot;acc:p30304]	Divided	258.558	252.916	1.02231
	ubiquitin carboxyl-terminal hydrolase 8 (ec 3.1.2.15) (ubiquitin thiolesterase 8) (ubiquitin-specific processing protease 8) (deubiquitinating enzyme 8). [swissprot;acc:p40818]	Subtracted	218.47	213.876	4.594
1344	exonuclease 1 isoform b; rad2 nuclease family member, homolog of s. cerevisiae exonuclease 1. [refseq;acc:nm_006027]	Divided	216.772	221.594	1.02224
	rod1 regulator of differentiation 1; fission yeast differentiation regulator; regulator of differentiation (in s. pombi) 1; regulator of differentiation (in s. pombe) 1. [refseq;acc:nm_005156]	Subtracted	218.47	213.876	4.594
1345	phd finger protein 9. [refseq;acc:nm_018062]	Divided	216.772	221.594	1.02224
	polypyrimidine tract binding protein 2; neural polypyrimidine tract binding protein; ptb-like protein. [refseq;acc:nm_021190]	Subtracted	218.47	213.876	4.594
1346	adaptor-associated kinase 1. [refseq;acc:nm_014911]
	small optic lobes homolog; small optic lobes, drosophila, homolog of. [refseq;acc:nm_005632]	Divided	216.772	221.594	1.02224
1347	lipoic acid synthetase, mitochondrial (lip-syn) (lipoate synthase) (hussy-01) (fragment). [swissprot;acc:o43766]		204.961	209.517	1.02223
	rho-gtpase activating protein 10. [refseq;acc:nm_020824]	Subtracted	218.47	213.876	4.594
1348	growth-arrest-specific protein 7 (gas-7). [swissprot;acc:o60861]
	zinc finger protein zic 1 (zinc finger protein of the cerebellum 1). [swissprot;acc:q15915]	Divided	218.569	213.832	1.02215
1349	40s ribosomal protein s8. [swissprot;acc:p09058]	Subtracted	218.64	214.049	4.591
	zinc finger protein zic 3 (zinc finger protein of the cerebellum 3). [swissprot;acc:o60481]	Divided	218.572	213.841	1.02212
1350	eyes absent homolog 1. [swissprot;acc:q99502]	Subtracted	218.463	213.872	4.591
	zinc finger protein zic 2 (zinc finger protein of the cerebellum 2). [swissprot;acc:o95409]	Divided	218.574	213.847	1.0221
1351	eyes absent homolog 4. [swissprot;acc:o95677]	Subtracted	218.449	213.864	4.585
	prohibitin. [swissprot;acc:p35232]	Divided	211.513	206.941	1.02209
1352		Subtracted			4.572
	repressor of estrogen receptor activity; b-cell associated protein. [refseq;acc:nm_007273]	Divided			1.02209
1353	heparin sulfate n-deacetylase/n-sulfotransferase (ec 2.8.2.-) (n- hsst) (n-heparin sulfate sulfotransferase) (glucosaminyl n- deacetylase/n-sulfotransferase). [swissprot;acc:p52849]		228.409	223.475	1.02208
	repressor of estrogen receptor activity; b-cell associated protein. [refseq;acc:nm_007273]	Subtracted	211.513	206.941	4.572
1354	eyes absent homolog 2. [swissprot;acc:o00167]		218.417	213.848	4.569

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.