Scientific

MK5 Microarray Data


Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

  • value_type as 'ranked' since this provides a very robust analysis method.
  • intercation map as 'high confidence'
  • network_comparison type as 'Divided' since this leads to a natural grouping of similar proteins
  • filtered as 'true' since this will only use the microarray measurements that have a sufficiently large confidence level.

  • Navigation/Query Panel:
    Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].
    Rank Gene Hugo description Value Type Network Comparison Type Interaction Map Filtered red green network_comparison
    Results: HTML CSV LaTeX Showing element 2813 to 2862 of 3228 in total
    Value Type	Ranked
    Network Comparison Type Divided
    Interaction Map High confidence
    Filtered 1
    red 0.00001
    green 0.00001
    network_comparison 1
    Rank Hugo description 2813 HDAC3 histone deacetylase 3 (hd3) (rpd3-2). [source:swissprot;acc:o15379] 2814 SPSB1 spry domain-containing socs box protein ssb-1. [source:refseq;acc:nm_025106] 2815 NMUR1 g protein-coupled receptor 66. [source:refseq;acc:nm_006056] 2816 TIGD1 tigger transposable element derived 1; jerky (mouse) homolog-like. [source:refseq;acc:nm_145702] 2817 TBCA tubulin-specific chaperone a (tubulin-folding cofactor a) (cfa) (tcp1-chaperonin cofactor a). [source:swissprot;acc:o75347] 2818 UGT2B7 udp-glucuronosyltransferase 2b7 precursor, microsomal (ec 2.4.1.17) (udpgt) (3,4-catechol estrogen specific) (udpgth-2). [source:swissprot;acc:p16662] 2819 udp-glucuronosyltransferase 2b11 precursor, microsomal (ec 2.4.1.17) (udpgt). [source:swissprot;acc:o75310] 2820 peregrin (bromodomain and phd finger-containing protein 1) (br140 protein). [source:swissprot;acc:p55201] 2821 ATP6V0E2 vacuolar proton-atpase subunit. [source:sptrembl;acc:q8nhe4] 2822 SLC30A1 zinc transporter 1 (znt-1). [source:swissprot;acc:q9y6m5] 2823 NFRKB nuclear factor related to kappa b binding protein. [source:refseq;acc:nm_006165] 2824 HSPB2 heat-shock protein, beta-2 (hspb2) (dmpk-binding protein) (mkbp). [source:swissprot;acc:q16082] 2825 mitochondrial 28s ribosomal protein s6 (mrp-s6). [source:swissprot;acc:p82932] 2826 suppressor of actin 1. [source:refseq;acc:nm_014016] 2827 GPS1 cop9 signalosome complex subunit 1 (g protein pathway suppressor 1) (gps1 protein) (mfh protein). [source:swissprot;acc:q13098] 2828 ubiquitin-conjugating enzyme e2-18 kda ubch7 (ec 6.3.2.19) (ubiquitin- protein ligase) (ubiquitin carrier protein) (ubcm4) (e2-f1) (l-ubc). [source:swissprot;acc:p51966] 2829 ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1; aspl protein; renal cell carcinoma gene on chromosome 17; renal cell carcinoma, papillary, 17 gene; aspscr1/tfe3 fusion gene, included. [source:refseq;acc:nm_024083] 2830 CSNK1G1 casein kinase i, gamma 1 isoform (ec 2.7.1.-) (cki-gamma 1). [source:swissprot;acc:q9hcp0] 2831 FEN1 flap endonuclease-1 (ec 3.-.-.-) (maturation factor 1) (mf1). [source:swissprot;acc:p39748] 2832 SEMA6B semaphorin 6b precursor (semaphorin z) (sema z). [source:swissprot;acc:q9h3t3] 2833 TPM4 tropomyosin alpha 4 chain (tropomyosin 4) (tm30p1). [source:swissprot;acc:p07226] 2834 ATP5L atp synthase g chain, mitochondrial (ec 3.6.3.14) (atpase subunit g). [source:swissprot;acc:o75964] 2835 UGT1A9 udp-glucuronosyltransferase 1-6 precursor, microsomal (ec 2.4.1.17) (udp-glucuronosyltransferase 1a6) (udpgt) (ugt1*6) (ugt1-06) (ugt1.6) (ugt-1f) (ugt1f) (phenol-metabolizing udp-glucuronosyltransferase). [source:swissprot;acc:p19224] 2836 COG1 conserved oligomeric golgi complex component 1. [source:swissprot;acc:q8wtw3] 2837 TK2 thymidine kinase 2, mitochondrial precursor (ec 2.7.1.21) (mt-tk). [source:swissprot;acc:o00142] 2838 DCHS1 protocadherin 16 precursor (cadherin 19) (cadherin fibroblast 1). [source:swissprot;acc:q96jq0] 2839 TAF10 transcription initiation factor tfiid 30 kda subunit (tafii-30) (tafii30). [source:swissprot;acc:q12962] 2840 CUL5 vasopressin-activated calcium-mobilizing receptor (vacm-1) (cullin homolog 5) (cul-5). [source:swissprot;acc:q93034] 2841 COPS2 cop9 signalosome complex subunit 2 (signalosome subunit 2) (sgn2) (thyroid receptor interacting protein 15) (trip15). [source:swissprot;acc:q15647] 2842 NOLC1 nucleolar phosphoprotein p130 (nucleolar 130 kda protein) (140 kda nucleolar phosphoprotein) (nopp140) (nucleolar and coiled-body phosphoprotein 1). [source:swissprot;acc:q14978] 2843 SENP8 sentrin-specific protease 8 (ec 3.4.22.-) (sentrin/sumo-specific protease senp8) (cysteine protease fksg8). [source:swissprot;acc:q96ld8] 2844 FBN1 fibrillin 1 precursor. [source:swissprot;acc:p35555] 2845 PACSIN3 protein kinase c and casein kinase substrate in neurons protein 3 (sh3 domain-containing protein 6511) (endophilin i). [source:swissprot;acc:q9uks6] 2846 C10orf118 ctcl tumor antigen l14-2. [source:refseq;acc:nm_018017] 2847 DACH1 dachshund homolog isoform a. [source:refseq;acc:nm_080759] 2848 GTF2A1 transcription initiation factor iia alpha and beta chains (tfiia p35 and p19 subunits) (tfiia-42) (tfiial). [source:swissprot;acc:p52655] 2849 SNAPC3 snrna activating protein complex 50 kda subunit (snapc 50 kda subunit) (proximal sequence element-binding transcription factor beta subunit) (pse-binding factor beta subunit) (ptf beta subunit). [source:swissprot;acc:q92966] 2850 CDK5 cell division protein kinase 5 (ec 2.7.1.-) (tau protein kinase ii catalytic subunit) (tpkii catalytic subunit) (serine/threonine protein kinase pssalre). [source:swissprot;acc:q00535] 2851 ORC5L origin recognition complex subunit 5. [source:swissprot;acc:o43913] 2852 HIST1H2AA histone h2a; h2a histone family, member r. [source:refseq;acc:nm_170745] 2853 TIGD6 tigger transposable element derived 6. [source:refseq;acc:nm_030953] 2854 NARG1 transcriptional coactivator tubedown-100 isoform 1; putative n-acetyltransferase; gastric cancer antigen ga19. [source:refseq;acc:nm_057175] 2855 HPGD 15-hydroxyprostaglandin dehydrogenase [nad(+)] (ec 1.1.1.141) (pgdh). [source:swissprot;acc:p15428] 2856 HMGB2 high mobility group protein 2 (hmg-2). [source:swissprot;acc:p26583] 2857 PRKCD protein kinase c, delta type (ec 2.7.1.-) (npkc-delta). [source:swissprot;acc:q05655] 2858 RYK tyrosine-protein kinase ryk precursor (ec 2.7.1.112). [source:swissprot;acc:p34925] 2859 NKX6-1 homeobox protein nkx-6.1. [source:swissprot;acc:p78426] 2860 importin 9. [source:refseq;acc:nm_018085] 2861 GNPDA2 glucosamine-6-phosphate isomerase. [source:refseq;acc:nm_138335] 2862 SDC3 syndecan-3 (synd3). [source:swissprot;acc:o75056] Legend: - Rank is the rank after comparing the two networks - Hugo is the HGNC identifier if it exists - Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions. - Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them - Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions. - Filtered specifies whether we only included the high confidence microarry measurements or not.

    - http://analysis.yellowcouch.org/