MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	description	Hugo	Network Comparison Type	Value Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 1308 to 1357 of 8289 in total

Network Comparison Type  : Divided
Value Type  : Ranked
Filtered  : 1

Rank	description	Hugo	Interaction Map	red	green	network_comparison
654	zinc finger homeobox protein 1b (smad interacting protein 1) (smadip1) (hrihfb2411). [swissprot;acc:o60315]	ZEB2	Low confidence	205.995	200.27	1.02859
655	docking protein 1 (p62(dok)) (downstream of tyrosine kinase 1) (pp62). [swissprot;acc:q99704]	DOK1	High confidence	216.504	204.622	1.05807
	transcription factor 8 (nil-2-a zinc finger protein) (negative regulator of il2). [swissprot;acc:p37275]	ZEB1	Low confidence	205.995	200.27	1.02859
656	integrin beta-2 precursor (cell surface adhesion glycoproteins lfa- 1/cr3/p150,95 beta-subunit) (cd18) (complement receptor c3 beta- subunit). [swissprot;acc:p05107]	ITGB2		206.339	200.608	1.02857
	tyrosine-protein kinase frk (ec 2.7.1.112) (nuclear tyrosine protein kinase rak). [swissprot;acc:p42685]	FRK	High confidence	216.504	204.622	1.05807
657	integrin beta-7 precursor. [swissprot;acc:p26010]	ITGB7	Low confidence	206.341	200.609	1.02857
	synapsin iii. [swissprot;acc:o14994]	SYN3	High confidence	229.072	216.576	1.0577
658	aspartate beta-hydroxylase isoform b; junctin isoform 1; junctate; aspartyl/asparaginyl-beta-hydroxylase; peptide-aspartate beta-dioxygenase; humbug. [refseq;acc:nm_032468]	no value
	integrin beta-3 precursor (platelet membrane glycoprotein iiia) (gpiiia) (cd61 antigen). [swissprot;acc:p05106]	ITGB3	Low confidence	206.342	200.61	1.02857
659	hairy/enhancer-of-split related with yrpw motif 1 (hairy and enhancer of split related-1) (hesr-1) (cardiovascular helix-loop-helix factor 2) (hes-related repressor protein 2 herp2). [swissprot;acc:q9y5j3]	HEY1	High confidence	229.072	216.576	1.0577
	tumor protein p53 inducible protein 3; quinone oxidoreductase homolog; p53-induced gene 3 protein. [refseq;acc:nm_004881]	TP53I3	Low confidence	175.504	170.633	1.02855
660	actin binding lim protein 2. [refseq;acc:nm_032432]	ABLIM2	High confidence	229.072	216.576	1.0577
	integrin alpha-7 precursor. [swissprot;acc:q13683]	ITGA7	Low confidence	206.32	200.601	1.02851
661	hairy/enhancer-of-split related with yrpw motif-like. [refseq;acc:nm_014571]	HEYL	High confidence	229.072	216.576	1.0577
	son of sevenless protein homolog 1 (sos-1). [swissprot;acc:q07889]	SOS1	Low confidence	200.62	195.059	1.02851
662	integrin alpha-6 precursor (vla-6) (cd49f). [swissprot;acc:p23229]	ITGA6		206.321	200.601
	synapsin ii. [swissprot;acc:q92777]	SYN2	High confidence	229.072	216.576	1.0577
663	integrin alpha-3 precursor (galactoprotein b3) (gapb3) (vla-3 alpha chain) (cd49c). [swissprot;acc:p26006]	ITGA3	Low confidence	206.32	200.601	1.02851
	mitochondrial ribosome recycling factor. [refseq;acc:nm_138777]	MRRF	High confidence	229.072	216.576	1.0577
664	peroxisomal targeting signal 1 receptor (peroxismore receptor 1) (peroxisomal c-terminal targeting signal import receptor) (pts1-bp) (peroxin-5) (pts1 receptor). [swissprot;acc:p50542]	PEX5
	pre-mrna processing factor 31 homolog; pre-mrna processing factor 31 homolog (yeast). [refseq;acc:nm_015629]	PRPF31	Low confidence	201.821	196.233	1.02848
665	hairy/enhancer-of-split related with yrpw motif 2; gridlock; hes-related repressor protein 1. [refseq;acc:nm_012259]	HEY2	High confidence	229.072	216.576	1.0577
	s-phase kinase-associated protein 1a (cyclin a/cdk2-associated protein p19) (p19a) (p19skp1) (rna polymerase ii elongation factor-like protein) (organ of corti protein 2) (ocp-ii protein) (ocp-2) (transcription elongation factor b) (siii). [swissprot;acc:p34991]	SKP1A	Low confidence	204.882	199.214	1.02845
666	son of sevenless protein homolog 2 (sos-2). [swissprot;acc:q07890]	SOS2		200.639	195.092	1.02843
	transcription factor hes-1 (hairy and enhancer of split 1) (hairy- like) (hhl) (hairy homolog). [swissprot;acc:q14469]	HES1	High confidence	229.072	216.576	1.0577
667	ba528a10.3.2 (novel protein similar to kiaa0161, isoform 2) (fragment). [sptrembl;acc:q9bx39]	RNF144B	Low confidence	208.62	202.855	1.02842
	delta3,5-delta2,4-dienoyl-coa isomerase, mitochondrial precursor (ec 5.3.3.-). [swissprot;acc:q13011]	ECH1	High confidence	229.072	216.576	1.0577
668	actin-binding lim protein 1 isoform a; lim actin-binding protein 1; limatin; actin-binding lim protein. [refseq;acc:nm_002313]	ABLIM1
	inositol oxygenase (ec 1.13.99.1) (myo-inositol oxygenase) (aldehyde reductase-like 6) (renal-specific oxidoreductase) (kidney-specific protein 32). [swissprot;acc:q9ugb7]	MIOX	Low confidence	212.062	206.202	1.02842
669	cytochrome p450 3a43 (ec 1.14.14.1). [swissprot;acc:q9hb55]	CYP3A43		203.712	198.082
	synapsin i (brain protein 4.1). [swissprot;acc:p17600]	SYN1	High confidence	229.072	216.576	1.0577
670	autoantigen ngp-1. [swissprot;acc:q13823]	GNL2		250.302	236.817	1.05694
	tgf beta-inducible nuclear protein 1; hairy cell leukemia protein 1. [refseq;acc:nm_014886]	no value	Low confidence	204.551	198.901	1.02841
671	integrin beta-1 precursor (fibronectin receptor beta subunit) (cd29 antigen) (integrin vla-4 beta subunit). [swissprot;acc:p05556]	ITGB1		206.277	200.582	1.02839
	nucleotide-binding protein 1 (nbp 1). [swissprot;acc:p53384]	NUBP1	High confidence	210.739	199.398	1.05688
672	cytochrome p450 3a7 (ec 1.14.14.1) (cypiiia7) (p450-hfla). [swissprot;acc:p24462]	CYP3A7	Low confidence	203.727	198.116	1.02832
	nucleotide binding protein 2 (nbp 2). [swissprot;acc:q9y5y2]	NUBP2	High confidence	210.739	199.398	1.05688
673	dead (asp-glu-ala-asp) box polypeptide 31 isoform 1; dead/dexh helicase ddx31. [refseq;acc:nm_022779]	DDX31	Low confidence	203.604	197.996	1.02832
	peripheral plasma membrane protein cask (ec 2.7.1.-) (hcask) (calcium/calmodulin-dependent serine protein kinase) (lin-2 homolog). [swissprot;acc:o14936]	CASK	High confidence	226.497	214.355	1.05664
674	enteropeptidase precursor (ec 3.4.21.9) (enterokinase). [swissprot;acc:p98073]	PRSS7	Low confidence	204.81	199.174	1.0283
	hypoxia-inducible factor-3 alpha isoform a; inhibitory pas domain protein. [refseq;acc:nm_152794]	HIF3A	High confidence	226.497	214.355	1.05664
675	cytochrome p450 3a5 (ec 1.14.14.1) (cypiiia5) (p450-pcn3). [swissprot;acc:p20815]	CYP3A5	Low confidence	203.702	198.095	1.0283
	single-minded homolog 1. [swissprot;acc:p81133]	SIM1	High confidence	226.497	214.355	1.05664
676	deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial precursor (ec 3.6.1.23) (dutpase) (dutp pyrophosphatase). [swissprot;acc:p33316]	DUT	Low confidence	202.698	197.124	1.02828
	dna-directed rna polymerase ii 19 kda polypeptide (ec 2.7.7.6) (rpb7). [swissprot;acc:p52433]	POLR2G	High confidence	232.469	245.613	1.05654
677	protein ad-016 (protein cgi-116) (x0009). [swissprot;acc:q9y3c0]	CCDC53	Low confidence	207.03	201.339	1.02827
	u6 snrna-associated sm-like protein lsm4 (glycine-rich protein) (grp). [swissprot;acc:q9y4z0]	LSM4	High confidence	228.944	216.745	1.05628
678	cytochrome p450 3a4 (ec 1.14.13.67) (quinine 3-monooxygenase) (cypiiia4) (nifedipine oxidase) (nf-25) (p450-pcn1). [swissprot;acc:p08684]	CYP3A4	Low confidence	203.747	198.152	1.02824
	sorting nexin 5. [swissprot;acc:q9y5x3]	SNX5	High confidence	208.482	220.175	1.05609
679	glioma-amplified sequence-41; numa binding protein 1. [refseq;acc:nm_006530]	YEATS4	Low confidence	198.424	192.974	1.02824

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.