MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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description	Gene	Network Comparison Type	Rank	Value Type	Hugo	Interaction Map	red	Filtered	network_comparison	green

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Showing element 2562 to 2611 of 25824 in total

Interaction Map  : High confidence
Filtered  : 1

description	Network Comparison Type	Rank	Value Type	Hugo	red	network_comparison	green
aryl-hydrocarbon interacting protein-like 1. [swissprot;acc:q9nzn9]	Divided	1156	Ranked	AIPL1	224.307	1.02646	230.242
		1903	Measured		5204.25	1.06261	5530.11
		2657	Rooted		58.9993	1.00507	59.2983
	Subtracted	1074	Ranked		224.307	5.935	230.242
		1090	Squared		22126.7	3271.8	25398.5
		2013	Measured		5204.25	325.86	5530.11
		2668	Rooted		58.9993	0.299	59.2983
asc-1 complex subunit p100. [refseq;acc:nm_032204]	Divided	1169		ASCC2	62.8958	1.04757	65.8878
		1206	Measured		5946.33	1.08635	6459.79
		1374	Ranked		216.542	1.02187	211.908
		1904	Squared		27114.7	1.09399	29663.3
	Subtracted	1126	Measured		5946.33	513.46	6459.79
		1141	Rooted		62.8958	2.992	65.8878
		1324	Ranked		216.542	4.634	211.908
		1583	Squared		27114.7	2548.6	29663.3
asparagine synthetase [glutamine-hydrolyzing] (ec 6.3.5.4) (glutamine- dependent asparagine synthetase) (ts11 cell cycle control protein). [swissprot;acc:p08243]	Divided	576		ASNS	26570.7	1.18569	31504.6
		730	Measured		6000.23	1.11611	6696.89
		865	Rooted		62.7551	1.06202	66.6474
		1057	Ranked		219.01	1.03079	212.468
	Subtracted	549	Squared		26570.7	4933.9	31504.6
		676	Measured		6000.23	696.66	6696.89
		852	Rooted		62.7551	3.8923	66.6474
		1033	Ranked		219.01	6.542	212.468
asparaginyl-trna synthetase, cytoplasmic (ec 6.1.1.22) (asparagine-- trna ligase) (asnrs). [swissprot;acc:o43776]	Divided	957	Squared	NARS	26822.8	1.15243	30911.4
		2103	Measured		6847.82	1.05486	7223.51
		2323	Ranked		192.773	1.00476	193.691
		2392	Rooted		70.8454	1.01598	71.9775
	Subtracted	764	Squared		26822.8	4088.6	30911.4
		1840	Measured		6847.82	375.69	7223.51
		2352	Ranked		192.773	0.918	193.691
		2354	Rooted		70.8454	1.1321	71.9775
aspartate beta-hydroxylase isoform b; junctin isoform 1; junctate; aspartyl/asparaginyl-beta-hydroxylase; peptide-aspartate beta-dioxygenase; humbug. [refseq;acc:nm_032468]	Divided	630		no value	60.0129	1.07872	64.7371
		658	Ranked		229.072	1.0577	216.576
		1010	Measured		5791.82	1.0948	6340.86
		2330	Squared		28264.4	1.07508	30386.4
	Subtracted	619	Rooted		60.0129	4.7242	64.7371
		623	Ranked		229.072	12.496	216.576
		965	Measured		5791.82	549.04	6340.86
		1935	Squared		28264.4	2122	30386.4
aspartyl-trna synthetase (ec 6.1.1.12) (aspartate--trna ligase) (asprs). [swissprot;acc:p14868]	Divided	991		DARS	26705.9	1.14952	30699
		2026	Measured		6766.45	1.0575	7155.54
		2327	Rooted		70.2102	1.01857	71.5141
		2541	Ranked		194.505	1.00204	194.902
	Subtracted	794	Squared		26705.9	3993.1	30699
		1755	Measured		6766.45	389.09	7155.54
		2280	Rooted		70.2102	1.3039	71.5141
		2544	Ranked		194.505	0.397	194.902
associated molecule with the sh3 domain of stam (amsh) like protein. [refseq;acc:nm_020799]	Divided	49	Squared	STAMBPL1	28994.2	1.69212	17134.8
		126	Ranked		94	1.21277	114
		146	Measured		11068	1.30082	8508.5

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.