MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Gene	Value Type	description	Network Comparison Type	Filtered	Rank	Interaction Map	green	network_comparison	red

Results: HTML CSV LaTeX

Showing element 1 to 50 of 38536 in total

Value Type  : Measured
Network Comparison Type  : Divided

description	Filtered	Rank	Interaction Map	green	network_comparison	red
1,4-alpha-glucan branching enzyme (ec 2.4.1.18) (glycogen branching enzyme) (brancher enzyme). [swissprot;acc:q04446]	0	37	High confidence	934.348	2.79409	334.401
		131	Low confidence	851.77	1.31954	645.504
	1	60	High confidence	2765.82	1.6231	4489.19
		4914	Low confidence	7900.54	1.00597	7853.62
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha (ec 2.3.1.51) (1- agp acyltransferase 1) (1-agpat 1) (lysophosphatidic acid acyltransferase-alpha) (lpaat-alpha) (1-acylglycerol-3-phosphate o- acyltransferase 1) (g15 protein). [swissprot;acc:q99943]		509	High confidence	8630.06	1.14278	7551.8
		885	Low confidence	8585.64	1.03993	8255.95
1-acyl-sn-glycerol-3-phosphate acyltransferase beta (ec 2.3.1.51) (1- agp acyltransferase 2) (1-agpat 2) (lysophosphatidic acid acyltransferase-beta) (lpaat-beta) (1-acylglycerol-3-phosphate o- acyltransferase 2). [swissprot;acc:o15120]		508	High confidence	8636.87	1.14293	7556.75
		880	Low confidence	8587.03	1.04001	8256.68
1-acyl-sn-glycerol-3-phosphate acyltransferase delta (ec 2.3.1.51) (1- agp acyltransferase 4) (1-agpat 4) (lysophosphatidic acid acyltransferase-delta) (lpaat-delta) (1-acylglycerol-3-phosphate o- acyltransferase 4). [swissprot;acc:q9nrz5]		237		9081.29	1.06457	8530.51
		514	High confidence	8532.02	1.1411	7477
1-acyl-sn-glycerol-3-phosphate acyltransferase gamma (ec 2.3.1.51) (1- agp acyltransferase 3) (1-agpat 3) (lysophosphatidic acid acyltransferase-gamma) (lpaat-gamma) (1-acylglycerol-3-phosphate o- acyltransferase 3). [swissprot;acc:q9nrz7]		252	Low confidence	9018.94	1.06194	8492.92
		513	High confidence	8543.66	1.14143	7485.08
1-aminocyclopropane-1-carboxylate synthase. [refseq;acc:nm_032592]		2035	Low confidence	8323.04	1.03199	8065.05
1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 4 (ec 3.1.4.11) (phosphoinositide phospholipase c) (plc-beta-4) (phospholipase c-beta-4). [swissprot;acc:q15147]		2882		8175.27	1.02859	7948.01
		3126	High confidence	0.00001	1	0.00001
10 kda heat shock protein, mitochondrial (hsp10) (10 kda chaperonin) (cpn10). [swissprot;acc:q04984]		1136		6303.92	1.08864	5790.65
		2182	Low confidence	8386.58	1.03148	8130.62
10-formyltetrahydrofolate dehydrogenase (ec 1.5.1.6) (10-fthfdh). [swissprot;acc:o75891]		1693		8246.34	1.03323	7981.12
		2922	High confidence	0.00001	1	0.00001
130 kda leucine-rich protein (lrp 130) (gp130) (leucine-rich ppr-motif containing protein). [swissprot;acc:p42704]		4071	Low confidence	8067.47	1.02166	7896.47
14-3-3 protein beta/alpha (protein kinase c inhibitor protein-1) (kcip-1) (protein 1054). [swissprot;acc:p31946]		575		8965.49	1.04579	8572.9
		1411	High confidence	6262.07	1.07743	5812.02
14-3-3 protein epsilon (mitochondrial import stimulation factor l subunit) (protein kinase c inhibitor protein-1) (kcip-1) (14-3-3e). [swissprot;acc:p42655]		3088		0.00001	1	0.00001
		3095	Low confidence	8370.12	1.02772	8144.39
14-3-3 protein zeta/delta (protein kinase c inhibitor protein-1) (kcip-1) (factor activating exoenzyme s) (fas). [swissprot;acc:p29312]		591		8956.98	1.04562	8566.17
		1415	High confidence	6265.44	1.0774	5815.33
14.5 kda translational inhibitor protein (p14.5) (uk114 antigen homolog). [swissprot;acc:p52758]		993	Low confidence	8288.57	1.03829	7982.87
		1600	High confidence	6788.96	1.07145	6336.22
15 kda selenoprotein precursor. [swissprot;acc:o60613]		1043		6933.36	1.09283	6344.41
		3577	Low confidence	8083.96	1.02563	7881.96
15-hydroxyprostaglandin dehydrogenase [nad(+)] (ec 1.1.1.141) (pgdh). [swissprot;acc:p15428]		2067		8425.81	1.03184	8165.8
		2855	High confidence	0.00001	1	0.00001
16.7kd protein. [refseq;acc:nm_016139]		4005	Low confidence	8483.17	1.02235	8297.71
17 beta-hydroxysteroid dehydrogenase. [sptrembl;acc:q13034]		1051		8498.04	1.0377	8189.31
		2521	High confidence	6113.96	1.02511	5964.17
17-beta-hydroxysteroid dehydrogenase type vii-like. [refseq;acc:nm_182829]	0	778	Low confidence	4869.42	1.00902	4825.89
	1	631		8689.28	1.04487	8316.12
2,4-dienoyl coa reductase 2, peroxisomal; peroxisomal 2,4-dienoyl-coa reductase. [refseq;acc:nm_020664]		4609		8354	1.01654	8218.07
2-hydroxyacylsphingosine 1-beta-galactosyltransferase precursor (ec 2.4.1.45) (udp-galactose-ceramide galactosyltransferase) (ceramide udp-galactosyltransferase) (cerebroside synthase). [swissprot;acc:q16880]		2443		7708.55	1.03048	7480.51
2-hydroxyphytanoyl-coa lyase (ec 4.1.-.-) (2-hpcl) (hspc279). [swissprot;acc:q9uj83]		1393	High confidence	6192.72	1.07824	5743.36
		1973	Low confidence	7938.52	1.03229	7690.22
2-oxoglutarate dehydrogenase e1 component, mitochondrial precursor (ec 1.2.4.2) (alpha-ketoglutarate dehydrogenase). [swissprot;acc:q02218]		1032		8332.97	1.03784	8029.13
		2506	High confidence	6362.25	1.0261	6200.39
2-oxoisovalerate dehydrogenase alpha subunit, mitochondrial precursor (ec 1.2.4.4) (branched-chain alpha-keto acid dehydrogenase e1 component alpha chain) (bckdh e1-alpha). [swissprot;acc:p12694]		2451		6957.34	1.03268	6737.15
		3458	Low confidence	8054.46	1.02623	7848.62
2-oxoisovalerate dehydrogenase beta subunit, mitochondrial precursor (ec 1.2.4.4) (branched-chain alpha-keto acid dehydrogenase e1 component beta chain) (bckdh e1-beta). [swissprot;acc:p21953]		2288	High confidence	6048.94	1.04585	5783.76
		4165	Low confidence	8033.99	1.02067	7871.26
20 kda nuclear cap binding protein (ncbp 20 kda subunit) (cbp20) (ncbp interacting protein 1) (nip1). [swissprot;acc:p52298]		107	High confidence	5843.51	1.36977	4266.04
		234	Low confidence	8143.47	1.06489	7647.22
25 kda brain-specific protein (p25-alpha). [swissprot;acc:o94811]		863		8007.43	1.04033	7697.01

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.